PERSONALISATION OF IMMUNOSUPPRESSION BY MONITORING VIRAL LOAD POST KIDNEY TRANSPLANTATION - A RANDOMISED CONTROLLED PHASE II TRIAL

Información del proyecto

TTV GUIDE TX

Identificador del acuerdo de subvención: 896932

DOI

10.3030/896932

Fecha de la firma de la CE 2 Febrero 2021

Fecha de inicio 1 Mayo 2021

Fecha de finalización 30 Abril 2026

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 6 099 831,00

Aportación de la UE

€ 6 099 831,00

Coordinado por

MEDIZINISCHE UNIVERSITAET WIEN
Austria

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (4)

M30 Review Report

Public report on activities of the project

Ethics and Governance framework
Conclusions from the Kick-off
M18 Review report

Public report on activities of the project

Websites, patent fillings, videos etc. (1)

TTV GUIDE TX public website

Publicaciones

Peer reviewed articles (34)

Comparison of Torque Teno Virus DNA Load in Plasma and Whole Blood

Autores: Aurélie Truffot, Lara Cabezas, Manon Gnesotto, Julien Lupo, Patrice Morand, Thomas Jouve, Johan Noble, Raphaële Germi
Publicado en: Kidney International Reports, 2025, ISSN 2468-0249
Editor: Elsevier BV
DOI: 10.1016/j.ekir.2025.04.033

Attenuation of Torque teno viral load over time in kidney transplantation recipients treated with calcineurin inhibitors is mitigated after conversion to belatacept

Autores: O. W. Bredewold, W. T. Moest, J. W. de Fijter, E. Meijers, A. Bruchfeld, K. Skov, M. H. S. Svensson, J. Chan, L. Mjornstedt, S. S. Sorensen, B. Fellstrom, M. C. W. Feltkamp, A. J. van Zonneveld, J. I. Rotmans
Publicado en: Journal of Medical Virology, Edición 96, 2024, ISSN 0146-6615
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jmv.29905

Evaluation of Torque Teno Virus DNA Load as a Predictive Biomarker in Kidney Transplant Recipients Converted from Calcineurin Inhibitors to Belatacept

Autores: Lara Cabezas 1 2, Aurelie Truffot 3 4, Raphaele Germi 3 4, Mathilde Bugnazet 1, Paolo Malvezzi 1 2, Manon Gnesotto 4, Lionel Rostaing 1 2, Thomas Jouve 1 2, Johan Noble
Publicado en: KI Reports, 2024, ISSN 0085-2538
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.ekir.2024.03.006

Torquetenovirus Loads in Peripheral Blood Predict Both the Humoral and Cell-Mediated Responses to SARS-CoV-2 Elicited by the mRNA Vaccine in Liver Transplant Recipients

Autores: Claudia Minosse, Giulia Matusali, Silvia Meschi, Germana Grassi, Massimo Francalancia, Gianpiero D’Offizi, Pietro Giorgio Spezia, Anna Rosa Garbuglia, Marzia Montalbano, Daniele Focosi, Enrico Girardi, Francesco Vaia, Giuseppe Maria Ettorre, Fabrizio Maggi
Publicado en: Vaccines, Edición 11, 2023, Página(s) 1656, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11111656

Smoking, Alcohol Intake and Torque Teno Virus in Stable Kidney Transplant Recipients

Autores: Caecilia S. E. Doorenbos, Jip Jonker, Jiasi Hao, Edmund J. Gore, Daan Kremer, Tim J. Knobbe, Anoek A. E. de Joode, Jan Stephan F. Sanders, Olivier Thaunat, Hubert G. M. Niesters, Coretta C. Van Leer-Buter, Stephan J. L. Bakker
Publicado en: Viruses, Edición 15, 2023, Página(s) 2387, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v15122387

Validation, implementation and quality control of a Torque Teno Virus qPCR in a multinational clinical trial

Autores: E.J. Gore, L. Gard, P. Bourgeois, D. Kulifaj, E. McCulloch, P.G. Spezia, H.G.M. Niesters, F. Maggi, G. Bond, C. Van Leer-Buter
Publicado en: Journal of Clinical Virology, Edición 175, 2024, Página(s) 105738, ISSN 1386-6532
Editor: Elsevier BV
DOI: 10.1016/j.jcv.2024.105738

Integrated Immunologic Monitoring in Solid Organ Transplantation: The Road Toward Torque Teno Virus-guided Immunosuppression

Autores: Peter Jaksch, Irene Görzer, Elisabeth Puchhammer-Stöckl, Gregor Bond
Publicado en: Transplantation, Edición 106, 2023, Página(s) 1940-1951, ISSN 0041-1337
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000004153

