Viruses and Epitranscriptomics: seeking novel targets for antiviral therapy

Información del proyecto

EpiViral

Identificador del acuerdo de subvención: 952373

DOI

10.3030/952373

Proyecto cerrado

Fecha de la firma de la CE 2 Julio 2020

Fecha de inicio 1 Enero 2021

Fecha de finalización 30 Junio 2024

Financiado con arreglo a

• Twinning of research institutions

Coste total

€ 878 446,25

Aportación de la UE

€ 878 446,25

Coordinado por

UNIVERSIDADE DE AVEIRO
Portugal

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (5)

Third EpiViral newsletter
Second EpiViral newsletter
Project website
First EpiViral newsletter
Social media accounts

Documents, reports (7)

Second Summer School

Report on Second Summer School

First Summer School

Report on the organization of the First Summer School

First Annual Symposium

Report on First Annual Symposium

Third Annual Symposium

Report on Third Annual Symposium

International Conference Organization

Report on International Conference Organization

Launch of repository of project results
Second Annual Symposium

Report on Second Annual Symposium

Publicaciones

Thesis and dissertations (12)

The crosstalk between miRNAs and tRNA modifying enzymes: an alternative pathway to regulate the tRNA epitranscriptome

Autores: Diana Bastos
Publicado en: 2022
Editor: University of Aveiro

Uncovering the impact of peroxisome biogenesis deficiencies on the susceptibility to influenza A virus infections

Autores: Catarina Luís
Publicado en: 2023
Editor: University of Aveiro

Functional analysis of the peroxisomal and mitochondrial proteins MFF and FIS1 in HCMV evasion of the cellular antiviral response

Autores: Ana Gouveia
Publicado en: 2021
Editor: University of Aveiro

Novel tools to study the interplay between peroxisomes and lipid droplets in hepatitis C virus infection

Autores: Ariana Carvalho
Publicado en: 2021
Editor: Universidade de Aveiro

Identification of novel therapeutic targets to modulate proteostasis in humans

Autores: Marisa de Almeida Pereira
Publicado en: 2023
Editor: University of Aveiro

Steroid-based compounds as novel broad-spectrum antivirals

Autores: Francisco Mendes
Publicado en: 2022
Editor: University of Aveiro

Small non-coding RNAs as determinants of viral replication

Autores: Rafaela Salvador
Publicado en: 2022
Editor: University of Aveiro

Unravelling the profile and role of tRNA-derived small RNAs in Influenza A virus infection

Autores: Daniel Monteiro
Publicado en: 2021
Editor: University of Aveiro

Deciphering the crosstalk between MAVS- and STING- dependent antiviral responses

Autores: Rui Ferreira
Publicado en: 2022
Editor: University of Aveiro

Exploring the antiviral potential of steroid compounds against influenza A virus infection

Autores: Jéssica Oliveira
Publicado en: 2021
Editor: University of Aveiro

Uncovering potential targets for new host-directed antiviral therapies against influenza A virus infection

Autores: Mariana Marques
Publicado en: 2023
Editor: University of Aveiro

Mass spectrometric studies of RNA modification patterns in mammals

Autores: Paria Asadi Atoi
Publicado en: 2023
Editor: Goethe University of Frankfurt

Peer reviewed articles (19)

Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site

Autores: Vera J. E. van Vliet, Nhan Huynh, Judith Palà, Ankoor Patel, Alex Singer, Cole Slater, Jacky Chung, Mariska van Huizen, Joan Teyra, Shane Miersch, Gia-Khanh Luu, Wei Ye, Nitin Sharma, Safder S. Ganaie, Raquel Russell, Chao Chen, Mindy Maynard, Gaya K. Amarasinghe, Brian L. Mark, Marjolein Kikkert, Sachdev S. Sidhu
Publicado en: PLOS Pathogens, Edición 18(12): e1011065, 2022, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1011065

The physiological functions of human peroxisomes

Autores: Ronald J. A. Wanders, Myriam Baes, Daniela Ribeiro, Sacha Ferdinandusse, Hans R. Waterham
Publicado en: Physiological Reviews, 2023, ISSN 0031-9333
Editor: American Physiological Society
DOI: 10.1152/physrev.00051.2021

Emerging roles of peroxisomes in viral infections

Autores: Ana Rita Ferreira; Mariana Marques; Bruno Ramos; Jonathan C. Kagan; Daniela Ribeiro
Publicado en: Trends in Cell Biology, 2022, ISSN 0962-8924
Editor: Elsevier BV
DOI: 10.1016/j.tcb.2021.09.010

Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo

Autores: Mariska van Huizen,Jonna R. Bloeme - ter Horst,Heidi L. M. de Gruyter,Paul P. Geurink,Gerbrand J. van der Heden van Noort,Robert C. M. Knaap,Tessa Nelemans,Natacha S. Ogando,Anouk A. Leijs,Nadya Urakova,Brian L. Mark,Eric J. Snijder,Sebenzile K. Myeni, Marjolein Kikkert
Publicado en: PLOS Pathogens, 2024, ISSN 1544-9173
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1012100

Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis

Autores: Marisa Pereira, Diana R. Ribeiro, Maximilian Berg, Andy P. Tsai, Chuanpeng Dong, Kwangsik Nho, Stefanie Kaiser, Miguel Moutinho, Ana R. Soares
Publicado en: BBA Molecular Basis of Disease, 2023, ISSN 0925-4439
Editor: Elsevier BV
DOI: 10.1016/j.bbadis.2023.166857

Human Cytomegalovirus vMIA Inhibits MAVS Oligomerization at Peroxisomes in an MFF-Dependent Manner

Autores: Ana Rita Ferreira, Ana Gouveia, Ana Cristina Magalhães, Isabel Valença, Mariana Marques, Jonathan C Kagan, Daniela Ribeiro
Publicado en: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Editor: Frontiers
DOI: 10.3389/fcell.2022.871977

Pitfalls in RNA Modification Quantification Using Nucleoside Mass Spectrometry

Autores: Gregor Ammann, Maximilian Berg, Jan Felix Dalwigk, and Stefanie M. Kaiser
Publicado en: Accounts of Chemical Research, 2023, ISSN 0001-4842
Editor: American Chemical Society
DOI: 10.1021/acs.accounts.3c00402

The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections

Autores: Diana Roberta Ribeiro, Alexandre Nunes, Daniela Ribeiro, Ana Raquel Soares
Publicado en: Frontiers in Genetics, 2023, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2023.1245683

Novel approaches for the rapid development of rationally designed arbovirus vaccines

Autores: Joyce W M van Bree, Imke Visser, Jo M Duyvestyn, Muriel Aguilar-Bretones, Eleanor M Marshall, Martijn J van Hemert, Gorben P Pijlman, Gijsbert P van Nierop, Marjolein Kikkert, Barry H G Rockx , Pascal Miesen, Jelke J Fros
Publicado en: One Health, 2023, ISSN 2352-7714
Editor: Elsevier B.V.
DOI: 10.1016/j.onehlt.2023.100565

Different modification pathways for m1A58 incorporation in yeast elongator and initiator tRNAs

Autores: Marcel-Joseph Yared, Yasemin Yoluç, Marjorie Catala, Carine Tisné, Stefanie Kaiser, Pierre Barraud
Publicado en: Nucleic Acids Research, 2023, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkad722

Editorial: Viruses and Epitranscriptomes: Regulation of Infection and Antiviral Response

Autores: Ana Raquel Soares, Marjolein Kikkert, Stefanie Kellner-Kaiser, Daniela Ribeiro
Publicado en: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Editor: Frontiers
DOI: 10.3389/fcell.2022.917894

Emerging roles of the Protein Phosphatase 1 (PP1) in the context of viral infections.

Autores: Pedro O. Corda, Mathieu Bollen, Daniela Ribeiro, Margarida Fardilha
Publicado en: Cell communication and Signaling, 2024, ISSN 1478-811X
Editor: BioMed Central
DOI: 10.1186/s12964-023-01468-8

The Main Protease of Middle East Respiratory Syndrome Coronavirus Induces Cleavage of Mitochondrial Antiviral Signaling Protein to Antagonize the Innate Immune Response

Autores: Mariska van Huizen; Xavier M. Vendrell; Heidi L. M. de Gruyter; A. Linda Boomaars-van der Zanden; Yvonne van der Meer; Eric J. Snijder; Marjolein Kikkert; Sebenzile K. Myeni
Publicado en: Viruses, 2024, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16020256

Viral deubiquitinating proteases and the promising strategies of their inhibition

Autores: Vera J E van Vliet, Anuradha De Silva, Brian L Mark, Marjolein Kikkert
Publicado en: Virus Research, 2024, ISSN 1872-7492
Editor: Elsevier
DOI: 10.1016/j.virusres.2024.199368

