Viruses and Epitranscriptomics: seeking novel targets for antiviral therapy

Informacje na temat projektu

EpiViral

Identyfikator umowy o grant: 952373

DOI

10.3030/952373

Projekt został zamknięty

Data podpisania przez KE 2 Lipca 2020

Data rozpoczęcia 1 Stycznia 2021

Data zakończenia 30 Czerwca 2024

Finansowanie w ramach

• Twinning of research institutions

Koszt całkowity

€ 878 446,25

Wkład UE

€ 878 446,25

Koordynowany przez

UNIVERSIDADE DE AVEIRO
Portugal

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Websites, patent fillings, videos etc. (5)

Third EpiViral newsletter
Second EpiViral newsletter
Project website
First EpiViral newsletter
Social media accounts

Documents, reports (7)

Second Summer School

Report on Second Summer School

First Summer School

Report on the organization of the First Summer School

First Annual Symposium

Report on First Annual Symposium

Third Annual Symposium

Report on Third Annual Symposium

International Conference Organization

Report on International Conference Organization

Launch of repository of project results
Second Annual Symposium

Report on Second Annual Symposium

Publikacje

Thesis and dissertations (12)

The crosstalk between miRNAs and tRNA modifying enzymes: an alternative pathway to regulate the tRNA epitranscriptome

Autorzy: Diana Bastos
Opublikowane w: 2022
Wydawca: University of Aveiro

Uncovering the impact of peroxisome biogenesis deficiencies on the susceptibility to influenza A virus infections

Autorzy: Catarina Luís
Opublikowane w: 2023
Wydawca: University of Aveiro

Functional analysis of the peroxisomal and mitochondrial proteins MFF and FIS1 in HCMV evasion of the cellular antiviral response

Autorzy: Ana Gouveia
Opublikowane w: 2021
Wydawca: University of Aveiro

Novel tools to study the interplay between peroxisomes and lipid droplets in hepatitis C virus infection

Autorzy: Ariana Carvalho
Opublikowane w: 2021
Wydawca: Universidade de Aveiro

Identification of novel therapeutic targets to modulate proteostasis in humans

Autorzy: Marisa de Almeida Pereira
Opublikowane w: 2023
Wydawca: University of Aveiro

Steroid-based compounds as novel broad-spectrum antivirals

Autorzy: Francisco Mendes
Opublikowane w: 2022
Wydawca: University of Aveiro

Small non-coding RNAs as determinants of viral replication

Autorzy: Rafaela Salvador
Opublikowane w: 2022
Wydawca: University of Aveiro

Unravelling the profile and role of tRNA-derived small RNAs in Influenza A virus infection

Autorzy: Daniel Monteiro
Opublikowane w: 2021
Wydawca: University of Aveiro

Deciphering the crosstalk between MAVS- and STING- dependent antiviral responses

Autorzy: Rui Ferreira
Opublikowane w: 2022
Wydawca: University of Aveiro

Exploring the antiviral potential of steroid compounds against influenza A virus infection

Autorzy: Jéssica Oliveira
Opublikowane w: 2021
Wydawca: University of Aveiro

Uncovering potential targets for new host-directed antiviral therapies against influenza A virus infection

Autorzy: Mariana Marques
Opublikowane w: 2023
Wydawca: University of Aveiro

Mass spectrometric studies of RNA modification patterns in mammals

Autorzy: Paria Asadi Atoi
Opublikowane w: 2023
Wydawca: Goethe University of Frankfurt

Peer reviewed articles (19)

Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site

Autorzy: Vera J. E. van Vliet, Nhan Huynh, Judith Palà, Ankoor Patel, Alex Singer, Cole Slater, Jacky Chung, Mariska van Huizen, Joan Teyra, Shane Miersch, Gia-Khanh Luu, Wei Ye, Nitin Sharma, Safder S. Ganaie, Raquel Russell, Chao Chen, Mindy Maynard, Gaya K. Amarasinghe, Brian L. Mark, Marjolein Kikkert, Sachdev S. Sidhu
Opublikowane w: PLOS Pathogens, Numer 18(12): e1011065, 2022, ISSN 1553-7366
Wydawca: Public Library of Science
DOI: 10.1371/journal.ppat.1011065

The physiological functions of human peroxisomes

Autorzy: Ronald J. A. Wanders, Myriam Baes, Daniela Ribeiro, Sacha Ferdinandusse, Hans R. Waterham
Opublikowane w: Physiological Reviews, 2023, ISSN 0031-9333
Wydawca: American Physiological Society
DOI: 10.1152/physrev.00051.2021

