Viruses and Epitranscriptomics: seeking novel targets for antiviral therapy

Informazioni relative al progetto

EpiViral

ID dell’accordo di sovvenzione: 952373

DOI

10.3030/952373

Progetto chiuso

Data della firma CE 2 Luglio 2020

Data di avvio 1 Gennaio 2021

Data di completamento 30 Giugno 2024

Finanziato da

• Twinning of research institutions

Costo totale

€ 878 446,25

Contributo UE

€ 878 446,25

Coordinato da

UNIVERSIDADE DE AVEIRO
Portugal

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (5)

Third EpiViral newsletter
Second EpiViral newsletter
Project website
First EpiViral newsletter
Social media accounts

Documents, reports (7)

Second Summer School

Report on Second Summer School

First Summer School

Report on the organization of the First Summer School

First Annual Symposium

Report on First Annual Symposium

Third Annual Symposium

Report on Third Annual Symposium

International Conference Organization

Report on International Conference Organization

Launch of repository of project results
Second Annual Symposium

Report on Second Annual Symposium

Pubblicazioni

Thesis and dissertations (12)

The crosstalk between miRNAs and tRNA modifying enzymes: an alternative pathway to regulate the tRNA epitranscriptome

Autori: Diana Bastos
Pubblicato in: 2022
Editore: University of Aveiro

Uncovering the impact of peroxisome biogenesis deficiencies on the susceptibility to influenza A virus infections

Autori: Catarina Luís
Pubblicato in: 2023
Editore: University of Aveiro

Functional analysis of the peroxisomal and mitochondrial proteins MFF and FIS1 in HCMV evasion of the cellular antiviral response

Autori: Ana Gouveia
Pubblicato in: 2021
Editore: University of Aveiro

Novel tools to study the interplay between peroxisomes and lipid droplets in hepatitis C virus infection

Autori: Ariana Carvalho
Pubblicato in: 2021
Editore: Universidade de Aveiro

Identification of novel therapeutic targets to modulate proteostasis in humans

Autori: Marisa de Almeida Pereira
Pubblicato in: 2023
Editore: University of Aveiro

Steroid-based compounds as novel broad-spectrum antivirals

Autori: Francisco Mendes
Pubblicato in: 2022
Editore: University of Aveiro

Small non-coding RNAs as determinants of viral replication

Autori: Rafaela Salvador
Pubblicato in: 2022
Editore: University of Aveiro

Unravelling the profile and role of tRNA-derived small RNAs in Influenza A virus infection

Autori: Daniel Monteiro
Pubblicato in: 2021
Editore: University of Aveiro

Deciphering the crosstalk between MAVS- and STING- dependent antiviral responses

Autori: Rui Ferreira
Pubblicato in: 2022
Editore: University of Aveiro

Exploring the antiviral potential of steroid compounds against influenza A virus infection

Autori: Jéssica Oliveira
Pubblicato in: 2021
Editore: University of Aveiro

Uncovering potential targets for new host-directed antiviral therapies against influenza A virus infection

Autori: Mariana Marques
Pubblicato in: 2023
Editore: University of Aveiro

Mass spectrometric studies of RNA modification patterns in mammals

Autori: Paria Asadi Atoi
Pubblicato in: 2023
Editore: Goethe University of Frankfurt

Peer reviewed articles (19)

Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site

Autori: Vera J. E. van Vliet, Nhan Huynh, Judith Palà, Ankoor Patel, Alex Singer, Cole Slater, Jacky Chung, Mariska van Huizen, Joan Teyra, Shane Miersch, Gia-Khanh Luu, Wei Ye, Nitin Sharma, Safder S. Ganaie, Raquel Russell, Chao Chen, Mindy Maynard, Gaya K. Amarasinghe, Brian L. Mark, Marjolein Kikkert, Sachdev S. Sidhu
Pubblicato in: PLOS Pathogens, Numero 18(12): e1011065, 2022, ISSN 1553-7366
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1011065

The physiological functions of human peroxisomes

Autori: Ronald J. A. Wanders, Myriam Baes, Daniela Ribeiro, Sacha Ferdinandusse, Hans R. Waterham
Pubblicato in: Physiological Reviews, 2023, ISSN 0031-9333
Editore: American Physiological Society
DOI: 10.1152/physrev.00051.2021

