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CORDIS - EU research results
CORDIS

A KEY TO THE RATIONAL DESIGN OF EXTRACELLULAR VESICLES-MIMICKING NANOPARTICLES

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Protocol on synthesis of breakable hard-shell organosilica NPs (opens in new window)

The deliverable will consist in a report on the synthesis of hybrid hard organosilica NPs that are cleaved in the presence of specific biomolecules and are able to allow the cargo release

Report on EVs derived from tumor/osteoblastic cells ready and characterized (opens in new window)

The deliverable will consist of a report describing the tumorosteoblastic cells chosen as source of EVs and of the protocols used for EV extraction and characterization and related results

Quantitative estimation of protein numbers and distribution for EVs (opens in new window)

The deliverable will consist of a report containing the following parameters: i) size of EVs; ii) number of multiple surface protein per EV; iii) the distribution of these quantities in the EV population.

Kick-off meeting report (opens in new window)

Report on the kickoff meeting describing the coordination and partners roles organization of the consortium and of the research work

Selection of 2 natural EVs bone-targeting candidates (opens in new window)

A report describing the use of natural EVs containing CTSK RANKL or other bone targeting candidates for in vivo application on healthy mice to evaluate the biodistribution

Website and logo (opens in new window)

Website creation and continuous update planningsSocial profiles creation and pages actions and planning for the dissemination to broad publics logo creation and planning for its use

Molecular models and simulations for lipid-covered hard-core NPs. (opens in new window)

The deliverable will consist in a report on modelling and simulations to compare the dynamics of lipid bilayers having the inner leaflet bound to the hard-core NP surface

Molecular models and simulations for lipid-covered hard-core NPs with different geometries (opens in new window)

The deliverable will consist in in a report on modelling and simulations to compare the dynamics of lipid bilayers in perfect/flat domains vs. in the presence of discontinuities/edges at the NP surface (NP shape effect)

Molecular models and simulations for EV lipid bilayer envelopes (opens in new window)

The deliverable will consist in a report on the modelling and simulations to characterize the dynamics and stability of various EV lipid bilayers envelops.

Publications

Automatic multi-objective optimization of coarse-grained lipid force fields using SwarmCG (opens in new window)

Author(s): Charly Empereur-mot, Riccardo Capelli, Mattia Perrone, Cristina Caruso, Giovanni Doni, Giovanni M. Pavan
Published in: J. Chem. Phys, Issue 156, 2022, ISSN 0021-9606
Publisher: American Institute of Physics
DOI: 10.1063/5.0079044

Cargo-loaded lipid-shielded breakable organosilica nanocages for enhanced drug delivery (opens in new window)

Author(s): María Sancho-Albero, Giada Rosso, Luisa De Cola, Valentina Cauda
Published in: Nanoscale, Issue 15, 2023, Page(s) 14628-14640, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3nr02155f

Biomimicking Extracellular Vesicles with Fully Artificial Ones: A Rational Design of EV-BIOMIMETICS toward Effective Theranostic Tools in Nanomedicine (opens in new window)

Author(s): Giada Rosso, Valentina Cauda
Published in: ACS Biomater. Sci. Eng., Issue 2023, 9, 11, 2023, Page(s) 5924–5932, ISSN 2373-9878
Publisher: American Chemical Society
DOI: 10.1021/acsbiomaterials.2c01025

Artificial and Naturally Derived Phospholipidic Bilayers as Smart Coatings of Solid-State Nanoparticles: Current Works and Perspectives in Cancer Therapy (opens in new window)

Author(s): Nicolò Maria Percivalle; Marco Carofiglio; Marzia Conte; Giada Rosso; Alessandro Bentivogli; Giulia Mesiano; Veronica Vighetto; Valentina Cauda
Published in: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Issue 23 (15815), 2022, Page(s) 1-28, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232415815

Lipidic Formulations Inspired by COVID Vaccines as Smart Coatings to Enhance Nanoparticle-Based Cancer Therapy (opens in new window)

Author(s): Marzia Conte; Marco Carofiglio; Giada Rosso; Valentina Cauda
Published in: Nanomaterials; Volume 13; Issue 15; Pages: 2250, Issue 4, 2023, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano13152250

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