BoneFix: A Paradigm Shift in Fracture Fixations via On-Site Fabrication of Bone Restoration Patches

Informations projet

BoneFix

N° de convention de subvention: 952150

DOI

10.3030/952150

Projet clôturé

Date de signature de la CE 24 Juin 2020

Date de début 1 Octobre 2020

Date de fin 30 Juin 2025

Financé au titre de

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coût total

€ 3 983 468,13

Contribution de l’UE

€ 3 983 468,13

Coordonné par

KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (2)

Training media

Videos aimed at surgeons describing the application and advantages of BoneFix

Project website

BMB will establish and update the project website in conjunction with the project coordinator The website will be continuously updated with publishable reports and other information relevant to stakeholders and the broader public

Documents, reports (2)

Publication of in vivo pain study results

Scientific publication describing pain-related behaviours in mice with BoneFix fixed fractures compared to the implantation of metal screws.

Scientific articles

The dissemination of the results will follow the dissemination plan and will be the responsibility of the project coordinator (KTH) and the consortium partners that conducted the research.

Publications

Peer reviewed articles (16)

Cyclic testing reliability analysis on a novel light-curable bone fixation technique

Auteurs: Paula M. N. Cameron, Daniel J. Hutchinson, Micheal Malkoch, Peter Varga, Peter Schwarzenberg
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 13, 2025, ISSN 2296-4185
Éditeur: Frontiers Media SA
DOI: 10.3389/fbioe.2025.1515319

Biomechanical Performance of a Novel-Curable Bone Fixation Technique

Auteurs: Schwarzenberg, Peter; Colding-Rasmussen, Thomas; Hutchinson, Daniel J; Mischler, Dominic; Horstmann, Peter; Petersen, Michael Meork; Jacobsen, Stine; Pastor, Tatjana; Malkock, Michael; Wong, Christian; Varga, Peter
Publié dans: Scientific Reports, Numéro 13, 2023, Page(s) 9339, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-35706-3

First steps in the development of an ovine proximal phalanx fracture and bone defect model: a study of animal welfare and bone healing

Auteurs: Nanett Kvist Nikolaisen, Thomas Colding-Rasmussen, Peter F. Horstmann, Anna V. Müller, José Joaquín Cerón, Michael Mørk Petersen, Christian Nai En Tierp-Wong, Stine Jacobsen
Publié dans: Frontiers in Veterinary Science, Numéro 12, 2025, ISSN 2297-1769
Éditeur: Frontiers Media SA
DOI: 10.3389/fvets.2025.1662553

Determination of the internal loads experienced by proximal phalanx fracture fixations during rehabilitation exercises

Auteurs: Peter Schwarzenberg, Thomas Colding-Rasmussen, Daniel J. Hutchinson, Jorge San Jacinto Garcia, Viktor Granskog, Michael Mørk Petersen, Tatjana Pastor, Tine Weis, Michael Malkoch, Christian Nai En Tierp-Wong, Peter Varga
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 12, 2024, ISSN 2296-4185
Éditeur: Frontiers
DOI: 10.3389/fbioe.2024.1388399

Photo‐Curable Triazinetrione Composites With Tunable Degradation for Fracture Stabilization and Flexible Thin‐Film Applications

Auteurs: Jorge San Jacinto Garcia, Natalia Sanz del Olmo, Daniel J. Hutchinson, Michael Malkoch
Publié dans: Journal of Applied Polymer Science, 2025, ISSN 0021-8995
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/app.57068

Biomechanical Variability and Usability of a Novel Customizable Fracture Fixation Technique

Auteurs: Colding-Rasmussen, Thomas; Schwarzenberg, Peter; Horstmann, Peter Frederik; Ottesen, Casper Bent Smedegaard; Garcia, Jorge San Jacinto; Hutchinson, Daniel John; Malkoch, Michael; Petersen, Michael Mørk; Varga, Peter; Tierp-Wong, Christian Nai En
Publié dans: Bioengineering, Numéro 10, 2023, Page(s) 1146, ISSN 2306-5354
Éditeur: MDPI
DOI: 10.3390/bioengineering10101146

Injectable Dendritic Hydrogels Curable by High-Energy Visible Light for Cell Delivery in Bone Regeneration

Auteurs: Noemi Molina, Francesco Torelli, Samih Mohamed-Ahmed, Daniel J. Hutchinson, Cecilie Gjerde, Ahmad Rashad, Kamal Mustafa, Michael Malkoch
Publié dans: Chemistry of Materials, 2025, ISSN 0897-4756
Éditeur: American Chemical Society
DOI: 10.1021/acs.chemmater.5c00063

