Skin Tissue Engineering and Regenerative Medicine: From skin repair to regeneration

Información del proyecto

SkinTERM

Identificador del acuerdo de subvención: 955722

DOI

10.3030/955722

Proyecto cerrado

Fecha de la firma de la CE 28 Agosto 2020

Fecha de inicio 1 Octubre 2020

Fecha de finalización 31 Julio 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 192 735,96

Aportación de la UE

€ 3 192 735,96

Coordinado por

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (26)

Report on the outcome of pharmacological and genetic intervention of candidate genes involved in human sweat gland formation in human skin organoids
Report on the establishment and optimisation of novel proto-follicle structures within skin constructs
Report on the identification of cell types involved in scarless skin regeneration in dorsal skin wound models in Acomys and Mus
Report on the effect of transplantations of Acomys decellularised skin on Mus and vice versa
Report on the histological, compositional and functional characterizations of sweat glands in human skin organoids
Report on effects between nerve cells and endothelial cells in skin substitutes
Report on the establishment of human induced pluripotent stem cells (iPSC)-derived skin organoid model with the optimization of the formulation of growth factors that promote sweat glands formation

Report on the establishment of human induced pluripotent stem cells iPSCderived skin organoid model with the optimization of the formulation of growth factors that promote sweat glands formation

Report on effects of hair follicles onto vascular plexus and nerve fibre formation in skin substitutes
Report on optimized single nuclei sequencing from skin wounds in Acomys and Mus
Report on the activities of skin constructs containing proto-follicle structures after grafting and their influence on skin architecture
Report on the outcome of pharmacological intervention of candidate genes involved in human fibroblast differentiation in vivo mouse wound model
Report on a culture protocol to induce polarisation of macrophages in vitro
Report on the establishment of human induced pluripotent stem cells (iPSC)-derived skin organoid model

Report on the establishment of human induced pluripotent stem cells iPSCderived skin organoid model

Report on the intrinsic properties of human foetal/adult/eschar mesenchymal cell populations on scarring in vitro
Report on the time-course proteomics study for scarless foetal skin regeneration process in Mus
Report on the in vitro analysis of scaffolds containing matrix/effector molecules and glycosaminoglycan(mimetics)
Report on the construction of scaffolds containing matrix/effector molecules and glycosaminoglycan(mimetics)

Report on the construction of scaffolds containing matrixeffector molecules and glycosaminoglycanmimetics

Report on the establishment of decellularisation protocols in Acomys and Mus
Report on the in vitro analysis of elastin preparations
Report on the influence of extracellular matrix, soluble factors and wound environment on scarring in vitro
Report on pharmacologically treated iPSC-derived skin organoids ex vivo
Report on the effect of human skin grafts with distinct macrophage subsets on in vitro/in vivo behaviour
Report on the identification of anti-fibrotic factors secreted by distinct subsets of macrophages
Report on the preparation/characterisation of defined elastin preparations

Report on the preparationcharacterisation of defined elastin preparations

Report on the analysed differences between Acomys and Mus as assessed by proteomic analysis
Report on transplanted prevascularised skin substitutes containing nerve cells and hair follicles regarding sensory restoration

Other (5)

Dissemination to patient organisations completed
Dissemination to general public completed
Dissemination to industry completed
Dissemination to policy makers completed
SkinTERM International Symposium

Data sets, microdata, etc (1)

List of all PhD theses and degrees of ESRs

Websites, patent fillings, videos etc. (1)

Twelve ESR video clips posted publicly

Publicaciones

Peer reviewed articles (12)

Elastogenesis in Focus: Navigating Elastic Fibers Synthesis for Advanced Dermal Biomaterial Formulation

Autores: Roman Krymchenko, Gizem Coşar Kutluoğlu, Noor van Hout, Dominique Manikowski, Claudia Doberenz, Toin H. van Kuppevelt, Willeke F. Daamen
Publicado en: Advanced Healthcare Materials, 2024, ISSN 2192-2640
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202400484

Breathing new life into tissue engineering: exploring cutting-edge vascularization strategies for skin substitutes

Autores: M. Zohaib Iqbal, Mahrukh Riaz, Thomas Biedermann, Agnes S. Klar
Publicado en: Angiogenesis, Edición Volume 27, Edición 4, August 2024, 2024, Página(s) 631-648, ISSN 0969-6970
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10456-024-09928-6

Multiscale investigation of collagen structure in human skin and gel matrices using polarization resolved second harmonic generation microscopy

Autores: Mengyao Zhou, Madalena Pinto Gomes, Anouk Elgersma, H. Ibrahim Korkmaz, Bouke K. H. L. Boekema, Marie Louise Groot
Publicado en: Scientific Reports, Edición 15, 2025, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-025-02536-4

