BoneFix: A Paradigm Shift in Fracture Fixations via On-Site Fabrication of Bone Restoration Patches

Informacje na temat projektu

BoneFix

Identyfikator umowy o grant: 952150

DOI

10.3030/952150

Projekt został zamknięty

Data podpisania przez KE 24 Czerwca 2020

Data rozpoczęcia 1 Października 2020

Data zakończenia 30 Czerwca 2025

Finansowanie w ramach

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Koszt całkowity

€ 3 983 468,13

Wkład UE

€ 3 983 468,13

Koordynowany przez

KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Websites, patent fillings, videos etc. (2)

Training media

Videos aimed at surgeons describing the application and advantages of BoneFix

Project website

BMB will establish and update the project website in conjunction with the project coordinator The website will be continuously updated with publishable reports and other information relevant to stakeholders and the broader public

Documents, reports (2)

Publication of in vivo pain study results

Scientific publication describing pain-related behaviours in mice with BoneFix fixed fractures compared to the implantation of metal screws.

Scientific articles

The dissemination of the results will follow the dissemination plan and will be the responsibility of the project coordinator (KTH) and the consortium partners that conducted the research.

Publikacje

Peer reviewed articles (16)

Cyclic testing reliability analysis on a novel light-curable bone fixation technique

Autorzy: Paula M. N. Cameron, Daniel J. Hutchinson, Micheal Malkoch, Peter Varga, Peter Schwarzenberg
Opublikowane w: Frontiers in Bioengineering and Biotechnology, Numer 13, 2025, ISSN 2296-4185
Wydawca: Frontiers Media SA
DOI: 10.3389/fbioe.2025.1515319

Biomechanical Performance of a Novel-Curable Bone Fixation Technique

Autorzy: Schwarzenberg, Peter; Colding-Rasmussen, Thomas; Hutchinson, Daniel J; Mischler, Dominic; Horstmann, Peter; Petersen, Michael Meork; Jacobsen, Stine; Pastor, Tatjana; Malkock, Michael; Wong, Christian; Varga, Peter
Opublikowane w: Scientific Reports, Numer 13, 2023, Strona(/y) 9339, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-023-35706-3

First steps in the development of an ovine proximal phalanx fracture and bone defect model: a study of animal welfare and bone healing

Autorzy: Nanett Kvist Nikolaisen, Thomas Colding-Rasmussen, Peter F. Horstmann, Anna V. Müller, José Joaquín Cerón, Michael Mørk Petersen, Christian Nai En Tierp-Wong, Stine Jacobsen
Opublikowane w: Frontiers in Veterinary Science, Numer 12, 2025, ISSN 2297-1769
Wydawca: Frontiers Media SA
DOI: 10.3389/fvets.2025.1662553

Determination of the internal loads experienced by proximal phalanx fracture fixations during rehabilitation exercises

Autorzy: Peter Schwarzenberg, Thomas Colding-Rasmussen, Daniel J. Hutchinson, Jorge San Jacinto Garcia, Viktor Granskog, Michael Mørk Petersen, Tatjana Pastor, Tine Weis, Michael Malkoch, Christian Nai En Tierp-Wong, Peter Varga
Opublikowane w: Frontiers in Bioengineering and Biotechnology, Numer 12, 2024, ISSN 2296-4185
Wydawca: Frontiers
DOI: 10.3389/fbioe.2024.1388399

Photo‐Curable Triazinetrione Composites With Tunable Degradation for Fracture Stabilization and Flexible Thin‐Film Applications

Autorzy: Jorge San Jacinto Garcia, Natalia Sanz del Olmo, Daniel J. Hutchinson, Michael Malkoch
Opublikowane w: Journal of Applied Polymer Science, 2025, ISSN 0021-8995
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/app.57068

Biomechanical Variability and Usability of a Novel Customizable Fracture Fixation Technique

Autorzy: Colding-Rasmussen, Thomas; Schwarzenberg, Peter; Horstmann, Peter Frederik; Ottesen, Casper Bent Smedegaard; Garcia, Jorge San Jacinto; Hutchinson, Daniel John; Malkoch, Michael; Petersen, Michael Mørk; Varga, Peter; Tierp-Wong, Christian Nai En
Opublikowane w: Bioengineering, Numer 10, 2023, Strona(/y) 1146, ISSN 2306-5354
Wydawca: MDPI
DOI: 10.3390/bioengineering10101146

Injectable Dendritic Hydrogels Curable by High-Energy Visible Light for Cell Delivery in Bone Regeneration

