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Proof of Principle of the best-in-class therapeutic mRNA cancer vaccine

Project description

New vaccine for HPV16-positive cancer tested

The EU-funded TIGER project will demonstrate the benefits of a novel mRNA cancer vaccine platform optimised for intravenous administration into patients. The antigens that will be used to deliver proof of principle comprise mRNAs encoding the proteins E6 and E7 of the human papillomavirus strain 16 (HPV16) and TriMix mRNAs that act as an adjuvant to stimulate dendritic cells to initiate strong T-cell responses. The study will be in patients with recurrent HPV16-positive cancer without and with a PD-1 checkpoint inhibitor. Safety, immunogenicity and clinical benefit will be key endpoints for this study. Once validated, the platform will be readily translatable to a wide range of cancers using other tumour antigens.

Call for proposal

H2020-SC1-2020-Two-Stage-RTD
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Funding Scheme

RIA - Research and Innovation action

Coordinator

ETHERNA IMMUNOTHERAPIES
Address
Galileilaan 19
2845 Niel
Belgium
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 5 094 401,25

Participants (7)

SAGA DIAGNOSTICS AB
Sweden
EU contribution
€ 186 187,50
Address
Scheelevagen 2, Mv-401
223 81 Lund
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STICHTING VUMC
Netherlands
EU contribution
€ 241 226,25
Address
De Boelelaan 1117
1081 HV Amsterdam
Activity type
Research Organisations
CLINIQUES UNIVERSITAIRES SAINT-LUC
Belgium
EU contribution
€ 311 435
Address
Avenue Hippocrate 10
1200 Bruxelles
Activity type
Research Organisations
EUROPEAN CANCER PATIENT COALITION
Belgium
EU contribution
€ 223 125
Address
Rue Montoyer 40
1000 Bruxelles
Activity type
Other
ONCORADIOMICS
Belgium
EU contribution
€ 400 000
Address
Clos Chanmurly 13
4000 Liege
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CERATIUM BV
Netherlands
EU contribution
€ 221 812,50
Address
Veemkade 240
1019 HD Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PATERGRUS BVBA
Belgium
EU contribution
€ 221 812,50
Address
Sparhoekdreef 57
9880 Aalter
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)