RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs

Publicaciones

SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp® simulator

Autores: Khalidi H, Onasanwo A, Islam B, Jo H, Fisher C, Aidley R, Gardner I, Bois FY.
Publicado en: Frontiers in Pharmacology, Edición 25 August 2022, 2022, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.929200

Generation of Human Nociceptor-Enriched Sensory Neurons for the Study of Pain-Related Dysfunctions

Autores: Holzer, A. K., Karreman, C., Suciu, I., Furmanowsky, L. S., Wohlfarth, H., Loser, D., Dirks, W. G., Pardo González, E., and Leist, M.
Publicado en: Stem Cells Transl Med., Edición 11(7), July 2022, 2022, Página(s) 727–741, ISSN 0029-3970
Editor: Oxford University Press
DOI: 10.1093/stcltm/szac031

A framework for chemical safety assessment incorporating new approach methodologies within REACH

Autores: Ball N, Bars R, Botham PA, Cuciureanu A, Cronin MTD, Doe JE, Dudzina T, Gant TW, Leist M, van Ravenzwaay B
Publicado en: Arch Toxicol., 2022, ISSN 2193-1801
Editor: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-021-03215-9

Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective

Autores: Pallocca G., Moné J. M., Kamp H., Luijten M., van de Water B., Leist M.
Publicado en: Altex, Edición 39 (2), 7 April 2022, 2022, ISSN 2193-1801
Editor: Springer Science and Business Media Deutschland GmbH
DOI: 10.14573/altex.2204051

Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays

Autores: Dolde X, Karreman C, Wiechers M, Schildknecht S, Leist M
Publicado en: International Journal of Molecular Sciences, Edición 22(18):10079, 2021, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221810079

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

Autores: van der Stel W, Yang H, Vrijenhoek NG, Schimming JP, Callegaro G, Carta G, Darici S, Delp J, Forsby A, White A, le Dévédec S, Leist M, Jennings P, Beltman JB, van de Water B, Danen EHJ
Publicado en: Archives of Toxicology, Edición 96(1), January 2022, 2022, ISSN 1868-8551
Editor: Springer-Spektrum
DOI: 10.1007/s00204-021-03160-7

Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro

Autores: Holzer, Anna-Katharina, Ilinca Suciu, Christiaan Karreman, Thomas Goj, and Marcel Leist
Publicado en: International Journal of Molecular Sciences, Edición 23(7), 29 March 2022, 2022, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073734

Current Status and Challenges of Human Induced Pluripotent Stem Cell-Derived Liver Models in Drug Discovery

Autores: Tricot T, Verfaillie C, Kumar M
Publicado en: Cells, Edición january 27, 2022; 11: 442, 2022, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11030442

Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals

Autores: Blum J, Masjosthusmann S, Bartmann K, Bendt F, Dolde X, Dönmez A, Förster N, Holzer AK, Hübenthal U, Keßel HE, Kilic S, Klose J, Pahl M, Stürzl LC, Mangas I, Terron A, Crofton KM, Scholze M, Mosig A, Leist M, Fritsche E.
Publicado en: Chemosphere, Edición 31;311(Pt 2):137035, 2022, ISSN 1879-1298
Editor: Elsevier
DOI: 10.1016/j.chemosphere.2022.137035

Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment

Autores: Jaklin M, Zhang JD, Schäfer N, Clemann N, Barrow P, Küng E, Sach-Peltason L, McGinnis C, Leist M, Kustermann S.
Publicado en: Toxicological Sciences, Edición 188(1):17-33, 2022, ISSN 0029-3970
Editor: Oxford University Press
DOI: 10.1093/toxsci/kfac046

Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson’s Disease

Autores: Carecho R, Figueira I, Terrasso AP, Godinho-Pereira J, de Oliveira Sequeira C, Pereira SA, Milenkovic D, Leist M, Brito C, Nunes Dos Santos C.
Publicado en: Mol. Nutr. Food Res., Edición 29 December 2021, 2021, ISSN 1613-4125
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.202100959

Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses

Autores: Ter Braak B, Klip JE, Wink S, Hiemstra S, Cooper SL, Middleton A, White A, van de Water B
Publicado en: Toxicology In Vitro, 2022, ISSN 1879-1298
Editor: Elsevier
DOI: 10.1016/j.tiv.2022.105419

