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CORDIS - EU research results
CORDIS

Viruses and Epitranscriptomics: seeking novel targets for antiviral therapy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Publications

The crosstalk between miRNAs and tRNA modifying enzymes: an alternative pathway to regulate the tRNA epitranscriptome

Author(s): Diana Bastos
Published in: 2022
Publisher: University of Aveiro

Uncovering the impact of peroxisome biogenesis deficiencies on the susceptibility to influenza A virus infections

Author(s): Catarina Luís
Published in: 2023
Publisher: University of Aveiro

Functional analysis of the peroxisomal and mitochondrial proteins MFF and FIS1 in HCMV evasion of the cellular antiviral response

Author(s): Ana Gouveia
Published in: 2021
Publisher: University of Aveiro

Novel tools to study the interplay between peroxisomes and lipid droplets in hepatitis C virus infection

Author(s): Ariana Carvalho
Published in: 2021
Publisher: Universidade de Aveiro

Identification of novel therapeutic targets to modulate proteostasis in humans

Author(s): Marisa de Almeida Pereira
Published in: 2023
Publisher: University of Aveiro

Steroid-based compounds as novel broad-spectrum antivirals

Author(s): Francisco Mendes
Published in: 2022
Publisher: University of Aveiro

Small non-coding RNAs as determinants of viral replication

Author(s): Rafaela Salvador
Published in: 2022
Publisher: University of Aveiro

Unravelling the profile and role of tRNA-derived small RNAs in Influenza A virus infection

Author(s): Daniel Monteiro
Published in: 2021
Publisher: University of Aveiro

Deciphering the crosstalk between MAVS- and STING- dependent antiviral responses

Author(s): Rui Ferreira
Published in: 2022
Publisher: University of Aveiro

Exploring the antiviral potential of steroid compounds against influenza A virus infection

Author(s): Jéssica Oliveira
Published in: 2021
Publisher: University of Aveiro

Uncovering potential targets for new host-directed antiviral therapies against influenza A virus infection

Author(s): Mariana Marques
Published in: 2023
Publisher: University of Aveiro

Mass spectrometric studies of RNA modification patterns in mammals

Author(s): Paria Asadi Atoi
Published in: 2023
Publisher: Goethe University of Frankfurt

Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site (opens in new window)

Author(s): Vera J. E. van Vliet, Nhan Huynh, Judith Palà, Ankoor Patel, Alex Singer, Cole Slater, Jacky Chung, Mariska van Huizen, Joan Teyra, Shane Miersch, Gia-Khanh Luu, Wei Ye, Nitin Sharma, Safder S. Ganaie, Raquel Russell, Chao Chen, Mindy Maynard, Gaya K. Amarasinghe, Brian L. Mark, Marjolein Kikkert, Sachdev S. Sidhu
Published in: PLOS Pathogens, Issue 18(12): e1011065, 2022, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1011065

The physiological functions of human peroxisomes (opens in new window)

Author(s): Ronald J. A. Wanders, Myriam Baes, Daniela Ribeiro, Sacha Ferdinandusse, Hans R. Waterham
Published in: Physiological Reviews, 2023, ISSN 0031-9333
Publisher: American Physiological Society
DOI: 10.1152/physrev.00051.2021

Emerging roles of peroxisomes in viral infections (opens in new window)

Author(s): Ana Rita Ferreira; Mariana Marques; Bruno Ramos; Jonathan C. Kagan; Daniela Ribeiro
Published in: Trends in Cell Biology, 2022, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2021.09.010

Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo (opens in new window)

Author(s): Mariska van Huizen,Jonna R. Bloeme - ter Horst,Heidi L. M. de Gruyter,Paul P. Geurink,Gerbrand J. van der Heden van Noort,Robert C. M. Knaap,Tessa Nelemans,Natacha S. Ogando,Anouk A. Leijs,Nadya Urakova,Brian L. Mark,Eric J. Snijder,Sebenzile K. Myeni, Marjolein Kikkert
Published in: PLOS Pathogens, 2024, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1012100

Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis (opens in new window)

