RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Genomic and proteomic biomarker landscape in clinical trials

Autores: Piñero J, Rodriguez Fraga PS, Valls-Margarit J, Ronzano F, Accuosto P, Lambea
Publicado en: Computational and structural biotechnology journal, 2023, ISSN 2001-0370
Editor: Elsevier
DOI: 10.1016/j.csbj.2023.03.014

SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp® simulator

Autores: Khalidi H, Onasanwo A, Islam B, Jo H, Fisher C, Aidley R, Gardner I, Bois FY.
Publicado en: Frontiers in Pharmacology, Edición 25 August 2022, 2022, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.929200

Acceptance criteria for new approach methods in toxicology and human health-relevant life science research – part I

Autores: Holzer, A.-K., Dreser, N., Pallocca, G., Mangerich, A., Stacey, G., Dipalo, M., van de Water, B., Rovida, C., Wirtz, P. H., van Vugt, B., Panzarella, G., Hartung, T., Terron, A., Mangas, I., Herzler, M., Marx-Stoelting, P., Coecke, S. and Leist, M.
Publicado en: ALTEX, 2023, ISSN 1868-596X
Editor: Springer
DOI: 10.14573/altex.2310021

An Adverse Outcome Pathway Network for Chemically Induced Oxidative Stress Leading to (Non)genotoxic Carcinogenesis

Autores: Christina H. J. Veltman; Jeroen L. A. Pennings; Bob van de Water; Mirjam Luijten
Publicado en: Chemical Research in Toxicology, Edición 3, 2023, ISSN 0893-228X
Editor: American Chemical Society
DOI: 10.1021/acs.chemrestox.2c00396

Generation of Human Nociceptor-Enriched Sensory Neurons for the Study of Pain-Related Dysfunctions

Autores: Holzer, A. K., Karreman, C., Suciu, I., Furmanowsky, L. S., Wohlfarth, H., Loser, D., Dirks, W. G., Pardo González, E., and Leist, M.
Publicado en: Stem Cells Transl Med., Edición 11(7), July 2022, 2022, Página(s) 727–741, ISSN 0029-3970
Editor: Oxford University Press
DOI: 10.1093/stcltm/szac031

A framework for chemical safety assessment incorporating new approach methodologies within REACH

Autores: Ball N, Bars R, Botham PA, Cuciureanu A, Cronin MTD, Doe JE, Dudzina T, Gant TW, Leist M, van Ravenzwaay B
Publicado en: Arch Toxicol., 2022, ISSN 2193-1801
Editor: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-021-03215-9

Preparation of Viable Human Neurites for Neurobiological and Neurodegeneration Studies

Autores: Brüll M, Geese N, CelardoI, Laumann M, Leist M
Publicado en: Cells, 2024, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells13030242

Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective

Autores: Pallocca G., Moné J. M., Kamp H., Luijten M., van de Water B., Leist M.
Publicado en: Altex, Edición 39 (2), 7 April 2022, 2022, ISSN 2193-1801
Editor: Springer Science and Business Media Deutschland GmbH
DOI: 10.14573/altex.2204051

Modeling ferroptosis in human dopaminergic neurons: pitfalls and opportunities for neurodegeneration research

Autores: Renner N, Schöb F, Pape R, Suciu I, Spreng AS, Ückert AK, Cöllen E, Bovio F, Chilian B, Bauere J, Röpcke S, Bergemann J, Leist M, Schildknecht S
Publicado en: Redox Biology, 2024, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2024.103165

Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays

Autores: Dolde X, Karreman C, Wiechers M, Schildknecht S, Leist M
Publicado en: International Journal of Molecular Sciences, Edición 22(18):10079, 2021, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221810079

Bioactivity descriptors for in vivo toxicity prediction: now and the future

Autores: Helmke P, Füzi B, Ecker GF
Publicado en: Expert Opinion on Drug Metabolism & Toxicology, 2024, ISSN 1742-5255
Editor: Ashley Publications Ltd.
DOI: 10.1080/17425255.2024.2334308

Qualitative and quantitative concentration-response modelling of gene co-expression networks to unlock hepatotoxic mechanisms for next generation chemical safety assessment.

