Skin Tissue Engineering and Regenerative Medicine: From skin repair to regeneration

Project Information

SkinTERM

Grant agreement ID: 955722

DOI

10.3030/955722

Project closed

EC signature date 28 August 2020

Start date 1 October 2020

End date 31 July 2025

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 3 192 735,96

EU contribution

€ 3 192 735,96

Coordinated by

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (5)

Report on the establishment of human induced pluripotent stem cells (iPSC)-derived skin organoid model with the optimization of the formulation of growth factors that promote sweat glands formation

Report on the establishment of human induced pluripotent stem cells iPSCderived skin organoid model with the optimization of the formulation of growth factors that promote sweat glands formation

Report on the establishment of human induced pluripotent stem cells (iPSC)-derived skin organoid model

Report on the establishment of human induced pluripotent stem cells iPSCderived skin organoid model

Report on the construction of scaffolds containing matrix/effector molecules and glycosaminoglycan(mimetics)

Report on the construction of scaffolds containing matrixeffector molecules and glycosaminoglycanmimetics

Report on the establishment of decellularisation protocols in Acomys and Mus
Report on the preparation/characterisation of defined elastin preparations

Report on the preparationcharacterisation of defined elastin preparations

Publications

Peer reviewed articles (12)

Elastogenesis in Focus: Navigating Elastic Fibers Synthesis for Advanced Dermal Biomaterial Formulation

Author(s): Roman Krymchenko, Gizem Coşar Kutluoğlu, Noor van Hout, Dominique Manikowski, Claudia Doberenz, Toin H. van Kuppevelt, Willeke F. Daamen
Published in: Advanced Healthcare Materials, 2024, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202400484

Breathing new life into tissue engineering: exploring cutting-edge vascularization strategies for skin substitutes

Author(s): M. Zohaib Iqbal, Mahrukh Riaz, Thomas Biedermann, Agnes S. Klar
Published in: Angiogenesis, Issue Volume 27, Issue 4, August 2024, 2024, Page(s) 631-648, ISSN 0969-6970
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10456-024-09928-6

Multiscale investigation of collagen structure in human skin and gel matrices using polarization resolved second harmonic generation microscopy

Author(s): Mengyao Zhou, Madalena Pinto Gomes, Anouk Elgersma, H. Ibrahim Korkmaz, Bouke K. H. L. Boekema, Marie Louise Groot
Published in: Scientific Reports, Issue 15, 2025, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-025-02536-4

Simple method for the production of rete ridges in human dermo-epidermal skin substitutes

Author(s): Luca Pontiggia, Vanuchija Someswaran, Roth Devi Long, Mahrukh Riaz, Jonas Lussi, Bradley J. Nelson, Agnes S. Klar, Thomas Biedermann, Ueli Moehrlen
Published in: Experimental Cell Research, Issue 452, 2025, Page(s) 114694, ISSN 0014-4827
Publisher: Academic Press
DOI: 10.1016/j.yexcr.2025.114694

Organ dependency on fascia connective tissue

Author(s): Yue Lin, Ruoxuan Dai, George Vogelaar, Yuval Rinkevich
Published in: American Journal of Physiology-Cell Physiology, Issue 327, 2024, Page(s) C357-C361, ISSN 0363-6143
Publisher: American Physiological Society
DOI: 10.1152/ajpcell.00350.2024

Fetal Skin Wound Healing: Key Extracellular Matrix Components and Regulators in Scarless Healing

Author(s): Madalena Lopes Natário Pinto Gomes, Paul A.J. Krijnen, Esther Middelkoop, Hans W.M. Niessen, Bouke K.H.L. Boekema
Published in: Journal of Investigative Dermatology, 2024, ISSN 0022-202X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2024.05.027

Preparation, fractionation, and characterization of solubilized elastin and comparison of cellular response on fibroblasts and macrophages

Author(s): Roman Krymchenko, Maren Pfirrmann, Sjoerd van der Leeuw, Nancy Avila-Martinez, Elly M.M. Versteeg, Rob T.C. Meuwese, Marcel Vlig, Martijn Verdoes, Bouke K.H.L. Boekema, Toin H. van Kuppevelt, Willeke F. Daamen
Published in: International Journal of Biological Macromolecules, Issue 315, 2025, Page(s) 144548, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2025.144548

Comparison of dermal and eschar fibroblasts in full skin equivalents

Author(s): Gizem Coşar Kutluoğlu, Marcel Vlig, Anouk Elgersma, Bouke K. H. L. Boekema, Willeke F. Daamen, Claudia Doberenz, Dominique Manikowski
Published in: Wound Repair and Regeneration, Issue 33, 2025, ISSN 1067-1927
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/wrr.70001

Exploring mesenchymal stem cells homing mechanisms and improvement strategies

Author(s): Umar Sajjad, Muhammad Ahmed, M Zohaib Iqbal, Mahrukh Riaz, Muhammad Mustafa, Thomas Biedermann, Agnes S Klar
Published in: Stem Cells Translational Medicine, Issue 13, 2024, Page(s) 1161-1177, ISSN 2157-6564
Publisher: AlphaMed Press
DOI: 10.1093/stcltm/szae045

Effect of Hyaluronan in Collagen Biomaterials on Human Macrophages and Fibroblasts In Vitro

Author(s): Nancy Avila-Martinez, Maren Pfirrmann, Madalena L. N. P. Gomes, Roman Krymchenko, Elly M. M. Versteeg, Marcel Vlig, Martijn Verdoes, Toin H. van Kuppevelt, Bouke K. H. L. Boekema, Willeke F. Daamen
Published in: Journal of Functional Biomaterials, Issue 16, 2025, Page(s) 167, ISSN 2079-4983
Publisher: MDPI AG
DOI: 10.3390/jfb16050167

Matrisomal components involved in regenerative wound healing in axolotl and <i>Acomys</i>: implications for biomaterial development

Author(s): Nancy Avila-Martinez, Merel Gansevoort, Juul Verbakel, Haarshaadri Jayaprakash, Ines Maria Araujo, Marta Vitorino, Gustavo Tiscornia, Toin H. van Kuppevelt, Willeke F. Daamen
Published in: Biomaterials Science, Issue 11, 2024, Page(s) 6060-6081, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3bm00835e

Collagen-elastin dermal scaffolds enhance tissue regeneration and reduce scarring in preclinical models

Author(s): Roman Krymchenko, Nancy Avila-Martinez, Merel Gansevoort, Gert-Jan Bakker, Madalena L.N.P. Gomes, Marcel Vlig, Elly M.M. Versteeg, Bouke K.H.L. Boekema, Toin H. van Kuppevelt, Willeke F. Daamen
Published in: Materials Today Bio, Issue 34, 2025, Page(s) 102239, ISSN 2590-0064
Publisher: Elsevier BV
DOI: 10.1016/j.mtbio.2025.102239