A fully integrated, animal-free, end-to-end modelling approach to oral drug product development

Deliverables

Public Engagement & Dissemination (PED) Plan published

Public Engagement Dissemination PED Plan published

InPharma-in-schools outreach activities report
Gap analysis on in vitro methods for enabling formulations

InPharma Science Slam videos published on website
Ask Me Anything (AMA) InPharma

Ask Me Anything AMA InPharma

Publications

Understanding the conditions under which drugs are transferred from the stomach through the upper small intestine after the standard high-calorie, high-fat meal

Author(s): Shirin Dietrich, Jens Ceulemans, Eline Hermans, Maria Vertzoni, Christos Reppas
Published in: Journal of Pharmaceutical Sciences, 2024, ISSN 0022-3549
Publisher: John Wiley & Sons Inc.
DOI: 10.1016/j.xphs.2024.01.001

Exploring the Cocrystal Landscape of Posaconazole by Combining High-Throughput Screening Experimentation with Computational Chemistry

Author(s): Matteo Guidetti, Rolf Hilfiker, Martin Kuentz, Annette Bauer-Brandl, Fritz Blatter
Published in: Crystal Growth & Design, Issue 23, 2, 2022, Page(s) 842-852, ISSN 1528-7483
Publisher: American Chemical Society
DOI: 10.1021/acs.cgd.2c01072

Polymer-embedded deep eutectic solvents (PEDES) as a novel bio-enabling formulation approach

Author(s): Shaida Panbachi , Josef Beranek, Martin Kuentz
Published in: European Journal of Pharmaceutical Sciences, Issue Volume 186, 1 July 2023, 2023, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2023.106463

Digestion is a critical element for absorption of cinnarizine from supersaturated lipid-based type I formulations

Author(s): Felix Paulus, Annette Bauer-Brandl, Jef Stappaerts, Rene Holm
Published in: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2023.106634

A comparison of USP 2 and µDISS Profiler™ apparatus for studying dissolution phenomena of ibuprofen and its salts

Author(s): Laurin Zöller, Alex Avdeef, Eva Karlsson, Anders Borde, Sara Carlert, Christoph Saal, Jennifer Dressman
Published in: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2023.106684

A study of hydrophobic domain formation of polymeric drug precipitation inhibitors in aqueous solution

Author(s): Egis Zeneli, Justus Johann Lange, Martin Kuentz, René Holm, Justus Lange
Published in: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2024.106791

Combining in vitro dissolution/permeation with microdialysis sampling: Capabilities and limitations for biopharmaceutical assessments of supersaturating drug formulations

Author(s): Florentin Lukas Holzem, Iben Højgaard Jensen, Jeannine Petrig Schaffland, Cordula Stillhart, Martin Brandl, Annette Bauer-Brandl
Published in: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2023.106533

Projection of Target Drug Particle Size in Oral Formulations Using the Refined Developability Classification System (rDCS)

Author(s): Kristian Beran; Eline Hermans; René Holm; Kia Sepassi; Jennifer Dressman
Published in: Pharmaceutics; Volume 15; Issue 7; Pages: 1909, Issue 1, 2023, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15071909

Developing an in vitro lipolysis model for real-time analysis of drug concentrations during digestion of lipid-based formulations

Author(s): Lotte Ejskjær, Patrick O’Dwyer, Rene Holm, Martin Kuentz, Karl Box, Brendan Griffin
Published in: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2023.106681

On the processes limiting oral drug absorption when amorphous solid dispersions are adminstred after a high-calorie. high-fat meal: Sporanox®pellets

Author(s): Shirin Dietrich, Jens Ceulemans, Eline Hermans, Maria Vertzoni, Christos Reppas
Published in: European Journal of Pharmaceutical Sciences, 2024, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2024.106798

Microdialysis and nanofiltration allow to distinguish molecularly dissolved from colloid-associated drug concentrations during biomimetic dissolution testing of supersaturating formulations

Author(s): Florentin Lukas Holzem, Jeannine Petrig Schaffland, Martin Brandl, Annette Bauer-Brandl, Cordula Stillhart
Published in: European Journal of Pharmaceutical Sciences, Issue Volume 174, 1 July 2022, 2022, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2022.106166

Leveraging the use of in vitro and computational methods to support the development of enabling oral drug products: An InPharma commentary

Author(s): Christos Reppas, Martin Kuentz, Annette Bauer-Brandl, Sara Carlert, André Dallmann, Shirin Dietrich, Jennifer Dressman, Lotte Ejskjaer, Sebastian Frechen, Matteo Guidetti, Rene Holm, Florentin Lukas Holzem, Εva Karlsson, Edmund Kostewicz, Shaida Panbachi, Felix Paulus, Malte Senniksen, Cordula Stillhart, David B. Turner, Maria Vertzoni, Paul Vrenken, Laurin Zoller, Brendan T. Griffin, Patrick J
Published in: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2023.106505

Biopredictive capability assessment of two dissolution/permeation assays, µFLUXTM and PermeaLoopTM, using supersaturating formulations of Posaconazole

Author(s): Florentin Lukas Holzem, Anika Weck, Jeannine Petrig Schaffland, Cordula Stillhart, Sandra Klein, Annette Bauer-Brandl, Martin Brandl
Published in: European Journal of Pharmaceutical Sciences, Issue 176, 2022, Page(s) 106260, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2022.106260

Water-mediated phase transformations of posaconazole: An intricate jungle of crystal forms

Author(s): Matteo Guidetti, Fritz Blatter, Rolf Hilfiker, Annette Bauer-Brandl, Martin Kuentz
Published in: European Journal of Pharmaceutical Sciences, 2024, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2024.106722

Comparative Analysis of Chemical Descriptors by Machine Learning Reveals Atomistic Insights into Solute–Lipid Interactions

Author(s): Justus Johann Lange, Andrea Anelli, Jochem Alsenz, Martin Kuentz, Patrick J. O’Dwyer, Wiebke Saal, Nicole Wyttenbach, Brendan T. Griffin
Published in: Molecular Pharmaceutics, 2024, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.4c00080?urlappend=%3fref%3dpdf&jav=vor&rel=cite-as

Predictive computational tools to analyse effects of Co-milling with PVP on drug dissolution

Author(s): Nicolas Pätzmann, Patrick J. O'Dwyer, Josef Beránek, Martin Kuentz, Brendan T. Griffin
Published in: European Journal of Pharmaceutical Sciences, 2024, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2024.106780

Using molecularly dissolved drug concentrations in PBBMs improves the prediction of oral absorption from supersaturating formulations

Author(s): Florentin Holzem, Jeannine Petrig Schaffland, Cordula Stillhart, Martin Brandl, Annette-Bauer Brandl
Published in: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2024.106703

Advancing Algorithmic Drug Development: Recommendation for Machine Learning Approaches in Drug Formulation

Author(s): Jack Murray, Justus Lange, Harriet Bennett-Lenane, Rene Holm, Martin Kuentz, Patrick O’Dwyer, Brendan Griffin
Published in: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2023.106562

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