Autores: Kunnen SJ, Arnesdotter E, Willenbockel CT, Vinken M, van de Water B
Publicado en: ALTEX, 2024, ISSN 1868-596X
Editor: Springer
DOI: 10.14573/altex.2309201

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

Autores: van der Stel W, Yang H, Vrijenhoek NG, Schimming JP, Callegaro G, Carta G, Darici S, Delp J, Forsby A, White A, le Dévédec S, Leist M, Jennings P, Beltman JB, van de Water B, Danen EHJ
Publicado en: Archives of Toxicology, Edición 96(1), January 2022, 2022, ISSN 1868-8551
Editor: Springer-Spektrum
DOI: 10.1007/s00204-021-03160-7

Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro

Autores: Holzer, Anna-Katharina, Ilinca Suciu, Christiaan Karreman, Thomas Goj, and Marcel Leist
Publicado en: International Journal of Molecular Sciences, Edición 23(7), 29 March 2022, 2022, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073734

New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project

Autores: Tal T, Myhre O, Fritsche E, Rüegg J, Craenen K, Aiello K, Agrillo C, Babin PJ, Escher BI, Dirven H, Hellsten K, Dolva K, Heusinkveld H, Hadzhiev Y, Hurem S, Jagiełło K, Judzinska B, Klüver N, Knoll-Gellida A, Kühne BA, Leist M, Lislien M, Lyche JL, Müller F, Neuhaus W, Pallocca G, Seeger B, Scharkin I, Scholz S, Spjuth O, Torres-Ruiz M, Bartmann K
Publicado en: Frontiers in Toxicology, 2024, ISSN 2673-3080
Editor: Frontiers
DOI: 10.3389/ftox.2024.1359507

A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury

Autores: Lukas S Wijaya, Attila Gabor, Iris E Pot, Luca van de Have, Julio Saez-Rodriguez, James L Stevens, Sylvia E Le Dévédec, Giulia Callegaro, Bob van de Water
Publicado en: Toxicological Sciences, Edición 198, 2024, Página(s) 14-30, ISSN 1096-6080
Editor: Oxford University Press
DOI: 10.1093/toxsci/kfad121

Development of an adverse outcome pathway network for nephrotoxicity

Autores: Barnes DA, Firman JW, Belfield SJ, Cronin MTD, Vinken M, Janssen MJ, Masereeuw R
Publicado en: Archives of Toxicology, 2024, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-023-03637-7

Current Status and Challenges of Human Induced Pluripotent Stem Cell-Derived Liver Models in Drug Discovery

Autores: Tricot T, Verfaillie C, Kumar M
Publicado en: Cells, Edición january 27, 2022; 11: 442, 2022, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11030442

Definition of the Neurotoxicity-Associated Metabolic Signature Triggered by Berberine and Other Respiratory Chain Inhibitors

Autores: Suciu I, Delp J, Gutbier S, Suess J, Henschke L, Celardo I, Mayer TU, Amelio I, Leist M.
Publicado en: Antioxidants, 2023, ISSN 2076-3921
Editor: MPDI
DOI: 10.3390/antiox13010049

Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals

Autores: Blum J, Masjosthusmann S, Bartmann K, Bendt F, Dolde X, Dönmez A, Förster N, Holzer AK, Hübenthal U, Keßel HE, Kilic S, Klose J, Pahl M, Stürzl LC, Mangas I, Terron A, Crofton KM, Scholze M, Mosig A, Leist M, Fritsche E.
Publicado en: Chemosphere, Edición 31;311(Pt 2):137035, 2022, ISSN 1879-1298
Editor: Elsevier
DOI: 10.1016/j.chemosphere.2022.137035

Recommendations on fit-for-purpose criteria to establish quality managementfor microphysiological systems and for monitoring their reproducibility

Autores: David Pamies,Jason Ekert,Marie-Gabrielle Zurich,Olivier Frey,Sophie Werner,Monica Piergiovanni,Benjamin S. Freedman,Adrian Kee Keong Teo,Hendrik Erfurth,Darwin R. Reyes,Peter Loskill,Pelin Candarlioglu,Laura Suter-Dick,Shan Wang,Thomas Hartung,Sandra Coecke,Glyn N. Stacey,Beren Atac Wagegg,Eva-Maria Dehne,Francesca Pistollato,Marcel Leist
Publicado en: Stem cell Reports, 2024, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2024.03.009

