RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Genomic and proteomic biomarker landscape in clinical trials

Autores: Piñero J, Rodriguez Fraga PS, Valls-Margarit J, Ronzano F, Accuosto P, Lambea
Publicado en: Computational and structural biotechnology journal, 2023, ISSN 2001-0370
Editor: Elsevier
DOI: 10.1016/j.csbj.2023.03.014

SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp® simulator

Autores: Khalidi H, Onasanwo A, Islam B, Jo H, Fisher C, Aidley R, Gardner I, Bois FY.
Publicado en: Frontiers in Pharmacology, Edición 25 August 2022, 2022, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.929200

Acceptance criteria for new approach methods in toxicology and human health-relevant life science research – part I

Autores: Holzer, A.-K., Dreser, N., Pallocca, G., Mangerich, A., Stacey, G., Dipalo, M., van de Water, B., Rovida, C., Wirtz, P. H., van Vugt, B., Panzarella, G., Hartung, T., Terron, A., Mangas, I., Herzler, M., Marx-Stoelting, P., Coecke, S. and Leist, M.
Publicado en: ALTEX, 2023, ISSN 1868-596X
Editor: Springer
DOI: 10.14573/altex.2310021

Advancing transcriptomics-based mechanistic assessment of nephrotoxicity in vitro using the human RPTEC/TERT1 TXG-MAPr gene co-expression network

Autores: Hugo W van Kessel, Steven J Kunnen, Giulia Callegaro, Bob van de Water
Publicado en: Toxicological Sciences, Edición 209, 2026, ISSN 1096-6080
Editor: Oxford University Press
DOI: 10.1093/toxsci/kfaf159

AOP-informed qIVIVE modelling for liver steatosis using triazoles

Autores: A.M. Steinbach, C.T. Willenbockel, P. Marx-Stoelting, M.T.D. Cronin, V. Städele
Publicado en: Computational Toxicology, Edición 36, 2026, Página(s) 100382, ISSN 2468-1113
Editor: Elsevier BV
DOI: 10.1016/j.comtox.2025.100382

Computational Strategies for Assessing Adverse Outcome Pathways: Hepatic Steatosis as a Case Study

Autores: Ortega-Vallbona, R.; Palomino-Schätzlein, M.; Tolosa, L.; Benfenati, E.; Ecker, G.F.; Gozalbes, R.; Serrano-Candelas, E.
Publicado en: International Journal of Molecular Sciences, 2024, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)

Nutrient environment improves drug metabolic activity in human iPSC-derived hepatocytes and HepG2

Autores: Victoria Pozo Garcia, Tuğçe S. Çobanoğlu, Helen Sophie Hammer, Rita Carlota, Kasper Holm, Catherine Verfaillie, Oliver Poetz, Paul Jennings, Sofia Moco
Publicado en: Archives of Toxicology, Edición 99, 2025, Página(s) 4493-4511, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-025-04139-4

Assessment of pulmonary fibrosis using weighted gene co-expression network analysis

Autores: Christina Drake, Walter Zobl, Sylvia E. Escher
Publicado en: Frontiers in Toxicology, Edición 6, 2024, ISSN 2673-3080
Editor: Frontiers Media SA
DOI: 10.3389/ftox.2024.1465704

Testing Strategies for Metabolite-Mediated Neurotoxicity

Autores: Julian Suess, Moritz Reinmoeller, Viktoria Magel, Baiba Gukalova, Edgars Liepinsh, Iain Gardner, Nadine Dreser, Anna-Katharina Holzer, Marcel Leist
Publicado en: International Journal of Molecular Sciences, Edición 26, 2025, Página(s) 8338, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26178338

Cell morphology and gene expression: tracking changes and complementarity across time and cell lines

Autores: Vanille Lejal, David Rouquié, Olivier Taboureau
Publicado en: Toxicology and Applied Pharmacology, Edición 504, 2025, Página(s) 117530, ISSN 0041-008X
Editor: Academic Press
DOI: 10.1016/j.taap.2025.117530

Utilizing rat kidney gene co-expression networks to enhance safety assessment biomarker identification and human translation

Autores: Steven J. Kunnen, Giulia Callegaro, Jeffrey J. Sutherland, Panuwat Trairatphisan, Hugo W. van Kessel, Lukas S. Wijaya, Git Chung, Keith Pye, Keith M. Goldstein, Claire R. Teague, Ciaran P. Fisher, Julio Saez-Rodriguez, Colin Brown, Susan A. Elmore, Kathleen M. Heinz-Taheny, James L. Stevens, Bob van de Water
Publicado en: iScience, Edición 28, 2025, Página(s) 112978, ISSN 2589-0042
Editor: Elsevier BV
DOI: 10.1016/j.isci.2025.112978

Interdependency of estradiol-mediated ERα activation and subsequent PR and GREB1 induction to control cell cycle progression

Autores: M.M. Heldring, B. Duijndam, A. Kyriakidou, O.M. van der Meer, M. Tedeschi, J.W. van der Laan, B. van de Water, J.B. Beltman
Publicado en: Heliyon, Edición 10, 2025, Página(s) e38406, ISSN 2405-8440
Editor: Elsevier BV
DOI: 10.1016/j.heliyon.2024.e38406

Refining Drug-Induced Cholestasis Prediction: An Explainable Consensus Model Integrating Chemical and Biological Fingerprints

Autores: Palle S. Helmke, Gerhard F. Ecker
Publicado en: Journal of Chemical Information and Modeling, Edición 65, 2025, Página(s) 5301-5316, ISSN 1549-9596
Editor: American Chemical Society
DOI: 10.1021/acs.jcim.4c02363

A perfused iPSC-derived proximal tubule model for predicting drug-induced kidney injury

Autores: Michelle Lechtenberg, Coraline Chéneau, Kevin Riquin, Leopold Koenig, Carlos Mota, Franck Halary, Eva-Maria Dehne
Publicado en: Toxicology in Vitro, Edición 105, 2025, Página(s) 106038, ISSN 0887-2333
Editor: Elsevier BV
DOI: 10.1016/j.tiv.2025.106038