Simple method for the production of rete ridges in human dermo-epidermal skin substitutes

Autores: Luca Pontiggia, Vanuchija Someswaran, Roth Devi Long, Mahrukh Riaz, Jonas Lussi, Bradley J. Nelson, Agnes S. Klar, Thomas Biedermann, Ueli Moehrlen
Publicado en: Experimental Cell Research, Edición 452, 2025, Página(s) 114694, ISSN 0014-4827
Editor: Academic Press
DOI: 10.1016/j.yexcr.2025.114694

Organ dependency on fascia connective tissue

Autores: Yue Lin, Ruoxuan Dai, George Vogelaar, Yuval Rinkevich
Publicado en: American Journal of Physiology-Cell Physiology, Edición 327, 2024, Página(s) C357-C361, ISSN 0363-6143
Editor: American Physiological Society
DOI: 10.1152/ajpcell.00350.2024

Fetal Skin Wound Healing: Key Extracellular Matrix Components and Regulators in Scarless Healing

Autores: Madalena Lopes Natário Pinto Gomes, Paul A.J. Krijnen, Esther Middelkoop, Hans W.M. Niessen, Bouke K.H.L. Boekema
Publicado en: Journal of Investigative Dermatology, 2024, ISSN 0022-202X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2024.05.027

Preparation, fractionation, and characterization of solubilized elastin and comparison of cellular response on fibroblasts and macrophages

Autores: Roman Krymchenko, Maren Pfirrmann, Sjoerd van der Leeuw, Nancy Avila-Martinez, Elly M.M. Versteeg, Rob T.C. Meuwese, Marcel Vlig, Martijn Verdoes, Bouke K.H.L. Boekema, Toin H. van Kuppevelt, Willeke F. Daamen
Publicado en: International Journal of Biological Macromolecules, Edición 315, 2025, Página(s) 144548, ISSN 0141-8130
Editor: Elsevier BV
DOI: 10.1016/j.ijbiomac.2025.144548

Comparison of dermal and eschar fibroblasts in full skin equivalents

Autores: Gizem Coşar Kutluoğlu, Marcel Vlig, Anouk Elgersma, Bouke K. H. L. Boekema, Willeke F. Daamen, Claudia Doberenz, Dominique Manikowski
Publicado en: Wound Repair and Regeneration, Edición 33, 2025, ISSN 1067-1927
Editor: Blackwell Publishing Inc.
DOI: 10.1111/wrr.70001

Exploring mesenchymal stem cells homing mechanisms and improvement strategies

Autores: Umar Sajjad, Muhammad Ahmed, M Zohaib Iqbal, Mahrukh Riaz, Muhammad Mustafa, Thomas Biedermann, Agnes S Klar
Publicado en: Stem Cells Translational Medicine, Edición 13, 2024, Página(s) 1161-1177, ISSN 2157-6564
Editor: AlphaMed Press
DOI: 10.1093/stcltm/szae045

Effect of Hyaluronan in Collagen Biomaterials on Human Macrophages and Fibroblasts In Vitro

Autores: Nancy Avila-Martinez, Maren Pfirrmann, Madalena L. N. P. Gomes, Roman Krymchenko, Elly M. M. Versteeg, Marcel Vlig, Martijn Verdoes, Toin H. van Kuppevelt, Bouke K. H. L. Boekema, Willeke F. Daamen
Publicado en: Journal of Functional Biomaterials, Edición 16, 2025, Página(s) 167, ISSN 2079-4983
Editor: MDPI AG
DOI: 10.3390/jfb16050167

Matrisomal components involved in regenerative wound healing in axolotl and <i>Acomys</i>: implications for biomaterial development

Autores: Nancy Avila-Martinez, Merel Gansevoort, Juul Verbakel, Haarshaadri Jayaprakash, Ines Maria Araujo, Marta Vitorino, Gustavo Tiscornia, Toin H. van Kuppevelt, Willeke F. Daamen
Publicado en: Biomaterials Science, Edición 11, 2024, Página(s) 6060-6081, ISSN 2047-4830
Editor: Royal Society of Chemistry
DOI: 10.1039/d3bm00835e

Collagen-elastin dermal scaffolds enhance tissue regeneration and reduce scarring in preclinical models

Autores: Roman Krymchenko, Nancy Avila-Martinez, Merel Gansevoort, Gert-Jan Bakker, Madalena L.N.P. Gomes, Marcel Vlig, Elly M.M. Versteeg, Bouke K.H.L. Boekema, Toin H. van Kuppevelt, Willeke F. Daamen
Publicado en: Materials Today Bio, Edición 34, 2025, Página(s) 102239, ISSN 2590-0064
Editor: Elsevier BV
DOI: 10.1016/j.mtbio.2025.102239