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

Autores: Loser D, Grillberger K, Hinojosa MG, Blum J, Haufe Y, Danker T, Johansson Y, Möller C, Nicke A, Bennekou SH, Gardner I, Bauch C, Walker P, Forsby A, Ecker GF, Kraushaar U, Leist M.
Publicado en: Arch Toxicol, Edición 95(12).3695-3716, 2021, ISSN 2193-1801
Editor: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-021-03168-z

Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models

Autores: Capinha L, Zhang Y, Holzer AK, Ückert AK, Zana M, Carta G, Murphy C, Baldovini J, Mazidi Z, Grillari J, Dinnyes A, van de Water B, Leist M, Commandeur JNM, Jennings P
Publicado en: Archives of Toxicology, 2023, ISSN 2193-1801
Editor: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-022-03436-6

Studying Metabolism by NMR-Based Metabolomics

Autores: Sofia Moco
Publicado en: Frontiers Molecular Biosciences, Edición 9:882487, 2022, 2022, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fmolb.2022.882487

Metabolic regulation by p53 prevents R-loop-associated genomic instability

Autores: Emanuele Panatta, Alessio Butera, Eleonora Mammarella, Consuelo Pitolli, Alessandro Mauriello, Marcel Leist, Richard A. Knight, Gerry Melino, Ivano Amelio
Publicado en: Cell Reports, Edición Volume 41, Edición 5, 1 November 2022, 2022, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2022.111568

High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation

Autores: Seidel F, Cherianidou A, Kappenberg F, Marta M, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Scholtz-Illigens A, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG.
Publicado en: Cells, Edición 11(21):3404, 2022, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11213404

Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons

Autores: Suciu, I.; Delp, J.; Gutbier, S.; Ückert, A.-K.; Spreng, A.-S.; Eberhard, P.; Karreman, C.; Schreiber, F.; Madjar, K.; Rahnenführer, J.; Celardo, I.; Amelio, I.; Leist, M
Publicado en: Antioxidants, 2023, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/antiox12010164

Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation

Autores: Spreng AS, Brüll M, Leisner H, Suciu I, Leist M.
Publicado en: Human Stem Cells in Disease Modelling, Drug Discovery and Regenerative Medicine, Edición 11(17):2644, 25 August 2022, 2022, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11172644

Use of metabolic glycoengineering and pharmacological inhibitors to assess lipid and protein sialylation on cells.

Autores: Kranaster P, Blum J, Dold JEGA, Wittmann V, Leist M.
Publicado en: Neurochem, 2022, ISSN 1613-4125
Editor: John Wiley & Sons Ltd.
DOI: 10.1111/jnc.15737

Large-scale perfused tissues via synthetic 3D soft microfluidics

Autores: Grebenyuk S, Abdel Fattah AR, Kumar M, Toprakhisar B, Rustandi G, Vananroye A, Salmon I, Verfaillie C, Grillo M, Ranga A
Publicado en: Nat Commun, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-35619-1

On the Usefulness of Animals as a Model System (Part II): Considering Benefits within Distinct Use Domains

Autores: G. Pallocca, M. Leist
Publicado en: ALTEX- Alternatives to Animal Experimentation, Edición 39(3), 20 July 2022, 2022, ISSN 1868-8551
Editor: Springer Spektrum
DOI: 10.14573/altex.2207111

Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation

Autores: Scheibe C, Karreman C, Schildknecht S, Leist M, Hauser K.
Publicado en: Biomolecules, Edición 11(8): 1067, Aug 2021, 2021, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom11081067

Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test

Autores: Cherianidou A, Seidel F, Kappenberg F, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG.
Publicado en: Chemical Research in Toxicology, 2022, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/acs.chemrestox.1c00392

Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0

Autores: Pamies D, Leist M, Coecke S, Bowe G, Allen DG, Gstraunthaler G, Bal-Price A, Pistollato F, de Vries RBM, Hogberg HT, Hartung T, Stacey G.
Publicado en: ALTEX, Edición 39:30-70, 2022, ISSN 1868-8551
Editor: Springer Spektrum
DOI: 10.14573/altex.2111011

On the usefulness of animals as a model system (part I): Overview of criteria and focus on robustness

Autores: Pallocca G., Rovida C., Leist M
Publicado en: ALTEX, Edición 2022;39(2):347-353, 2022, ISSN 2193-1801
Editor: Springer Science and Business Media Deutschland GmbH
DOI: 10.14573/altex.2203291

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