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CORDIS - Forschungsergebnisse der EU
CORDIS

A KEY TO THE RATIONAL DESIGN OF EXTRACELLULAR VESICLES-MIMICKING NANOPARTICLES

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Protocol on synthesis of breakable hard-shell organosilica NPs (öffnet in neuem Fenster)

The deliverable will consist in a report on the synthesis of hybrid hard organosilica NPs that are cleaved in the presence of specific biomolecules and are able to allow the cargo release

Report on EVs derived from tumor/osteoblastic cells ready and characterized (öffnet in neuem Fenster)

The deliverable will consist of a report describing the tumorosteoblastic cells chosen as source of EVs and of the protocols used for EV extraction and characterization and related results

Quantitative estimation of protein numbers and distribution for EVs (öffnet in neuem Fenster)

The deliverable will consist of a report containing the following parameters: i) size of EVs; ii) number of multiple surface protein per EV; iii) the distribution of these quantities in the EV population.

Kick-off meeting report (öffnet in neuem Fenster)

Report on the kickoff meeting describing the coordination and partners roles organization of the consortium and of the research work

Selection of 2 natural EVs bone-targeting candidates (öffnet in neuem Fenster)

A report describing the use of natural EVs containing CTSK RANKL or other bone targeting candidates for in vivo application on healthy mice to evaluate the biodistribution

Website and logo (öffnet in neuem Fenster)

Website creation and continuous update planningsSocial profiles creation and pages actions and planning for the dissemination to broad publics logo creation and planning for its use

Molecular models and simulations for lipid-covered hard-core NPs. (öffnet in neuem Fenster)

The deliverable will consist in a report on modelling and simulations to compare the dynamics of lipid bilayers having the inner leaflet bound to the hard-core NP surface

Molecular models and simulations for lipid-covered hard-core NPs with different geometries (öffnet in neuem Fenster)

The deliverable will consist in in a report on modelling and simulations to compare the dynamics of lipid bilayers in perfect/flat domains vs. in the presence of discontinuities/edges at the NP surface (NP shape effect)

Molecular models and simulations for EV lipid bilayer envelopes (öffnet in neuem Fenster)

The deliverable will consist in a report on the modelling and simulations to characterize the dynamics and stability of various EV lipid bilayers envelops.

Veröffentlichungen

Automatic multi-objective optimization of coarse-grained lipid force fields using SwarmCG (öffnet in neuem Fenster)

Autoren: Charly Empereur-mot, Riccardo Capelli, Mattia Perrone, Cristina Caruso, Giovanni Doni, Giovanni M. Pavan
Veröffentlicht in: J. Chem. Phys, Ausgabe 156, 2022, ISSN 0021-9606
Herausgeber: American Institute of Physics
DOI: 10.1063/5.0079044

Cargo-loaded lipid-shielded breakable organosilica nanocages for enhanced drug delivery (öffnet in neuem Fenster)

Autoren: María Sancho-Albero, Giada Rosso, Luisa De Cola, Valentina Cauda
Veröffentlicht in: Nanoscale, Ausgabe 15, 2023, Seite(n) 14628-14640, ISSN 2040-3372
Herausgeber: Royal Society of Chemistry
DOI: 10.1039/d3nr02155f

Biomimicking Extracellular Vesicles with Fully Artificial Ones: A Rational Design of EV-BIOMIMETICS toward Effective Theranostic Tools in Nanomedicine (öffnet in neuem Fenster)

Autoren: Giada Rosso, Valentina Cauda
Veröffentlicht in: ACS Biomater. Sci. Eng., Ausgabe 2023, 9, 11, 2023, Seite(n) 5924–5932, ISSN 2373-9878
Herausgeber: American Chemical Society
DOI: 10.1021/acsbiomaterials.2c01025

Artificial and Naturally Derived Phospholipidic Bilayers as Smart Coatings of Solid-State Nanoparticles: Current Works and Perspectives in Cancer Therapy (öffnet in neuem Fenster)

Autoren: Nicolò Maria Percivalle; Marco Carofiglio; Marzia Conte; Giada Rosso; Alessandro Bentivogli; Giulia Mesiano; Veronica Vighetto; Valentina Cauda
Veröffentlicht in: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Ausgabe 23 (15815), 2022, Seite(n) 1-28, ISSN 1422-0067
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232415815

Lipidic Formulations Inspired by COVID Vaccines as Smart Coatings to Enhance Nanoparticle-Based Cancer Therapy (öffnet in neuem Fenster)

Autoren: Marzia Conte; Marco Carofiglio; Giada Rosso; Valentina Cauda
Veröffentlicht in: Nanomaterials; Volume 13; Ausgabe 15; Pages: 2250, Ausgabe 4, 2023, ISSN 2079-4991
Herausgeber: MDPI
DOI: 10.3390/nano13152250

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