Soft Hydroxyapatite Composites Based on Triazine–Trione Systems as Potential Biomedical Engineering Frameworks

Auteurs: Lin, Jinjian; Fan, Yanmiao; Hutchinson, Daniel J.; Malkoch, Michael
Publié dans: ACS Appl Mater Interfaces, Numéro 15, 2023, Page(s) 7329-7339, ISSN 1944-8244
Éditeur: American Chemical Society
DOI: 10.1021/acsami.2c16235

Impact of Polyester Dendrimers as Branched Multifunctional Cross-Linking Additives in Triazine-Trione-Based Composites Developed via High-Energy Visible Light Thiol-ene Chemistry

Auteurs: Lin, Jinjian; Sanz del Olmo, Natalia; San Jacinto Garcia, Jorge; Hutchinson, Daniel J.; Malkoch, Michael
Publié dans: ACS Applied Polymer Materials, Numéro 5, 2023, Page(s) 10395-10403, ISSN 2637-6105
Éditeur: American Chemical Society
DOI: 10.1021/acsapm.3c02246

Synthesis and Characterization of Amino-Functional Polyester Dendrimers Based On Bis-MPA with Enhanced Hydrolytic Stability and Inherent Antibacterial Properties

Auteurs: Namata, Faridah; Sanz del Olmo, Natalia; Molina, Noemi; Malkoch, Michael
Publié dans: Biomacromolecules, Numéro 24, 2023, Page(s) 858-867, ISSN 1525-7797
Éditeur: American Chemical Society
DOI: 10.1021/acs.biomac.2c01286

Antibacterial Hydrogel Adhesives Based on Bifunctional Telechelic Dendritic-Linear–Dendritic Block Copolymers

Auteurs: Sanz del Olmo, Natalia; Molina, Noemi; Fan, Yanmiao; Hutchinson, Daniel J.; Malkoch, Michael
Publié dans: J. Am. Chem. Soc., Numéro 146, 2024, Page(s) 17240-17249, ISSN 0002-7863
Éditeur: American Chemical Society
DOI: 10.1021/jacs.4c03673

Biomechanical Characterization of Metacarpal Fixation: Internal Load Determination and Evaluation of a Novel Adhesive Osteosynthesis

Auteurs: Peter Schwarzenberg, Gordian Banzer, Guillaume Patt‐Lafitte, Jérôme Schlatter, Daniel J. Hutchinson, Michael Malkoch, Peter Varga, Tatjana Pastor
Publié dans: Journal of Orthopaedic Research, 2025, ISSN 0736-0266
Éditeur: Elsevier BV
DOI: 10.1002/jor.70027

Toughening and strengthening of visible light-cured hydroxyapatite thiol-ene resin composite intended as bone fixation using 2D textile

Auteurs: Patt-Lafitte, Guillaume; Valfort, Oliver; Hutchinson, Daniel J.; Malkoch, Michael; Eglin, David
Publié dans: Journal of Materials Research and Technology, Numéro 29, 2024, Page(s) 982-990, ISSN 2238-7854
Éditeur: Elsevier Editora Ltda
DOI: 10.1016/j.jmrt.2024.01.127

Enhanced Degradability of Thiol–Ene Composites through the Inclusion of Isosorbide-Based Polycarbonates

Auteurs: Jorge San Jacinto Garcia, Natalia Sanz del Olmo, Daniel J. Hutchinson, Michael Malkoch
Publié dans: ACS Applied Materials & Interfaces, Numéro 16, 2024, Page(s) 40056-40068, ISSN 1944-8244
Éditeur: American Chemical Society
DOI: 10.1021/acsami.4c09626

Photo‐Clickable Triazine‐Trione Thermosets as Promising 3D Scaffolds for Tissue Engineering Applications

Auteurs: Åshild Johansen, Jinjian Lin, Shuntaro Yamada, Samih Mohamed‐Ahmed, Mohammed A. Yassin, Cecilie Gjerde, Daniel J. Hutchinson, Kamal Mustafa, Michael Malkoch
Publié dans: Advanced Healthcare Materials, Numéro 16, 2024, Page(s) 40056, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202401202

Novel Customizable Fracture Fixation Technique vs. Conventional Metal Locking Plate: An Exploratory Comparative Study of Fixation Stability in an Experimental In Vivo Ovine Bilateral Phalangeal Fracture Model