Emerging roles of peroxisomes in viral infections

Autorzy: Ana Rita Ferreira; Mariana Marques; Bruno Ramos; Jonathan C. Kagan; Daniela Ribeiro
Opublikowane w: Trends in Cell Biology, 2022, ISSN 0962-8924
Wydawca: Elsevier BV
DOI: 10.1016/j.tcb.2021.09.010

Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo

Autorzy: Mariska van Huizen,Jonna R. Bloeme - ter Horst,Heidi L. M. de Gruyter,Paul P. Geurink,Gerbrand J. van der Heden van Noort,Robert C. M. Knaap,Tessa Nelemans,Natacha S. Ogando,Anouk A. Leijs,Nadya Urakova,Brian L. Mark,Eric J. Snijder,Sebenzile K. Myeni, Marjolein Kikkert
Opublikowane w: PLOS Pathogens, 2024, ISSN 1544-9173
Wydawca: Public Library of Science
DOI: 10.1371/journal.ppat.1012100

Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis

Autorzy: Marisa Pereira, Diana R. Ribeiro, Maximilian Berg, Andy P. Tsai, Chuanpeng Dong, Kwangsik Nho, Stefanie Kaiser, Miguel Moutinho, Ana R. Soares
Opublikowane w: BBA Molecular Basis of Disease, 2023, ISSN 0925-4439
Wydawca: Elsevier BV
DOI: 10.1016/j.bbadis.2023.166857

Human Cytomegalovirus vMIA Inhibits MAVS Oligomerization at Peroxisomes in an MFF-Dependent Manner

Autorzy: Ana Rita Ferreira, Ana Gouveia, Ana Cristina Magalhães, Isabel Valença, Mariana Marques, Jonathan C Kagan, Daniela Ribeiro
Opublikowane w: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Wydawca: Frontiers
DOI: 10.3389/fcell.2022.871977

Pitfalls in RNA Modification Quantification Using Nucleoside Mass Spectrometry

Autorzy: Gregor Ammann, Maximilian Berg, Jan Felix Dalwigk, and Stefanie M. Kaiser
Opublikowane w: Accounts of Chemical Research, 2023, ISSN 0001-4842
Wydawca: American Chemical Society
DOI: 10.1021/acs.accounts.3c00402

The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections

Autorzy: Diana Roberta Ribeiro, Alexandre Nunes, Daniela Ribeiro, Ana Raquel Soares
Opublikowane w: Frontiers in Genetics, 2023, ISSN 1664-8021
Wydawca: Frontiers Media
DOI: 10.3389/fgene.2023.1245683

Novel approaches for the rapid development of rationally designed arbovirus vaccines

Autorzy: Joyce W M van Bree, Imke Visser, Jo M Duyvestyn, Muriel Aguilar-Bretones, Eleanor M Marshall, Martijn J van Hemert, Gorben P Pijlman, Gijsbert P van Nierop, Marjolein Kikkert, Barry H G Rockx , Pascal Miesen, Jelke J Fros
Opublikowane w: One Health, 2023, ISSN 2352-7714
Wydawca: Elsevier B.V.
DOI: 10.1016/j.onehlt.2023.100565

Different modification pathways for m1A58 incorporation in yeast elongator and initiator tRNAs

Autorzy: Marcel-Joseph Yared, Yasemin Yoluç, Marjorie Catala, Carine Tisné, Stefanie Kaiser, Pierre Barraud
Opublikowane w: Nucleic Acids Research, 2023, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkad722

Editorial: Viruses and Epitranscriptomes: Regulation of Infection and Antiviral Response

Autorzy: Ana Raquel Soares, Marjolein Kikkert, Stefanie Kellner-Kaiser, Daniela Ribeiro
Opublikowane w: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Wydawca: Frontiers
DOI: 10.3389/fcell.2022.917894

Emerging roles of the Protein Phosphatase 1 (PP1) in the context of viral infections.

Autorzy: Pedro O. Corda, Mathieu Bollen, Daniela Ribeiro, Margarida Fardilha
Opublikowane w: Cell communication and Signaling, 2024, ISSN 1478-811X
Wydawca: BioMed Central
DOI: 10.1186/s12964-023-01468-8

The Main Protease of Middle East Respiratory Syndrome Coronavirus Induces Cleavage of Mitochondrial Antiviral Signaling Protein to Antagonize the Innate Immune Response

Autorzy: Mariska van Huizen; Xavier M. Vendrell; Heidi L. M. de Gruyter; A. Linda Boomaars-van der Zanden; Yvonne van der Meer; Eric J. Snijder; Marjolein Kikkert; Sebenzile K. Myeni
Opublikowane w: Viruses, 2024, ISSN 1999-4915
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16020256

Viral deubiquitinating proteases and the promising strategies of their inhibition

