A fully integrated, animal-free, end-to-end modelling approach to oral drug product development

Informations projet

InPharma

N° de convention de subvention: 955756

DOI

10.3030/955756

Projet clôturé

Date de signature de la CE 7 Septembre 2020

Date de début 1 Janvier 2021

Date de fin 31 Decembre 2024

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 3 464 964,00

Contribution de l’UE

€ 3 464 964,00

Coordonné par

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (5)

International Conference at end of project
InPharma ‘Shark tank'

InPharma ‘Shark tank’

InPharma Science Slam videos published on website
Ask Me Anything (AMA) InPharma

Ask Me Anything AMA InPharma

InPharma website established

Documents, reports (4)

Public Engagement & Dissemination (PED) Plan published

Public Engagement Dissemination PED Plan published

Peer Reviewed Scientific Publications and Patents
InPharma-in-schools outreach activities report
Gap analysis on in vitro methods for enabling formulations

Other (2)

Research publications from WP2 (min. 10)
Research publications from WP1 (min 10)

Publications

Peer reviewed articles (30)

Understanding the conditions under which drugs are transferred from the stomach through the upper small intestine after the standard high-calorie, high-fat meal

Auteurs: Shirin Dietrich, Jens Ceulemans, Eline Hermans, Maria Vertzoni, Christos Reppas
Publié dans: Journal of Pharmaceutical Sciences, 2024, ISSN 0022-3549
Éditeur: John Wiley & Sons Inc.
DOI: 10.1016/j.xphs.2024.01.001

Hydrophobic deep eutectic solvent (HDES) as oil phase in lipid-based drug formulations

Auteurs: Shaida Panbachi, Josef Beranek, Martin Kuentz
Publié dans: International Journal of Pharmaceutics, Numéro 661, 2024, Page(s) 124418, ISSN 0378-5173
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpharm.2024.124418

Exploring the Cocrystal Landscape of Posaconazole by Combining High-Throughput Screening Experimentation with Computational Chemistry

Auteurs: Matteo Guidetti, Rolf Hilfiker, Martin Kuentz, Annette Bauer-Brandl, Fritz Blatter
Publié dans: Crystal Growth & Design, Numéro 23, 2, 2022, Page(s) 842-852, ISSN 1528-7483
Éditeur: American Chemical Society
DOI: 10.1021/acs.cgd.2c01072

Abiraterone acetate fixed-dosed combinations with ibuprofen-based therapeutic eutectic and deep eutectic solvents

Auteurs: Shaida Panbachi, Josef Beranek, Martin Kuentz
Publié dans: International Journal of Pharmaceutics, Numéro 671, 2025, Page(s) 125279, ISSN 0378-5173
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpharm.2025.125279

Polymer-embedded deep eutectic solvents (PEDES) as a novel bio-enabling formulation approach

Auteurs: Shaida Panbachi , Josef Beranek, Martin Kuentz
Publié dans: European Journal of Pharmaceutical Sciences, Numéro Volume 186, 1 July 2023, 2023, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2023.106463

Digestion is a critical element for absorption of cinnarizine from supersaturated lipid-based type I formulations

Auteurs: Felix Paulus, Annette Bauer-Brandl, Jef Stappaerts, Rene Holm
Publié dans: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2023.106634

A comparison of USP 2 and µDISS Profiler™ apparatus for studying dissolution phenomena of ibuprofen and its salts

Auteurs: Laurin Zöller, Alex Avdeef, Eva Karlsson, Anders Borde, Sara Carlert, Christoph Saal, Jennifer Dressman
Publié dans: European Journal of Pharmaceutical Sciences, Numéro 193106684, 2023, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2023.106684

A study of hydrophobic domain formation of polymeric drug precipitation inhibitors in aqueous solution

Auteurs: Egis Zeneli, Justus Johann Lange, Martin Kuentz, René Holm, Justus Lange
Publié dans: European Journal of Pharmaceutical Sciences, Numéro 198, 2023, Page(s) 106791, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2024.106791

Combining in vitro dissolution/permeation with microdialysis sampling: Capabilities and limitations for biopharmaceutical assessments of supersaturating drug formulations

Auteurs: Florentin Lukas Holzem, Iben Højgaard Jensen, Jeannine Petrig Schaffland, Cordula Stillhart, Martin Brandl, Annette Bauer-Brandl
Publié dans: European Journal of Pharmaceutical Sciences, Numéro 188, 2023, Page(s) 106533, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2023.106533

Mechanistic Investigation into the Phase Separation Behavior of Soluplus in the Presence of Biorelevant Media