Emerging roles of peroxisomes in viral infections

Autori: Ana Rita Ferreira; Mariana Marques; Bruno Ramos; Jonathan C. Kagan; Daniela Ribeiro
Pubblicato in: Trends in Cell Biology, 2022, ISSN 0962-8924
Editore: Elsevier BV
DOI: 10.1016/j.tcb.2021.09.010

Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo

Autori: Mariska van Huizen,Jonna R. Bloeme - ter Horst,Heidi L. M. de Gruyter,Paul P. Geurink,Gerbrand J. van der Heden van Noort,Robert C. M. Knaap,Tessa Nelemans,Natacha S. Ogando,Anouk A. Leijs,Nadya Urakova,Brian L. Mark,Eric J. Snijder,Sebenzile K. Myeni, Marjolein Kikkert
Pubblicato in: PLOS Pathogens, 2024, ISSN 1544-9173
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1012100

Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis

Autori: Marisa Pereira, Diana R. Ribeiro, Maximilian Berg, Andy P. Tsai, Chuanpeng Dong, Kwangsik Nho, Stefanie Kaiser, Miguel Moutinho, Ana R. Soares
Pubblicato in: BBA Molecular Basis of Disease, 2023, ISSN 0925-4439
Editore: Elsevier BV
DOI: 10.1016/j.bbadis.2023.166857

Human Cytomegalovirus vMIA Inhibits MAVS Oligomerization at Peroxisomes in an MFF-Dependent Manner

Autori: Ana Rita Ferreira, Ana Gouveia, Ana Cristina Magalhães, Isabel Valença, Mariana Marques, Jonathan C Kagan, Daniela Ribeiro
Pubblicato in: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2022.871977

Pitfalls in RNA Modification Quantification Using Nucleoside Mass Spectrometry

Autori: Gregor Ammann, Maximilian Berg, Jan Felix Dalwigk, and Stefanie M. Kaiser
Pubblicato in: Accounts of Chemical Research, 2023, ISSN 0001-4842
Editore: American Chemical Society
DOI: 10.1021/acs.accounts.3c00402

The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections

Autori: Diana Roberta Ribeiro, Alexandre Nunes, Daniela Ribeiro, Ana Raquel Soares
Pubblicato in: Frontiers in Genetics, 2023, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2023.1245683

Novel approaches for the rapid development of rationally designed arbovirus vaccines

Autori: Joyce W M van Bree, Imke Visser, Jo M Duyvestyn, Muriel Aguilar-Bretones, Eleanor M Marshall, Martijn J van Hemert, Gorben P Pijlman, Gijsbert P van Nierop, Marjolein Kikkert, Barry H G Rockx , Pascal Miesen, Jelke J Fros
Pubblicato in: One Health, 2023, ISSN 2352-7714
Editore: Elsevier B.V.
DOI: 10.1016/j.onehlt.2023.100565

Different modification pathways for m1A58 incorporation in yeast elongator and initiator tRNAs

Autori: Marcel-Joseph Yared, Yasemin Yoluç, Marjorie Catala, Carine Tisné, Stefanie Kaiser, Pierre Barraud
Pubblicato in: Nucleic Acids Research, 2023, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkad722

Editorial: Viruses and Epitranscriptomes: Regulation of Infection and Antiviral Response

Autori: Ana Raquel Soares, Marjolein Kikkert, Stefanie Kellner-Kaiser, Daniela Ribeiro
Pubblicato in: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2022.917894

Emerging roles of the Protein Phosphatase 1 (PP1) in the context of viral infections.

Autori: Pedro O. Corda, Mathieu Bollen, Daniela Ribeiro, Margarida Fardilha
Pubblicato in: Cell communication and Signaling, 2024, ISSN 1478-811X
Editore: BioMed Central
DOI: 10.1186/s12964-023-01468-8

The Main Protease of Middle East Respiratory Syndrome Coronavirus Induces Cleavage of Mitochondrial Antiviral Signaling Protein to Antagonize the Innate Immune Response

Autori: Mariska van Huizen; Xavier M. Vendrell; Heidi L. M. de Gruyter; A. Linda Boomaars-van der Zanden; Yvonne van der Meer; Eric J. Snijder; Marjolein Kikkert; Sebenzile K. Myeni
Pubblicato in: Viruses, 2024, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16020256

Viral deubiquitinating proteases and the promising strategies of their inhibition

Autori: Vera J E van Vliet, Anuradha De Silva, Brian L Mark, Marjolein Kikkert
Pubblicato in: Virus Research, 2024, ISSN 1872-7492
Editore: Elsevier
DOI: 10.1016/j.virusres.2024.199368

