A KEY TO THE RATIONAL DESIGN OF EXTRACELLULAR VESICLES-MIMICKING NANOPARTICLES

Project Information

MIMIC-KeY

Grant agreement ID: 964386

DOI

10.3030/964386

Project closed

EC signature date 19 January 2021

Start date 1 June 2021

End date 30 November 2025

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost

€ 2 902 527,50

EU contribution

€ 2 902 527,50

Coordinated by

POLITECNICO DI TORINO
Italy

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (5)

Protocol on synthesis of breakable hard-shell organosilica NPs

The deliverable will consist in a report on the synthesis of hybrid hard organosilica NPs that are cleaved in the presence of specific biomolecules and are able to allow the cargo release

Report on EVs derived from tumor/osteoblastic cells ready and characterized

The deliverable will consist of a report describing the tumorosteoblastic cells chosen as source of EVs and of the protocols used for EV extraction and characterization and related results

Quantitative estimation of protein numbers and distribution for EVs

The deliverable will consist of a report containing the following parameters: i) size of EVs; ii) number of multiple surface protein per EV; iii) the distribution of these quantities in the EV population.

Kick-off meeting report

Report on the kickoff meeting describing the coordination and partners roles organization of the consortium and of the research work

Selection of 2 natural EVs bone-targeting candidates

A report describing the use of natural EVs containing CTSK RANKL or other bone targeting candidates for in vivo application on healthy mice to evaluate the biodistribution

Websites, patent fillings, videos etc. (1)

Website and logo

Website creation and continuous update planningsSocial profiles creation and pages actions and planning for the dissemination to broad publics logo creation and planning for its use

Demonstrators, pilots, prototypes (3)

Molecular models and simulations for lipid-covered hard-core NPs.

The deliverable will consist in a report on modelling and simulations to compare the dynamics of lipid bilayers having the inner leaflet bound to the hard-core NP surface

Molecular models and simulations for lipid-covered hard-core NPs with different geometries

The deliverable will consist in in a report on modelling and simulations to compare the dynamics of lipid bilayers in perfect/flat domains vs. in the presence of discontinuities/edges at the NP surface (NP shape effect)

Molecular models and simulations for EV lipid bilayer envelopes

The deliverable will consist in a report on the modelling and simulations to characterize the dynamics and stability of various EV lipid bilayers envelops.

Publications

Peer reviewed articles (19)

Automatic multi-objective optimization of coarse-grained lipid force fields using SwarmCG

Author(s): Charly Empereur-mot, Riccardo Capelli, Mattia Perrone, Cristina Caruso, Giovanni Doni, Giovanni M. Pavan
Published in: J. Chem. Phys, Issue 156, 2022, ISSN 0021-9606
Publisher: American Institute of Physics
DOI: 10.1063/5.0079044

Cargo-loaded lipid-shielded breakable organosilica nanocages for enhanced drug delivery

Author(s): María Sancho-Albero, Giada Rosso, Luisa De Cola, Valentina Cauda
Published in: Nanoscale, Issue 15, 2023, Page(s) 14628-14640, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3nr02155f

Acoustically Driven Hybrid Nanocrystals for In Vivo Pancreatic Cancer Treatment

Author(s): Marzia Conte, Marco Carofiglio, Robin Shae Vander Pol, Anthony Wood, Nathanael Hernandez, Ashley Joubert, Camden Caffey, Corrine Ying Xuan Chua, Alessandro Grattoni, Valentina Cauda
Published in: ACS Applied Materials & Interfaces, Issue 17, 2025, Page(s) 11873-11887, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.4c21975

Extracellular Vesicles as Tools for Crossing the Blood–Brain Barrier to Treat Lysosomal Storage Diseases

Author(s): Giovanni Lerussi, Verónica Villagrasa-Araya, Marc Moltó-Abad, Mireia del Toro, Guillem Pintos-Morell, Joaquin Seras-Franzoso, Ibane Abasolo
Published in: Life, Issue 15, 2025, Page(s) 70, ISSN 2075-1729
Publisher: MDPI AG
DOI: 10.3390/life15010070

