Projektbeschreibung
Neuartige Medikamente stoppen die Influenza-Replikation
Influenzaviren sind für die saisonale Grippe verantwortlich und betreffen alljährlich Millionen Menschen weltweit. Angesichts des Potenzials der Influenza, Pandemien mit verheerenden Auswirkungen auf das Leben von Menschen sowie die Wirtschaft auszulösen, besteht ein dringender Bedarf an wirksamen antiviralen Arzneimitteln mit einem verringerten Risiko viralen Ausbrechens. Forschende des EU-finanzierten Projekts FluAttack haben eine neue Familie von Molekülen als wirksame Inhibitoren von Influenzaviren bestimmt. Diese Moleküle zielen auf eine zelluläre Funktion ab, die für das Überleben des Virus von größter Bedeutung ist, und werden in Modellen für Influenza-Infektionen weiteren Tests und Charakterisierungen unterzogen. Ziel des Projekts ist die zukünftige Entwicklung und präklinische Validierung dieser Anti-Grippe-Medikamente.
Ziel
With 3 to 5 million severe cases and up to 650,000 deaths per year worldwide, influenza viruses are not only major human pathogens, they are also a heavy economic burden to our societies. In addition, influenza pandemics can occur at any time with potential devastating effects in terms of lives and costs. Solutions to prevent infection, to treat severe influenza cases and to respond to a severe pandemic are currently extremely limited and rely on vaccination and on only few approved molecules. All these solutions have their limitations with respect to efficacy and all face the problem of viral resistance. Thus, the demand for new options against influenza infections is high. The World Health Organization (WHO) and influenza virus specialists agree that innovative and effective anti-influenza compounds with a reduced risk of viral escape are urgently needed. The main goal of this ERC PoC is to provide key data on a promising innovative therapeutic solution identified in the lab. Taking advantage of a powerful screening system we have developed during the ERC StG ANTIViR, we have identified a family of molecules as potent inhibitors of influenza virus (with IC50<100nM). The mode of action of these molecules is known and they actually target a cellular function essential to all influenza viruses. Preventing viral replication by targeting a cellular function is a novel approach, predicted to strongly reduce the risk of drug resistance. Importantly, one of our hits went through several phase II and III clinical trials as an anti-cancer agent, making this molecule a perfect candidate for drug repurposing. In this context, the specific objectives of this ERC PoC are: i) to further characterise and validate our best hit, in particular in commercial 3D human airway epithelial cells and in vivo in a mouse model, and ii) to secure IPR and to establish an exploitation strategy plan (patent licensing or creation of a start-up) to support future development and preclinical tests.
Wissenschaftliches Gebiet
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- natural sciencesbiological sciencesmicrobiologyvirology
- medical and health scienceshealth sciencespublic healthepidemiologypandemics
- medical and health scienceshealth sciencesinfectious diseasesRNA virusesinfluenza
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantivirals
Schlüsselbegriffe
Programm/Programme
Thema/Themen
Finanzierungsplan
ERC-POC - Proof of Concept GrantGastgebende Einrichtung
75654 Paris
Frankreich