Skin Tissue Engineering and Regenerative Medicine: From skin repair to regeneration

Informations projet

SkinTERM

N° de convention de subvention: 955722

DOI

10.3030/955722

Projet clôturé

Date de signature de la CE 28 Août 2020

Date de début 1 Octobre 2020

Date de fin 31 Juillet 2025

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 3 192 735,96

Contribution de l’UE

€ 3 192 735,96

Coordonné par

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (26)

Report on the outcome of pharmacological and genetic intervention of candidate genes involved in human sweat gland formation in human skin organoids
Report on the establishment and optimisation of novel proto-follicle structures within skin constructs
Report on the identification of cell types involved in scarless skin regeneration in dorsal skin wound models in Acomys and Mus
Report on the effect of transplantations of Acomys decellularised skin on Mus and vice versa
Report on the histological, compositional and functional characterizations of sweat glands in human skin organoids
Report on effects between nerve cells and endothelial cells in skin substitutes
Report on the establishment of human induced pluripotent stem cells (iPSC)-derived skin organoid model with the optimization of the formulation of growth factors that promote sweat glands formation

Report on the establishment of human induced pluripotent stem cells iPSCderived skin organoid model with the optimization of the formulation of growth factors that promote sweat glands formation

Report on effects of hair follicles onto vascular plexus and nerve fibre formation in skin substitutes
Report on optimized single nuclei sequencing from skin wounds in Acomys and Mus
Report on the activities of skin constructs containing proto-follicle structures after grafting and their influence on skin architecture
Report on the outcome of pharmacological intervention of candidate genes involved in human fibroblast differentiation in vivo mouse wound model
Report on a culture protocol to induce polarisation of macrophages in vitro
Report on the establishment of human induced pluripotent stem cells (iPSC)-derived skin organoid model

Report on the establishment of human induced pluripotent stem cells iPSCderived skin organoid model

Report on the intrinsic properties of human foetal/adult/eschar mesenchymal cell populations on scarring in vitro
Report on the time-course proteomics study for scarless foetal skin regeneration process in Mus
Report on the in vitro analysis of scaffolds containing matrix/effector molecules and glycosaminoglycan(mimetics)
Report on the construction of scaffolds containing matrix/effector molecules and glycosaminoglycan(mimetics)

Report on the construction of scaffolds containing matrixeffector molecules and glycosaminoglycanmimetics

Report on the establishment of decellularisation protocols in Acomys and Mus
Report on the in vitro analysis of elastin preparations
Report on the influence of extracellular matrix, soluble factors and wound environment on scarring in vitro
Report on pharmacologically treated iPSC-derived skin organoids ex vivo
Report on the effect of human skin grafts with distinct macrophage subsets on in vitro/in vivo behaviour
Report on the identification of anti-fibrotic factors secreted by distinct subsets of macrophages
Report on the preparation/characterisation of defined elastin preparations

Report on the preparationcharacterisation of defined elastin preparations

Report on the analysed differences between Acomys and Mus as assessed by proteomic analysis
Report on transplanted prevascularised skin substitutes containing nerve cells and hair follicles regarding sensory restoration

Other (5)

Dissemination to patient organisations completed
Dissemination to general public completed
Dissemination to industry completed
Dissemination to policy makers completed
SkinTERM International Symposium

Data sets, microdata, etc (1)

List of all PhD theses and degrees of ESRs

Websites, patent fillings, videos etc. (1)

Twelve ESR video clips posted publicly

Publications

Peer reviewed articles (12)

Elastogenesis in Focus: Navigating Elastic Fibers Synthesis for Advanced Dermal Biomaterial Formulation

Auteurs: Roman Krymchenko, Gizem Coşar Kutluoğlu, Noor van Hout, Dominique Manikowski, Claudia Doberenz, Toin H. van Kuppevelt, Willeke F. Daamen
Publié dans: Advanced Healthcare Materials, 2024, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202400484

Breathing new life into tissue engineering: exploring cutting-edge vascularization strategies for skin substitutes

Auteurs: M. Zohaib Iqbal, Mahrukh Riaz, Thomas Biedermann, Agnes S. Klar
Publié dans: Angiogenesis, Numéro Volume 27, Numéro 4, August 2024, 2024, Page(s) 631-648, ISSN 0969-6970
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10456-024-09928-6

Multiscale investigation of collagen structure in human skin and gel matrices using polarization resolved second harmonic generation microscopy

Auteurs: Mengyao Zhou, Madalena Pinto Gomes, Anouk Elgersma, H. Ibrahim Korkmaz, Bouke K. H. L. Boekema, Marie Louise Groot
Publié dans: Scientific Reports, Numéro 15, 2025, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-025-02536-4