Prediction of adverse drug reactions due to genetic predisposition using deep neural networks

Autores: Dafniet B & Taboureau O.
Publicado en: Molecular Informatics, 2024, ISSN 1868-1751
Editor: Wiley
DOI: 10.1002/minf.202400021

Elements and development processes for test methods in toxicology and human health-relevant life science research

Autores: Cöllen E, Tanaskov Y, Holzer AK, Dipalo M, Schäfer J, Kraushaar U, Leist M
Publicado en: ALTEX, 2024, ISSN 1868-596X
Editor: Springer
DOI: 10.14573/altex.2401041

Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment

Autores: Jaklin M, Zhang JD, Schäfer N, Clemann N, Barrow P, Küng E, Sach-Peltason L, McGinnis C, Leist M, Kustermann S.
Publicado en: Toxicological Sciences, Edición 188(1):17-33, 2022, ISSN 0029-3970
Editor: Oxford University Press
DOI: 10.1093/toxsci/kfac046

Integrating Mechanistic and Toxicokinetic Information in Predictive Models of Cholestasis

Autores: Pablo Rodríguez-BelenguerVictor Mangas-SanjuanEmilio Soria-OlivasManuel Pastor*
Publicado en: Journal of Chemical Information and Modeling, 2023, ISSN 1549-9596
Editor: American Chemical Society
DOI: 10.1021/acs.jcim.3c00945

Usage of model combination in computational toxicology

Autores: Rodríguez-Belenguer, P., March-Vila, E., Pastor, M., Mangas-Sanjuan, V., & Soria-Olivas, E
Publicado en: Toxicology Letters, 2023, ISSN 0378-4274
Editor: Elsevier BV
DOI: 10.1016/j.toxlet.2023.10.013

Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson’s Disease

Autores: Carecho R, Figueira I, Terrasso AP, Godinho-Pereira J, de Oliveira Sequeira C, Pereira SA, Milenkovic D, Leist M, Brito C, Nunes Dos Santos C.
Publicado en: Mol. Nutr. Food Res., Edición 29 December 2021, 2021, ISSN 1613-4125
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.202100959

The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability

Autores: Vlasveld M, Callegaro G, Fisher C, Eakins J, Walker P, Lok S, van Oost S, de Jong B, Pellegrino-Coppola D, Burger G, Wink S, van de Water B.
Publicado en: Liver International, 2024, ISSN 1478-3231
Editor: John Wiley & Sons
DOI: 10.1111/liv.15822

Trust your gut: Establishing confidence in gastrointestinal models - An overview of the state of the science and contexts of use

Autores: Susan Debad, David Allen, Omari Bandele, Colin Bishop, Michaela Blaylock, Paul Brown, Maureen K. Bunger, Julia Y. Co, Lynn Crosby, Amber B. Daniel, Steve S. Ferguson, Kevin Ford, Gonçalo Gamboa da Costa, Kristin H. Gilchrist, Matthew W. Grogg, Maureen Gwinn, Thomas Hartung , Simon P. Hogan, Ye Eun Jeong, George E. N. Kass, Elaina Kenyon, Nicole C. Kleinstreuer, Ville Kujala, Patrik Lundquist, Jo
Publicado en: ALTEX, 2024, ISSN 1868-596X
Editor: Springer
DOI: 10.14573/altex.2403261

Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses

Autores: Ter Braak B, Klip JE, Wink S, Hiemstra S, Cooper SL, Middleton A, White A, van de Water B
Publicado en: Toxicology In Vitro, 2022, ISSN 1879-1298
Editor: Elsevier
DOI: 10.1016/j.tiv.2022.105419

REACH out-numbered! The future of REACH and animal numbers.

