HEPARIN AND HEPARAN SULPHATE: FROM SEQUENCE DETERMINATION TO THERAPEUTIC STRATEGIES FOR PARKINSON’S DISEASE

Rezultaty

Prototype MS-IMS-IR instrument based on Waters SYNAPT G2S

Prototype MSIMSIR instrument based on Waters SYNAPT G2S

Automation platform for chemoenzymatic synthesis of HS saccharide standards
Advanced separations methods for natural heparin and HS
Workflows for phage-display antibodies development using synthetic and cellular HS

Workflows for phagedisplay antibodies development using synthetic and cellular HS

Data Management Plan

Public website

Publikacje

A reference human induced pluripotent stem cell line for large-scale collaborative studies

Autorzy: Pantazis C.B., Yang A., Lara E., McDonough J.A., Blauwendraat C., Peng L., Oguro H., Kanaujiya J., Zou J., Sebesta D., Pratt G., Cross E., Blockwick J., Buxton P., Kinner-Bibeau L., Medura C., Tompkins C., Hughes S., Santiana M., Faghri F., Nalls M.A., Vitale D., Ballard S., Qi Y.A., Ramos D.M., Anderson K.M., Stadler J., Narayan P., Papademetriou J., Reilly L., Nelson M.P., Aggarwal S., Rosen L.U
Opublikowane w: Cell Stem Cell, 2022, Strona(/y) 1685-1702 e22, ISSN 1934-5909
Wydawca: Cell Press
DOI: 10.1016/j.stem.2022.11.004

Heparin increases the antibiotic efficacy of colistin

Autorzy: Szekeres G.P., Hanozin E., Diehn R., Horlebein J., Polewski L., Zappe A., Lauster D., Pagel K.
Opublikowane w: Frontiers in Analytical Science, 2023, ISSN 2673-9283
Wydawca: Frontiers
DOI: 10.3389/frans.2023.1154391

Chondroitin Sulfate Disaccharides in the Gas Phase: Differentiation and Conformational Constraints

Autorzy: Maike Lettow, Kim Greis, Márkó Grabarics, Jan Horlebein, Rebecca L. Miller, Gerard Meijer, Gert von Helden, Kevin Pagel
Opublikowane w: The Journal of Physical Chemistry A, Numer 125/20, 2021, Strona(/y) 4373-4379, ISSN 1089-5639
Wydawca: American Chemical Society
DOI: 10.1021/acs.jpca.1c02463

Predicting structural motifs of glycosaminoglycans using cryogenic infrared spectroscopy and random forest

Autorzy: Riedel J., Lettow M., Grabarics M., Gotze M., Miller R.L., Boons G.J., Meijer G., von Helden G., Szekeres G.P., Pagel K.
Opublikowane w: J. Am. Chem. Soc., 2023, Strona(/y) 7859-7868, ISSN 0002-7863
Wydawca: American Chemical Society
DOI: 10.1021/jacs.2c12762

Analytical challenges of glycosaminoglycans at biological interfaces

Autorzy: Gergo Peter Szekeres, Kevin Pagel, Zsuzsanna Heiner
Opublikowane w: Analytical and Bioanalytical Chemistry, 2021, ISSN 1618-2642
Wydawca: Springer Verlag
DOI: 10.1007/s00216-021-03705-w

Mass Spectrometry-Based Techniques to Elucidate the Sugar Code

Autorzy: Márkó Grabarics, Maike Lettow, Carla Kirschbaum, Kim Greis, Christian Manz, Kevin Pagel
Opublikowane w: Chemical Reviews, 2021, ISSN 0009-2665
Wydawca: American Chemical Society
DOI: 10.1021/acs.chemrev.1c00380

The interaction of chondroitin sulfate with a lipid monolayer observed by using nonlinear vibrational spectroscopy

Autorzy: Gergo Peter Szekeres, Szilvia Krekic, Rebecca L. Miller, Mark Mero, Kevin Pagel, Zsuzsanna Heiner
Opublikowane w: Physical Chemistry Chemical Physics, Numer 23/23, 2021, Strona(/y) 13389-13395, ISSN 1463-9076
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d1cp01975a

Well-defined heparin mimetics can inhibit binding of the trimeric spike of SARS—COV2 in a length-dependent manner

Autorzy: Sun L., Chopra P., Tomris I., van der Woude R., Liu L., de Vries R.P., Boons G.J.
Opublikowane w: JACS Au, 2023, Strona(/y) 1185-1195, ISSN 2691-3704
Wydawca: American Chemical Society
DOI: 10.1021/jacsau.3c00042

Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors

Autorzy: Gray A.L., Karlsson R., Roberts A.R.E., Ridley A.J.L., Pun N., Khan B., Lawless C., Luis R., Szpakowska M., Chevigne A., Hughes C.E., Medina-Ruiz L., Birchenough H.L., Mulholland I.Z., Salanga C.L., Yates E.A., Turnbull J.E., Handel T.M., Graham G.J., Jowitt T.A., Schiessl I., Richter R.P., Miller R.L., Dyer D.P.
Opublikowane w: Cell Rep, 2023, Strona(/y) 111930, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2022.111930

Chemoenzymatic Synthesis of Heparan Sulfate Oligosaccharides having a Domain Structure**

Autorzy: Sun, Lifeng; Chopra, Pradeep; Boons, Geert-Jan; Afd Chemical Biology and Drug Discovery; Sub Chemical Biology and Drug Discovery; Chemical Biology and Drug Discovery; Chemical Biology and Drug Discovery
Opublikowane w: Angewandte Chemie-International Edition, 2022, Strona(/y) e202211112, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202211112

State‐of‐the‐art glycosaminoglycan characterization

Autorzy: Andreas Zappe, Rebecca L. Miller, Weston B. Struwe, Kevin Pagel
Opublikowane w: Mass Spectrometry Reviews, 2021, ISSN 0277-7037
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/mas.21737

Protein Secondary Structure Affects Glycan Clustering in Native Mass Spectrometry

Autorzy: Hao Yan, Julia Lockhauserbäumer, Gergo Peter Szekeres, Alvaro Mallagaray, Robert Creutznacher, Stefan Taube, Thomas Peters, Kevin Pagel, Charlotte Uetrecht
Opublikowane w: Life, Numer 11/6, 2021, Strona(/y) 554, ISSN 2075-1729
Wydawca: MDPI
DOI: 10.3390/life11060554

Rezultaty

Publikacje

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