Engineering potent live attenuated coronavirus vaccines by targeted inactivation of the immune evasive viral deubiquitinase

Autores: Sebenzile K. Myeni, Peter J. Bredenbeek, Robert C. M. Knaap, Tim J. Dalebout, Shessy Torres Morales, Igor A. Sidorov, Marissa E. Linger, Nadia Oreshkova, Sophie van Zanen-Gerhardt, Serge A. L. Zander, Luis Enjuanes, Isabel Sola,Eric J. Snijder, Marjolein Kikkert
Publicado en: Nature Communications, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-36754-z

Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates

Autores: Mariana Marques, Bruno Ramos, Hélio Albuquerque, Marisa Pereira, Diana Roberta Ribeiro, Alexandre Nunes, Jéssica Sarabando, Daniela Brás, Ana Rita Ferreira, Rui Vitorino, Maria João Amorim, Artur M.S. Silva, Ana Raquel Soares, Daniela Ribeiro
Publicado en: iScience, Edición 27, 2024, ISSN 2589-0042
Editor: Cell Press Elsevier Inc
DOI: 10.1016/j.isci.2024.109100

m5U54 tRNA Hypomodification by Lack of TRMT2A Drives the Generation of tRNA-Derived Small RNAs

Autores: Marisa Pereira, Diana R. Ribeiro, Miguel M. Pinheiro, Margarida Ferreira, Stefanie Kellner, Ana R. Soares
Publicado en: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22062941

Upregulation of tRNA-Ser-AGA-2-1 Promotes Malignant Behavior in Normal Bronchial Cells

Autores: Mafalda Santos; Mafalda Santos; Mafalda Santos; Ana Fidalgo; Ana Sofia Varanda; Ana Sofia Varanda; Ana Sofia Varanda; Ana Raquel Soares; Gabriela M. Almeida; Gabriela M. Almeida; Gabriela M. Almeida; Diana Martins; Diana Martins; Nuno Mendes; Nuno Mendes; Carla Oliveira; Carla Oliveira; Carla Oliveira; Manuel A. S. Santos
Publicado en: Frontiers in Molecular Biosciences, 2022, ISSN 2296-889X
Editor: Frontiers
DOI: 10.3389/fmolb.2022.809985

Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis

Autores: Ben A. Bailey-Elkin, Robert C. M. Knaap, Anuradha De Silva, Ilse M. Boekhoud, Sandra Mous, Niek van Vught, Mazdak Khajehpour, Erwin van den Born, Marjolein Kikkert, Brian L. Mark
Publicado en: PLOS Pathogens, 2023, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1011872

Book chapters (3)

Determining the Importance of Peroxisomal Proteins for Viral Infections in Cultured Mammalian Cells.

Autores: Marques, Mariana; Ferreira, Ana Rita; Ribeiro, Daniela
Publicado en: Methods in Molecular Biology, Edición 2, 2023, ISBN 978-1-0716-3047-1
Editor: Humana
DOI: 10.1007/978-1-0716-3048-8_21

Peroxisomes and Viruses: Overview on Current Knowledge and Experimental Approaches

Autores: Ferreira, Vanessa; Ferreira, Ana Rita; Ribeiro, Daniela
Publicado en: Peroxisomes. Methods in Molecular Biology, 2023, ISBN 978-1-0716-3047-1
Editor: Humana
DOI: 10.1007/978-1-0716-3048-8_19

Tools to Investigate the Peroxisome-Dependent Antiviral Response

Autores: Ramos, Bruno; Ferreira, Ana Rita; Ribeiro, Daniela
Publicado en: Methods in Molecular Biology, 2024, ISBN 978-1-0716-3048-8
Editor: Humana
DOI: 10.1007/978-1-0716-3048-8_20

Non-peer reviewed articles (1)

Temporal resolution of NAIL-MS of tRNA, rRNA and Poly-A RNA is overcome by actinomycin D

Autores: Felix Hagelskamp, Kayla Borland, Gregor Ammann, Stefanie M. Kaiser
Publicado en: RSC Chemical Biology, 2023, ISSN 2633-0679
Editor: Royal Society of Chemistry
DOI: 10.1039/d2cb00243d

Conference proceedings (1)

Identification of novel therapeutic targets to modulate proteostasis in humans

Autores: Pereira, Marisa; Soares, Ana; Mano, Miguel
Publicado en: 2021
Editor: University of Aveiro