Descrizione del progetto
Svelare la natura poliedrica della neuroplasticità sensoriale negli esseri umani adulti
La capacità del nostro cervello di cambiare in risposta alle pressioni ambientali viene definita con il termine neuroplasticità, processo in cui è evidente il picco della nostra capacità di apprendimento nella prima infanzia e che ci consente di adattarci al mondo esterno. Il potenziale di plasticità cerebrale diminuisce tuttavia con l’età e ciò significa che è più difficile per il nostro cervello sensoriale reagire a lesioni e perdite sensoriali. In questo contesto, il progetto HOPLA, finanziato dall’UE, svelerà la natura poliedrica della neuroplasticità sensoriale negli esseri umani adulti, chiarirà i meccanismi sottostanti ed esaminerà nuove forme di plasticità. In particolare, abbinerà le classiche misurazioni comportamentali della percezione visiva e uditiva con tecniche di neuroimaging e ambienti di realtà virtuale.
Obiettivo
Fine-tuning of our sensory systems, learning, memory and cognition rely on neuroplasticity, the capability of our brain to change in response to environmental pressures. Neuroplasticity is maximal during development, underlying the peak of our ability to learn in early childhood and also allowing us to adapt to the external world. As we age, the plastic potential of the brain decreases, especially for sensory cortices. The classical view is that the sensory brain becomes hard-wired after the temporal window of maximal plasticity called critical period (6-7 years in humans). As a consequence, the ability of our sensory brain to react to injury, sensory loss and to recover from conditions established during development becomes limited in adulthood.
In my previous research I have shown that a particular form of neuroplasticity called homeostatic plasticity is relatively preserved beyond the critical period, opening new horizons on adult sensory plasticity. Building on these observations, in project HOPLA I will unravel the multifaceted nature of sensory neuroplasticity in adult humans, elucidate the underlying mechanisms and explore new forms of plasticity.
The project is articulated around four unresolved issues:
1- What is the relationship between Hebbian and homeostatic plasticity?
2- What is the role of excitation/inhibition balance in enhancing and consolidating homeostatic plasticity?
3- Is it possible to elicit new forms of visual and auditory homeostatic plasticity?
4- What is the interplay between neuroplasticity occurring between and within sensory modalities?
To address these questions, I will combine classic behavioural measurements of visual and auditory perception with state-of-the-art neuroimaging techniques and virtual reality environments both in healthy and clinical populations (amblyopic and deaf adults). The proposed research is based on strong theoretical hypotheses and has outstanding applications for neuro-rehabilitation in adult humans.
Parole chiave
Programma(i)
Argomento(i)
Meccanismo di finanziamento
ERC-STG - Starting GrantIstituzione ospitante
75794 Paris
Francia