Torque Teno Virus: A Promising Biomarker in Kidney Transplant Recipients

Autores: Sara Dal Lago, Paola Brani, Giuseppe Ietto, Daniela Dalla Gasperina, Francesco Gianfagna, Cristina Giaroni, Annalisa Bosi, Francesca Drago Ferrante, Angelo Genoni, Hafza Zahira Manzoor, Andrea Ambrosini, Marco De Cicco, Corradina Dina Quartarone, Sara Khemara, Giulio Carcano, Fabrizio Maggi, Andreina Baj
Publicado en: International Journal of Molecular Sciences, Edición 25, 2024, Página(s) 7744, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25147744

Torque Teno Virus DNA Load in Blood as an Immune Status Biomarker in Adult Hematological Patients: The State of the Art and Future Prospects

Autores: Eliseo Albert, Estela Giménez, Rafael Hernani, José Luis Piñana, Carlos Solano, David Navarro
Publicado en: Viruses, Edición 16, 2024, Página(s) 459, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16030459

Torque teno virus viral load predicts SARS‐CoV‐2 vaccine response in kidney transplant recipients

Autores: Morgane Solis, Ilies Benotmane, Floriane Gallais, Sophie Caillard, Samira Fafi‐Kremer
Publicado en: Journal of Medical Virology, Edición 95, 2023, ISSN 0146-6615
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jmv.28936

Torque Teno Virus Control by the Classical Pathway of Complement Activation—A Retrospective Analysis From a First‐in‐Human Trial Utilizing Sutimlimab

Autores: Sebastian Kapps, Jakob Mühlbacher, Dorian Kulifaj, Sophie Courjal, Farsad Eskandary, Martin Schiemann, Bernd Jilma, Georg A. Böhmig, Gregor Bond, Markus Wahrmann
Publicado en: Journal of Medical Virology, Edición 96, 2024, ISSN 0146-6615
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jmv.70039

The association of Torque Teno viral load with CMV and BKV infection in pediatric and adolescent kidney transplant patients.

Autores: Fabian Eibensteiner, Ines Messner, Phoebe Uhl, Gregor Bond, Elisabeth Puchhammer-Stoeckl, Thomas Mueller-Sacherer, Christoph Aufricht, Krisztina Rusai
Publicado en: Journal of Clinical Virology, Edición 172, 2024, Página(s) 105673, ISSN 1386-6532
Editor: Elsevier BV
DOI: 10.1016/j.jcv.2024.105673

Torque Teno Virus (TTV) in Renal Transplant Recipients: Species Diversity and Variability

Autores: Noelia Soledad Reyes, Pietro Giorgio Spezia, Raquel Jara, Fabio Filippini, Natalia Boccia, Gonzalo García, Eliana Hermida, Fernando Adrian Poletta, Mauro Pistello, Gustavo Laham, Fabrizio Maggi, Marcela Echavarria
Publicado en: Viruses, Edición 16, 2024, Página(s) 432, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16030432

Torque teno virus load as marker of rejection and infection in solid organ transplantation – A systematic review and meta‐analysis

Autores: AL van Rijn, R Roos, FW Dekker, JI Rotmans, MCW Feltkamp
Publicado en: Reviews in Medical Virology, Edición 33, 2024, ISSN 1052-9276
Editor: John Wiley & Sons Inc.
DOI: 10.1002/rmv.2393

Torquetenovirus Viremia Quantification Using Real-Time PCR Developed on a Fully Automated, Random-Access Platform

Autores: Pietro Giorgio Spezia, Fabrizio Carletti, Federica Novazzi, Eliana Specchiarello, Angelo Genoni, Francesca Drago Ferrante, Claudia Minosse, Giulia Matusali, Nicasio Mancini, Daniele Focosi, Guido Antonelli, Enrico Girardi, Fabrizio Maggi
Publicado en: Viruses, Edición 16, 2024, Página(s) 963, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16060963

The Emerging Tool of the Human Anellovirome

Autores: Daniele Focosi, Pietro Giorgio Spezia, Fabrizio Maggi
Publicado en: Viruses, Edición 16, 2024, Página(s) 990, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16060990

Torque Teno Viral Plasma Load for Immunologic Monitoring in Solid Organ Transplantation: One Step Further

Autores: Frederik Haupenthal, Gregor Bond
Publicado en: Transplantation, 2023, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.1097/tp.0000000000004817

Self-reported Non-adherence to Immunosuppressive Medication Detected by the BAASIS Predicts Allograft Rejections in Kidney Transplant Recipients

Autores: Frederik Haupenthal , Konstantin Doberer , Sebastian Kapps , Johannes Kläger , Florian Bauernfeind , Kris Denhaerynck , Alexander Kainz , Sabina De Geest , Gregor Bond
Publicado en: Nephrology Dialysis Transplantation, 2025, ISSN 1460-2385
Editor: Oxford University Press

