BoneFix: A Paradigm Shift in Fracture Fixations via On-Site Fabrication of Bone Restoration Patches

Informazioni relative al progetto

BoneFix

ID dell’accordo di sovvenzione: 952150

DOI

10.3030/952150

Progetto chiuso

Data della firma CE 24 Giugno 2020

Data di avvio 1 Ottobre 2020

Data di completamento 30 Giugno 2025

Finanziato da

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Costo totale

€ 3 983 468,13

Contributo UE

€ 3 983 468,13

Coordinato da

KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (2)

Training media

Videos aimed at surgeons describing the application and advantages of BoneFix

Project website

BMB will establish and update the project website in conjunction with the project coordinator The website will be continuously updated with publishable reports and other information relevant to stakeholders and the broader public

Documents, reports (2)

Publication of in vivo pain study results

Scientific publication describing pain-related behaviours in mice with BoneFix fixed fractures compared to the implantation of metal screws.

Scientific articles

The dissemination of the results will follow the dissemination plan and will be the responsibility of the project coordinator (KTH) and the consortium partners that conducted the research.

Pubblicazioni

Peer reviewed articles (15)

Cyclic testing reliability analysis on a novel light-curable bone fixation technique

Autori: Paula M. N. Cameron, Daniel J. Hutchinson, Micheal Malkoch, Peter Varga, Peter Schwarzenberg
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 13, 2025, ISSN 2296-4185
Editore: Frontiers Media SA
DOI: 10.3389/fbioe.2025.1515319

Biomechanical Performance of a Novel-Curable Bone Fixation Technique

Autori: Schwarzenberg, Peter; Colding-Rasmussen, Thomas; Hutchinson, Daniel J; Mischler, Dominic; Horstmann, Peter; Petersen, Michael Meork; Jacobsen, Stine; Pastor, Tatjana; Malkock, Michael; Wong, Christian; Varga, Peter
Pubblicato in: Scientific Reports, Numero 13, 2023, Pagina/e 9339, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-35706-3

Determination of the internal loads experienced by proximal phalanx fracture fixations during rehabilitation exercises

Autori: Peter Schwarzenberg, Thomas Colding-Rasmussen, Daniel J. Hutchinson, Jorge San Jacinto Garcia, Viktor Granskog, Michael Mørk Petersen, Tatjana Pastor, Tine Weis, Michael Malkoch, Christian Nai En Tierp-Wong, Peter Varga
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 12, 2024, ISSN 2296-4185
Editore: Frontiers
DOI: 10.3389/fbioe.2024.1388399

Photo‐Curable Triazinetrione Composites With Tunable Degradation for Fracture Stabilization and Flexible Thin‐Film Applications

Autori: Jorge San Jacinto Garcia, Natalia Sanz del Olmo, Daniel J. Hutchinson, Michael Malkoch
Pubblicato in: Journal of Applied Polymer Science, 2025, ISSN 0021-8995
Editore: John Wiley & Sons Inc.
DOI: 10.1002/app.57068

Biomechanical Variability and Usability of a Novel Customizable Fracture Fixation Technique

Autori: Colding-Rasmussen, Thomas; Schwarzenberg, Peter; Horstmann, Peter Frederik; Ottesen, Casper Bent Smedegaard; Garcia, Jorge San Jacinto; Hutchinson, Daniel John; Malkoch, Michael; Petersen, Michael Mørk; Varga, Peter; Tierp-Wong, Christian Nai En
Pubblicato in: Bioengineering, Numero 10, 2023, Pagina/e 1146, ISSN 2306-5354
Editore: MDPI
DOI: 10.3390/bioengineering10101146

Injectable Dendritic Hydrogels Curable by High-Energy Visible Light for Cell Delivery in Bone Regeneration

Autori: Noemi Molina, Francesco Torelli, Samih Mohamed-Ahmed, Daniel J. Hutchinson, Cecilie Gjerde, Ahmad Rashad, Kamal Mustafa, Michael Malkoch
Pubblicato in: Chemistry of Materials, 2025, ISSN 0897-4756
Editore: American Chemical Society
DOI: 10.1021/acs.chemmater.5c00063