An Adverse Outcome Pathway Network for Chemically Induced Oxidative Stress Leading to (Non)genotoxic Carcinogenesis

Autores: Christina H. J. Veltman; Jeroen L. A. Pennings; Bob van de Water; Mirjam Luijten
Publicado en: Chemical Research in Toxicology, Edición 3, 2023, ISSN 0893-228X
Editor: American Chemical Society
DOI: 10.1021/acs.chemrestox.2c00396

Developmental neurotoxicity (DNT): A call for implementation of new approach methodologies for regulatory purposes: Summary of the 5th International Conference on DNT Testing

Autores: Ivana Celardo, Michael Aschner, Randolph S. Ashton, Kelly E. Carstens, Andrea Cediel-Ulloa, Eike Cöllen, Kevin M. Crofton, Susan J. Debad, Nadine Dreser, Suzanne Fitzpatrick, Ellen Fritsche, Sebastian Gutsfeld, Barry Hardy, Thomas Hartung, Ellen Hessel, Harm Heusinkveld, Helena T. Hogberg, Jui-Hua Hsieh, Yasunari Kanda, Gavin T. Knight, Thomas Knudsen, Katharina Koch, Eliska Kuchovska, Iris Manga
Publicado en: ALTEX, Edición 42, 2025, ISSN 1868-596X
Editor: ALTEX Edition
DOI: 10.14573/altex.2503191

Generation of Human Nociceptor-Enriched Sensory Neurons for the Study of Pain-Related Dysfunctions

Autores: Holzer, A. K., Karreman, C., Suciu, I., Furmanowsky, L. S., Wohlfarth, H., Loser, D., Dirks, W. G., Pardo González, E., and Leist, M.
Publicado en: Stem Cells Transl Med., Edición 11(7), July 2022, 2022, Página(s) 727–741, ISSN 0029-3970
Editor: Oxford University Press
DOI: 10.1093/stcltm/szac031

A framework for chemical safety assessment incorporating new approach methodologies within REACH

Autores: Ball N, Bars R, Botham PA, Cuciureanu A, Cronin MTD, Doe JE, Dudzina T, Gant TW, Leist M, van Ravenzwaay B
Publicado en: Arch Toxicol., 2022, ISSN 2193-1801
Editor: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-021-03215-9

Preparation of Viable Human Neurites for Neurobiological and Neurodegeneration Studies

Autores: Brüll M, Geese N, CelardoI, Laumann M, Leist M
Publicado en: Cells, 2024, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells13030242

Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective

Autores: Pallocca G., Moné J. M., Kamp H., Luijten M., van de Water B., Leist M.
Publicado en: Altex, Edición 39 (2), 7 April 2022, 2022, ISSN 2193-1801
Editor: Springer Science and Business Media Deutschland GmbH
DOI: 10.14573/altex.2204051

Chemical and Biological Mechanisms Relevant to the Rescue of MG-132-Treated Neurons by Cysteine

Autores: Anna-Katharina Ückert, Ilinca Suciu, Anja Land, Anna-Sophie Spreng, Hannah Welte, Doreen Herzog, Michael Basler, Marcel Leist
Publicado en: Antioxidants, Edición 14, 2025, Página(s) 128, ISSN 2076-3921
Editor: MDPI AG
DOI: 10.3390/antiox14020128

Modeling ferroptosis in human dopaminergic neurons: pitfalls and opportunities for neurodegeneration research

Autores: Renner N, Schöb F, Pape R, Suciu I, Spreng AS, Ückert AK, Cöllen E, Bovio F, Chilian B, Bauere J, Röpcke S, Bergemann J, Leist M, Schildknecht S
Publicado en: Redox Biology, 2024, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2024.103165

Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays

Autores: Dolde X, Karreman C, Wiechers M, Schildknecht S, Leist M
Publicado en: International Journal of Molecular Sciences, Edición 22(18):10079, 2021, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221810079

Bioactivity descriptors for in vivo toxicity prediction: now and the future

Autores: Helmke P, Füzi B, Ecker GF
Publicado en: Expert Opinion on Drug Metabolism & Toxicology, 2024, ISSN 1742-5255
Editor: Ashley Publications Ltd.
DOI: 10.1080/17425255.2024.2334308

Qualitative and quantitative concentration-response modelling of gene co-expression networks to unlock hepatotoxic mechanisms for next generation chemical safety assessment.

Autores: Kunnen SJ, Arnesdotter E, Willenbockel CT, Vinken M, van de Water B
Publicado en: ALTEX, 2024, ISSN 1868-596X
Editor: Springer
DOI: 10.14573/altex.2309201

Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing

Autores: Cöllen E, Bartmann K, Blum J, Carstens K, Celardo I, Chatterjee N, Corvaro M, Dreser N, Fritsche E, Hartung T, Hogberg HT, Knudsen T, Koch K, Kreutz A, Lislien M, Magel V, Marty MS, Pallocca G, Bal-Price A, Rovida C, Sachana M, Shafer TJ, Smirnova L, Suciu I, Tanaskov Y, Tangianu S, Wolfbeisz C, Leist M.
Publicado en: ALTEX, Edición 42, 2025, ISSN 1868-596X
Editor: ALTEX Edition
DOI: 10.14573/altex.2501091

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

Autores: van der Stel W, Yang H, Vrijenhoek NG, Schimming JP, Callegaro G, Carta G, Darici S, Delp J, Forsby A, White A, le Dévédec S, Leist M, Jennings P, Beltman JB, van de Water B, Danen EHJ
Publicado en: Archives of Toxicology, Edición 96(1), January 2022, 2022, ISSN 1868-8551
Editor: Springer-Spektrum
DOI: 10.1007/s00204-021-03160-7

Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro

Autores: Holzer, Anna-Katharina, Ilinca Suciu, Christiaan Karreman, Thomas Goj, and Marcel Leist
Publicado en: International Journal of Molecular Sciences, Edición 23(7), 29 March 2022, 2022, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073734

An Alternative Safety Profiling Algorithm (ASPA) to transform next generation risk assessment into a structured and transparent process

Autores: Leist M, Tangianu S, Affourtit F, Braakhuis H, Colbourne J, Cöllen E, Dreser N, Escher SE, Gardner I, Hahn S, Hardy B, Herzler M, Islam B, Kamp H, Magel V, Marx-Stoelting P, Moné MJ, Lundquist P, Ottenbros I, Ouedraogo G, Pallocca G, van de Water B, Vinken M, White A, Pastor M, Luijten M.
Publicado en: ALTEX, Edición 26, 2025, ISSN 1868-596X
Editor: ALTEX Edition
DOI: 10.14573/altex.2509081

New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project

Autores: Tal T, Myhre O, Fritsche E, Rüegg J, Craenen K, Aiello K, Agrillo C, Babin PJ, Escher BI, Dirven H, Hellsten K, Dolva K, Heusinkveld H, Hadzhiev Y, Hurem S, Jagiełło K, Judzinska B, Klüver N, Knoll-Gellida A, Kühne BA, Leist M, Lislien M, Lyche JL, Müller F, Neuhaus W, Pallocca G, Seeger B, Scharkin I, Scholz S, Spjuth O, Torres-Ruiz M, Bartmann K
Publicado en: Frontiers in Toxicology, 2024, ISSN 2673-3080
Editor: Frontiers
DOI: 10.3389/ftox.2024.1359507

A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury

Autores: Lukas S Wijaya, Attila Gabor, Iris E Pot, Luca van de Have, Julio Saez-Rodriguez, James L Stevens, Sylvia E Le Dévédec, Giulia Callegaro, Bob van de Water
Publicado en: Toxicological Sciences, Edición 198, 2024, Página(s) 14-30, ISSN 1096-6080
Editor: Oxford University Press
DOI: 10.1093/toxsci/kfad121

Development of an adverse outcome pathway network for nephrotoxicity

Autores: Barnes DA, Firman JW, Belfield SJ, Cronin MTD, Vinken M, Janssen MJ, Masereeuw R
Publicado en: Archives of Toxicology, 2024, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-023-03637-7

Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare

Autores: Marx U, Beken S, Chen Z, Dehne EM, Doherty A, Ewart L, Fitzpatrick SC, Griffith LG, Gu Z, Hartung T, Hickman J, Ingber DE, Ishida S, Jeong J, Leist M, Levin L, Mendrick DL, Pallocca G, Platz S, Raschke M, Smirnova L, Tagle DA, Trapecar M, van Balkom BWM, van den Eijnden-van Raaij J, van der Meer A, Roth A.
Publicado en: ALTEX, Edición 42, 2025, ISSN 1868-596X
Editor: ALTEX Edition
DOI: 10.14573/altex.2410112

Current Status and Challenges of Human Induced Pluripotent Stem Cell-Derived Liver Models in Drug Discovery

Autores: Tricot T, Verfaillie C, Kumar M
Publicado en: Cells, Edición january 27, 2022; 11: 442, 2022, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11030442

Inhibition of Neural Crest Cell Migration by Strobilurin Fungicides and Other Mitochondrial Toxicants

Autores: Viktoria Magel, Jonathan Blum, Xenia Dolde, Heidrun Leisner, Karin Grillberger, Hiba Khalidi, Iain Gardner, Gerhard F. Ecker, Giorgia Pallocca, Nadine Dreser, Marcel Leist
Publicado en: Cells, Edición 13, 2025, Página(s) 2057, ISSN 2073-4409
Editor: MDPI AG
DOI: 10.3390/cells13242057

Interdisciplinary risks – a delicate balance between trust and critical review

Autores: Ullrika Sahlin, Henrik Thorén
Publicado en: Journal of Risk Research, Edición 28, 2025, Página(s) 197-202, ISSN 1366-9877
Editor: Carfax Publishing Ltd.
DOI: 10.1080/13669877.2025.2526473

Differential Responses of Human iPSC-Derived Microglia to Stimulation with Diverse Inflammogens

Autores: Chiara Wolfbeisz, Julian Suess, Nadine Dreser, Heidrun Leisner, Markus Brüll, Madeleine Fandrich, Nicole Schneiderhan-Marra, Oliver Poetz, Thomas Hartung, Marcel Leist
Publicado en: Cells, Edición 14, 2025, Página(s) 1687, ISSN 2073-4409
Editor: MDPI AG
DOI: 10.3390/cells14211687

Definition of the Neurotoxicity-Associated Metabolic Signature Triggered by Berberine and Other Respiratory Chain Inhibitors

Autores: Suciu I, Delp J, Gutbier S, Suess J, Henschke L, Celardo I, Mayer TU, Amelio I, Leist M.
Publicado en: Antioxidants, 2023, ISSN 2076-3921
Editor: MPDI
DOI: 10.3390/antiox13010049

Computational Strategies for Assessing Adverse Outcome Pathways: Hepatic Steatosis as a Case Study

Autores: Rita Ortega-Vallbona, Martina Palomino-Schätzlein, Laia Tolosa, Emilio Benfenati, Gerhard F. Ecker, Rafael Gozalbes, Eva Serrano-Candelas
Publicado en: International Journal of Molecular Sciences, Edición 25, 2025, Página(s) 11154, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms252011154

Integrating human exposome data into next-generation risk assessment: a systematic framework to infer real-life exposure levels and prioritize chemical compounds for testing

Autores: Yifeng Dai, Bob van de Water, Jaione Telleria, Laura I. Furlong, Roel C.H. Vermeulen, Jelle Vlaanderen
Publicado en: Environment International, Edición 208, 2026, Página(s) 110110, ISSN 0160-4120
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2026.110110

Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals

Autores: Blum J, Masjosthusmann S, Bartmann K, Bendt F, Dolde X, Dönmez A, Förster N, Holzer AK, Hübenthal U, Keßel HE, Kilic S, Klose J, Pahl M, Stürzl LC, Mangas I, Terron A, Crofton KM, Scholze M, Mosig A, Leist M, Fritsche E.
Publicado en: Chemosphere, Edición 31;311(Pt 2):137035, 2022, ISSN 1879-1298
Editor: Elsevier
DOI: 10.1016/j.chemosphere.2022.137035

MolCompass: multi-tool for the navigation in chemical space and visual validation of QSAR/QSPR models

Autores: Sergey Sosnin
Publicado en: Journal of Cheminformatics, 2024, ISSN 1758-2946
Editor: Chemistry Central

Organobodies: A robust and size-controllable system for generating scalable hiPSC-derived liver organoids for drug toxicity screening

Autores: Mostafa Kiamehr, Stefano Manzini, Burak Toprakhisar, Rodrigo F. Madeiro da Costa, Guillem García-Llorens, Birhanu Belay, Mustapha Najimi, José V Castell, Wolfgang Moritz, Giulia Chiesa, Katriina Aalto-Setälä, Catherine Verfaillie
Publicado en: Bioarchives, 2026, ISSN 2692-8205
Editor: openRxiv
DOI: 10.1101/2025.10.20.683433

Recommendations on fit-for-purpose criteria to establish quality managementfor microphysiological systems and for monitoring their reproducibility

Autores: David Pamies,Jason Ekert,Marie-Gabrielle Zurich,Olivier Frey,Sophie Werner,Monica Piergiovanni,Benjamin S. Freedman,Adrian Kee Keong Teo,Hendrik Erfurth,Darwin R. Reyes,Peter Loskill,Pelin Candarlioglu,Laura Suter-Dick,Shan Wang,Thomas Hartung,Sandra Coecke,Glyn N. Stacey,Beren Atac Wagegg,Eva-Maria Dehne,Francesca Pistollato,Marcel Leist
Publicado en: Stem cell Reports, 2024, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2024.03.009

The predictivity of QSARs for toxicity: Recommendations for improving model performance

Autores: Mark T.D. Cronin, Homa Basiri, Georgios Chrysochoou, Steven J. Enoch, James W. Firman, Nicoleta Spînu, Judith C. Madden
Publicado en: Computational Toxicology, Edición 33, 2025, Página(s) 100338, ISSN 2468-1113
Editor: Elsevier BV
DOI: 10.1016/j.comtox.2024.100338

Prediction of adverse drug reactions due to genetic predisposition using deep neural networks

Autores: Dafniet B & Taboureau O.
Publicado en: Molecular Informatics, 2024, ISSN 1868-1751
Editor: Wiley
DOI: 10.1002/minf.202400021

Elements and development processes for test methods in toxicology and human health-relevant life science research

Autores: Cöllen E, Tanaskov Y, Holzer AK, Dipalo M, Schäfer J, Kraushaar U, Leist M
Publicado en: ALTEX, 2024, ISSN 1868-596X
Editor: Springer
DOI: 10.14573/altex.2401041

Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment

Autores: Jaklin M, Zhang JD, Schäfer N, Clemann N, Barrow P, Küng E, Sach-Peltason L, McGinnis C, Leist M, Kustermann S.
Publicado en: Toxicological Sciences, Edición 188(1):17-33, 2022, ISSN 0029-3970
Editor: Oxford University Press
DOI: 10.1093/toxsci/kfac046

Identifying human toxicodynamic variability: A systematic evidence map of the current knowledge

Autores: Annika Boye Petersen, Lea Bredsdorff, Natasha Tahir, Marije Niemeijer, George E.N. Kass, Aiste Vitkauskaite, Matthijs Moerland, Frederic Y. Bois, Nadia Quignot, Bob van de Water, Susanne Hougaard Bennekou
Publicado en: Regulatory Toxicology and Pharmacology, Edición 161, 2025, Página(s) 105842, ISSN 0273-2300
Editor: Academic Press
DOI: 10.1016/j.yrtph.2025.105842

Integrating Mechanistic and Toxicokinetic Information in Predictive Models of Cholestasis

Autores: Pablo Rodríguez-BelenguerVictor Mangas-SanjuanEmilio Soria-OlivasManuel Pastor*
Publicado en: Journal of Chemical Information and Modeling, 2023, ISSN 1549-9596
Editor: American Chemical Society
DOI: 10.1021/acs.jcim.3c00945

Usage of model combination in computational toxicology

Autores: Rodríguez-Belenguer, P., March-Vila, E., Pastor, M., Mangas-Sanjuan, V., & Soria-Olivas, E
Publicado en: Toxicology Letters, 2023, ISSN 0378-4274
Editor: Elsevier BV
DOI: 10.1016/j.toxlet.2023.10.013

Moving towards making (quantitative) structure-activity relationships ((Q)SARs) for toxicity-related endpoints findable, accessible, interoperable and reusable (FAIR)

Autores: Belfield SJ, Basiri H, Swapnil C, Chrysochoou G, Enoch SJ, Firman JW, Gomatam A, Hardy B, Helmke PS, Madden JC, Maran U, March-Vila E, Nikolov NG, Pastor M, Piir G, Sild S, Smajić A, Spînu N, Wedebye EB, Cronin MTD
Publicado en: ALTEX, 2025, ISSN 1868-596X
Editor: ALTEX Edition
DOI: 10.14573/altex.2411161

Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson’s Disease

Autores: Carecho R, Figueira I, Terrasso AP, Godinho-Pereira J, de Oliveira Sequeira C, Pereira SA, Milenkovic D, Leist M, Brito C, Nunes Dos Santos C.
Publicado en: Mol. Nutr. Food Res., Edición 29 December 2021, 2021, ISSN 1613-4125
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.202100959