Autores: Rovida C, Busquet F, Leist M, Hartung T.
Publicado en: ALTEX, 2023, ISSN 1868-8551
Editor: Springer
DOI: 10.14573/altex.2307121

Linking chemicals, genes and morphological perturbations to diseases

Autores: Cerisier N, Dafniet B, Badel A, Taboureau O.
Publicado en: Toxicology and Applied Pharmacology, 2023, ISSN 0041-008X
Editor: Academic Press
DOI: 10.1016/j.taap.2023.116407

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

Autores: Loser D, Grillberger K, Hinojosa MG, Blum J, Haufe Y, Danker T, Johansson Y, Möller C, Nicke A, Bennekou SH, Gardner I, Bauch C, Walker P, Forsby A, Ecker GF, Kraushaar U, Leist M.
Publicado en: Arch Toxicol, Edición 95(12).3695-3716, 2021, ISSN 2193-1801
Editor: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-021-03168-z

Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models

Autores: Capinha L, Zhang Y, Holzer AK, Ückert AK, Zana M, Carta G, Murphy C, Baldovini J, Mazidi Z, Grillari J, Dinnyes A, van de Water B, Leist M, Commandeur JNM, Jennings P
Publicado en: Archives of Toxicology, 2023, ISSN 2193-1801
Editor: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-022-03436-6

Studying Metabolism by NMR-Based Metabolomics

Autores: Sofia Moco
Publicado en: Frontiers Molecular Biosciences, Edición 9:882487, 2022, 2022, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fmolb.2022.882487

Controversy on health-based guidance values for bisphenol A—the need of criteria for studies that serve as a basis for risk assessment.

Autores: Leist M, Buettner A, Diel P, Eisenbrand G, Epe B, Först P, Grune T, Haller D, Heinz V, Hellwig M, Humpf HU, Jäger H, Kulling SE, Mally A, Marko D, Nöthlings U, Röhrdanz E, Spranger J, Vieths S, Wätjen W, Hengstler JG.
Publicado en: Archives of Toxicology, 2024, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-024-03778-3

Analysis of health concerns not addressed by REACH for low tonnage chemicals and opportunities for new approach methodology

Autores: Botham P, Cronin MTD, Currie R, et al.
Publicado en: Archives of Toxycology, 2023, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-023-03601-5

Metabolic regulation by p53 prevents R-loop-associated genomic instability

Autores: Emanuele Panatta, Alessio Butera, Eleonora Mammarella, Consuelo Pitolli, Alessandro Mauriello, Marcel Leist, Richard A. Knight, Gerry Melino, Ivano Amelio
Publicado en: Cell Reports, Edición Volume 41, Edición 5, 1 November 2022, 2022, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2022.111568

Characterization of Organic Anion and Cation Transport in Three Human Renal Proximal Tubular Epithelial Models

Autores: Meijer, T., da Costa Pereira, D., Klatt, O.C., Buitenhuis, J., Jennings, P., & Wilmes, A.
Publicado en: Cells, 2024, ISSN 2073-4409
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells13121008

Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells

Autores: Olivier J. M. BéquignonJose C. Gómez-TamayoEelke B. LenselinkSteven WinkSteven HiemstraChi Chung LamDomenico GadaletaAlessandra RoncaglioniUlf NorinderBob van de WaterManuel PastorGerard J. P. van Westen*
Publicado en: Journal of Chemical Information and Modeling, 2023, ISSN 1549-9596
Editor: American Chemical Society
DOI: 10.1021/acs.jcim.3c00220

Protectiveness of NAM-Based Hazard Assessment – Which Testing Scope is Required?

Autores: Zobl W, Bitsch A, Blum J, Boei JJWA, Capinha L, Carta G, Castell J, Davoli E, Drake C, Fisher CP, Heldring MM, Islam B, Jennings P, Leist M, Pellegrino-Coppola D, Schimming JP, Snijders KE, Tolosa L, van de Water B, van Vugt-Lussenburg BMA, Walker P, Wehr MM, Wijaya LS, Escher SE
Publicado en: ALTEX, 2024, ISSN 1868-596X
Editor: Springer
DOI: 10.14573/altex.2309081

4.2 million and counting… The animal toll for REACH systemic toxicity studies

Autores: Knight J, Hartung T, Rovida C.
Publicado en: ALTEX, 2023, ISSN 1868-596X
Editor: Springer
DOI: 10.14573/altex.2303201

Mapping Interindividual Variability of Toxicodynamics Using High-ThroughputTranscriptomics and Primary Human Hepatocytes from Fifty Donors