Soft Hydroxyapatite Composites Based on Triazine–Trione Systems as Potential Biomedical Engineering Frameworks

Autori: Lin, Jinjian; Fan, Yanmiao; Hutchinson, Daniel J.; Malkoch, Michael
Pubblicato in: ACS Appl Mater Interfaces, Numero 15, 2023, Pagina/e 7329-7339, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.2c16235

Impact of Polyester Dendrimers as Branched Multifunctional Cross-Linking Additives in Triazine-Trione-Based Composites Developed via High-Energy Visible Light Thiol-ene Chemistry

Autori: Lin, Jinjian; Sanz del Olmo, Natalia; San Jacinto Garcia, Jorge; Hutchinson, Daniel J.; Malkoch, Michael
Pubblicato in: ACS Applied Polymer Materials, Numero 5, 2023, Pagina/e 10395-10403, ISSN 2637-6105
Editore: American Chemical Society
DOI: 10.1021/acsapm.3c02246

Synthesis and Characterization of Amino-Functional Polyester Dendrimers Based On Bis-MPA with Enhanced Hydrolytic Stability and Inherent Antibacterial Properties

Autori: Namata, Faridah; Sanz del Olmo, Natalia; Molina, Noemi; Malkoch, Michael
Pubblicato in: Biomacromolecules, Numero 24, 2023, Pagina/e 858-867, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.2c01286

Antibacterial Hydrogel Adhesives Based on Bifunctional Telechelic Dendritic-Linear–Dendritic Block Copolymers

Autori: Sanz del Olmo, Natalia; Molina, Noemi; Fan, Yanmiao; Hutchinson, Daniel J.; Malkoch, Michael
Pubblicato in: J. Am. Chem. Soc., Numero 146, 2024, Pagina/e 17240-17249, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.4c03673

Biomechanical Characterization of Metacarpal Fixation: Internal Load Determination and Evaluation of a Novel Adhesive Osteosynthesis

Autori: Peter Schwarzenberg, Gordian Banzer, Guillaume Patt‐Lafitte, Jérôme Schlatter, Daniel J. Hutchinson, Michael Malkoch, Peter Varga, Tatjana Pastor
Pubblicato in: Journal of Orthopaedic Research, 2025, ISSN 0736-0266
Editore: Elsevier BV
DOI: 10.1002/jor.70027

Toughening and strengthening of visible light-cured hydroxyapatite thiol-ene resin composite intended as bone fixation using 2D textile

Autori: Patt-Lafitte, Guillaume; Valfort, Oliver; Hutchinson, Daniel J.; Malkoch, Michael; Eglin, David
Pubblicato in: Journal of Materials Research and Technology, Numero 29, 2024, Pagina/e 982-990, ISSN 2238-7854
Editore: Elsevier Editora Ltda
DOI: 10.1016/j.jmrt.2024.01.127

Enhanced Degradability of Thiol–Ene Composites through the Inclusion of Isosorbide-Based Polycarbonates

Autori: Jorge San Jacinto Garcia, Natalia Sanz del Olmo, Daniel J. Hutchinson, Michael Malkoch
Pubblicato in: ACS Applied Materials & Interfaces, Numero 16, 2024, Pagina/e 40056-40068, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.4c09626

Photo‐Clickable Triazine‐Trione Thermosets as Promising 3D Scaffolds for Tissue Engineering Applications

Autori: Åshild Johansen, Jinjian Lin, Shuntaro Yamada, Samih Mohamed‐Ahmed, Mohammed A. Yassin, Cecilie Gjerde, Daniel J. Hutchinson, Kamal Mustafa, Michael Malkoch
Pubblicato in: Advanced Healthcare Materials, Numero 16, 2024, Pagina/e 40056, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202401202

Novel Customizable Fracture Fixation Technique vs. Conventional Metal Locking Plate: An Exploratory Comparative Study of Fixation Stability in an Experimental In Vivo Ovine Bilateral Phalangeal Fracture Model

Autori: Thomas Colding-Rasmussen, Nanett Kvist Nikolaisen, Peter Frederik Horstmann, Michael Mørk Petersen, Daniel John Hutchinson, Michael Malkoch, Stine Jacobsen, Christian Nai En Tierp-Wong
Pubblicato in: Materials, Numero 18, 2025, Pagina/e 3359, ISSN 1996-1944
Editore: MDPI Open Access Publishing
DOI: 10.3390/ma18143359