Auteurs: Thomas Colding-Rasmussen, Nanett Kvist Nikolaisen, Peter Frederik Horstmann, Michael Mørk Petersen, Daniel John Hutchinson, Michael Malkoch, Stine Jacobsen, Christian Nai En Tierp-Wong
Publié dans: Materials, Numéro 18, 2025, Page(s) 3359, ISSN 1996-1944
Éditeur: MDPI Open Access Publishing
DOI: 10.3390/ma18143359

Conference proceedings (9)

Dendritic-Linear-Dendritic (DLD) Based Materials and Their Potential Use inBiomedical Applications

Auteurs: Molina, Noemi; Sanz del Olmo, Natalia; Hutchinson, Daniel J.; Malkoch, Michael
Publié dans: ARI Abstracts Periodical, Numéro 3, 2023, Page(s) 177, ISSN 2960-2483
Éditeur: AO Research Institute Davos

Strong photo-curable thiol-ene based composites for use in the fixation of bonefractures

Auteurs: Hutchinson, Daniel J.; Granskog, Viktor; Malkoch, Michael
Publié dans: ARI Abstracts Periodical, Numéro 3, 2023, Page(s) 153, ISSN 2960-2483
Éditeur: AO Research Institute Davos

Degradable thiol-ene composites for bone repair

Auteurs: San Jacinto, Jorge; Hutchinson, Daniel J.; Sanz del Olmo, Natalia; Malkoch, Michael
Publié dans: ARI Abstracts Periodical, Numéro 3, 2023, Page(s) 303, ISSN 2960-2483
Éditeur: AO Research Institute Davos

Fabrication of biodegradable high strength and shape-shifting polylactic acidmembrane for reinforcement of a photo-curable composite bone fixation patch

Auteurs: Patt-Lafitte, Guillaume; Hutchinson, Daniel J.; Malkoch, Michael; Eglin, David
Publié dans: ARI Abstracts Periodical, Numéro 3, 2023, Page(s) 462, ISSN 2960-2483
Éditeur: AO Research Institute Davos

Welfare monitoring in the novel ovine thoracic limb, bilateral, single-toeostectomy model (OBST)

Auteurs: Nikolaisen, Nannet Kvist.; Tierp-Wong, Christian Nai En.; Colding-Rasmussen, Thomas; Petersen, Michael Mork; Hutchinson, Daniel; Lindegaard, Casper; Jacobsen, Stine
Publié dans: ARI Abstracts Periodical, Numéro 3, 2023, Page(s) 144, ISSN 2960-2483
Éditeur: AO Research Insitute Davos

Biomechanical analysis of a novel osteosynthesis device with standard andphysiological testing

Auteurs: Schwarzenberg, Peter; Colding-Rasmussen, Thomas; Hutchinson, Daniel J.; San Jacinto Garcia, Jorge; Jacobsen, Stine; Horstmann, Peter; Petersen, Michael Mork; Mischler, Dominic; Granskog, V.; Pastor, Tatjana; Weis, Tine; Malkoch, Michael; Wong, Christian; Varga, Peter
Publié dans: ARI Abstracts Periodical, Numéro 3, 2023, Page(s) 314, ISSN 2960-2483
Éditeur: AO Research Institute Davos

The effect of PET meshes on the mechanical and structural properties of a photo-curable hydroxyapatite composite intended as internal fixation in complex bonefractures

Auteurs: Patt-Lafitte, Guillaume, Rasolonjatovo, Sarah; Hutchinson, Daniel J.; Malkoch, Michael; Eglin, David
Publié dans: ARI Abstracts Periodical, Numéro 3, 2023, Page(s) 228, ISSN 2960-2483
Éditeur: AO Research Institute Davos

Cytocompatibility and osteogenic differentiation of mesenchymal stem cellswithin phototunable polyester-based PEGylated dendritic hydrogels

Auteurs: Torelli, Francesco; Mohamed-Ahmed, Samih; Rashad, Ahmad; Cabeza, Noemi M.; Hutchinson, Daniel J.; Malkoch, Michael; Mustafa, Kamal
Publié dans: ARI Abstracts Periodical, Numéro 3, 2023, Page(s) 492, ISSN 2960-2483
Éditeur: AO Research Institute Davos

From bench to chairside: Mesenchymal stem cells and biomedical engineering inbone regeneration

Auteurs: Mustafa, Kamal E.
Publié dans: ARI Abstracts Periodical, Numéro 3, 2023, Page(s) 312, ISSN 2960-2483
Éditeur: AO Research Institute Davos