Autores: Niemeijer M, Więcek W, Fu S, Huppelschoten S, Bouwman P, Baze A, Parmentier C, Richert L, Paules RS, Bois FY, van de Water B
Publicado en: Environmental Health Perspectives, 2024, ISSN 0091-6765
Editor: US Department of Health and Human Services
DOI: 10.1289/ehp11891

Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis

Autores: Lambrecht R, Rudolf F, Ückert AK, Sladky VC, Phan TS, Jansen J, Naim S, Kaufmann T, Keogh A, Kirschnek S, Mangerich A, Stengel F, Leist M, Villunger A, Brunner T
Publicado en: Cell Death & Differentiation, 2024, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-023-01245-7

Structural Insights into Neonicotinoids and N-Unsubstituted Metabolites on Human nAChRs by Molecular Docking, Dynamics Simulations, and Calcium Imaging

Autores: K. Grillberger, E. Cöllen, C. I. Trivisani, J. Blum, M. Leist, and G. F. Ecker
Publicado en: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241713170

PathwayNexus: a tool for interactive metabolic data analysis

Autores: Eberhard P, Aichem M, Kern M, Klein K, Delp J, Suciu I, Dietrich D, Leist M, Schreiber F
Publicado en: Bioinformatics, 2024, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btae310

Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration

Autores: Anna-Katharina Ückert, Sina Rütschlin, Simon Gutbier, Nathalie Christine Wörz, Mahfuzur R. Miah, Airton C. Martins, Isa Hauer, Anna-Katharina Holzer, Birthe Meyburg, Ann-Kathrin Mix, Christof Hauck, Michael Aschner, Thomas Böttcher, Marcel Leist
Publicado en: Environment International, 2023, ISSN 0160-4120
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.108229

High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation

Autores: Seidel F, Cherianidou A, Kappenberg F, Marta M, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Scholtz-Illigens A, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG.
Publicado en: Cells, Edición 11(21):3404, 2022, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11213404

Making in silico predictive models for toxicology FAIR

Autores: Cronin MTD, Belfield SJ, Briggs KA, Enoch SJ, Firman JW, Frericks M, Garrard C, Maccallum PH, Madden JC, Pastor M, Sanz F, Soininen I, Sousoni D.
Publicado en: Regulatory Toxicology and Pharmacology, 2023, ISSN 0273-2300
Editor: Academic Press
DOI: 10.1016/j.yrtph.2023.105385

Knowledge infrastructure for integrated data management and analysis supporting new approach methods in predictive toxicology and risk assessment

Autores: Barry Hardy, Tomaz Mohoric,Thomas Exner, Joh Dokler, Maja Brajnik, Daniel Bachler, Ody Mbegbu, Nora Kleisli, Lucian Farcal, Krzysztof Maciejczuk, Haris Rašidagić, Ghada Tagorti, Pascal Ankli, Daniel Burgwinkel, Divanshu Anand, Ugis Sarkans, Awais Athar
Publicado en: Toxicology in Vitro, 2024, ISSN 0887-2333
Editor: Elsevier BV
DOI: 10.1016/j.tiv.2024.105903

Deconvoluting gene and environmentinteractions to develop an “epigeneticscore meter” of disease

Autores: Butera, A, Smirnova, L., Ferrando-May, E., Hartung, T., Brunner, T., Leist, M., Amelio, I.
Publicado en: EMBO Molecular Medicine, 2023, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202318208

Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons

Autores: Suciu, I.; Delp, J.; Gutbier, S.; Ückert, A.-K.; Spreng, A.-S.; Eberhard, P.; Karreman, C.; Schreiber, F.; Madjar, K.; Rahnenführer, J.; Celardo, I.; Amelio, I.; Leist, M
Publicado en: Antioxidants, 2023, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/antiox12010164

Assessing network-based methods in the context of system toxicology

Autores: Valls-Margarit J, Piñero J, Füzi B, Cerisier N, Taboureau O, Furlong LI
Publicado en: Frontiers in Pharmacology, 2023, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1225697

Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation

Autores: Spreng AS, Brüll M, Leisner H, Suciu I, Leist M.
Publicado en: Human Stem Cells in Disease Modelling, Drug Discovery and Regenerative Medicine, Edición 11(17):2644, 25 August 2022, 2022, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11172644

Use of metabolic glycoengineering and pharmacological inhibitors to assess lipid and protein sialylation on cells.

