Skin Tissue Engineering and Regenerative Medicine: From skin repair to regeneration

Informazioni relative al progetto

SkinTERM

ID dell’accordo di sovvenzione: 955722

DOI

10.3030/955722

Progetto chiuso

Data della firma CE 28 Agosto 2020

Data di avvio 1 Ottobre 2020

Data di completamento 31 Luglio 2025

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 192 735,96

Contributo UE

€ 3 192 735,96

Coordinato da

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (26)

Report on the outcome of pharmacological and genetic intervention of candidate genes involved in human sweat gland formation in human skin organoids
Report on the establishment and optimisation of novel proto-follicle structures within skin constructs
Report on the identification of cell types involved in scarless skin regeneration in dorsal skin wound models in Acomys and Mus
Report on the effect of transplantations of Acomys decellularised skin on Mus and vice versa
Report on the histological, compositional and functional characterizations of sweat glands in human skin organoids
Report on effects between nerve cells and endothelial cells in skin substitutes
Report on the establishment of human induced pluripotent stem cells (iPSC)-derived skin organoid model with the optimization of the formulation of growth factors that promote sweat glands formation

Report on the establishment of human induced pluripotent stem cells iPSCderived skin organoid model with the optimization of the formulation of growth factors that promote sweat glands formation

Report on effects of hair follicles onto vascular plexus and nerve fibre formation in skin substitutes
Report on optimized single nuclei sequencing from skin wounds in Acomys and Mus
Report on the activities of skin constructs containing proto-follicle structures after grafting and their influence on skin architecture
Report on the outcome of pharmacological intervention of candidate genes involved in human fibroblast differentiation in vivo mouse wound model
Report on a culture protocol to induce polarisation of macrophages in vitro
Report on the establishment of human induced pluripotent stem cells (iPSC)-derived skin organoid model

Report on the establishment of human induced pluripotent stem cells iPSCderived skin organoid model

Report on the intrinsic properties of human foetal/adult/eschar mesenchymal cell populations on scarring in vitro
Report on the time-course proteomics study for scarless foetal skin regeneration process in Mus
Report on the in vitro analysis of scaffolds containing matrix/effector molecules and glycosaminoglycan(mimetics)
Report on the construction of scaffolds containing matrix/effector molecules and glycosaminoglycan(mimetics)

Report on the construction of scaffolds containing matrixeffector molecules and glycosaminoglycanmimetics

Report on the establishment of decellularisation protocols in Acomys and Mus
Report on the in vitro analysis of elastin preparations
Report on the influence of extracellular matrix, soluble factors and wound environment on scarring in vitro
Report on pharmacologically treated iPSC-derived skin organoids ex vivo
Report on the effect of human skin grafts with distinct macrophage subsets on in vitro/in vivo behaviour
Report on the identification of anti-fibrotic factors secreted by distinct subsets of macrophages
Report on the preparation/characterisation of defined elastin preparations

Report on the preparationcharacterisation of defined elastin preparations

Report on the analysed differences between Acomys and Mus as assessed by proteomic analysis
Report on transplanted prevascularised skin substitutes containing nerve cells and hair follicles regarding sensory restoration

Other (5)

Dissemination to patient organisations completed
Dissemination to general public completed
Dissemination to industry completed
Dissemination to policy makers completed
SkinTERM International Symposium

Data sets, microdata, etc (1)

List of all PhD theses and degrees of ESRs

Websites, patent fillings, videos etc. (1)

Twelve ESR video clips posted publicly

Pubblicazioni

Peer reviewed articles (12)

Elastogenesis in Focus: Navigating Elastic Fibers Synthesis for Advanced Dermal Biomaterial Formulation

Autori: Roman Krymchenko, Gizem Coşar Kutluoğlu, Noor van Hout, Dominique Manikowski, Claudia Doberenz, Toin H. van Kuppevelt, Willeke F. Daamen
Pubblicato in: Advanced Healthcare Materials, 2024, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202400484

Breathing new life into tissue engineering: exploring cutting-edge vascularization strategies for skin substitutes

Autori: M. Zohaib Iqbal, Mahrukh Riaz, Thomas Biedermann, Agnes S. Klar
Pubblicato in: Angiogenesis, Numero Volume 27, Numero 4, August 2024, 2024, Pagina/e 631-648, ISSN 0969-6970
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10456-024-09928-6

Multiscale investigation of collagen structure in human skin and gel matrices using polarization resolved second harmonic generation microscopy

Autori: Mengyao Zhou, Madalena Pinto Gomes, Anouk Elgersma, H. Ibrahim Korkmaz, Bouke K. H. L. Boekema, Marie Louise Groot
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-025-02536-4

Simple method for the production of rete ridges in human dermo-epidermal skin substitutes

