BoneFix: A Paradigm Shift in Fracture Fixations via On-Site Fabrication of Bone Restoration Patches

Información del proyecto

BoneFix

Identificador del acuerdo de subvención: 952150

DOI

10.3030/952150

Proyecto cerrado

Fecha de la firma de la CE 24 Junio 2020

Fecha de inicio 1 Octubre 2020

Fecha de finalización 30 Junio 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coste total

€ 3 983 468,13

Aportación de la UE

€ 3 983 468,13

Coordinado por

KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (2)

Training media

Videos aimed at surgeons describing the application and advantages of BoneFix

Project website

BMB will establish and update the project website in conjunction with the project coordinator The website will be continuously updated with publishable reports and other information relevant to stakeholders and the broader public

Documents, reports (2)

Publication of in vivo pain study results

Scientific publication describing pain-related behaviours in mice with BoneFix fixed fractures compared to the implantation of metal screws.

Scientific articles

The dissemination of the results will follow the dissemination plan and will be the responsibility of the project coordinator (KTH) and the consortium partners that conducted the research.

Publicaciones

Peer reviewed articles (15)

Cyclic testing reliability analysis on a novel light-curable bone fixation technique

Autores: Paula M. N. Cameron, Daniel J. Hutchinson, Micheal Malkoch, Peter Varga, Peter Schwarzenberg
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 13, 2025, ISSN 2296-4185
Editor: Frontiers Media SA
DOI: 10.3389/fbioe.2025.1515319

Biomechanical Performance of a Novel-Curable Bone Fixation Technique

Autores: Schwarzenberg, Peter; Colding-Rasmussen, Thomas; Hutchinson, Daniel J; Mischler, Dominic; Horstmann, Peter; Petersen, Michael Meork; Jacobsen, Stine; Pastor, Tatjana; Malkock, Michael; Wong, Christian; Varga, Peter
Publicado en: Scientific Reports, Edición 13, 2023, Página(s) 9339, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-35706-3

Determination of the internal loads experienced by proximal phalanx fracture fixations during rehabilitation exercises

Autores: Peter Schwarzenberg, Thomas Colding-Rasmussen, Daniel J. Hutchinson, Jorge San Jacinto Garcia, Viktor Granskog, Michael Mørk Petersen, Tatjana Pastor, Tine Weis, Michael Malkoch, Christian Nai En Tierp-Wong, Peter Varga
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 12, 2024, ISSN 2296-4185
Editor: Frontiers
DOI: 10.3389/fbioe.2024.1388399

Photo‐Curable Triazinetrione Composites With Tunable Degradation for Fracture Stabilization and Flexible Thin‐Film Applications

Autores: Jorge San Jacinto Garcia, Natalia Sanz del Olmo, Daniel J. Hutchinson, Michael Malkoch
Publicado en: Journal of Applied Polymer Science, 2025, ISSN 0021-8995
Editor: John Wiley & Sons Inc.
DOI: 10.1002/app.57068

Biomechanical Variability and Usability of a Novel Customizable Fracture Fixation Technique

Autores: Colding-Rasmussen, Thomas; Schwarzenberg, Peter; Horstmann, Peter Frederik; Ottesen, Casper Bent Smedegaard; Garcia, Jorge San Jacinto; Hutchinson, Daniel John; Malkoch, Michael; Petersen, Michael Mørk; Varga, Peter; Tierp-Wong, Christian Nai En
Publicado en: Bioengineering, Edición 10, 2023, Página(s) 1146, ISSN 2306-5354
Editor: MDPI
DOI: 10.3390/bioengineering10101146

Injectable Dendritic Hydrogels Curable by High-Energy Visible Light for Cell Delivery in Bone Regeneration

Autores: Noemi Molina, Francesco Torelli, Samih Mohamed-Ahmed, Daniel J. Hutchinson, Cecilie Gjerde, Ahmad Rashad, Kamal Mustafa, Michael Malkoch
Publicado en: Chemistry of Materials, 2025, ISSN 0897-4756
Editor: American Chemical Society
DOI: 10.1021/acs.chemmater.5c00063

Soft Hydroxyapatite Composites Based on Triazine–Trione Systems as Potential Biomedical Engineering Frameworks

