A fully integrated, animal-free, end-to-end modelling approach to oral drug product development

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Public Engagement Dissemination PED Plan published

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Gap analysis on in vitro methods for enabling formulations

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Publicaciones

Understanding the conditions under which drugs are transferred from the stomach through the upper small intestine after the standard high-calorie, high-fat meal

Autores: Shirin Dietrich, Jens Ceulemans, Eline Hermans, Maria Vertzoni, Christos Reppas
Publicado en: Journal of Pharmaceutical Sciences, 2024, ISSN 0022-3549
Editor: John Wiley & Sons Inc.
DOI: 10.1016/j.xphs.2024.01.001

Hydrophobic deep eutectic solvent (HDES) as oil phase in lipid-based drug formulations

Autores: Shaida Panbachi, Josef Beranek, Martin Kuentz
Publicado en: International Journal of Pharmaceutics, Edición 661, 2024, Página(s) 124418, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/j.ijpharm.2024.124418

Exploring the Cocrystal Landscape of Posaconazole by Combining High-Throughput Screening Experimentation with Computational Chemistry

Autores: Matteo Guidetti, Rolf Hilfiker, Martin Kuentz, Annette Bauer-Brandl, Fritz Blatter
Publicado en: Crystal Growth & Design, Edición 23, 2, 2022, Página(s) 842-852, ISSN 1528-7483
Editor: American Chemical Society
DOI: 10.1021/acs.cgd.2c01072

Polymer-embedded deep eutectic solvents (PEDES) as a novel bio-enabling formulation approach

Autores: Shaida Panbachi , Josef Beranek, Martin Kuentz
Publicado en: European Journal of Pharmaceutical Sciences, Edición Volume 186, 1 July 2023, 2023, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2023.106463

Digestion is a critical element for absorption of cinnarizine from supersaturated lipid-based type I formulations

Autores: Felix Paulus, Annette Bauer-Brandl, Jef Stappaerts, Rene Holm
Publicado en: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2023.106634

A comparison of USP 2 and µDISS Profiler™ apparatus for studying dissolution phenomena of ibuprofen and its salts

Autores: Laurin Zöller, Alex Avdeef, Eva Karlsson, Anders Borde, Sara Carlert, Christoph Saal, Jennifer Dressman
Publicado en: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2023.106684

A study of hydrophobic domain formation of polymeric drug precipitation inhibitors in aqueous solution

Autores: Egis Zeneli, Justus Johann Lange, Martin Kuentz, René Holm, Justus Lange
Publicado en: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2024.106791

Combining in vitro dissolution/permeation with microdialysis sampling: Capabilities and limitations for biopharmaceutical assessments of supersaturating drug formulations

Autores: Florentin Lukas Holzem, Iben Højgaard Jensen, Jeannine Petrig Schaffland, Cordula Stillhart, Martin Brandl, Annette Bauer-Brandl
Publicado en: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2023.106533

Using the refined Developability Classification System (rDCS) to guide the design of oral formulations

Autores: Kristian Beran, Eline Hermans, René Holm, Kia Sepassi, Jennifer Dressman
Publicado en: Journal of Pharmaceutical Sciences, 2024, ISSN 0022-3549
Editor: John Wiley & Sons Inc.
DOI: 10.1016/j.xphs.2024.09.022

Oral Absorption from Surfactant-Based Drug Formulations: The Impact of Molecularly Dissolved Drug on Bioavailability

Autores: Florentin Lukas Holzem, Neil Parrott, Jeannine Petrig Schaffland, Martin Brandl, Annette Bauer-Brandl, Cordula Stillhart
Publicado en: Journal of Pharmaceutical Sciences, Edición 113, 2024, Página(s) 3054-3064, ISSN 0022-3549
Editor: John Wiley & Sons Inc.
DOI: 10.1016/j.xphs.2024.07.017

Projection of Target Drug Particle Size in Oral Formulations Using the Refined Developability Classification System (rDCS)

Autores: Kristian Beran; Eline Hermans; René Holm; Kia Sepassi; Jennifer Dressman
Publicado en: Pharmaceutics; Volume 15; Edición 7; Pages: 1909, Edición 1, 2023, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15071909

Developing an in vitro lipolysis model for real-time analysis of drug concentrations during digestion of lipid-based formulations

Autores: Lotte Ejskjær, Patrick O’Dwyer, Rene Holm, Martin Kuentz, Karl Box, Brendan Griffin
Publicado en: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2023.106681

On the processes limiting oral drug absorption when amorphous solid dispersions are adminstred after a high-calorie. high-fat meal: Sporanox®pellets

Autores: Shirin Dietrich, Jens Ceulemans, Eline Hermans, Maria Vertzoni, Christos Reppas
Publicado en: European Journal of Pharmaceutical Sciences, 2024, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2024.106798

