Microbiota and immune responses at weaning predict the susceptibility to chronic inflammatory diseases in adulthood

Informazioni relative al progetto

WePredict

ID dell’accordo di sovvenzione: 949613

DOI

10.3030/949613

Data della firma CE 14 Luglio 2021

Data di avvio 1 Settembre 2021

Data di completamento 30 Giugno 2027

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 555 650,00

Contributo UE

€ 1 555 650,00

Coordinato da

UNIVERSITAET BERN
Switzerland

Periodic Reporting for period 3 - WePredict (Microbiota and immune responses at weaning predict the susceptibility to chronic inflammatory diseases in adulthood)

Periodo di rendicontazione: 2024-09-01 al 2026-02-28

Sintesi del contesto e degli obiettivi generali del progetto

The expansion of microbiota during the weaning of infants following breast milk cessation generates an immune memory, which is important in preventing the development of allergies and chronic inflammatory diseases (such as obesity and inflammatory bowel diseases) later in life. We are studying how and why this is the case. The ERC-funded WePredict project focuses on investigation how microbial and nutritional signatures at weaning predict the susceptibility to develop chronic inflammatory pathologies. We are using high-throughput sequencing, machine-learning algorithms and special mouse models. The findings will shed light on the biological processes and define the microbial and nutritional signatures at weaning that predict the susceptibility to adult pathology

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

WePredict project aims to understand which and how intestinal bacteria lead to generation of immune memory during weaning that affect inflammatory bowel diseases and obesity in adult mice. We now have a full characterization of which immune cells are involved in generation of immune memory during weaning and their causal effect on susceptibility to develop colitis and obesity but we have not yet identified the beneficial microbiota and their mechanistic of action.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

We would like now to determine which bacteria taxa upon weaning are required for immune memory generation using the high-throughput sequencing and machine-learning algorithms. We are also planing to link the microbial and dietary metabolites upon weaning that leads to either generation of healthy or pathological memory leading to prevention or promoting inflammatory immune responses. Inhibition of pathological memory in adult will be addressed using gnotobiotic mouse models.