Viruses and Epitranscriptomics: seeking novel targets for antiviral therapy

Informations projet

EpiViral

N° de convention de subvention: 952373

DOI

10.3030/952373

Projet clôturé

Date de signature de la CE 2 Juillet 2020

Date de début 1 Janvier 2021

Date de fin 30 Juin 2024

Financé au titre de

• Twinning of research institutions

Coût total

€ 878 446,25

Contribution de l’UE

€ 878 446,25

Coordonné par

UNIVERSIDADE DE AVEIRO
Portugal

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (5)

Third EpiViral newsletter
Second EpiViral newsletter
Project website
First EpiViral newsletter
Social media accounts

Documents, reports (7)

Second Summer School

Report on Second Summer School

First Summer School

Report on the organization of the First Summer School

First Annual Symposium

Report on First Annual Symposium

Third Annual Symposium

Report on Third Annual Symposium

International Conference Organization

Report on International Conference Organization

Launch of repository of project results
Second Annual Symposium

Report on Second Annual Symposium

Publications

Thesis and dissertations (12)

The crosstalk between miRNAs and tRNA modifying enzymes: an alternative pathway to regulate the tRNA epitranscriptome

Auteurs: Diana Bastos
Publié dans: 2022
Éditeur: University of Aveiro

Uncovering the impact of peroxisome biogenesis deficiencies on the susceptibility to influenza A virus infections

Auteurs: Catarina Luís
Publié dans: 2023
Éditeur: University of Aveiro

Functional analysis of the peroxisomal and mitochondrial proteins MFF and FIS1 in HCMV evasion of the cellular antiviral response

Auteurs: Ana Gouveia
Publié dans: 2021
Éditeur: University of Aveiro

Novel tools to study the interplay between peroxisomes and lipid droplets in hepatitis C virus infection

Auteurs: Ariana Carvalho
Publié dans: 2021
Éditeur: Universidade de Aveiro

Identification of novel therapeutic targets to modulate proteostasis in humans

Auteurs: Marisa de Almeida Pereira
Publié dans: 2023
Éditeur: University of Aveiro

Steroid-based compounds as novel broad-spectrum antivirals

Auteurs: Francisco Mendes
Publié dans: 2022
Éditeur: University of Aveiro

Small non-coding RNAs as determinants of viral replication

Auteurs: Rafaela Salvador
Publié dans: 2022
Éditeur: University of Aveiro

Unravelling the profile and role of tRNA-derived small RNAs in Influenza A virus infection

Auteurs: Daniel Monteiro
Publié dans: 2021
Éditeur: University of Aveiro

Deciphering the crosstalk between MAVS- and STING- dependent antiviral responses

Auteurs: Rui Ferreira
Publié dans: 2022
Éditeur: University of Aveiro

Exploring the antiviral potential of steroid compounds against influenza A virus infection

Auteurs: Jéssica Oliveira
Publié dans: 2021
Éditeur: University of Aveiro

Uncovering potential targets for new host-directed antiviral therapies against influenza A virus infection

Auteurs: Mariana Marques
Publié dans: 2023
Éditeur: University of Aveiro

Mass spectrometric studies of RNA modification patterns in mammals

Auteurs: Paria Asadi Atoi
Publié dans: 2023
Éditeur: Goethe University of Frankfurt

Peer reviewed articles (19)

Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site

Auteurs: Vera J. E. van Vliet, Nhan Huynh, Judith Palà, Ankoor Patel, Alex Singer, Cole Slater, Jacky Chung, Mariska van Huizen, Joan Teyra, Shane Miersch, Gia-Khanh Luu, Wei Ye, Nitin Sharma, Safder S. Ganaie, Raquel Russell, Chao Chen, Mindy Maynard, Gaya K. Amarasinghe, Brian L. Mark, Marjolein Kikkert, Sachdev S. Sidhu
Publié dans: PLOS Pathogens, Numéro 18(12): e1011065, 2022, ISSN 1553-7366
Éditeur: Public Library of Science
DOI: 10.1371/journal.ppat.1011065

The physiological functions of human peroxisomes

Auteurs: Ronald J. A. Wanders, Myriam Baes, Daniela Ribeiro, Sacha Ferdinandusse, Hans R. Waterham
Publié dans: Physiological Reviews, 2023, ISSN 0031-9333
Éditeur: American Physiological Society
DOI: 10.1152/physrev.00051.2021

Emerging roles of peroxisomes in viral infections

Auteurs: Ana Rita Ferreira; Mariana Marques; Bruno Ramos; Jonathan C. Kagan; Daniela Ribeiro
Publié dans: Trends in Cell Biology, 2022, ISSN 0962-8924
Éditeur: Elsevier BV
DOI: 10.1016/j.tcb.2021.09.010

Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo

Auteurs: Mariska van Huizen,Jonna R. Bloeme - ter Horst,Heidi L. M. de Gruyter,Paul P. Geurink,Gerbrand J. van der Heden van Noort,Robert C. M. Knaap,Tessa Nelemans,Natacha S. Ogando,Anouk A. Leijs,Nadya Urakova,Brian L. Mark,Eric J. Snijder,Sebenzile K. Myeni, Marjolein Kikkert
Publié dans: PLOS Pathogens, 2024, ISSN 1544-9173
Éditeur: Public Library of Science
DOI: 10.1371/journal.ppat.1012100

Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis

Auteurs: Marisa Pereira, Diana R. Ribeiro, Maximilian Berg, Andy P. Tsai, Chuanpeng Dong, Kwangsik Nho, Stefanie Kaiser, Miguel Moutinho, Ana R. Soares
Publié dans: BBA Molecular Basis of Disease, 2023, ISSN 0925-4439
Éditeur: Elsevier BV
DOI: 10.1016/j.bbadis.2023.166857

Human Cytomegalovirus vMIA Inhibits MAVS Oligomerization at Peroxisomes in an MFF-Dependent Manner

Auteurs: Ana Rita Ferreira, Ana Gouveia, Ana Cristina Magalhães, Isabel Valença, Mariana Marques, Jonathan C Kagan, Daniela Ribeiro
Publié dans: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Éditeur: Frontiers
DOI: 10.3389/fcell.2022.871977

Pitfalls in RNA Modification Quantification Using Nucleoside Mass Spectrometry

Auteurs: Gregor Ammann, Maximilian Berg, Jan Felix Dalwigk, and Stefanie M. Kaiser
Publié dans: Accounts of Chemical Research, 2023, ISSN 0001-4842
Éditeur: American Chemical Society
DOI: 10.1021/acs.accounts.3c00402

The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections

Auteurs: Diana Roberta Ribeiro, Alexandre Nunes, Daniela Ribeiro, Ana Raquel Soares
Publié dans: Frontiers in Genetics, 2023, ISSN 1664-8021
Éditeur: Frontiers Media
DOI: 10.3389/fgene.2023.1245683

Novel approaches for the rapid development of rationally designed arbovirus vaccines

Auteurs: Joyce W M van Bree, Imke Visser, Jo M Duyvestyn, Muriel Aguilar-Bretones, Eleanor M Marshall, Martijn J van Hemert, Gorben P Pijlman, Gijsbert P van Nierop, Marjolein Kikkert, Barry H G Rockx , Pascal Miesen, Jelke J Fros
Publié dans: One Health, 2023, ISSN 2352-7714
Éditeur: Elsevier B.V.
DOI: 10.1016/j.onehlt.2023.100565

Different modification pathways for m1A58 incorporation in yeast elongator and initiator tRNAs

Auteurs: Marcel-Joseph Yared, Yasemin Yoluç, Marjorie Catala, Carine Tisné, Stefanie Kaiser, Pierre Barraud
Publié dans: Nucleic Acids Research, 2023, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkad722

Editorial: Viruses and Epitranscriptomes: Regulation of Infection and Antiviral Response

Auteurs: Ana Raquel Soares, Marjolein Kikkert, Stefanie Kellner-Kaiser, Daniela Ribeiro
Publié dans: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Éditeur: Frontiers
DOI: 10.3389/fcell.2022.917894

Emerging roles of the Protein Phosphatase 1 (PP1) in the context of viral infections.

Auteurs: Pedro O. Corda, Mathieu Bollen, Daniela Ribeiro, Margarida Fardilha
Publié dans: Cell communication and Signaling, 2024, ISSN 1478-811X
Éditeur: BioMed Central
DOI: 10.1186/s12964-023-01468-8

The Main Protease of Middle East Respiratory Syndrome Coronavirus Induces Cleavage of Mitochondrial Antiviral Signaling Protein to Antagonize the Innate Immune Response

Auteurs: Mariska van Huizen; Xavier M. Vendrell; Heidi L. M. de Gruyter; A. Linda Boomaars-van der Zanden; Yvonne van der Meer; Eric J. Snijder; Marjolein Kikkert; Sebenzile K. Myeni
Publié dans: Viruses, 2024, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v16020256

Viral deubiquitinating proteases and the promising strategies of their inhibition

Auteurs: Vera J E van Vliet, Anuradha De Silva, Brian L Mark, Marjolein Kikkert
Publié dans: Virus Research, 2024, ISSN 1872-7492
Éditeur: Elsevier
DOI: 10.1016/j.virusres.2024.199368

