Skin Tissue Engineering and Regenerative Medicine: From skin repair to regeneration

Informacje na temat projektu

SkinTERM

Identyfikator umowy o grant: 955722

DOI

10.3030/955722

Projekt został zamknięty

Data podpisania przez KE 28 Sierpnia 2020

Data rozpoczęcia 1 Października 2020

Data zakończenia 31 Lipca 2025

Finansowanie w ramach

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Koszt całkowity

€ 3 192 735,96

Wkład UE

€ 3 192 735,96

Koordynowany przez

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (26)

Report on the outcome of pharmacological and genetic intervention of candidate genes involved in human sweat gland formation in human skin organoids
Report on the establishment and optimisation of novel proto-follicle structures within skin constructs
Report on the identification of cell types involved in scarless skin regeneration in dorsal skin wound models in Acomys and Mus
Report on the effect of transplantations of Acomys decellularised skin on Mus and vice versa
Report on the histological, compositional and functional characterizations of sweat glands in human skin organoids
Report on effects between nerve cells and endothelial cells in skin substitutes
Report on the establishment of human induced pluripotent stem cells (iPSC)-derived skin organoid model with the optimization of the formulation of growth factors that promote sweat glands formation

Report on the establishment of human induced pluripotent stem cells iPSCderived skin organoid model with the optimization of the formulation of growth factors that promote sweat glands formation

Report on effects of hair follicles onto vascular plexus and nerve fibre formation in skin substitutes
Report on optimized single nuclei sequencing from skin wounds in Acomys and Mus
Report on the activities of skin constructs containing proto-follicle structures after grafting and their influence on skin architecture
Report on the outcome of pharmacological intervention of candidate genes involved in human fibroblast differentiation in vivo mouse wound model
Report on a culture protocol to induce polarisation of macrophages in vitro
Report on the establishment of human induced pluripotent stem cells (iPSC)-derived skin organoid model

Report on the establishment of human induced pluripotent stem cells iPSCderived skin organoid model

Report on the intrinsic properties of human foetal/adult/eschar mesenchymal cell populations on scarring in vitro
Report on the time-course proteomics study for scarless foetal skin regeneration process in Mus
Report on the in vitro analysis of scaffolds containing matrix/effector molecules and glycosaminoglycan(mimetics)
Report on the construction of scaffolds containing matrix/effector molecules and glycosaminoglycan(mimetics)

Report on the construction of scaffolds containing matrixeffector molecules and glycosaminoglycanmimetics

Report on the establishment of decellularisation protocols in Acomys and Mus
Report on the in vitro analysis of elastin preparations
Report on the influence of extracellular matrix, soluble factors and wound environment on scarring in vitro
Report on pharmacologically treated iPSC-derived skin organoids ex vivo
Report on the effect of human skin grafts with distinct macrophage subsets on in vitro/in vivo behaviour
Report on the identification of anti-fibrotic factors secreted by distinct subsets of macrophages
Report on the preparation/characterisation of defined elastin preparations

Report on the preparationcharacterisation of defined elastin preparations

Report on the analysed differences between Acomys and Mus as assessed by proteomic analysis
Report on transplanted prevascularised skin substitutes containing nerve cells and hair follicles regarding sensory restoration

Other (5)

Dissemination to patient organisations completed
Dissemination to general public completed
Dissemination to industry completed
Dissemination to policy makers completed
SkinTERM International Symposium

Data sets, microdata, etc (1)

List of all PhD theses and degrees of ESRs

Websites, patent fillings, videos etc. (1)

Twelve ESR video clips posted publicly

Publikacje

Peer reviewed articles (12)

Elastogenesis in Focus: Navigating Elastic Fibers Synthesis for Advanced Dermal Biomaterial Formulation

Autorzy: Roman Krymchenko, Gizem Coşar Kutluoğlu, Noor van Hout, Dominique Manikowski, Claudia Doberenz, Toin H. van Kuppevelt, Willeke F. Daamen
Opublikowane w: Advanced Healthcare Materials, 2024, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202400484

Breathing new life into tissue engineering: exploring cutting-edge vascularization strategies for skin substitutes

Autorzy: M. Zohaib Iqbal, Mahrukh Riaz, Thomas Biedermann, Agnes S. Klar
Opublikowane w: Angiogenesis, Numer Volume 27, Numer 4, August 2024, 2024, Strona(/y) 631-648, ISSN 0969-6970
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10456-024-09928-6

Multiscale investigation of collagen structure in human skin and gel matrices using polarization resolved second harmonic generation microscopy

Autorzy: Mengyao Zhou, Madalena Pinto Gomes, Anouk Elgersma, H. Ibrahim Korkmaz, Bouke K. H. L. Boekema, Marie Louise Groot
Opublikowane w: Scientific Reports, Numer 15, 2025, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-025-02536-4