Conference proceedings (9)

Dendritic-Linear-Dendritic (DLD) Based Materials and Their Potential Use inBiomedical Applications

Autori: Molina, Noemi; Sanz del Olmo, Natalia; Hutchinson, Daniel J.; Malkoch, Michael
Pubblicato in: ARI Abstracts Periodical, Numero 3, 2023, Pagina/e 177, ISSN 2960-2483
Editore: AO Research Institute Davos

Strong photo-curable thiol-ene based composites for use in the fixation of bonefractures

Autori: Hutchinson, Daniel J.; Granskog, Viktor; Malkoch, Michael
Pubblicato in: ARI Abstracts Periodical, Numero 3, 2023, Pagina/e 153, ISSN 2960-2483
Editore: AO Research Institute Davos

Degradable thiol-ene composites for bone repair

Autori: San Jacinto, Jorge; Hutchinson, Daniel J.; Sanz del Olmo, Natalia; Malkoch, Michael
Pubblicato in: ARI Abstracts Periodical, Numero 3, 2023, Pagina/e 303, ISSN 2960-2483
Editore: AO Research Institute Davos

Fabrication of biodegradable high strength and shape-shifting polylactic acidmembrane for reinforcement of a photo-curable composite bone fixation patch

Autori: Patt-Lafitte, Guillaume; Hutchinson, Daniel J.; Malkoch, Michael; Eglin, David
Pubblicato in: ARI Abstracts Periodical, Numero 3, 2023, Pagina/e 462, ISSN 2960-2483
Editore: AO Research Institute Davos

Welfare monitoring in the novel ovine thoracic limb, bilateral, single-toeostectomy model (OBST)

Autori: Nikolaisen, Nannet Kvist.; Tierp-Wong, Christian Nai En.; Colding-Rasmussen, Thomas; Petersen, Michael Mork; Hutchinson, Daniel; Lindegaard, Casper; Jacobsen, Stine
Pubblicato in: ARI Abstracts Periodical, Numero 3, 2023, Pagina/e 144, ISSN 2960-2483
Editore: AO Research Insitute Davos

Biomechanical analysis of a novel osteosynthesis device with standard andphysiological testing

Autori: Schwarzenberg, Peter; Colding-Rasmussen, Thomas; Hutchinson, Daniel J.; San Jacinto Garcia, Jorge; Jacobsen, Stine; Horstmann, Peter; Petersen, Michael Mork; Mischler, Dominic; Granskog, V.; Pastor, Tatjana; Weis, Tine; Malkoch, Michael; Wong, Christian; Varga, Peter
Pubblicato in: ARI Abstracts Periodical, Numero 3, 2023, Pagina/e 314, ISSN 2960-2483
Editore: AO Research Institute Davos

The effect of PET meshes on the mechanical and structural properties of a photo-curable hydroxyapatite composite intended as internal fixation in complex bonefractures

Autori: Patt-Lafitte, Guillaume, Rasolonjatovo, Sarah; Hutchinson, Daniel J.; Malkoch, Michael; Eglin, David
Pubblicato in: ARI Abstracts Periodical, Numero 3, 2023, Pagina/e 228, ISSN 2960-2483
Editore: AO Research Institute Davos

Cytocompatibility and osteogenic differentiation of mesenchymal stem cellswithin phototunable polyester-based PEGylated dendritic hydrogels

Autori: Torelli, Francesco; Mohamed-Ahmed, Samih; Rashad, Ahmad; Cabeza, Noemi M.; Hutchinson, Daniel J.; Malkoch, Michael; Mustafa, Kamal
Pubblicato in: ARI Abstracts Periodical, Numero 3, 2023, Pagina/e 492, ISSN 2960-2483
Editore: AO Research Institute Davos

From bench to chairside: Mesenchymal stem cells and biomedical engineering inbone regeneration

Autori: Mustafa, Kamal E.
Pubblicato in: ARI Abstracts Periodical, Numero 3, 2023, Pagina/e 312, ISSN 2960-2483
Editore: AO Research Institute Davos