Autores: Lin, Jinjian; Fan, Yanmiao; Hutchinson, Daniel J.; Malkoch, Michael
Publicado en: ACS Appl Mater Interfaces, Edición 15, 2023, Página(s) 7329-7339, ISSN 1944-8244
Editor: American Chemical Society
DOI: 10.1021/acsami.2c16235

Impact of Polyester Dendrimers as Branched Multifunctional Cross-Linking Additives in Triazine-Trione-Based Composites Developed via High-Energy Visible Light Thiol-ene Chemistry

Autores: Lin, Jinjian; Sanz del Olmo, Natalia; San Jacinto Garcia, Jorge; Hutchinson, Daniel J.; Malkoch, Michael
Publicado en: ACS Applied Polymer Materials, Edición 5, 2023, Página(s) 10395-10403, ISSN 2637-6105
Editor: American Chemical Society
DOI: 10.1021/acsapm.3c02246

Synthesis and Characterization of Amino-Functional Polyester Dendrimers Based On Bis-MPA with Enhanced Hydrolytic Stability and Inherent Antibacterial Properties

Autores: Namata, Faridah; Sanz del Olmo, Natalia; Molina, Noemi; Malkoch, Michael
Publicado en: Biomacromolecules, Edición 24, 2023, Página(s) 858-867, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.2c01286

Antibacterial Hydrogel Adhesives Based on Bifunctional Telechelic Dendritic-Linear–Dendritic Block Copolymers

Autores: Sanz del Olmo, Natalia; Molina, Noemi; Fan, Yanmiao; Hutchinson, Daniel J.; Malkoch, Michael
Publicado en: J. Am. Chem. Soc., Edición 146, 2024, Página(s) 17240-17249, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.4c03673

Biomechanical Characterization of Metacarpal Fixation: Internal Load Determination and Evaluation of a Novel Adhesive Osteosynthesis

Autores: Peter Schwarzenberg, Gordian Banzer, Guillaume Patt‐Lafitte, Jérôme Schlatter, Daniel J. Hutchinson, Michael Malkoch, Peter Varga, Tatjana Pastor
Publicado en: Journal of Orthopaedic Research, 2025, ISSN 0736-0266
Editor: Elsevier BV
DOI: 10.1002/jor.70027

Toughening and strengthening of visible light-cured hydroxyapatite thiol-ene resin composite intended as bone fixation using 2D textile

Autores: Patt-Lafitte, Guillaume; Valfort, Oliver; Hutchinson, Daniel J.; Malkoch, Michael; Eglin, David
Publicado en: Journal of Materials Research and Technology, Edición 29, 2024, Página(s) 982-990, ISSN 2238-7854
Editor: Elsevier Editora Ltda
DOI: 10.1016/j.jmrt.2024.01.127

Enhanced Degradability of Thiol–Ene Composites through the Inclusion of Isosorbide-Based Polycarbonates

Autores: Jorge San Jacinto Garcia, Natalia Sanz del Olmo, Daniel J. Hutchinson, Michael Malkoch
Publicado en: ACS Applied Materials & Interfaces, Edición 16, 2024, Página(s) 40056-40068, ISSN 1944-8244
Editor: American Chemical Society
DOI: 10.1021/acsami.4c09626

Photo‐Clickable Triazine‐Trione Thermosets as Promising 3D Scaffolds for Tissue Engineering Applications

Autores: Åshild Johansen, Jinjian Lin, Shuntaro Yamada, Samih Mohamed‐Ahmed, Mohammed A. Yassin, Cecilie Gjerde, Daniel J. Hutchinson, Kamal Mustafa, Michael Malkoch
Publicado en: Advanced Healthcare Materials, Edición 16, 2024, Página(s) 40056, ISSN 2192-2640
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202401202

Novel Customizable Fracture Fixation Technique vs. Conventional Metal Locking Plate: An Exploratory Comparative Study of Fixation Stability in an Experimental In Vivo Ovine Bilateral Phalangeal Fracture Model