TTV and other anelloviruses: The astonishingly wide spread of a viral infection

Autores: Pietro Giorgio Spezia, Daniele Focosi, Andreina Baj, Federica Novazzi, Francesca Drago Ferrante, Fabrizio Carletti, Claudia Minosse, Giulia Matusali, Fabrizio Maggi
Publicado en: Aspects of Molecular Medicine, 2023, ISSN 2949-6888
Editor: Elsevier
DOI: 10.1016/j.amolm.2023.100006

Evaluate the host cellular immune response to better prevent and diagnose viral infections

Autores: William Mouton, Jean-Marc Gombert, Anne Barra, Morgane Solis, Samira Fafi-Kremer, Nicolas Lévêque, Sophie Trouillet-Assant, Marine Mommert-Tripon, Edouard Tuaillon, Patrice Morand
Publicado en: Virologie, Edición 28, 2024, Página(s) 327-339, ISSN 1267-8694
Editor: John Libbey Eurotext
DOI: 10.1684/vir.2024.1064

Polyomavirus Nephropathy in ABO Blood Group-Incompatible Kidney Transplantation: Torque Teno Virus and Immunosuppressive Burden as an Approximation to the Problem

Autores: Michael Eder, Tarek A. Schrag, Ella F. Havel, Alexander Kainz, Haris Omic, Konstantin Doberer, Nicolas Kozakowski, Günther F. Körmöczi, Marlies Schönbacher, Gottfried Fischer, Robert Strassl, Monika Breuer, Lukas Weseslindtner, Frederik Haupenthal, Georg A. Böhmig, Elisabeth Puchhammer-Stöckl, Gregor Bond, Irene Görzer and Farsad Eskandary
Publicado en: KI Reports, 2024, ISSN 1178-7058
Editor: Dove Medical Press Limited
DOI: 10.1016/j.ekir.2024.04.003

Longitudinal monitoring of Torque Teno virus DNAemia in kidney transplant recipients correlates with long‐term complications of inadequate immunosuppression

Autores: Luc Chauvelot, Thomas Barba, Carole Saison, Evangelia Siska, Dorian Kulifaj, Stephan J. L. Bakker, Alice Koenig, Maud Rabeyrin, Fanny Buron, Cécile Picard, Frédérique Dijoud, Louis Manière, Bruno Lina, Emmanuel Morelon, Valerie Dubois, Olivier Thaunat
Publicado en: Journal of Medical Virology, Edición 96, 2024, ISSN 0146-6615
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jmv.29806

The kinetics of Torque Teno virus plasma load following calcineurin inhibitor dose change in kidney transplant recipients

Autores: Florina Regele, Frederik Haupenthal, Konstantin Doberer, Irene Görzer, Sebastian Kapps, Robert Strassl, Gregor Bond
Publicado en: Journal of Medical Virology, Edición 96, 2024, ISSN 0146-6615
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jmv.29554

Validation of plasma Torque Teno viral load applying a CE-certified PCR for risk stratification of rejection and infection post kidney transplantation

Autores: Irene Görzer, Frederik Haupenthal, Fabrizio Maggi, Fanny Gelas, Dorian Kulifaj, Ludovic Brossault, Elisabeth Puchhammer-Stöckl, Gregor Bond
Publicado en: Journal of Clinical Virology, Edición 158, 2024, Página(s) 105348, ISSN 1386-6532
Editor: Elsevier BV
DOI: 10.1016/j.jcv.2022.105348

Uncovering the persistent gap: The ongoing challenge of integrating sex and gender in biomedical research

Autores: Janet Delgado, Mónica Cano Abadía, Kaya Akyüz, Melanie Goisauf, David Rodríguez-Arias
Publicado en: The Journal of Biomedical Research, Edición 38, 2024, Página(s) 1, ISSN 1674-8301
Editor: Elsevier
DOI: 10.7555/jbr.38.20240157

Torque Teno Virus–guided monitoring of immunosuppressive therapy

Autores: Sebastian Kapps, Frederik Haupenthal, Gregor Bond
Publicado en: Nephrology Dialysis Transplantation, 2024, ISSN 0931-0509
Editor: Oxford University Press
DOI: 10.1093/ndt/gfae149

High-Density Lipoprotein Particles and Torque Teno Virus in Stable Outpatient Kidney Transplant Recipients