Author(s): Marisa Pereira, Diana R. Ribeiro, Maximilian Berg, Andy P. Tsai, Chuanpeng Dong, Kwangsik Nho, Stefanie Kaiser, Miguel Moutinho, Ana R. Soares
Published in: BBA Molecular Basis of Disease, 2023, ISSN 0925-4439
Publisher: Elsevier BV
DOI: 10.1016/j.bbadis.2023.166857

Human Cytomegalovirus vMIA Inhibits MAVS Oligomerization at Peroxisomes in an MFF-Dependent Manner (opens in new window)

Author(s): Ana Rita Ferreira, Ana Gouveia, Ana Cristina Magalhães, Isabel Valença, Mariana Marques, Jonathan C Kagan, Daniela Ribeiro
Published in: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2022.871977

Pitfalls in RNA Modification Quantification Using Nucleoside Mass Spectrometry (opens in new window)

Author(s): Gregor Ammann, Maximilian Berg, Jan Felix Dalwigk, and Stefanie M. Kaiser
Published in: Accounts of Chemical Research, 2023, ISSN 0001-4842
Publisher: American Chemical Society
DOI: 10.1021/acs.accounts.3c00402

The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections (opens in new window)

Author(s): Diana Roberta Ribeiro, Alexandre Nunes, Daniela Ribeiro, Ana Raquel Soares
Published in: Frontiers in Genetics, 2023, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2023.1245683

Novel approaches for the rapid development of rationally designed arbovirus vaccines (opens in new window)

Author(s): Joyce W M van Bree, Imke Visser, Jo M Duyvestyn, Muriel Aguilar-Bretones, Eleanor M Marshall, Martijn J van Hemert, Gorben P Pijlman, Gijsbert P van Nierop, Marjolein Kikkert, Barry H G Rockx , Pascal Miesen, Jelke J Fros
Published in: One Health, 2023, ISSN 2352-7714
Publisher: Elsevier B.V.
DOI: 10.1016/j.onehlt.2023.100565

Different modification pathways for m1A58 incorporation in yeast elongator and initiator tRNAs (opens in new window)

Author(s): Marcel-Joseph Yared, Yasemin Yoluç, Marjorie Catala, Carine Tisné, Stefanie Kaiser, Pierre Barraud
Published in: Nucleic Acids Research, 2023, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkad722

Editorial: Viruses and Epitranscriptomes: Regulation of Infection and Antiviral Response (opens in new window)

Author(s): Ana Raquel Soares, Marjolein Kikkert, Stefanie Kellner-Kaiser, Daniela Ribeiro
Published in: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2022.917894

Emerging roles of the Protein Phosphatase 1 (PP1) in the context of viral infections. (opens in new window)

Author(s): Pedro O. Corda, Mathieu Bollen, Daniela Ribeiro, Margarida Fardilha
Published in: Cell communication and Signaling, 2024, ISSN 1478-811X
Publisher: BioMed Central
DOI: 10.1186/s12964-023-01468-8

The Main Protease of Middle East Respiratory Syndrome Coronavirus Induces Cleavage of Mitochondrial Antiviral Signaling Protein to Antagonize the Innate Immune Response (opens in new window)

Author(s): Mariska van Huizen; Xavier M. Vendrell; Heidi L. M. de Gruyter; A. Linda Boomaars-van der Zanden; Yvonne van der Meer; Eric J. Snijder; Marjolein Kikkert; Sebenzile K. Myeni
Published in: Viruses, 2024, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16020256

Viral deubiquitinating proteases and the promising strategies of their inhibition (opens in new window)

Author(s): Vera J E van Vliet, Anuradha De Silva, Brian L Mark, Marjolein Kikkert
Published in: Virus Research, 2024, ISSN 1872-7492
Publisher: Elsevier
DOI: 10.1016/j.virusres.2024.199368

Engineering potent live attenuated coronavirus vaccines by targeted inactivation of the immune evasive viral deubiquitinase (opens in new window)