Targeted lipid-coated ZnO nanoparticles coupled with ultrasound: A sonodynamic approach for the treatment of osteosarcoma as 3D spheroid models

Author(s): Marco Carofiglio, Giulia Mesiano, Giada Rosso, Marzia Conte, Marco Zuccheri, Ymera Pignochino, Valentina Cauda
Published in: Materials Today Communications, Issue 40, 2024, Page(s) 109826, ISSN 2352-4928
Publisher: Elsevier BV
DOI: 10.1016/j.mtcomm.2024.109826

Natural and Artificial Phospholipid Bilayer Coatings on Solid-State Nanoparticles, Current and Future Perspectives

Author(s): Bianca Dumontel, Giada Rosso, Valentina Cauda
Published in: Nanomedicine, Issue 19, 2024, Page(s) 653-655, ISSN 1743-5889
Publisher: Future Medicine Ltd.
DOI: 10.2217/nnm-2023-0358

Spotlight on innovation: key insights from the extracellular vesicle cluster meeting at the European Innovation Council

Author(s): Giorgia Adamo, Ioannis Amarantos, Iordanis Arzimanoglou, Paolo Bergese, Antonella Bongiovanni, Benedetta Bussolati, Valentina Cauda, Marcella Chiari, George A. Garinis, Bernd Giebel, Paolo Guazzi, Marcin Jurga, Christian Neri, Pelle Ohlsson, Eva Rohde, Goreti Sales, Irene Trapani, Pieter Vader, Seppo Vainio, Marca H.M. Wauben, María Yáñez-Mó, Natasa Zarovni
Published in: Cytotherapy, Issue 28, 2026, Page(s) 101976, ISSN 1465-3249
Publisher: Taylor & Francis
DOI: 10.1016/j.jcyt.2025.08.008

Glutathione Threshold‐Triggered Selective Breakability of Organosilica Nanocapsules

Author(s): Andrea Mosseri, Ana Rueda‐Flores, Jose L. Hueso, Esteban Urriolabeitia, Luisa De Cola, Jesus Santamaria
Published in: ChemCatChem, Issue 18, 2026, ISSN 1867-3880
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.70141

Biomimicking Extracellular Vesicles with Fully Artificial Ones: A Rational Design of EV-BIOMIMETICS toward Effective Theranostic Tools in Nanomedicine

Author(s): Giada Rosso, Valentina Cauda
Published in: ACS Biomater. Sci. Eng., Issue 2023, 9, 11, 2023, Page(s) 5924–5932, ISSN 2373-9878
Publisher: American Chemical Society
DOI: 10.1021/acsbiomaterials.2c01025

Enhancing Pt(IV) Complexes' Anticancer Activity upon Encapsulation in Stimuli‐Responsive Nanocages

Author(s): María Sancho‐Albero, Giorgio Facchetti, Nicolò Panini, Marina Meroni, Ezia Bello, Isabella Rimoldi, Massimo Zucchetti, Roberta Frapolli, Luisa De Cola
Published in: Advanced Healthcare Materials, Issue 12, 2025, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202202932

Two Different Responsive Organosilica Nanocarriers to Combine Chemo- and Immunotherapy against Cancer

Author(s): Maria Sancho-Albero, Alessia Lucrezia Fenaroli, Mirco Scaccaglia, Cristina Matteo, Chiara Grasselli, Massimo Zucchetti, Roberta Frapolli, Claudia Nastasi, Luisa De Cola
Published in: ACS Omega, Issue 9, 2024, Page(s) 41225-41235, ISSN 2470-1343
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acsomega.4c02838

Anti-CD38 targeted nanotrojan horses stimulated by acoustic waves as therapeutic nanotools selectively against Burkitt’s lymphoma cells

