Microbiota and immune responses at weaning predict the susceptibility to chronic inflammatory diseases in adulthood

Informacje na temat projektu

WePredict

Identyfikator umowy o grant: 949613

DOI

10.3030/949613

Data podpisania przez KE 14 Lipca 2021

Data rozpoczęcia 1 Września 2021

Data zakończenia 30 Czerwca 2027

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 1 555 650,00

Wkład UE

€ 1 555 650,00

Koordynowany przez

UNIVERSITAET BERN
Switzerland

Periodic Reporting for period 3 - WePredict (Microbiota and immune responses at weaning predict the susceptibility to chronic inflammatory diseases in adulthood)

Okres sprawozdawczy: 2024-09-01 do 2026-02-28

Podsumowanie kontekstu i ogólnych celów projektu

The expansion of microbiota during the weaning of infants following breast milk cessation generates an immune memory, which is important in preventing the development of allergies and chronic inflammatory diseases (such as obesity and inflammatory bowel diseases) later in life. We are studying how and why this is the case. The ERC-funded WePredict project focuses on investigation how microbial and nutritional signatures at weaning predict the susceptibility to develop chronic inflammatory pathologies. We are using high-throughput sequencing, machine-learning algorithms and special mouse models. The findings will shed light on the biological processes and define the microbial and nutritional signatures at weaning that predict the susceptibility to adult pathology

Prace wykonane od początku projektu do końca okresu sprawozdawczego oraz najważniejsze dotychczasowe rezultaty

WePredict project aims to understand which and how intestinal bacteria lead to generation of immune memory during weaning that affect inflammatory bowel diseases and obesity in adult mice. We now have a full characterization of which immune cells are involved in generation of immune memory during weaning and their causal effect on susceptibility to develop colitis and obesity but we have not yet identified the beneficial microbiota and their mechanistic of action.

Innowacyjność oraz oczekiwany potencjalny wpływ (w tym dotychczasowe znaczenie społeczno-gospodarcze i szersze implikacje społeczne projektu)

We would like now to determine which bacteria taxa upon weaning are required for immune memory generation using the high-throughput sequencing and machine-learning algorithms. We are also planing to link the microbial and dietary metabolites upon weaning that leads to either generation of healthy or pathological memory leading to prevention or promoting inflammatory immune responses. Inhibition of pathological memory in adult will be addressed using gnotobiotic mouse models.