Engineering potent live attenuated coronavirus vaccines by targeted inactivation of the immune evasive viral deubiquitinase

Auteurs: Sebenzile K. Myeni, Peter J. Bredenbeek, Robert C. M. Knaap, Tim J. Dalebout, Shessy Torres Morales, Igor A. Sidorov, Marissa E. Linger, Nadia Oreshkova, Sophie van Zanen-Gerhardt, Serge A. L. Zander, Luis Enjuanes, Isabel Sola,Eric J. Snijder, Marjolein Kikkert
Publié dans: Nature Communications, 2023, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-023-36754-z

Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates

Auteurs: Mariana Marques, Bruno Ramos, Hélio Albuquerque, Marisa Pereira, Diana Roberta Ribeiro, Alexandre Nunes, Jéssica Sarabando, Daniela Brás, Ana Rita Ferreira, Rui Vitorino, Maria João Amorim, Artur M.S. Silva, Ana Raquel Soares, Daniela Ribeiro
Publié dans: iScience, Numéro 27, 2024, ISSN 2589-0042
Éditeur: Cell Press Elsevier Inc
DOI: 10.1016/j.isci.2024.109100

m5U54 tRNA Hypomodification by Lack of TRMT2A Drives the Generation of tRNA-Derived Small RNAs

Auteurs: Marisa Pereira, Diana R. Ribeiro, Miguel M. Pinheiro, Margarida Ferreira, Stefanie Kellner, Ana R. Soares
Publié dans: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22062941

Upregulation of tRNA-Ser-AGA-2-1 Promotes Malignant Behavior in Normal Bronchial Cells

Auteurs: Mafalda Santos; Mafalda Santos; Mafalda Santos; Ana Fidalgo; Ana Sofia Varanda; Ana Sofia Varanda; Ana Sofia Varanda; Ana Raquel Soares; Gabriela M. Almeida; Gabriela M. Almeida; Gabriela M. Almeida; Diana Martins; Diana Martins; Nuno Mendes; Nuno Mendes; Carla Oliveira; Carla Oliveira; Carla Oliveira; Manuel A. S. Santos
Publié dans: Frontiers in Molecular Biosciences, 2022, ISSN 2296-889X
Éditeur: Frontiers
DOI: 10.3389/fmolb.2022.809985

Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis

Auteurs: Ben A. Bailey-Elkin, Robert C. M. Knaap, Anuradha De Silva, Ilse M. Boekhoud, Sandra Mous, Niek van Vught, Mazdak Khajehpour, Erwin van den Born, Marjolein Kikkert, Brian L. Mark
Publié dans: PLOS Pathogens, 2023, ISSN 1553-7366
Éditeur: Public Library of Science
DOI: 10.1371/journal.ppat.1011872

Book chapters (3)

Determining the Importance of Peroxisomal Proteins for Viral Infections in Cultured Mammalian Cells.

Auteurs: Marques, Mariana; Ferreira, Ana Rita; Ribeiro, Daniela
Publié dans: Methods in Molecular Biology, Numéro 2, 2023, ISBN 978-1-0716-3047-1
Éditeur: Humana
DOI: 10.1007/978-1-0716-3048-8_21

Peroxisomes and Viruses: Overview on Current Knowledge and Experimental Approaches

Auteurs: Ferreira, Vanessa; Ferreira, Ana Rita; Ribeiro, Daniela
Publié dans: Peroxisomes. Methods in Molecular Biology, 2023, ISBN 978-1-0716-3047-1
Éditeur: Humana
DOI: 10.1007/978-1-0716-3048-8_19

Tools to Investigate the Peroxisome-Dependent Antiviral Response

Auteurs: Ramos, Bruno; Ferreira, Ana Rita; Ribeiro, Daniela
Publié dans: Methods in Molecular Biology, 2024, ISBN 978-1-0716-3048-8
Éditeur: Humana
DOI: 10.1007/978-1-0716-3048-8_20

Non-peer reviewed articles (1)

Temporal resolution of NAIL-MS of tRNA, rRNA and Poly-A RNA is overcome by actinomycin D

Auteurs: Felix Hagelskamp, Kayla Borland, Gregor Ammann, Stefanie M. Kaiser
Publié dans: RSC Chemical Biology, 2023, ISSN 2633-0679
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2cb00243d

Conference proceedings (1)

Identification of novel therapeutic targets to modulate proteostasis in humans

Auteurs: Pereira, Marisa; Soares, Ana; Mano, Miguel
Publié dans: 2021
Éditeur: University of Aveiro