Autorzy: Noemi Molina, Francesco Torelli, Samih Mohamed-Ahmed, Daniel J. Hutchinson, Cecilie Gjerde, Ahmad Rashad, Kamal Mustafa, Michael Malkoch
Opublikowane w: Chemistry of Materials, 2025, ISSN 0897-4756
Wydawca: American Chemical Society
DOI: 10.1021/acs.chemmater.5c00063

Soft Hydroxyapatite Composites Based on Triazine–Trione Systems as Potential Biomedical Engineering Frameworks

Autorzy: Lin, Jinjian; Fan, Yanmiao; Hutchinson, Daniel J.; Malkoch, Michael
Opublikowane w: ACS Appl Mater Interfaces, Numer 15, 2023, Strona(/y) 7329-7339, ISSN 1944-8244
Wydawca: American Chemical Society
DOI: 10.1021/acsami.2c16235

Impact of Polyester Dendrimers as Branched Multifunctional Cross-Linking Additives in Triazine-Trione-Based Composites Developed via High-Energy Visible Light Thiol-ene Chemistry

Autorzy: Lin, Jinjian; Sanz del Olmo, Natalia; San Jacinto Garcia, Jorge; Hutchinson, Daniel J.; Malkoch, Michael
Opublikowane w: ACS Applied Polymer Materials, Numer 5, 2023, Strona(/y) 10395-10403, ISSN 2637-6105
Wydawca: American Chemical Society
DOI: 10.1021/acsapm.3c02246

Synthesis and Characterization of Amino-Functional Polyester Dendrimers Based On Bis-MPA with Enhanced Hydrolytic Stability and Inherent Antibacterial Properties

Autorzy: Namata, Faridah; Sanz del Olmo, Natalia; Molina, Noemi; Malkoch, Michael
Opublikowane w: Biomacromolecules, Numer 24, 2023, Strona(/y) 858-867, ISSN 1525-7797
Wydawca: American Chemical Society
DOI: 10.1021/acs.biomac.2c01286

Antibacterial Hydrogel Adhesives Based on Bifunctional Telechelic Dendritic-Linear–Dendritic Block Copolymers

Autorzy: Sanz del Olmo, Natalia; Molina, Noemi; Fan, Yanmiao; Hutchinson, Daniel J.; Malkoch, Michael
Opublikowane w: J. Am. Chem. Soc., Numer 146, 2024, Strona(/y) 17240-17249, ISSN 0002-7863
Wydawca: American Chemical Society
DOI: 10.1021/jacs.4c03673

Biomechanical Characterization of Metacarpal Fixation: Internal Load Determination and Evaluation of a Novel Adhesive Osteosynthesis

Autorzy: Peter Schwarzenberg, Gordian Banzer, Guillaume Patt‐Lafitte, Jérôme Schlatter, Daniel J. Hutchinson, Michael Malkoch, Peter Varga, Tatjana Pastor
Opublikowane w: Journal of Orthopaedic Research, 2025, ISSN 0736-0266
Wydawca: Elsevier BV
DOI: 10.1002/jor.70027

Toughening and strengthening of visible light-cured hydroxyapatite thiol-ene resin composite intended as bone fixation using 2D textile

Autorzy: Patt-Lafitte, Guillaume; Valfort, Oliver; Hutchinson, Daniel J.; Malkoch, Michael; Eglin, David
Opublikowane w: Journal of Materials Research and Technology, Numer 29, 2024, Strona(/y) 982-990, ISSN 2238-7854
Wydawca: Elsevier Editora Ltda
DOI: 10.1016/j.jmrt.2024.01.127

Enhanced Degradability of Thiol–Ene Composites through the Inclusion of Isosorbide-Based Polycarbonates

Autorzy: Jorge San Jacinto Garcia, Natalia Sanz del Olmo, Daniel J. Hutchinson, Michael Malkoch
Opublikowane w: ACS Applied Materials & Interfaces, Numer 16, 2024, Strona(/y) 40056-40068, ISSN 1944-8244
Wydawca: American Chemical Society
DOI: 10.1021/acsami.4c09626

Photo‐Clickable Triazine‐Trione Thermosets as Promising 3D Scaffolds for Tissue Engineering Applications

Autorzy: Åshild Johansen, Jinjian Lin, Shuntaro Yamada, Samih Mohamed‐Ahmed, Mohammed A. Yassin, Cecilie Gjerde, Daniel J. Hutchinson, Kamal Mustafa, Michael Malkoch
Opublikowane w: Advanced Healthcare Materials, Numer 16, 2024, Strona(/y) 40056, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202401202

Novel Customizable Fracture Fixation Technique vs. Conventional Metal Locking Plate: An Exploratory Comparative Study of Fixation Stability in an Experimental In Vivo Ovine Bilateral Phalangeal Fracture Model