Auteurs: Justus Johann Lange, Malte Bøgh Senniksen, Nicole Wyttenbach, Susanne Page, Lorraine M. Bateman, Patrick J. O’Dwyer, Wiebke Saal, Martin Kuentz, Brendan T. Griffin
Publié dans: Molecular Pharmaceutics, 2025, ISSN 1543-8384
Éditeur: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.4c01140

Using the refined Developability Classification System (rDCS) to guide the design of oral formulations

Auteurs: Kristian Beran, Eline Hermans, René Holm, Kia Sepassi, Jennifer Dressman
Publié dans: Journal of Pharmaceutical Sciences, Numéro 113, 2024, Page(s) 3497-3517, ISSN 0022-3549
Éditeur: John Wiley & Sons Inc.
DOI: 10.1016/j.xphs.2024.09.022

Oral Absorption from Surfactant-Based Drug Formulations: The Impact of Molecularly Dissolved Drug on Bioavailability

Auteurs: Florentin Lukas Holzem, Neil Parrott, Jeannine Petrig Schaffland, Martin Brandl, Annette Bauer-Brandl, Cordula Stillhart
Publié dans: Journal of Pharmaceutical Sciences, Numéro 113, 2024, Page(s) 3054-3064, ISSN 0022-3549
Éditeur: John Wiley & Sons Inc.
DOI: 10.1016/j.xphs.2024.07.017

Projection of Target Drug Particle Size in Oral Formulations Using the Refined Developability Classification System (rDCS)

Auteurs: Kristian Beran; Eline Hermans; René Holm; Kia Sepassi; Jennifer Dressman
Publié dans: Pharmaceutics, Numéro 15(7), 2023, Page(s) 1909, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15071909

Developing an in vitro lipolysis model for real-time analysis of drug concentrations during digestion of lipid-based formulations

Auteurs: Lotte Ejskjær, Patrick O’Dwyer, Rene Holm, Martin Kuentz, Karl Box, Brendan Griffin
Publié dans: European Journal of Pharmaceutical Sciences, Numéro 194 (106681), 2023, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2023.106681

On the processes limiting oral drug absorption when amorphous solid dispersions are adminstred after a high-calorie. high-fat meal: Sporanox®pellets

Auteurs: Shirin Dietrich, Jens Ceulemans, Eline Hermans, Maria Vertzoni, Christos Reppas
Publié dans: European Journal of Pharmaceutical Sciences, Numéro 199, 2024, Page(s) 106798, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2024.106798

Microdialysis and nanofiltration allow to distinguish molecularly dissolved from colloid-associated drug concentrations during biomimetic dissolution testing of supersaturating formulations

Auteurs: Florentin Lukas Holzem, Jeannine Petrig Schaffland, Martin Brandl, Annette Bauer-Brandl, Cordula Stillhart
Publié dans: European Journal of Pharmaceutical Sciences, Numéro Volume 174, 1 July 2022, 2022, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2022.106166

Leveraging the use of in vitro and computational methods to support the development of enabling oral drug products: An InPharma commentary

Auteurs: Christos Reppas, Martin Kuentz, Annette Bauer-Brandl, Sara Carlert, André Dallmann, Shirin Dietrich, Jennifer Dressman, Lotte Ejskjaer, Sebastian Frechen, Matteo Guidetti, Rene Holm, Florentin Lukas Holzem, Εva Karlsson, Edmund Kostewicz, Shaida Panbachi, Felix Paulus, Malte Senniksen, Cordula Stillhart, David B. Turner, Maria Vertzoni, Paul Vrenken, Laurin Zoller, Brendan T. Griffin, Patrick J
Publié dans: European Journal of Pharmaceutical Sciences, Numéro 188 (106505), 2023, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2023.106505

Biopredictive capability assessment of two dissolution/permeation assays, µFLUXTM and PermeaLoopTM, using supersaturating formulations of Posaconazole

Auteurs: Florentin Lukas Holzem, Anika Weck, Jeannine Petrig Schaffland, Cordula Stillhart, Sandra Klein, Annette Bauer-Brandl, Martin Brandl
Publié dans: European Journal of Pharmaceutical Sciences, Numéro 176, 2022, Page(s) 106260, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2022.106260

Biowaiver monographs for immediate-release solid oral dosage forms: Voriconazole

Auteurs: Kristian Beran, Bertil Abrahamsson, Naseem Charoo, Rodrigo Cristofoletti, René Holm, Atsushi Kambayashi, Peter Langguth, Alan Parr, James E. Polli, Vinod P. Shah, Jennifer Dressman
Publié dans: Journal of Pharmaceutical Sciences, Numéro 114, 2025, Page(s) 660-680, ISSN 0022-3549
Éditeur: John Wiley & Sons Inc.
DOI: 10.1016/j.xphs.2024.10.055

Water-mediated phase transformations of posaconazole: An intricate jungle of crystal forms