Engineering potent live attenuated coronavirus vaccines by targeted inactivation of the immune evasive viral deubiquitinase

Autori: Sebenzile K. Myeni, Peter J. Bredenbeek, Robert C. M. Knaap, Tim J. Dalebout, Shessy Torres Morales, Igor A. Sidorov, Marissa E. Linger, Nadia Oreshkova, Sophie van Zanen-Gerhardt, Serge A. L. Zander, Luis Enjuanes, Isabel Sola,Eric J. Snijder, Marjolein Kikkert
Pubblicato in: Nature Communications, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-36754-z

Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates

Autori: Mariana Marques, Bruno Ramos, Hélio Albuquerque, Marisa Pereira, Diana Roberta Ribeiro, Alexandre Nunes, Jéssica Sarabando, Daniela Brás, Ana Rita Ferreira, Rui Vitorino, Maria João Amorim, Artur M.S. Silva, Ana Raquel Soares, Daniela Ribeiro
Pubblicato in: iScience, Numero 27, 2024, ISSN 2589-0042
Editore: Cell Press Elsevier Inc
DOI: 10.1016/j.isci.2024.109100

m5U54 tRNA Hypomodification by Lack of TRMT2A Drives the Generation of tRNA-Derived Small RNAs

Autori: Marisa Pereira, Diana R. Ribeiro, Miguel M. Pinheiro, Margarida Ferreira, Stefanie Kellner, Ana R. Soares
Pubblicato in: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22062941

Upregulation of tRNA-Ser-AGA-2-1 Promotes Malignant Behavior in Normal Bronchial Cells

Autori: Mafalda Santos; Mafalda Santos; Mafalda Santos; Ana Fidalgo; Ana Sofia Varanda; Ana Sofia Varanda; Ana Sofia Varanda; Ana Raquel Soares; Gabriela M. Almeida; Gabriela M. Almeida; Gabriela M. Almeida; Diana Martins; Diana Martins; Nuno Mendes; Nuno Mendes; Carla Oliveira; Carla Oliveira; Carla Oliveira; Manuel A. S. Santos
Pubblicato in: Frontiers in Molecular Biosciences, 2022, ISSN 2296-889X
Editore: Frontiers
DOI: 10.3389/fmolb.2022.809985

Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis

Autori: Ben A. Bailey-Elkin, Robert C. M. Knaap, Anuradha De Silva, Ilse M. Boekhoud, Sandra Mous, Niek van Vught, Mazdak Khajehpour, Erwin van den Born, Marjolein Kikkert, Brian L. Mark
Pubblicato in: PLOS Pathogens, 2023, ISSN 1553-7366
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1011872

Book chapters (3)

Determining the Importance of Peroxisomal Proteins for Viral Infections in Cultured Mammalian Cells.

Autori: Marques, Mariana; Ferreira, Ana Rita; Ribeiro, Daniela
Pubblicato in: Methods in Molecular Biology, Numero 2, 2023, ISBN 978-1-0716-3047-1
Editore: Humana
DOI: 10.1007/978-1-0716-3048-8_21

Peroxisomes and Viruses: Overview on Current Knowledge and Experimental Approaches

Autori: Ferreira, Vanessa; Ferreira, Ana Rita; Ribeiro, Daniela
Pubblicato in: Peroxisomes. Methods in Molecular Biology, 2023, ISBN 978-1-0716-3047-1
Editore: Humana
DOI: 10.1007/978-1-0716-3048-8_19

Tools to Investigate the Peroxisome-Dependent Antiviral Response

Autori: Ramos, Bruno; Ferreira, Ana Rita; Ribeiro, Daniela
Pubblicato in: Methods in Molecular Biology, 2024, ISBN 978-1-0716-3048-8
Editore: Humana
DOI: 10.1007/978-1-0716-3048-8_20

Non-peer reviewed articles (1)

Temporal resolution of NAIL-MS of tRNA, rRNA and Poly-A RNA is overcome by actinomycin D

Autori: Felix Hagelskamp, Kayla Borland, Gregor Ammann, Stefanie M. Kaiser
Pubblicato in: RSC Chemical Biology, 2023, ISSN 2633-0679
Editore: Royal Society of Chemistry
DOI: 10.1039/d2cb00243d

Conference proceedings (1)

Identification of novel therapeutic targets to modulate proteostasis in humans

Autori: Pereira, Marisa; Soares, Ana; Mano, Miguel
Pubblicato in: 2021
Editore: University of Aveiro