Microdialysis and nanofiltration allow to distinguish molecularly dissolved from colloid-associated drug concentrations during biomimetic dissolution testing of supersaturating formulations

Autores: Florentin Lukas Holzem, Jeannine Petrig Schaffland, Martin Brandl, Annette Bauer-Brandl, Cordula Stillhart
Publicado en: European Journal of Pharmaceutical Sciences, Edición Volume 174, 1 July 2022, 2022, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2022.106166

Leveraging the use of in vitro and computational methods to support the development of enabling oral drug products: An InPharma commentary

Autores: Christos Reppas, Martin Kuentz, Annette Bauer-Brandl, Sara Carlert, André Dallmann, Shirin Dietrich, Jennifer Dressman, Lotte Ejskjaer, Sebastian Frechen, Matteo Guidetti, Rene Holm, Florentin Lukas Holzem, Εva Karlsson, Edmund Kostewicz, Shaida Panbachi, Felix Paulus, Malte Senniksen, Cordula Stillhart, David B. Turner, Maria Vertzoni, Paul Vrenken, Laurin Zoller, Brendan T. Griffin, Patrick J
Publicado en: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2023.106505

Biopredictive capability assessment of two dissolution/permeation assays, µFLUXTM and PermeaLoopTM, using supersaturating formulations of Posaconazole

Autores: Florentin Lukas Holzem, Anika Weck, Jeannine Petrig Schaffland, Cordula Stillhart, Sandra Klein, Annette Bauer-Brandl, Martin Brandl
Publicado en: European Journal of Pharmaceutical Sciences, Edición 176, 2022, Página(s) 106260, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2022.106260

Water-mediated phase transformations of posaconazole: An intricate jungle of crystal forms

Autores: Matteo Guidetti, Fritz Blatter, Rolf Hilfiker, Annette Bauer-Brandl, Martin Kuentz
Publicado en: European Journal of Pharmaceutical Sciences, 2024, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2024.106722

Comparative Analysis of Chemical Descriptors by Machine Learning Reveals Atomistic Insights into Solute–Lipid Interactions

Autores: Justus Johann Lange, Andrea Anelli, Jochem Alsenz, Martin Kuentz, Patrick J. O’Dwyer, Wiebke Saal, Nicole Wyttenbach, Brendan T. Griffin
Publicado en: Molecular Pharmaceutics, 2024, ISSN 1543-8384
Editor: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.4c00080?urlappend=%3fref%3dpdf&jav=vor&rel=cite-as

Predictive computational tools to analyse effects of Co-milling with PVP on drug dissolution

Autores: Nicolas Pätzmann, Patrick J. O'Dwyer, Josef Beránek, Martin Kuentz, Brendan T. Griffin
Publicado en: European Journal of Pharmaceutical Sciences, 2024, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2024.106780

Using molecularly dissolved drug concentrations in PBBMs improves the prediction of oral absorption from supersaturating formulations

Autores: Florentin Holzem, Jeannine Petrig Schaffland, Cordula Stillhart, Martin Brandl, Annette-Bauer Brandl
Publicado en: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2024.106703

A Stratified Analysis of Supersaturation and Precipitation Effects Based on the Refined Developability Classification System (rDCS)

Autores: Kristian Beran, Eline Hermans, René Holm, Kia Sepassi, Jennifer Dressman
Publicado en: Journal of Pharmaceutical Sciences, Edición 113, 2024, Página(s) 2940-2946, ISSN 0022-3549
Editor: John Wiley & Sons Inc.
DOI: 10.1016/j.xphs.2024.06.014

Exploration of solubilisation effects facilitated by the combination of Soluplus® with ionic surfactants

Autores: Justus Johann Lange, Lukas Enzner, Martin Kuentz, Patrick J. O’Dwyer, Wiebke Saal, Brendan T. Griffin, Nicole Wyttenbach
Publicado en: European Journal of Pharmaceutical Sciences, 2024, Página(s) 106957, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2024.106957

Predictions of biorelevant solubility change during dispersion and digestion of lipid-based formulations

Autores: Lotte Ejskjær, René Holm, Martin Kuentz, Karl J. Box, Brendan T. Griffin, Patrick J. O'Dwyer
Publicado en: European Journal of Pharmaceutical Sciences, Edición 200, 2024, Página(s) 106833, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2024.106833

Advancing Algorithmic Drug Development: Recommendation for Machine Learning Approaches in Drug Formulation

Autores: Jack Murray, Justus Lange, Harriet Bennett-Lenane, Rene Holm, Martin Kuentz, Patrick O’Dwyer, Brendan Griffin
Publicado en: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2023.106562

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