Auteurs: Matteo Guidetti, Fritz Blatter, Rolf Hilfiker, Annette Bauer-Brandl, Martin Kuentz
Publié dans: European Journal of Pharmaceutical Sciences, 2024, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2024.106722

Comparative Analysis of Chemical Descriptors by Machine Learning Reveals Atomistic Insights into Solute–Lipid Interactions

Auteurs: Justus Johann Lange, Andrea Anelli, Jochem Alsenz, Martin Kuentz, Patrick J. O’Dwyer, Wiebke Saal, Nicole Wyttenbach, Brendan T. Griffin
Publié dans: Molecular Pharmaceutics, Numéro 21 (7), 2024, Page(s) 3343-3355, ISSN 1543-8384
Éditeur: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.4c00080?urlappend=%3fref%3dpdf&jav=vor&rel=cite-as

Predictive computational models for assessing the impact of co-milling on drug dissolution

Auteurs: Nicolas Pätzmann, Patrick J. O'Dwyer, Josef Beránek, Martin Kuentz, Brendan T. Griffin
Publié dans: European Journal of Pharmaceutical Sciences, Numéro 198, 2024, Page(s) 106780, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2024.106780

Using molecularly dissolved drug concentrations in PBBMs improves the prediction of oral absorption from supersaturating formulations

Auteurs: Florentin Holzem, Jeannine Petrig Schaffland, Cordula Stillhart, Martin Brandl, Annette-Bauer Brandl
Publié dans: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2024.106703

Biowaiver monographs for immediate-release solid oral dosage forms: Lemborexant

Auteurs: Kristian Beran, Bertil Abrahamsson, Naseem Charoo, Rodrigo Cristofoletti, René Holm, Atsushi Kambayashi, Peter Langguth, Mehul Mehta, Alan Parr, James E. Polli, Vinod P. Shah, Jennifer Dressman
Publié dans: Journal of Pharmaceutical Sciences, Numéro 114, 2025, Page(s) 644-659, ISSN 0022-3549
Éditeur: John Wiley & Sons Inc.
DOI: 10.1016/j.xphs.2024.10.030

A high-throughput micro-scale workflow to quantify molecularly dissolved drug concentrations under solubilizing conditions

Auteurs: Florentin Lukas Holzem, Rasmus Lind Mikkelsen, Jeannine Petrig Schaffland, Cordula Stillhart, Martin Brandl, Annette Bauer-Brandl
Publié dans: Journal of Pharmaceutical Sciences, Numéro 114, 2025, Page(s) 1485-1494, ISSN 0022-3549
Éditeur: John Wiley & Sons Inc.
DOI: 10.1016/j.xphs.2024.12.027

A Stratified Analysis of Supersaturation and Precipitation Effects Based on the Refined Developability Classification System (rDCS)

Auteurs: Kristian Beran, Eline Hermans, René Holm, Kia Sepassi, Jennifer Dressman
Publié dans: Journal of Pharmaceutical Sciences, Numéro 113, 2024, Page(s) 2940-2946, ISSN 0022-3549
Éditeur: John Wiley & Sons Inc.
DOI: 10.1016/j.xphs.2024.06.014

Exploration of solubilisation effects facilitated by the combination of Soluplus® with ionic surfactants

Auteurs: Justus Johann Lange, Lukas Enzner, Martin Kuentz, Patrick J. O’Dwyer, Wiebke Saal, Brendan T. Griffin, Nicole Wyttenbach
Publié dans: European Journal of Pharmaceutical Sciences, Numéro 205, 2024, Page(s) 106957, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2024.106957

Predictions of biorelevant solubility change during dispersion and digestion of lipid-based formulations

Auteurs: Lotte Ejskjær, René Holm, Martin Kuentz, Karl J. Box, Brendan T. Griffin, Patrick J. O'Dwyer
Publié dans: European Journal of Pharmaceutical Sciences, Numéro 200, 2024, Page(s) 106833, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2024.106833

Advancing Algorithmic Drug Development: Recommendation for Machine Learning Approaches in Drug Formulation

Auteurs: Jack Murray, Justus Lange, Harriet Bennett-Lenane, Rene Holm, Martin Kuentz, Patrick O’Dwyer, Brendan Griffin
Publié dans: European Journal of Pharmaceutical Sciences, Numéro 191 (106562), 2023, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2023.106562

Advantages of the refined developability classification system in early discovery

Auteurs: Kristian Beran, Jennifer Dressman, Eline Hermans, René Holm, Kia Sepassi
Publié dans: Journal of Pharmaceutical Sciences, Numéro 114, 2025, Page(s) 1444-1454, ISSN 0022-3549
Éditeur: John Wiley & Sons Inc.
DOI: 10.1016/j.xphs.2024.12.021