Author(s): Veronica Vighetto, Marzia Conte, Giada Rosso, Marco Carofiglio, Federica Sidoti Abate, Luisa Racca, Giulia Mesiano, Valentina Cauda
Published in: Discover Nano, Issue 19, 2024, ISSN 2731-9229
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/s11671-024-03976-z

Artificial and Naturally Derived Phospholipidic Bilayers as Smart Coatings of Solid-State Nanoparticles: Current Works and Perspectives in Cancer Therapy

Author(s): Nicolò Maria Percivalle; Marco Carofiglio; Marzia Conte; Giada Rosso; Alessandro Bentivogli; Giulia Mesiano; Veronica Vighetto; Valentina Cauda
Published in: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Issue 23 (15815), 2022, Page(s) 1-28, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232415815

Lipidic Formulations Inspired by COVID Vaccines as Smart Coatings to Enhance Nanoparticle-Based Cancer Therapy

Author(s): Marzia Conte; Marco Carofiglio; Giada Rosso; Valentina Cauda
Published in: Nanomaterials; Volume 13; Issue 15; Pages: 2250, Issue 4, 2023, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano13152250

Rational Design of EV-Mimicking Nanoparticles with Polarity-Based Recognition Potential for Advanced Nanocarrier Development

Author(s): Giada Rosso, Stijn M.A. Van Veen, María Sancho-Albero, Giulia Tamboia, Charly Empereur-Mot, Claudio Perego, Marije E. Kuipers, Bianca Dumontel, Alessandro Ajó, Esther N. Nolte-’t Hoen, Giovanni M. Pavan, Luisa De Cola, Lorenzo Albertazzi, Valentina Cauda
Published in: ACS Applied Nano Materials, Issue 8, 2025, Page(s) 13257-13273, ISSN 2574-0970
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acsanm.5c01459

Classifying soft self-assembled materials via unsupervised machine learning of defects

Author(s): Andrea Gardin, Claudio Perego, Giovanni Doni, Giovanni M. Pavan
Published in: Communications Chemistry, Issue 5, 2022, ISSN 2399-3669
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42004-022-00699-z

Automatic Optimization of Lipid Models in the Martini Force Field Using <i>SwarmCG</i>

Author(s): Charly Empereur-mot, Kasper B. Pedersen, Riccardo Capelli, Martina Crippa, Cristina Caruso, Mattia Perrone, Paulo C. T. Souza, Siewert J. Marrink, Giovanni M. Pavan
Published in: Journal of Chemical Information and Modeling, Issue 63, 2023, Page(s) 3827-3838, ISSN 1549-9596
Publisher: American Chemical Society
DOI: 10.1021/acs.jcim.3c00530

Acoustic waves and smart biomimetic nanoparticles: combination treatment from 2D to 3D colorectal cancer models

Author(s): Giada Rosso, Giulia Mesiano, Bianca Dumontel, Marco Carofiglio, Marzia Conte, Alessandro Grattoni, Valentina Cauda
Published in: Cancer Nanotechnology, Issue 15, 2024, ISSN 1868-6958
Publisher: Springer Science + Business Media
DOI: 10.1186/s12645-024-00281-3

The Martini 3 Lipidome: Expanded and Refined Parameters Improve Lipid Phase Behavior

Author(s): Kasper B. Pedersen, Helgi I. Ingólfsson, Daniel P. Ramirez-Echemendia, Luís Borges-Araújo, Mikkel D. Andreasen, Charly Empereur-mot, Josef Melcr, Tugba N. Ozturk, W. F. Drew Bennett, Lisbeth R. Kjølbye, Christopher Brasnett, Valentina Corradi, Hanif M. Khan, Elio A. Cino, Jackson Crowley, Hyuntae Kim, Balázs Fábián, Ana C. Borges-Araújo, Giovanni M. Pavan, Guillaume Launay, Fabio Lolicato,
Published in: ACS Central Science, Issue 11, 2025, Page(s) 1598-1610, ISSN 2374-7943
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acscentsci.5c00755