Autorzy: Thomas Colding-Rasmussen, Nanett Kvist Nikolaisen, Peter Frederik Horstmann, Michael Mørk Petersen, Daniel John Hutchinson, Michael Malkoch, Stine Jacobsen, Christian Nai En Tierp-Wong
Opublikowane w: Materials, Numer 18, 2025, Strona(/y) 3359, ISSN 1996-1944
Wydawca: MDPI Open Access Publishing
DOI: 10.3390/ma18143359

Conference proceedings (9)

Dendritic-Linear-Dendritic (DLD) Based Materials and Their Potential Use inBiomedical Applications

Autorzy: Molina, Noemi; Sanz del Olmo, Natalia; Hutchinson, Daniel J.; Malkoch, Michael
Opublikowane w: ARI Abstracts Periodical, Numer 3, 2023, Strona(/y) 177, ISSN 2960-2483
Wydawca: AO Research Institute Davos

Strong photo-curable thiol-ene based composites for use in the fixation of bonefractures

Autorzy: Hutchinson, Daniel J.; Granskog, Viktor; Malkoch, Michael
Opublikowane w: ARI Abstracts Periodical, Numer 3, 2023, Strona(/y) 153, ISSN 2960-2483
Wydawca: AO Research Institute Davos

Degradable thiol-ene composites for bone repair

Autorzy: San Jacinto, Jorge; Hutchinson, Daniel J.; Sanz del Olmo, Natalia; Malkoch, Michael
Opublikowane w: ARI Abstracts Periodical, Numer 3, 2023, Strona(/y) 303, ISSN 2960-2483
Wydawca: AO Research Institute Davos

Fabrication of biodegradable high strength and shape-shifting polylactic acidmembrane for reinforcement of a photo-curable composite bone fixation patch

Autorzy: Patt-Lafitte, Guillaume; Hutchinson, Daniel J.; Malkoch, Michael; Eglin, David
Opublikowane w: ARI Abstracts Periodical, Numer 3, 2023, Strona(/y) 462, ISSN 2960-2483
Wydawca: AO Research Institute Davos

Welfare monitoring in the novel ovine thoracic limb, bilateral, single-toeostectomy model (OBST)

Autorzy: Nikolaisen, Nannet Kvist.; Tierp-Wong, Christian Nai En.; Colding-Rasmussen, Thomas; Petersen, Michael Mork; Hutchinson, Daniel; Lindegaard, Casper; Jacobsen, Stine
Opublikowane w: ARI Abstracts Periodical, Numer 3, 2023, Strona(/y) 144, ISSN 2960-2483
Wydawca: AO Research Insitute Davos

Biomechanical analysis of a novel osteosynthesis device with standard andphysiological testing

Autorzy: Schwarzenberg, Peter; Colding-Rasmussen, Thomas; Hutchinson, Daniel J.; San Jacinto Garcia, Jorge; Jacobsen, Stine; Horstmann, Peter; Petersen, Michael Mork; Mischler, Dominic; Granskog, V.; Pastor, Tatjana; Weis, Tine; Malkoch, Michael; Wong, Christian; Varga, Peter
Opublikowane w: ARI Abstracts Periodical, Numer 3, 2023, Strona(/y) 314, ISSN 2960-2483
Wydawca: AO Research Institute Davos

The effect of PET meshes on the mechanical and structural properties of a photo-curable hydroxyapatite composite intended as internal fixation in complex bonefractures

Autorzy: Patt-Lafitte, Guillaume, Rasolonjatovo, Sarah; Hutchinson, Daniel J.; Malkoch, Michael; Eglin, David
Opublikowane w: ARI Abstracts Periodical, Numer 3, 2023, Strona(/y) 228, ISSN 2960-2483
Wydawca: AO Research Institute Davos

Cytocompatibility and osteogenic differentiation of mesenchymal stem cellswithin phototunable polyester-based PEGylated dendritic hydrogels

Autorzy: Torelli, Francesco; Mohamed-Ahmed, Samih; Rashad, Ahmad; Cabeza, Noemi M.; Hutchinson, Daniel J.; Malkoch, Michael; Mustafa, Kamal
Opublikowane w: ARI Abstracts Periodical, Numer 3, 2023, Strona(/y) 492, ISSN 2960-2483
Wydawca: AO Research Institute Davos

From bench to chairside: Mesenchymal stem cells and biomedical engineering inbone regeneration

Autorzy: Mustafa, Kamal E.
Opublikowane w: ARI Abstracts Periodical, Numer 3, 2023, Strona(/y) 312, ISSN 2960-2483
Wydawca: AO Research Institute Davos