A fully integrated, animal-free, end-to-end modelling approach to oral drug product development

Informations projet

InPharma

N° de convention de subvention: 955756

DOI 10.3030/955756

Date de signature de la CE 7 Septembre 2020

Date de début 1 Janvier 2021

Date de fin 31 Decembre 2024

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total € 3 464 964,00

Contribution de l’UE € 3 464 964,00

Coordonné par

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland

Livrables

Documents, reports (2)

Public Engagement & Dissemination (PED) Plan published

Public Engagement Dissemination PED Plan published

Gap analysis on in vitro methods for enabling formulations

Websites, patent fillings, videos etc. (3)

InPharma Science Slam videos published on website
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InPharma website established

Publications

Peer reviewed articles (5)

Exploring the Cocrystal Landscape of Posaconazole by Combining High-Throughput Screening Experimentation with Computational Chemistry

Auteurs: Matteo Guidetti, Rolf Hilfiker, Martin Kuentz, Annette Bauer-Brandl, Fritz Blatter
Publié dans: Crystal Growth & Design, Numéro 23, 2, 2022, Page(s) 842-852, ISSN 1528-7483
Éditeur: American Chemical Society
DOI: 10.1021/acs.cgd.2c01072

Polymer-embedded deep eutectic solvents (PEDES) as a novel bio-enabling formulation approach

Auteurs: Shaida Panbachi , Josef Beranek, Martin Kuentz
Publié dans: European Journal of Pharmaceutical Sciences, Numéro Volume 186, 1 July 2023, 2023, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2023.106463

Projection of Target Drug Particle Size in Oral Formulations Using the Refined Developability Classification System (rDCS)

Auteurs: Kristian Beran; Eline Hermans; René Holm; Kia Sepassi; Jennifer Dressman
Publié dans: Pharmaceutics; Volume 15; Numéro 7; Pages: 1909, Numéro 1, 2023, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15071909

Microdialysis and nanofiltration allow to distinguish molecularly dissolved from colloid-associated drug concentrations during biomimetic dissolution testing of supersaturating formulations

Auteurs: Florentin Lukas Holzem, Jeannine Petrig Schaffland, Martin Brandl, Annette Bauer-Brandl, Cordula Stillhart
Publié dans: European Journal of Pharmaceutical Sciences, Numéro Volume 174, 1 July 2022, 2022, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2022.106166

Biopredictive capability assessment of two dissolution/permeation assays, µFLUXTM and PermeaLoopTM, using supersaturating formulations of Posaconazole

Auteurs: Florentin Lukas Holzem, Anika Weck, Jeannine Petrig Schaffland, Cordula Stillhart, Sandra Klein, Annette Bauer-Brandl, Martin Brandl
Publié dans: European Journal of Pharmaceutical Sciences, Numéro 176, 2022, Page(s) 106260, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2022.106260