Simple method for the production of rete ridges in human dermo-epidermal skin substitutes

Autorzy: Luca Pontiggia, Vanuchija Someswaran, Roth Devi Long, Mahrukh Riaz, Jonas Lussi, Bradley J. Nelson, Agnes S. Klar, Thomas Biedermann, Ueli Moehrlen
Opublikowane w: Experimental Cell Research, Numer 452, 2025, Strona(/y) 114694, ISSN 0014-4827
Wydawca: Academic Press
DOI: 10.1016/j.yexcr.2025.114694

Organ dependency on fascia connective tissue

Autorzy: Yue Lin, Ruoxuan Dai, George Vogelaar, Yuval Rinkevich
Opublikowane w: American Journal of Physiology-Cell Physiology, Numer 327, 2024, Strona(/y) C357-C361, ISSN 0363-6143
Wydawca: American Physiological Society
DOI: 10.1152/ajpcell.00350.2024

Fetal Skin Wound Healing: Key Extracellular Matrix Components and Regulators in Scarless Healing

Autorzy: Madalena Lopes Natário Pinto Gomes, Paul A.J. Krijnen, Esther Middelkoop, Hans W.M. Niessen, Bouke K.H.L. Boekema
Opublikowane w: Journal of Investigative Dermatology, 2024, ISSN 0022-202X
Wydawca: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2024.05.027

Preparation, fractionation, and characterization of solubilized elastin and comparison of cellular response on fibroblasts and macrophages

Autorzy: Roman Krymchenko, Maren Pfirrmann, Sjoerd van der Leeuw, Nancy Avila-Martinez, Elly M.M. Versteeg, Rob T.C. Meuwese, Marcel Vlig, Martijn Verdoes, Bouke K.H.L. Boekema, Toin H. van Kuppevelt, Willeke F. Daamen
Opublikowane w: International Journal of Biological Macromolecules, Numer 315, 2025, Strona(/y) 144548, ISSN 0141-8130
Wydawca: Elsevier BV
DOI: 10.1016/j.ijbiomac.2025.144548

Comparison of dermal and eschar fibroblasts in full skin equivalents

Autorzy: Gizem Coşar Kutluoğlu, Marcel Vlig, Anouk Elgersma, Bouke K. H. L. Boekema, Willeke F. Daamen, Claudia Doberenz, Dominique Manikowski
Opublikowane w: Wound Repair and Regeneration, Numer 33, 2025, ISSN 1067-1927
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/wrr.70001

Exploring mesenchymal stem cells homing mechanisms and improvement strategies

Autorzy: Umar Sajjad, Muhammad Ahmed, M Zohaib Iqbal, Mahrukh Riaz, Muhammad Mustafa, Thomas Biedermann, Agnes S Klar
Opublikowane w: Stem Cells Translational Medicine, Numer 13, 2024, Strona(/y) 1161-1177, ISSN 2157-6564
Wydawca: AlphaMed Press
DOI: 10.1093/stcltm/szae045

Effect of Hyaluronan in Collagen Biomaterials on Human Macrophages and Fibroblasts In Vitro

Autorzy: Nancy Avila-Martinez, Maren Pfirrmann, Madalena L. N. P. Gomes, Roman Krymchenko, Elly M. M. Versteeg, Marcel Vlig, Martijn Verdoes, Toin H. van Kuppevelt, Bouke K. H. L. Boekema, Willeke F. Daamen
Opublikowane w: Journal of Functional Biomaterials, Numer 16, 2025, Strona(/y) 167, ISSN 2079-4983
Wydawca: MDPI AG
DOI: 10.3390/jfb16050167

Matrisomal components involved in regenerative wound healing in axolotl and <i>Acomys</i>: implications for biomaterial development

Autorzy: Nancy Avila-Martinez, Merel Gansevoort, Juul Verbakel, Haarshaadri Jayaprakash, Ines Maria Araujo, Marta Vitorino, Gustavo Tiscornia, Toin H. van Kuppevelt, Willeke F. Daamen
Opublikowane w: Biomaterials Science, Numer 11, 2024, Strona(/y) 6060-6081, ISSN 2047-4830
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d3bm00835e

Collagen-elastin dermal scaffolds enhance tissue regeneration and reduce scarring in preclinical models

Autorzy: Roman Krymchenko, Nancy Avila-Martinez, Merel Gansevoort, Gert-Jan Bakker, Madalena L.N.P. Gomes, Marcel Vlig, Elly M.M. Versteeg, Bouke K.H.L. Boekema, Toin H. van Kuppevelt, Willeke F. Daamen
Opublikowane w: Materials Today Bio, Numer 34, 2025, Strona(/y) 102239, ISSN 2590-0064
Wydawca: Elsevier BV
DOI: 10.1016/j.mtbio.2025.102239