Simple method for the production of rete ridges in human dermo-epidermal skin substitutes

Auteurs: Luca Pontiggia, Vanuchija Someswaran, Roth Devi Long, Mahrukh Riaz, Jonas Lussi, Bradley J. Nelson, Agnes S. Klar, Thomas Biedermann, Ueli Moehrlen
Publié dans: Experimental Cell Research, Numéro 452, 2025, Page(s) 114694, ISSN 0014-4827
Éditeur: Academic Press
DOI: 10.1016/j.yexcr.2025.114694

Organ dependency on fascia connective tissue

Auteurs: Yue Lin, Ruoxuan Dai, George Vogelaar, Yuval Rinkevich
Publié dans: American Journal of Physiology-Cell Physiology, Numéro 327, 2024, Page(s) C357-C361, ISSN 0363-6143
Éditeur: American Physiological Society
DOI: 10.1152/ajpcell.00350.2024

Fetal Skin Wound Healing: Key Extracellular Matrix Components and Regulators in Scarless Healing

Auteurs: Madalena Lopes Natário Pinto Gomes, Paul A.J. Krijnen, Esther Middelkoop, Hans W.M. Niessen, Bouke K.H.L. Boekema
Publié dans: Journal of Investigative Dermatology, 2024, ISSN 0022-202X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2024.05.027

Preparation, fractionation, and characterization of solubilized elastin and comparison of cellular response on fibroblasts and macrophages

Auteurs: Roman Krymchenko, Maren Pfirrmann, Sjoerd van der Leeuw, Nancy Avila-Martinez, Elly M.M. Versteeg, Rob T.C. Meuwese, Marcel Vlig, Martijn Verdoes, Bouke K.H.L. Boekema, Toin H. van Kuppevelt, Willeke F. Daamen
Publié dans: International Journal of Biological Macromolecules, Numéro 315, 2025, Page(s) 144548, ISSN 0141-8130
Éditeur: Elsevier BV
DOI: 10.1016/j.ijbiomac.2025.144548

Comparison of dermal and eschar fibroblasts in full skin equivalents

Auteurs: Gizem Coşar Kutluoğlu, Marcel Vlig, Anouk Elgersma, Bouke K. H. L. Boekema, Willeke F. Daamen, Claudia Doberenz, Dominique Manikowski
Publié dans: Wound Repair and Regeneration, Numéro 33, 2025, ISSN 1067-1927
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/wrr.70001

Exploring mesenchymal stem cells homing mechanisms and improvement strategies

Auteurs: Umar Sajjad, Muhammad Ahmed, M Zohaib Iqbal, Mahrukh Riaz, Muhammad Mustafa, Thomas Biedermann, Agnes S Klar
Publié dans: Stem Cells Translational Medicine, Numéro 13, 2024, Page(s) 1161-1177, ISSN 2157-6564
Éditeur: AlphaMed Press
DOI: 10.1093/stcltm/szae045

Effect of Hyaluronan in Collagen Biomaterials on Human Macrophages and Fibroblasts In Vitro

Auteurs: Nancy Avila-Martinez, Maren Pfirrmann, Madalena L. N. P. Gomes, Roman Krymchenko, Elly M. M. Versteeg, Marcel Vlig, Martijn Verdoes, Toin H. van Kuppevelt, Bouke K. H. L. Boekema, Willeke F. Daamen
Publié dans: Journal of Functional Biomaterials, Numéro 16, 2025, Page(s) 167, ISSN 2079-4983
Éditeur: MDPI AG
DOI: 10.3390/jfb16050167

Matrisomal components involved in regenerative wound healing in axolotl and <i>Acomys</i>: implications for biomaterial development

Auteurs: Nancy Avila-Martinez, Merel Gansevoort, Juul Verbakel, Haarshaadri Jayaprakash, Ines Maria Araujo, Marta Vitorino, Gustavo Tiscornia, Toin H. van Kuppevelt, Willeke F. Daamen
Publié dans: Biomaterials Science, Numéro 11, 2024, Page(s) 6060-6081, ISSN 2047-4830
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d3bm00835e

Collagen-elastin dermal scaffolds enhance tissue regeneration and reduce scarring in preclinical models

Auteurs: Roman Krymchenko, Nancy Avila-Martinez, Merel Gansevoort, Gert-Jan Bakker, Madalena L.N.P. Gomes, Marcel Vlig, Elly M.M. Versteeg, Bouke K.H.L. Boekema, Toin H. van Kuppevelt, Willeke F. Daamen
Publié dans: Materials Today Bio, Numéro 34, 2025, Page(s) 102239, ISSN 2590-0064
Éditeur: Elsevier BV
DOI: 10.1016/j.mtbio.2025.102239