Descrizione del progetto
Medicazioni proprietarie per il trattamento delle ferite croniche
Il trattamento delle ferite croniche che non si rimarginano rappresenta un’esigenza clinica non soddisfatta dalle apposite medicazioni convenzionali, che non sono in grado di proteggere dalle infezioni ricorrenti con un conseguente aumento della mortalità. L’incidenza crescente del diabete e dell’obesità, insieme alla resistenza agli antibiotici, aggrava la situazione. Il progetto WHILYAS-2, finanziato dall’UE, propone di affrontare il trattamento insufficiente delle ferite croniche attraverso una tecnologia proprietaria che utilizza chemochine come agenti terapeutici in somministrazione locale direttamente dai batteri dell’acido lattico geneticamente modificati. I partner, per verificare tale teoria, condurranno una sperimentazione clinica di fase II del loro farmaco topico candidato ILP100 su pazienti diabetici.
Obiettivo
ILYA PHARMA AB is a Swedish spin-out biotech company from Uppsala that develops next-generation biologics to treat wounds in skin and mucosa.
In the previous SME Instrument project, the Company reached the First in Human (FiH) Phase I clinical trial in the development of their technology platform (ILP) that utilizes chemokines as therapeutic agents through local administration from genetically modified lactic acid bacteria.
The WHILYAS-2 project addresses several critical problems and unmet medical needs related to the treatment of chronic wounds, both from patients and healthcare perspectives, namely the pandemic of obesity and diabetes (463 million people in 2019), an alarming pace of antibiotic resistance spreading (due to overuse of antibiotics), limited and insufficient treatment options (less than 25% of chronic wounds heal within 12 weeks), and vast and growing socio-economic burden (20 billion EUR per year in the US and Europe alone).
The technical, industrial, legal, and commercial feasibility of ILP100 Topical have all been confirmed over the course of our previous activities and developments.
In this project, Ilya Pharma intends to conduct exploratory clinical trials (Phase IIa) of their drug candidate, ILP100 Topical, in treatment of non-healing (chronic) wounds in populations with diabetes to achieve clinical Proof of Concept (PoC) in the relevant patient group. WHILYAS-2 will allow the Company to scale up and position it to be further investable for VCs and MedTech/Biopharma Companies or license ILP100 Topical to a partner capable of bringing it to the market through large-scale Phase IIb or pivotal (Phase III) clinical studies.
If these efforts are successful, ILP100 Topical is expected to be superior and best in class treatment for chronic wounds, offering ease of use, comparable to traditional wound dressings, >50% reduction of wound infections, significantly reduced 5-year mortality, as well as >50% decrease in treatment cost per wound.
Campo scientifico
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health scienceshealth sciencespublic healthepidemiologypandemics
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance
Parole chiave
Programma(i)
Argomento(i)
Invito a presentare proposte
Vedi altri progetti per questo bandoBando secondario
H2020-EIC-SMEInst-2018-2020-3
Meccanismo di finanziamento
SME-2 - SME instrument phase 2Coordinatore
752 37 Uppsala
Svezia
L’organizzazione si è definita una PMI (piccola e media impresa) al momento della firma dell’accordo di sovvenzione.