Autores: Jip Jonker, Caecilia S. E. Doorenbos, Daan Kremer, Edmund J. Gore, Hubert G. M. Niesters, Coretta van Leer-Buter, Philippe Bourgeois, Margery A. Connelly, Robin P. F. Dullaart, Stefan P. Berger, Jan-Stephan F. Sanders, Stephan J. L. Bakker
Publicado en: Viruses, Edición 16, 2024, Página(s) 143, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16010143

Evaluation of Torquetenovirus (TTV) Particle Integrity Utilizing PMAxx™

Autores: Giuseppe Sberna, Claudia Minosse, Cosmina Mija, Eliana Specchiarello, Pietro Giorgio Spezia, Sara Belladonna, Giulia Berno, Lavinia Fabeni, Giulia Matusali, Silvia Meschi, Daniele Focosi, Fabrizio Maggi
Publicado en: International Journal of Molecular Sciences, Edición 26, 2025, Página(s) 6542, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26136542

Torque Teno Virus-Guided Immunosuppression in Kidney Transplantation: Expanding the Application

Autores: Farsad Eskandary, Gregor Bond, Krithika Mohan
Publicado en: KI reports, 2024, ISSN 0085-2538
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.ekir.2024.04.057

Assessment of Torquetenominivirus (TTMV) and Torquetenomidivirus (TTMDV) as Complementary Biomarkers to Torquetenovirus (TTV)

Autores: Lilia Cinti, Pietro Giorgio Spezia, Piergiorgio Roberto, Gianluca Russo, Quirino Lai, Carolina Carillo, Federica Frasca, Guido Antonelli, Fabrizio Maggi
Publicado en: International Journal of Molecular Sciences, Edición 26, 2025, Página(s) 1022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26031022

A multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and torque teno virus-guided immunosuppression in kidney transplant recipients in the first year after transplantation: TTVguideIT

Autores: Frederik Haupenthal, Jette Rahn, Fabrizio Maggi, Fanny Gelas, Philippe Bourgeois, Christian Hugo, Bernd Jilma, Georg A. Böhmig, Harald Herkner, Michael Wolzt, Konstantin Doberer, Matthias Vossen, Daniele Focosi, Hannes Neuwirt, Miriam Banas, Bernhard Banas, Klemens Budde, Ondrej Viklicky, Paolo Malvezzi, Lionel Rostaing, Joris I. Rotmans, Stephan J. L. Bakker, Kathrin Eller, Daniel Cejka, Alberto
Publicado en: Trials, Edición 24, 2023, ISSN 1745-6215
Editor: BioMed Central
DOI: 10.1186/s13063-023-07216-0

Pre-Transplant Frequencies of FoxP3+CD25+ in CD3+CD8+ T Cells as Potential Predictors for CMV in CMV-Intermediate Risk Kidney Transplant Recipients

Autores: Agnes A. Mooslechner, Max Schuller, Verena Pfeifer, Konstantin A. Klötzer, Barbara Prietl, Alexander H. Kirsch, Philipp Stiegler, Robert Sucher, Harald Sourij, Alexander R. Rosenkranz, Kathrin Eller
Publicado en: Transplant International, Edición 37, 2024, ISSN 1432-2277
Editor: Frontiers
DOI: 10.3389/ti.2024.12963

Torque Teno Virus: Lights and Shades

Autores: Paola Brani, Hafza Zahira Manzoor, Pietro Giorgio Spezia, Andrea Vigezzi, Giuseppe Ietto, Daniela Dalla Gasperina, Claudia Minosse, Annalisa Bosi, Cristina Giaroni, Giulio Carcano, Fabrizio Maggi, Andreina Baj
Publicado en: Viruses, Edición 17, 2025, Página(s) 334, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v17030334

Prediction of humoral and cellular immune response to COVID-19 mRNA vaccination by TTV load in kidney transplant recipients and hemodialysis patients

Autores: Marianne Graninger, Julian Stumpf, Gregor Bond, Irene Görzer, David N. Springer, Friederike Kessel, Hannah Kröger, Kerstin Frank, Torsten Tonn, Christian Hugo, Elisabeth Puchhammer-Stöckl
Publicado en: Journal of Clinical Virology, Edición 162, 2024, Página(s) 105428, ISSN 1386-6532
Editor: Elsevier BV
DOI: 10.1016/j.jcv.2023.105428

Non-peer reviewed articles (1)

Protocol for Surveying Participants and Professionals’ Experiences in an International Kidney Transplant Clinical Trial

Autores: Janet Delgado, David Rodríguez-Arias, Alberto Molina-Pérez, Anibal Monasterio-Astobiza, Gonzalo Diaz-Cobacho, Gregor Bond, null null
Publicado en: Open Research Europe, Edición 4, 2024, Página(s) 241, ISSN 2732-5121
Editor: OPen Research Europe
DOI: 10.12688/openreseurope.18665.1