Autori: Luca Pontiggia, Vanuchija Someswaran, Roth Devi Long, Mahrukh Riaz, Jonas Lussi, Bradley J. Nelson, Agnes S. Klar, Thomas Biedermann, Ueli Moehrlen
Pubblicato in: Experimental Cell Research, Numero 452, 2025, Pagina/e 114694, ISSN 0014-4827
Editore: Academic Press
DOI: 10.1016/j.yexcr.2025.114694

Organ dependency on fascia connective tissue

Autori: Yue Lin, Ruoxuan Dai, George Vogelaar, Yuval Rinkevich
Pubblicato in: American Journal of Physiology-Cell Physiology, Numero 327, 2024, Pagina/e C357-C361, ISSN 0363-6143
Editore: American Physiological Society
DOI: 10.1152/ajpcell.00350.2024

Fetal Skin Wound Healing: Key Extracellular Matrix Components and Regulators in Scarless Healing

Autori: Madalena Lopes Natário Pinto Gomes, Paul A.J. Krijnen, Esther Middelkoop, Hans W.M. Niessen, Bouke K.H.L. Boekema
Pubblicato in: Journal of Investigative Dermatology, 2024, ISSN 0022-202X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2024.05.027

Preparation, fractionation, and characterization of solubilized elastin and comparison of cellular response on fibroblasts and macrophages

Autori: Roman Krymchenko, Maren Pfirrmann, Sjoerd van der Leeuw, Nancy Avila-Martinez, Elly M.M. Versteeg, Rob T.C. Meuwese, Marcel Vlig, Martijn Verdoes, Bouke K.H.L. Boekema, Toin H. van Kuppevelt, Willeke F. Daamen
Pubblicato in: International Journal of Biological Macromolecules, Numero 315, 2025, Pagina/e 144548, ISSN 0141-8130
Editore: Elsevier BV
DOI: 10.1016/j.ijbiomac.2025.144548

Comparison of dermal and eschar fibroblasts in full skin equivalents

Autori: Gizem Coşar Kutluoğlu, Marcel Vlig, Anouk Elgersma, Bouke K. H. L. Boekema, Willeke F. Daamen, Claudia Doberenz, Dominique Manikowski
Pubblicato in: Wound Repair and Regeneration, Numero 33, 2025, ISSN 1067-1927
Editore: Blackwell Publishing Inc.
DOI: 10.1111/wrr.70001

Exploring mesenchymal stem cells homing mechanisms and improvement strategies

Autori: Umar Sajjad, Muhammad Ahmed, M Zohaib Iqbal, Mahrukh Riaz, Muhammad Mustafa, Thomas Biedermann, Agnes S Klar
Pubblicato in: Stem Cells Translational Medicine, Numero 13, 2024, Pagina/e 1161-1177, ISSN 2157-6564
Editore: AlphaMed Press
DOI: 10.1093/stcltm/szae045

Effect of Hyaluronan in Collagen Biomaterials on Human Macrophages and Fibroblasts In Vitro

Autori: Nancy Avila-Martinez, Maren Pfirrmann, Madalena L. N. P. Gomes, Roman Krymchenko, Elly M. M. Versteeg, Marcel Vlig, Martijn Verdoes, Toin H. van Kuppevelt, Bouke K. H. L. Boekema, Willeke F. Daamen
Pubblicato in: Journal of Functional Biomaterials, Numero 16, 2025, Pagina/e 167, ISSN 2079-4983
Editore: MDPI AG
DOI: 10.3390/jfb16050167

Matrisomal components involved in regenerative wound healing in axolotl and <i>Acomys</i>: implications for biomaterial development

Autori: Nancy Avila-Martinez, Merel Gansevoort, Juul Verbakel, Haarshaadri Jayaprakash, Ines Maria Araujo, Marta Vitorino, Gustavo Tiscornia, Toin H. van Kuppevelt, Willeke F. Daamen
Pubblicato in: Biomaterials Science, Numero 11, 2024, Pagina/e 6060-6081, ISSN 2047-4830
Editore: Royal Society of Chemistry
DOI: 10.1039/d3bm00835e

Collagen-elastin dermal scaffolds enhance tissue regeneration and reduce scarring in preclinical models

Autori: Roman Krymchenko, Nancy Avila-Martinez, Merel Gansevoort, Gert-Jan Bakker, Madalena L.N.P. Gomes, Marcel Vlig, Elly M.M. Versteeg, Bouke K.H.L. Boekema, Toin H. van Kuppevelt, Willeke F. Daamen
Pubblicato in: Materials Today Bio, Numero 34, 2025, Pagina/e 102239, ISSN 2590-0064
Editore: Elsevier BV
DOI: 10.1016/j.mtbio.2025.102239