The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability

Autores: Vlasveld M, Callegaro G, Fisher C, Eakins J, Walker P, Lok S, van Oost S, de Jong B, Pellegrino-Coppola D, Burger G, Wink S, van de Water B.
Publicado en: Liver International, 2024, ISSN 1478-3231
Editor: John Wiley & Sons
DOI: 10.1111/liv.15822

Trust your gut: Establishing confidence in gastrointestinal models - An overview of the state of the science and contexts of use

Autores: Susan Debad, David Allen, Omari Bandele, Colin Bishop, Michaela Blaylock, Paul Brown, Maureen K. Bunger, Julia Y. Co, Lynn Crosby, Amber B. Daniel, Steve S. Ferguson, Kevin Ford, Gonçalo Gamboa da Costa, Kristin H. Gilchrist, Matthew W. Grogg, Maureen Gwinn, Thomas Hartung , Simon P. Hogan, Ye Eun Jeong, George E. N. Kass, Elaina Kenyon, Nicole C. Kleinstreuer, Ville Kujala, Patrik Lundquist, Jo
Publicado en: ALTEX, 2024, ISSN 1868-596X
Editor: Springer
DOI: 10.14573/altex.2403261

Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses

Autores: Ter Braak B, Klip JE, Wink S, Hiemstra S, Cooper SL, Middleton A, White A, van de Water B
Publicado en: Toxicology In Vitro, 2022, ISSN 1879-1298
Editor: Elsevier
DOI: 10.1016/j.tiv.2022.105419

REACH out-numbered! The future of REACH and animal numbers.

Autores: Rovida C, Busquet F, Leist M, Hartung T.
Publicado en: ALTEX, 2023, ISSN 1868-8551
Editor: Springer
DOI: 10.14573/altex.2307121

Linking chemicals, genes and morphological perturbations to diseases

Autores: Cerisier N, Dafniet B, Badel A, Taboureau O.
Publicado en: Toxicology and Applied Pharmacology, 2023, ISSN 0041-008X
Editor: Academic Press
DOI: 10.1016/j.taap.2023.116407

9-cis-Retinoic Acid Improves Disease Modelling in iPSC-Derived Liver Organoids

Autores: Mina Kazemzadeh Dastjerd, Vincent Merens, Ayla Smout, Rebeca De Wolf, Christophe Chesné, Catherine Verfaillie, Stefaan Verhulst, Leo A. van Grunsven
Publicado en: Cells, Edición 14, 2025, Página(s) 983, ISSN 2073-4409
Editor: MDPI AG
DOI: 10.3390/cells14130983

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

Autores: Loser D, Grillberger K, Hinojosa MG, Blum J, Haufe Y, Danker T, Johansson Y, Möller C, Nicke A, Bennekou SH, Gardner I, Bauch C, Walker P, Forsby A, Ecker GF, Kraushaar U, Leist M.
Publicado en: Arch Toxicol, Edición 95(12).3695-3716, 2021, ISSN 2193-1801
Editor: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-021-03168-z

Leveraging Consensus Docking Approaches for Human Mitochondrial Complexes I and III

Autores: Karin Grillberger, Viktoria Magel, Marcel Leist, Gerhard F. Ecker
Publicado en: Chemical Research in Toxicology, Edición 39, 2026, Página(s) 79-94, ISSN 0893-228X
Editor: American Chemical Society
DOI: 10.1021/acs.chemrestox.5c00348

Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models

Autores: Capinha L, Zhang Y, Holzer AK, Ückert AK, Zana M, Carta G, Murphy C, Baldovini J, Mazidi Z, Grillari J, Dinnyes A, van de Water B, Leist M, Commandeur JNM, Jennings P
Publicado en: Archives of Toxicology, 2023, ISSN 2193-1801
Editor: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-022-03436-6

Studying Metabolism by NMR-Based Metabolomics

Autores: Sofia Moco
Publicado en: Frontiers Molecular Biosciences, Edición 9:882487, 2022, 2022, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fmolb.2022.882487

TOXTRUST: a tool leveraging the Dempster-Shafer Theory for robust integration of NAM results in decision-making considering uncertainty

Autores: Karolina Kopańska, Adrian Cabrera, Manuel Pastor
Publicado en: NAM Journal, Edición 1, 2025, Página(s) 100043, ISSN 3050-6204
Editor: Elsevier BV
DOI: 10.1016/j.namjnl.2025.100043

Cell Painting PLUS: expanding the multiplexing capacity of Cell Painting-based phenotypic profiling using iterative staining-elution cycles

Autores: Elena von Coburg, Marlene Wedler, Jose M. Muino, Christopher Wolff, Nils Körber, Sebastian Dunst, Shu Liu
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-025-58765-8

Controversy on health-based guidance values for bisphenol A—the need of criteria for studies that serve as a basis for risk assessment.

Autores: Leist M, Buettner A, Diel P, Eisenbrand G, Epe B, Först P, Grune T, Haller D, Heinz V, Hellwig M, Humpf HU, Jäger H, Kulling SE, Mally A, Marko D, Nöthlings U, Röhrdanz E, Spranger J, Vieths S, Wätjen W, Hengstler JG.
Publicado en: Archives of Toxicology, 2024, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-024-03778-3

Analysis of health concerns not addressed by REACH for low tonnage chemicals and opportunities for new approach methodology

Autores: Botham P, Cronin MTD, Currie R, et al.
Publicado en: Archives of Toxycology, 2023, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-023-03601-5

Predicting xenobiotic metabolism: a computational approach mining LC–MS/MS data with SIRIUS and BioTransformer

Autores: Victoria Pozo Garcia, Mengqiu Zhang, Tuğçe S. Çobanoğlu, Kasper Holm, Paul Jennings, David A. Poole, Sofia Moco
Publicado en: Archives of Toxicology, 2025, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-025-04248-0

Mechanism-based drug safety testing using innovative <i>in vitro</i> liver models: from DILI prediction to idiosyncratic DILI liability assessment