Autores: Kranaster P, Blum J, Dold JEGA, Wittmann V, Leist M.
Publicado en: Neurochem, 2022, ISSN 1613-4125
Editor: John Wiley & Sons Ltd.
DOI: 10.1111/jnc.15737

Osmolar Modulation Drives Reversible Cell Cycle Exit and Human Pluripotent Cell Differentiation via NF-κВ and WNT Signaling

Autores: Jonathan Sai-Hong Chui , Teresa Izuel-Idoype , Alessandra Qualizza , Rita Pires de Almeida , Lindsey Piessens , Bernard K van der Veer , Gert Vanmarcke , Aneta Malesa , Paraskevi Athanasouli , Ruben Boon , Joris Vriens , Leo van Grunsven , Kian Peng Koh , Catherine M Verfaillie , Frederic Lluis
Publicado en: Advanced Science, 2024, ISSN 2198-3844
Editor: Wiley Online Library
DOI: 10.1002/advs.202307554

Uncertainty assessment of proarrhythmia predictions derived from multi‑level in silico models

Autores: Kopańska K, Rodríguez-Belenguer P, Llopis-Lorente J, Trenor B, Saiz J, Pastor M.
Publicado en: Archives of Toxicology, 2023, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-023-03557-6

Assessment of Drug-Induced Liver Injury through Cell Morphology and Gene Expression Analysisand Gene Expression Analysis

Autores: Lejal V, Cerisier N, Rouquié D, Taboureau O.
Publicado en: Chemical Research in Toxicology, 2023, ISSN 0893-228X
Editor: American Chemical Society
DOI: 10.1021/acs.chemrestox.2c00381

On the Usefulness of Animals as a Model System (Part II): Considering Benefits within Distinct Use Domains

Autores: G. Pallocca, M. Leist
Publicado en: ALTEX- Alternatives to Animal Experimentation, Edición 39(3), 20 July 2022, 2022, ISSN 1868-8551
Editor: Springer Spektrum
DOI: 10.14573/altex.2207111

Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation

Autores: Scheibe C, Karreman C, Schildknecht S, Leist M, Hauser K.
Publicado en: Biomolecules, Edición 11(8): 1067, Aug 2021, 2021, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom11081067

G × E interactions as a basis for toxicological uncertainty

Autores: Suciu I, Pamies D, Peruzzo R, Wirtz PH, Smirnova L, Pallocca G, Hauck C, Cronin MTD, Hengstler JG, Brunner T, Hartung T, Amelio I, Leist M.
Publicado en: Archives of Toxicology, 2023, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-023-03500-9

Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test

Autores: Cherianidou A, Seidel F, Kappenberg F, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG.
Publicado en: Chemical Research in Toxicology, 2022, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/acs.chemrestox.1c00392

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Autores: Smirnova L, Hogberg HT, Leist M, Hartung T
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Editor: Springer
DOI: 10.14573/altex.2403281

A continuous in silico learning strategy to identify safety liabilities in compounds used in the leather and textile industry

Autores: March-Vila E, Ferretti G, Terricabras E, Ardao I, Brea JM, Varela MJ, Arana Á, Rubiolo JA, Sanz F, Loza MI, Sánchez L, Alonso H, Pastor M
Publicado en: Archives of Toxicology, 2023, ISSN 1432-0738
Editor: Springer
DOI: 10.1007/s00204-023-03459-7

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Autores: Pamies D, Leist M, Coecke S, Bowe G, Allen DG, Gstraunthaler G, Bal-Price A, Pistollato F, de Vries RBM, Hogberg HT, Hartung T, Stacey G.
Publicado en: ALTEX, Edición 39:30-70, 2022, ISSN 1868-8551
Editor: Springer Spektrum
DOI: 10.14573/altex.2111011

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Publicado en: ALTEX, Edición 2022;39(2):347-353, 2022, ISSN 2193-1801
Editor: Springer Science and Business Media Deutschland GmbH
DOI: 10.14573/altex.2203291

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Autores: M Cronin, S Belfield, S Enoch, J Firman, Judith Madden, N Spinu
Publicado en: Altex Proceedings, 2023, ISSN 2194-0479
Editor: Springer Spektrum
DOI: 10.58847/ap.2302

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