Autorzy: Vera J E van Vliet, Anuradha De Silva, Brian L Mark, Marjolein Kikkert
Opublikowane w: Virus Research, 2024, ISSN 1872-7492
Wydawca: Elsevier
DOI: 10.1016/j.virusres.2024.199368

Engineering potent live attenuated coronavirus vaccines by targeted inactivation of the immune evasive viral deubiquitinase

Autorzy: Sebenzile K. Myeni, Peter J. Bredenbeek, Robert C. M. Knaap, Tim J. Dalebout, Shessy Torres Morales, Igor A. Sidorov, Marissa E. Linger, Nadia Oreshkova, Sophie van Zanen-Gerhardt, Serge A. L. Zander, Luis Enjuanes, Isabel Sola,Eric J. Snijder, Marjolein Kikkert
Opublikowane w: Nature Communications, 2023, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-36754-z

Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates

Autorzy: Mariana Marques, Bruno Ramos, Hélio Albuquerque, Marisa Pereira, Diana Roberta Ribeiro, Alexandre Nunes, Jéssica Sarabando, Daniela Brás, Ana Rita Ferreira, Rui Vitorino, Maria João Amorim, Artur M.S. Silva, Ana Raquel Soares, Daniela Ribeiro
Opublikowane w: iScience, Numer 27, 2024, ISSN 2589-0042
Wydawca: Cell Press Elsevier Inc
DOI: 10.1016/j.isci.2024.109100

m5U54 tRNA Hypomodification by Lack of TRMT2A Drives the Generation of tRNA-Derived Small RNAs

Autorzy: Marisa Pereira, Diana R. Ribeiro, Miguel M. Pinheiro, Margarida Ferreira, Stefanie Kellner, Ana R. Soares
Opublikowane w: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22062941

Upregulation of tRNA-Ser-AGA-2-1 Promotes Malignant Behavior in Normal Bronchial Cells

Autorzy: Mafalda Santos; Mafalda Santos; Mafalda Santos; Ana Fidalgo; Ana Sofia Varanda; Ana Sofia Varanda; Ana Sofia Varanda; Ana Raquel Soares; Gabriela M. Almeida; Gabriela M. Almeida; Gabriela M. Almeida; Diana Martins; Diana Martins; Nuno Mendes; Nuno Mendes; Carla Oliveira; Carla Oliveira; Carla Oliveira; Manuel A. S. Santos
Opublikowane w: Frontiers in Molecular Biosciences, 2022, ISSN 2296-889X
Wydawca: Frontiers
DOI: 10.3389/fmolb.2022.809985

Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis

Autorzy: Ben A. Bailey-Elkin, Robert C. M. Knaap, Anuradha De Silva, Ilse M. Boekhoud, Sandra Mous, Niek van Vught, Mazdak Khajehpour, Erwin van den Born, Marjolein Kikkert, Brian L. Mark
Opublikowane w: PLOS Pathogens, 2023, ISSN 1553-7366
Wydawca: Public Library of Science
DOI: 10.1371/journal.ppat.1011872

Book chapters (3)

Determining the Importance of Peroxisomal Proteins for Viral Infections in Cultured Mammalian Cells.

Autorzy: Marques, Mariana; Ferreira, Ana Rita; Ribeiro, Daniela
Opublikowane w: Methods in Molecular Biology, Numer 2, 2023, ISBN 978-1-0716-3047-1
Wydawca: Humana
DOI: 10.1007/978-1-0716-3048-8_21

Peroxisomes and Viruses: Overview on Current Knowledge and Experimental Approaches

Autorzy: Ferreira, Vanessa; Ferreira, Ana Rita; Ribeiro, Daniela
Opublikowane w: Peroxisomes. Methods in Molecular Biology, 2023, ISBN 978-1-0716-3047-1
Wydawca: Humana
DOI: 10.1007/978-1-0716-3048-8_19

Tools to Investigate the Peroxisome-Dependent Antiviral Response

Autorzy: Ramos, Bruno; Ferreira, Ana Rita; Ribeiro, Daniela
Opublikowane w: Methods in Molecular Biology, 2024, ISBN 978-1-0716-3048-8
Wydawca: Humana
DOI: 10.1007/978-1-0716-3048-8_20

Non-peer reviewed articles (1)

Temporal resolution of NAIL-MS of tRNA, rRNA and Poly-A RNA is overcome by actinomycin D

Autorzy: Felix Hagelskamp, Kayla Borland, Gregor Ammann, Stefanie M. Kaiser
Opublikowane w: RSC Chemical Biology, 2023, ISSN 2633-0679
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d2cb00243d

Conference proceedings (1)

Identification of novel therapeutic targets to modulate proteostasis in humans

Autorzy: Pereira, Marisa; Soares, Ana; Mano, Miguel
Opublikowane w: 2021
Wydawca: University of Aveiro