Autores: Sibel Bahtiri, Tessa M. S. Hagens, Bob van de Water, Marije Niemeijer
Publicado en: Expert Opinion on Drug Metabolism & Toxicology, Edición 21, 2025, Página(s) 769-787, ISSN 1742-5255
Editor: Ashley Publications Ltd.
DOI: 10.1080/17425255.2025.2516051

Metabolic regulation by p53 prevents R-loop-associated genomic instability

Autores: Emanuele Panatta, Alessio Butera, Eleonora Mammarella, Consuelo Pitolli, Alessandro Mauriello, Marcel Leist, Richard A. Knight, Gerry Melino, Ivano Amelio
Publicado en: Cell Reports, Edición Volume 41, Edición 5, 1 November 2022, 2022, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2022.111568

Characterization of Organic Anion and Cation Transport in Three Human Renal Proximal Tubular Epithelial Models

Autores: Meijer, T., da Costa Pereira, D., Klatt, O.C., Buitenhuis, J., Jennings, P., & Wilmes, A.
Publicado en: Cells, 2024, ISSN 2073-4409
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells13121008

Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells

Autores: Olivier J. M. BéquignonJose C. Gómez-TamayoEelke B. LenselinkSteven WinkSteven HiemstraChi Chung LamDomenico GadaletaAlessandra RoncaglioniUlf NorinderBob van de WaterManuel PastorGerard J. P. van Westen*
Publicado en: Journal of Chemical Information and Modeling, 2023, ISSN 1549-9596
Editor: American Chemical Society
DOI: 10.1021/acs.jcim.3c00220

Challenges and opportunities of read-across for the tumor promotion effects of microcystins

Autores: Cynthia B. Pestana, Daniela Morais Leme, Enzo Zini Moreira Silva, Sahra Kiessig, James W. Firman, Carsten Kneuer, Philip Marx-Stoelting, Mark T.D. Cronin
Publicado en: Regulatory Toxicology and Pharmacology, Edición 163, 2026, Página(s) 105938, ISSN 0273-2300
Editor: Academic Press
DOI: 10.1016/j.yrtph.2025.105938

The long way from raw data to NAM-based information: Overview on data layers and processing steps

Autores: Blum J, Brüll M, Hengstler JG, Dietrich DR, Gruber AJ, Dipalo M, Kraushaar U, Mangas I, Terron A, Fritsche E, Marx-Stoelting P, Hardy B, Schepky A, Escher S, Hartung T, Landsiedel R, Odermatt A, Sachana M, Koch K, Dönmez A, Masjosthusmann S, Bothe K, Schildknecht S, Beilmann M, Beltman JB, Fitzpatrick S, Mangerich A, Rehm M, Tangianu S, Zickgraf FM, Kamp H, Burger G, van de Water B, Kleinstreuer
Publicado en: ALTEX, Edición 42, 2025, ISSN 1868-596X
Editor: ALTEX Edition
DOI: 10.14573/altex.2412171

Protectiveness of NAM-Based Hazard Assessment – Which Testing Scope is Required?

Autores: Zobl W, Bitsch A, Blum J, Boei JJWA, Capinha L, Carta G, Castell J, Davoli E, Drake C, Fisher CP, Heldring MM, Islam B, Jennings P, Leist M, Pellegrino-Coppola D, Schimming JP, Snijders KE, Tolosa L, van de Water B, van Vugt-Lussenburg BMA, Walker P, Wehr MM, Wijaya LS, Escher SE
Publicado en: ALTEX, 2024, ISSN 1868-596X
Editor: Springer
DOI: 10.14573/altex.2309081

Towards a quantitative adverse outcome pathway for liver carcinogenesis: From proliferation to prediction

Autores: Christina H.J. Veltman, Hiba Khalidi, Elias Zgheib, Bob van de Water, Mirjam Luijten, Jeroen L.A. Pennings
Publicado en: Computational Toxicology, Edición 34, 2025, Página(s) 100359, ISSN 2468-1113
Editor: Elsevier BV
DOI: 10.1016/j.comtox.2025.100359

A broad kinase inhibitor library live cell imaging screen using liver, kidney and cardiac hiPSC-ICAM1-eGFP reporter lineages identifies liabilities for TNFα pathway modulation

Autores: Matthijs Vlasveld, Linda van den Berk, Janet Piñero, Palle S. Helmke, Gerhard F. Ecker, Rob van Rossom, Bela Z. Schmidt, Catherine Verfaillie, Konstantinos Tassis, Giulia Callegaro, Peter Bouwman, Bob van de Water
Publicado en: Archives of Toxicology, Edición 100, 2026, Página(s) 585-601, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-025-04226-6

Cell type heterogeneity in gene co-expression networks: implications for toxicological research

Autores: Imke B Bruns, Yingxue Li, James L Stevens, Bob van de Water, Giulia Callegaro
Publicado en: Briefings in Bioinformatics, Edición 26, 2025, ISSN 1467-5463
Editor: Oxford University Press
DOI: 10.1093/bib/bbaf421

The intracellular free concentration of endocrine disrupting chemicals enables translation between cell-free and cell-based estrogenic activity assays

Autores: Vesna Munic Kos, Staffan Arvidsson, Barira Islam, Violetta Nikiforova, Evgeniya Mickols, Alina Meyer, Richard Svensson, Ummu Gulsum Boztepe, Eirini Banti, Patrik Lundquist, Hiba Khalidi, Iain Gardner, Ola Spjuth, Ian Cotgreave, Per Artursson
Publicado en: Environmental Toxicology and Pharmacology, Edición 117, 2025, Página(s) 104750, ISSN 1382-6689
Editor: Elsevier BV
DOI: 10.1016/j.etap.2025.104750

4.2 million and counting… The animal toll for REACH systemic toxicity studies

Autores: Knight J, Hartung T, Rovida C.
Publicado en: ALTEX, 2023, ISSN 1868-596X
Editor: Springer
DOI: 10.14573/altex.2303201