Autores: Thomas Colding-Rasmussen, Nanett Kvist Nikolaisen, Peter Frederik Horstmann, Michael Mørk Petersen, Daniel John Hutchinson, Michael Malkoch, Stine Jacobsen, Christian Nai En Tierp-Wong
Publicado en: Materials, Edición 18, 2025, Página(s) 3359, ISSN 1996-1944
Editor: MDPI Open Access Publishing
DOI: 10.3390/ma18143359

Conference proceedings (9)

Dendritic-Linear-Dendritic (DLD) Based Materials and Their Potential Use inBiomedical Applications

Autores: Molina, Noemi; Sanz del Olmo, Natalia; Hutchinson, Daniel J.; Malkoch, Michael
Publicado en: ARI Abstracts Periodical, Edición 3, 2023, Página(s) 177, ISSN 2960-2483
Editor: AO Research Institute Davos

Strong photo-curable thiol-ene based composites for use in the fixation of bonefractures

Autores: Hutchinson, Daniel J.; Granskog, Viktor; Malkoch, Michael
Publicado en: ARI Abstracts Periodical, Edición 3, 2023, Página(s) 153, ISSN 2960-2483
Editor: AO Research Institute Davos

Degradable thiol-ene composites for bone repair

Autores: San Jacinto, Jorge; Hutchinson, Daniel J.; Sanz del Olmo, Natalia; Malkoch, Michael
Publicado en: ARI Abstracts Periodical, Edición 3, 2023, Página(s) 303, ISSN 2960-2483
Editor: AO Research Institute Davos

Fabrication of biodegradable high strength and shape-shifting polylactic acidmembrane for reinforcement of a photo-curable composite bone fixation patch

Autores: Patt-Lafitte, Guillaume; Hutchinson, Daniel J.; Malkoch, Michael; Eglin, David
Publicado en: ARI Abstracts Periodical, Edición 3, 2023, Página(s) 462, ISSN 2960-2483
Editor: AO Research Institute Davos

Welfare monitoring in the novel ovine thoracic limb, bilateral, single-toeostectomy model (OBST)

Autores: Nikolaisen, Nannet Kvist.; Tierp-Wong, Christian Nai En.; Colding-Rasmussen, Thomas; Petersen, Michael Mork; Hutchinson, Daniel; Lindegaard, Casper; Jacobsen, Stine
Publicado en: ARI Abstracts Periodical, Edición 3, 2023, Página(s) 144, ISSN 2960-2483
Editor: AO Research Insitute Davos

Biomechanical analysis of a novel osteosynthesis device with standard andphysiological testing

Autores: Schwarzenberg, Peter; Colding-Rasmussen, Thomas; Hutchinson, Daniel J.; San Jacinto Garcia, Jorge; Jacobsen, Stine; Horstmann, Peter; Petersen, Michael Mork; Mischler, Dominic; Granskog, V.; Pastor, Tatjana; Weis, Tine; Malkoch, Michael; Wong, Christian; Varga, Peter
Publicado en: ARI Abstracts Periodical, Edición 3, 2023, Página(s) 314, ISSN 2960-2483
Editor: AO Research Institute Davos

The effect of PET meshes on the mechanical and structural properties of a photo-curable hydroxyapatite composite intended as internal fixation in complex bonefractures

Autores: Patt-Lafitte, Guillaume, Rasolonjatovo, Sarah; Hutchinson, Daniel J.; Malkoch, Michael; Eglin, David
Publicado en: ARI Abstracts Periodical, Edición 3, 2023, Página(s) 228, ISSN 2960-2483
Editor: AO Research Institute Davos

Cytocompatibility and osteogenic differentiation of mesenchymal stem cellswithin phototunable polyester-based PEGylated dendritic hydrogels

Autores: Torelli, Francesco; Mohamed-Ahmed, Samih; Rashad, Ahmad; Cabeza, Noemi M.; Hutchinson, Daniel J.; Malkoch, Michael; Mustafa, Kamal
Publicado en: ARI Abstracts Periodical, Edición 3, 2023, Página(s) 492, ISSN 2960-2483
Editor: AO Research Institute Davos

From bench to chairside: Mesenchymal stem cells and biomedical engineering inbone regeneration

Autores: Mustafa, Kamal E.
Publicado en: ARI Abstracts Periodical, Edición 3, 2023, Página(s) 312, ISSN 2960-2483
Editor: AO Research Institute Davos