CORDIS - Forschungsergebnisse der EU
CORDIS

Stereoselective CO2 Capture through Sustainable Organocatalytic Alkene Activation

Projektbeschreibung

Alkene und CO2 für umweltfreundliche organokatalytische Reaktionen

Alkene und CO2 können für die Entwicklung asymmetrischer organokatalytischer Reaktionen in der umweltfreundlichen Herstellung medizinisch wichtiger Bausteine eingesetzt werden, die in Wirkstoffmolekülen und Agrochemikalien reichlich vorhanden sind. Dieses Ziel verfolgt das EU-finanzierte Projekt SusCat, dessen interdisziplinärer Ansatz Theorie, Experiment und Chemieinformatik miteinander verbindet. Im Rahmen des Projekts werden fortgeschrittene rechnerische Analysen und physikalisch-organische Experimente durchgeführt, um das Verständnis der molekularen Ebene zu erweitern. SusCat wird organische Synthese, computergestützte Modellierung und physikalisch-organische Untersuchungen miteinander verbinden. Damit bietet es eine einzigartige Alternative zur umweltschädlichen metallvermittelten Synthese und leistet einen Beitrag zu den Prioritäten der Strategie Europa 2020 im Hinblick auf nachhaltiges Wachstum und Ressourceneffizienz.

Ziel

SusCat aims to develop asymmetric organocatalytic reactions using cheap, commonplace starting materials (alkenes and CO2) to achieve environmentally-friendly manufacturing of medicinally important building blocks, which are abundant in drug molecules and agrochemicals. An atom economical manufacturing of these value-added products will be realized avoiding the use of intrinsically toxic reagents and production of waste chemical byproducts. We will adopt an interdisciplinary approach by combining experiment, theory and cheminformatics. SusCat promises to open new vistas in organocatalytic unbiased olefin activation, a longstanding quest in organic synthesis. This approach will also pave the way for the use of CO2 as a C1 synthon under mild conditions, which will not only help to reduce the carbon footprint but also add to the understanding of how nature uses CO2 as a source of energy. Moreover, the state-of-the-art computational analysis and physical organic experiments will be performed to gain insights on the molecular level. A detailed cheminformatics-based approach will be adopted to build a predictive statistical model and understand the structure activity relationship between the catalyst and the substrate. SusCat will equip the Experienced Researcher with new knowledge and skills in theory and experimentation, thus broadening his scientific background and enhancing his prospects as an independent researcher. At the same time, the Action and the Host group will benefit from the advanced knowledge in chemical catalysis acquired by the researcher during his stay. Overall, this study will create a bridge among organic synthesis, computational modelling and physical organic studies, providing not only a unique alternative to environmentally deleterious metal-mediated synthesis, but also contributing towards achieving the Europe 2020 strategy priorities: sustainable growth and resource efficiency.

Koordinator

MAX PLANCK INSTITUT FUER KOHLENFORSCHUNG
Netto-EU-Beitrag
€ 162 806,40
Adresse
KAISER WILHELM PLATZ 1
45470 Muelheim An Der Ruhr
Deutschland

Auf der Karte ansehen

Region
Nordrhein-Westfalen Düsseldorf Mülheim an der Ruhr
Aktivitätstyp
Research Organisations
Links
Gesamtkosten
€ 162 806,40