Mapping Interindividual Variability of Toxicodynamics Using High-ThroughputTranscriptomics and Primary Human Hepatocytes from Fifty Donors

Autores: Niemeijer M, Więcek W, Fu S, Huppelschoten S, Bouwman P, Baze A, Parmentier C, Richert L, Paules RS, Bois FY, van de Water B
Publicado en: Environmental Health Perspectives, 2024, ISSN 0091-6765
Editor: US Department of Health and Human Services
DOI: 10.1289/ehp11891

StreamChol: a web-based application for predicting cholestasis

Autores: Pablo Rodríguez-Belenguer, Emilio Soria-Olivas, Manuel Pastor
Publicado en: Journal of Cheminformatics, Edición 17, 2025, ISSN 1758-2946
Editor: Chemistry Central
DOI: 10.1186/s13321-024-00943-9

Computational prediction of mutagenicity through comprehensive cell painting analysis

Autores: Natacha Cerisier, Emily Truong, Taku Watanabe, Taro Oshiro, Tomohiro Takahashi, Shigeaki Ito, Olivier Taboureau
Publicado en: Mutagenesis, Edición 40, 2025, Página(s) 560-574, ISSN 0267-8357
Editor: Oxford University Press
DOI: 10.1093/mutage/geaf014

Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis

Autores: Lambrecht R, Rudolf F, Ückert AK, Sladky VC, Phan TS, Jansen J, Naim S, Kaufmann T, Keogh A, Kirschnek S, Mangerich A, Stengel F, Leist M, Villunger A, Brunner T
Publicado en: Cell Death & Differentiation, 2024, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-023-01245-7

Structural Insights into Neonicotinoids and N-Unsubstituted Metabolites on Human nAChRs by Molecular Docking, Dynamics Simulations, and Calcium Imaging

Autores: K. Grillberger, E. Cöllen, C. I. Trivisani, J. Blum, M. Leist, and G. F. Ecker
Publicado en: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241713170

PathwayNexus: a tool for interactive metabolic data analysis

Autores: Eberhard P, Aichem M, Kern M, Klein K, Delp J, Suciu I, Dietrich D, Leist M, Schreiber F
Publicado en: Bioinformatics, 2024, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btae310

Causal, Predictive or Observational? Different Understandings of Key Event Relationships for Adverse Outcome Pathways and their implications on practice

Autores: Zheng Zhou, Jeroen L.A. Pennings, Ullrika Sahlin
Publicado en: Environmental Toxicology and Pharmacology, 2024, ISSN 1382-6689
Editor: Elsevier BV

Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration

Autores: Anna-Katharina Ückert, Sina Rütschlin, Simon Gutbier, Nathalie Christine Wörz, Mahfuzur R. Miah, Airton C. Martins, Isa Hauer, Anna-Katharina Holzer, Birthe Meyburg, Ann-Kathrin Mix, Christof Hauck, Michael Aschner, Thomas Böttcher, Marcel Leist
Publicado en: Environment International, 2023, ISSN 0160-4120
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.108229

Cell viability imaging in tumor spheroids <i>via</i> DNA binding of a ruthenium(<scp>ii</scp>) light-switch complex

Autores: Vadde Ramu, Lukas S. Wijaya, Nataliia Beztsinna, Corjan Van de Griend, Bob van de Water, Sylvestre Bonnet, Sylvia E. Le Dévédec
Publicado en: Chemical Communications, Edición 60, 2024, Página(s) 6308-6311, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/d4cc01425a

High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation

Autores: Seidel F, Cherianidou A, Kappenberg F, Marta M, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Scholtz-Illigens A, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG.
Publicado en: Cells, Edición 11(21):3404, 2022, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11213404

Making in silico predictive models for toxicology FAIR

Autores: Cronin MTD, Belfield SJ, Briggs KA, Enoch SJ, Firman JW, Frericks M, Garrard C, Maccallum PH, Madden JC, Pastor M, Sanz F, Soininen I, Sousoni D.
Publicado en: Regulatory Toxicology and Pharmacology, 2023, ISSN 0273-2300
Editor: Academic Press
DOI: 10.1016/j.yrtph.2023.105385

Knowledge infrastructure for integrated data management and analysis supporting new approach methods in predictive toxicology and risk assessment

Autores: Barry Hardy, Tomaz Mohoric,Thomas Exner, Joh Dokler, Maja Brajnik, Daniel Bachler, Ody Mbegbu, Nora Kleisli, Lucian Farcal, Krzysztof Maciejczuk, Haris Rašidagić, Ghada Tagorti, Pascal Ankli, Daniel Burgwinkel, Divanshu Anand, Ugis Sarkans, Awais Athar
Publicado en: Toxicology in Vitro, 2024, ISSN 0887-2333
Editor: Elsevier BV
DOI: 10.1016/j.tiv.2024.105903

Deconvoluting gene and environmentinteractions to develop an “epigeneticscore meter” of disease

Autores: Butera, A, Smirnova, L., Ferrando-May, E., Hartung, T., Brunner, T., Leist, M., Amelio, I.
Publicado en: EMBO Molecular Medicine, 2023, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202318208

Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons

Autores: Suciu, I.; Delp, J.; Gutbier, S.; Ückert, A.-K.; Spreng, A.-S.; Eberhard, P.; Karreman, C.; Schreiber, F.; Madjar, K.; Rahnenführer, J.; Celardo, I.; Amelio, I.; Leist, M
Publicado en: Antioxidants, 2023, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/antiox12010164

Assessing network-based methods in the context of system toxicology

Autores: Valls-Margarit J, Piñero J, Füzi B, Cerisier N, Taboureau O, Furlong LI
Publicado en: Frontiers in Pharmacology, 2023, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1225697

Transcriptomic changes and mitochondrial toxicity in response to acute and repeat dose treatment with brequinar in human liver and kidney in vitro models

Autores: Tamara Meijer, Bas ter Braak, Liesanne Loonstra-Wolters, Steven J. Kunnen, Barira Islam, Ilinca Suciu, Iain Gardner, Oliver Hatley, Richard Currie, Barry Hardy, Marcel Leist, Bob van de Water, Paul Jennings, Anja Wilmes
Publicado en: Toxicology in Vitro, Edición 104, 2025, Página(s) 106010, ISSN 0887-2333
Editor: Elsevier BV
DOI: 10.1016/j.tiv.2025.106010

Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation

Autores: Spreng AS, Brüll M, Leisner H, Suciu I, Leist M.
Publicado en: Human Stem Cells in Disease Modelling, Drug Discovery and Regenerative Medicine, Edición 11(17):2644, 25 August 2022, 2022, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11172644

Use of metabolic glycoengineering and pharmacological inhibitors to assess lipid and protein sialylation on cells.