Author(s): Sebenzile K. Myeni, Peter J. Bredenbeek, Robert C. M. Knaap, Tim J. Dalebout, Shessy Torres Morales, Igor A. Sidorov, Marissa E. Linger, Nadia Oreshkova, Sophie van Zanen-Gerhardt, Serge A. L. Zander, Luis Enjuanes, Isabel Sola,Eric J. Snijder, Marjolein Kikkert
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-36754-z

Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates (opens in new window)

Author(s): Mariana Marques, Bruno Ramos, Hélio Albuquerque, Marisa Pereira, Diana Roberta Ribeiro, Alexandre Nunes, Jéssica Sarabando, Daniela Brás, Ana Rita Ferreira, Rui Vitorino, Maria João Amorim, Artur M.S. Silva, Ana Raquel Soares, Daniela Ribeiro
Published in: iScience, Issue 27, 2024, ISSN 2589-0042
Publisher: Cell Press Elsevier Inc
DOI: 10.1016/j.isci.2024.109100

m5U54 tRNA Hypomodification by Lack of TRMT2A Drives the Generation of tRNA-Derived Small RNAs (opens in new window)

Author(s): Marisa Pereira, Diana R. Ribeiro, Miguel M. Pinheiro, Margarida Ferreira, Stefanie Kellner, Ana R. Soares
Published in: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22062941

Upregulation of tRNA-Ser-AGA-2-1 Promotes Malignant Behavior in Normal Bronchial Cells (opens in new window)

Author(s): Mafalda Santos; Mafalda Santos; Mafalda Santos; Ana Fidalgo; Ana Sofia Varanda; Ana Sofia Varanda; Ana Sofia Varanda; Ana Raquel Soares; Gabriela M. Almeida; Gabriela M. Almeida; Gabriela M. Almeida; Diana Martins; Diana Martins; Nuno Mendes; Nuno Mendes; Carla Oliveira; Carla Oliveira; Carla Oliveira; Manuel A. S. Santos
Published in: Frontiers in Molecular Biosciences, 2022, ISSN 2296-889X
Publisher: Frontiers
DOI: 10.3389/fmolb.2022.809985

Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis (opens in new window)

Author(s): Ben A. Bailey-Elkin, Robert C. M. Knaap, Anuradha De Silva, Ilse M. Boekhoud, Sandra Mous, Niek van Vught, Mazdak Khajehpour, Erwin van den Born, Marjolein Kikkert, Brian L. Mark
Published in: PLOS Pathogens, 2023, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1011872

Determining the Importance of Peroxisomal Proteins for Viral Infections in Cultured Mammalian Cells. (opens in new window)

Author(s): Marques, Mariana; Ferreira, Ana Rita; Ribeiro, Daniela
Published in: Methods in Molecular Biology, Issue 2, 2023, ISBN 978-1-0716-3047-1
Publisher: Humana
DOI: 10.1007/978-1-0716-3048-8_21

Peroxisomes and Viruses: Overview on Current Knowledge and Experimental Approaches (opens in new window)

Author(s): Ferreira, Vanessa; Ferreira, Ana Rita; Ribeiro, Daniela
Published in: Peroxisomes. Methods in Molecular Biology, 2023, ISBN 978-1-0716-3047-1
Publisher: Humana
DOI: 10.1007/978-1-0716-3048-8_19

Tools to Investigate the Peroxisome-Dependent Antiviral Response (opens in new window)

Author(s): Ramos, Bruno; Ferreira, Ana Rita; Ribeiro, Daniela
Published in: Methods in Molecular Biology, 2024, ISBN 978-1-0716-3048-8
Publisher: Humana
DOI: 10.1007/978-1-0716-3048-8_20

Temporal resolution of NAIL-MS of tRNA, rRNA and Poly-A RNA is overcome by actinomycin D (opens in new window)

Author(s): Felix Hagelskamp, Kayla Borland, Gregor Ammann, Stefanie M. Kaiser
Published in: RSC Chemical Biology, 2023, ISSN 2633-0679
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2cb00243d

Identification of novel therapeutic targets to modulate proteostasis in humans

Author(s): Pereira, Marisa; Soares, Ana; Mano, Miguel
Published in: 2021
Publisher: University of Aveiro

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