Autores: Kranaster P, Blum J, Dold JEGA, Wittmann V, Leist M.
Publicado en: Neurochem, 2022, ISSN 1613-4125
Editor: John Wiley & Sons Ltd.
DOI: 10.1111/jnc.15737

Osmolar Modulation Drives Reversible Cell Cycle Exit and Human Pluripotent Cell Differentiation via NF-κВ and WNT Signaling

Autores: Jonathan Sai-Hong Chui , Teresa Izuel-Idoype , Alessandra Qualizza , Rita Pires de Almeida , Lindsey Piessens , Bernard K van der Veer , Gert Vanmarcke , Aneta Malesa , Paraskevi Athanasouli , Ruben Boon , Joris Vriens , Leo van Grunsven , Kian Peng Koh , Catherine M Verfaillie , Frederic Lluis
Publicado en: Advanced Science, 2024, ISSN 2198-3844
Editor: Wiley Online Library
DOI: 10.1002/advs.202307554

Uncertainty assessment of proarrhythmia predictions derived from multi‑level in silico models

Autores: Kopańska K, Rodríguez-Belenguer P, Llopis-Lorente J, Trenor B, Saiz J, Pastor M.
Publicado en: Archives of Toxicology, 2023, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-023-03557-6

Assessment of Drug-Induced Liver Injury through Cell Morphology and Gene Expression Analysisand Gene Expression Analysis

Autores: Lejal V, Cerisier N, Rouquié D, Taboureau O.
Publicado en: Chemical Research in Toxicology, 2023, ISSN 0893-228X
Editor: American Chemical Society
DOI: 10.1021/acs.chemrestox.2c00381

On the Usefulness of Animals as a Model System (Part II): Considering Benefits within Distinct Use Domains

Autores: G. Pallocca, M. Leist
Publicado en: ALTEX- Alternatives to Animal Experimentation, Edición 39(3), 20 July 2022, 2022, ISSN 1868-8551
Editor: Springer Spektrum
DOI: 10.14573/altex.2207111

Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation

Autores: Scheibe C, Karreman C, Schildknecht S, Leist M, Hauser K.
Publicado en: Biomolecules, Edición 11(8): 1067, Aug 2021, 2021, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom11081067

G × E interactions as a basis for toxicological uncertainty

Autores: Suciu I, Pamies D, Peruzzo R, Wirtz PH, Smirnova L, Pallocca G, Hauck C, Cronin MTD, Hengstler JG, Brunner T, Hartung T, Amelio I, Leist M.
Publicado en: Archives of Toxicology, 2023, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-023-03500-9

Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test

Autores: Cherianidou A, Seidel F, Kappenberg F, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG.
Publicado en: Chemical Research in Toxicology, 2022, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/acs.chemrestox.1c00392

Gap Junctional Communication Required for the Establishment of Long-Term Robust Ca2+ Oscillations Across Human Neuronal Spheroids and Extended 2D Cultures

Autores: Jasmin Kormann, Eike Cöllen, Ayla Aksoy-Aksel, Jana Schneider, Yaroslav Tanaskov, Kevin Wulkesch, Marcel Leist, Udo Kraushaar
Publicado en: Cells, Edición 14, 2025, Página(s) 1744, ISSN 2073-4409
Editor: MDPI AG
DOI: 10.3390/cells14211744

Revolutionizing Developmental Neurotoxicity Testing – A Journey from Animal Models to Advanced In Vitro Systems

Autores: Smirnova L, Hogberg HT, Leist M, Hartung T
Publicado en: ALTEX, 2024, ISSN 1868-596X
Editor: Springer
DOI: 10.14573/altex.2403281

A continuous in silico learning strategy to identify safety liabilities in compounds used in the leather and textile industry

Autores: March-Vila E, Ferretti G, Terricabras E, Ardao I, Brea JM, Varela MJ, Arana Á, Rubiolo JA, Sanz F, Loza MI, Sánchez L, Alonso H, Pastor M
Publicado en: Archives of Toxicology, 2023, ISSN 1432-0738
Editor: Springer
DOI: 10.1007/s00204-023-03459-7

Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0

Autores: Pamies D, Leist M, Coecke S, Bowe G, Allen DG, Gstraunthaler G, Bal-Price A, Pistollato F, de Vries RBM, Hogberg HT, Hartung T, Stacey G.
Publicado en: ALTEX, Edición 39:30-70, 2022, ISSN 1868-8551
Editor: Springer Spektrum
DOI: 10.14573/altex.2111011

On the usefulness of animals as a model system (part I): Overview of criteria and focus on robustness

Autores: Pallocca G., Rovida C., Leist M
Publicado en: ALTEX, Edición 2022;39(2):347-353, 2022, ISSN 2193-1801
Editor: Springer Science and Business Media Deutschland GmbH
DOI: 10.14573/altex.2203291

Status of quantifying adverse outcome pathways to support next generation risk assessment

Autores: M Cronin, S Belfield, S Enoch, J Firman, Judith Madden, N Spinu
Publicado en: Altex Proceedings, 2023, ISSN 2194-0479
Editor: Springer Spektrum
DOI: 10.58847/ap.2302

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