RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs

Informacje na temat projektu

RISK-HUNT3R

Identyfikator umowy o grant: 964537

DOI

10.3030/964537

Data podpisania przez KE 22 Stycznia 2021

Data rozpoczęcia 1 Czerwca 2021

Data zakończenia 31 Maja 2026

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 23 177 768,75

Wkład UE

€ 22 927 768,75

Koordynowany przez

UNIVERSITEIT LEIDEN
Netherlands

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (64)

Genomic and proteomic biomarker landscape in clinical trials

Autorzy: Piñero J, Rodriguez Fraga PS, Valls-Margarit J, Ronzano F, Accuosto P, Lambea
Opublikowane w: Computational and structural biotechnology journal, 2023, ISSN 2001-0370
Wydawca: Elsevier
DOI: 10.1016/j.csbj.2023.03.014

SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp® simulator

Autorzy: Khalidi H, Onasanwo A, Islam B, Jo H, Fisher C, Aidley R, Gardner I, Bois FY.
Opublikowane w: Frontiers in Pharmacology, Numer 25 August 2022, 2022, ISSN 1663-9812
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.929200

Acceptance criteria for new approach methods in toxicology and human health-relevant life science research – part I

Autorzy: Holzer, A.-K., Dreser, N., Pallocca, G., Mangerich, A., Stacey, G., Dipalo, M., van de Water, B., Rovida, C., Wirtz, P. H., van Vugt, B., Panzarella, G., Hartung, T., Terron, A., Mangas, I., Herzler, M., Marx-Stoelting, P., Coecke, S. and Leist, M.
Opublikowane w: ALTEX, 2023, ISSN 1868-596X
Wydawca: Springer
DOI: 10.14573/altex.2310021

An Adverse Outcome Pathway Network for Chemically Induced Oxidative Stress Leading to (Non)genotoxic Carcinogenesis

Autorzy: Christina H. J. Veltman; Jeroen L. A. Pennings; Bob van de Water; Mirjam Luijten
Opublikowane w: Chemical Research in Toxicology, Numer 3, 2023, ISSN 0893-228X
Wydawca: American Chemical Society
DOI: 10.1021/acs.chemrestox.2c00396

Generation of Human Nociceptor-Enriched Sensory Neurons for the Study of Pain-Related Dysfunctions

Autorzy: Holzer, A. K., Karreman, C., Suciu, I., Furmanowsky, L. S., Wohlfarth, H., Loser, D., Dirks, W. G., Pardo González, E., and Leist, M.
Opublikowane w: Stem Cells Transl Med., Numer 11(7), July 2022, 2022, Strona(/y) 727–741, ISSN 0029-3970
Wydawca: Oxford University Press
DOI: 10.1093/stcltm/szac031

A framework for chemical safety assessment incorporating new approach methodologies within REACH

Autorzy: Ball N, Bars R, Botham PA, Cuciureanu A, Cronin MTD, Doe JE, Dudzina T, Gant TW, Leist M, van Ravenzwaay B
Opublikowane w: Arch Toxicol., 2022, ISSN 2193-1801
Wydawca: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-021-03215-9

Preparation of Viable Human Neurites for Neurobiological and Neurodegeneration Studies

Autorzy: Brüll M, Geese N, CelardoI, Laumann M, Leist M
Opublikowane w: Cells, 2024, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells13030242

Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective

Autorzy: Pallocca G., Moné J. M., Kamp H., Luijten M., van de Water B., Leist M.
Opublikowane w: Altex, Numer 39 (2), 7 April 2022, 2022, ISSN 2193-1801
Wydawca: Springer Science and Business Media Deutschland GmbH
DOI: 10.14573/altex.2204051

Modeling ferroptosis in human dopaminergic neurons: pitfalls and opportunities for neurodegeneration research

Autorzy: Renner N, Schöb F, Pape R, Suciu I, Spreng AS, Ückert AK, Cöllen E, Bovio F, Chilian B, Bauere J, Röpcke S, Bergemann J, Leist M, Schildknecht S
Opublikowane w: Redox Biology, 2024, ISSN 2213-2317
Wydawca: Elsevier BV
DOI: 10.1016/j.redox.2024.103165

Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays

Autorzy: Dolde X, Karreman C, Wiechers M, Schildknecht S, Leist M
Opublikowane w: International Journal of Molecular Sciences, Numer 22(18):10079, 2021, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221810079

Bioactivity descriptors for in vivo toxicity prediction: now and the future

Autorzy: Helmke P, Füzi B, Ecker GF
Opublikowane w: Expert Opinion on Drug Metabolism & Toxicology, 2024, ISSN 1742-5255
Wydawca: Ashley Publications Ltd.
DOI: 10.1080/17425255.2024.2334308

Qualitative and quantitative concentration-response modelling of gene co-expression networks to unlock hepatotoxic mechanisms for next generation chemical safety assessment.

Autorzy: Kunnen SJ, Arnesdotter E, Willenbockel CT, Vinken M, van de Water B
Opublikowane w: ALTEX, 2024, ISSN 1868-596X
Wydawca: Springer
DOI: 10.14573/altex.2309201

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

Autorzy: van der Stel W, Yang H, Vrijenhoek NG, Schimming JP, Callegaro G, Carta G, Darici S, Delp J, Forsby A, White A, le Dévédec S, Leist M, Jennings P, Beltman JB, van de Water B, Danen EHJ
Opublikowane w: Archives of Toxicology, Numer 96(1), January 2022, 2022, ISSN 1868-8551
Wydawca: Springer-Spektrum
DOI: 10.1007/s00204-021-03160-7

Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro

Autorzy: Holzer, Anna-Katharina, Ilinca Suciu, Christiaan Karreman, Thomas Goj, and Marcel Leist
Opublikowane w: International Journal of Molecular Sciences, Numer 23(7), 29 March 2022, 2022, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073734

New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project

Autorzy: Tal T, Myhre O, Fritsche E, Rüegg J, Craenen K, Aiello K, Agrillo C, Babin PJ, Escher BI, Dirven H, Hellsten K, Dolva K, Heusinkveld H, Hadzhiev Y, Hurem S, Jagiełło K, Judzinska B, Klüver N, Knoll-Gellida A, Kühne BA, Leist M, Lislien M, Lyche JL, Müller F, Neuhaus W, Pallocca G, Seeger B, Scharkin I, Scholz S, Spjuth O, Torres-Ruiz M, Bartmann K
Opublikowane w: Frontiers in Toxicology, 2024, ISSN 2673-3080
Wydawca: Frontiers
DOI: 10.3389/ftox.2024.1359507

A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury

Autorzy: Lukas S Wijaya, Attila Gabor, Iris E Pot, Luca van de Have, Julio Saez-Rodriguez, James L Stevens, Sylvia E Le Dévédec, Giulia Callegaro, Bob van de Water
Opublikowane w: Toxicological Sciences, Numer 198, 2024, Strona(/y) 14-30, ISSN 1096-6080
Wydawca: Oxford University Press
DOI: 10.1093/toxsci/kfad121

Development of an adverse outcome pathway network for nephrotoxicity

Autorzy: Barnes DA, Firman JW, Belfield SJ, Cronin MTD, Vinken M, Janssen MJ, Masereeuw R
Opublikowane w: Archives of Toxicology, 2024, ISSN 0340-5761
Wydawca: Springer Verlag
DOI: 10.1007/s00204-023-03637-7

Current Status and Challenges of Human Induced Pluripotent Stem Cell-Derived Liver Models in Drug Discovery

Autorzy: Tricot T, Verfaillie C, Kumar M
Opublikowane w: Cells, Numer january 27, 2022; 11: 442, 2022, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11030442

Definition of the Neurotoxicity-Associated Metabolic Signature Triggered by Berberine and Other Respiratory Chain Inhibitors

Autorzy: Suciu I, Delp J, Gutbier S, Suess J, Henschke L, Celardo I, Mayer TU, Amelio I, Leist M.
Opublikowane w: Antioxidants, 2023, ISSN 2076-3921
Wydawca: MPDI
DOI: 10.3390/antiox13010049

Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals

Autorzy: Blum J, Masjosthusmann S, Bartmann K, Bendt F, Dolde X, Dönmez A, Förster N, Holzer AK, Hübenthal U, Keßel HE, Kilic S, Klose J, Pahl M, Stürzl LC, Mangas I, Terron A, Crofton KM, Scholze M, Mosig A, Leist M, Fritsche E.
Opublikowane w: Chemosphere, Numer 31;311(Pt 2):137035, 2022, ISSN 1879-1298
Wydawca: Elsevier
DOI: 10.1016/j.chemosphere.2022.137035

Recommendations on fit-for-purpose criteria to establish quality managementfor microphysiological systems and for monitoring their reproducibility

Autorzy: David Pamies,Jason Ekert,Marie-Gabrielle Zurich,Olivier Frey,Sophie Werner,Monica Piergiovanni,Benjamin S. Freedman,Adrian Kee Keong Teo,Hendrik Erfurth,Darwin R. Reyes,Peter Loskill,Pelin Candarlioglu,Laura Suter-Dick,Shan Wang,Thomas Hartung,Sandra Coecke,Glyn N. Stacey,Beren Atac Wagegg,Eva-Maria Dehne,Francesca Pistollato,Marcel Leist
Opublikowane w: Stem cell Reports, 2024, ISSN 2213-6711
Wydawca: Cell Press
DOI: 10.1016/j.stemcr.2024.03.009

Prediction of adverse drug reactions due to genetic predisposition using deep neural networks

Autorzy: Dafniet B & Taboureau O.
Opublikowane w: Molecular Informatics, 2024, ISSN 1868-1751
Wydawca: Wiley
DOI: 10.1002/minf.202400021

Elements and development processes for test methods in toxicology and human health-relevant life science research

Autorzy: Cöllen E, Tanaskov Y, Holzer AK, Dipalo M, Schäfer J, Kraushaar U, Leist M
Opublikowane w: ALTEX, 2024, ISSN 1868-596X
Wydawca: Springer
DOI: 10.14573/altex.2401041

Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment

Autorzy: Jaklin M, Zhang JD, Schäfer N, Clemann N, Barrow P, Küng E, Sach-Peltason L, McGinnis C, Leist M, Kustermann S.
Opublikowane w: Toxicological Sciences, Numer 188(1):17-33, 2022, ISSN 0029-3970
Wydawca: Oxford University Press
DOI: 10.1093/toxsci/kfac046

Integrating Mechanistic and Toxicokinetic Information in Predictive Models of Cholestasis

Autorzy: Pablo Rodríguez-BelenguerVictor Mangas-SanjuanEmilio Soria-OlivasManuel Pastor*
Opublikowane w: Journal of Chemical Information and Modeling, 2023, ISSN 1549-9596
Wydawca: American Chemical Society
DOI: 10.1021/acs.jcim.3c00945

Usage of model combination in computational toxicology

Autorzy: Rodríguez-Belenguer, P., March-Vila, E., Pastor, M., Mangas-Sanjuan, V., & Soria-Olivas, E
Opublikowane w: Toxicology Letters, 2023, ISSN 0378-4274
Wydawca: Elsevier BV
DOI: 10.1016/j.toxlet.2023.10.013

Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson’s Disease

Autorzy: Carecho R, Figueira I, Terrasso AP, Godinho-Pereira J, de Oliveira Sequeira C, Pereira SA, Milenkovic D, Leist M, Brito C, Nunes Dos Santos C.
Opublikowane w: Mol. Nutr. Food Res., Numer 29 December 2021, 2021, ISSN 1613-4125
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.202100959

The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability

Autorzy: Vlasveld M, Callegaro G, Fisher C, Eakins J, Walker P, Lok S, van Oost S, de Jong B, Pellegrino-Coppola D, Burger G, Wink S, van de Water B.
Opublikowane w: Liver International, 2024, ISSN 1478-3231
Wydawca: John Wiley & Sons
DOI: 10.1111/liv.15822

Trust your gut: Establishing confidence in gastrointestinal models - An overview of the state of the science and contexts of use

Autorzy: Susan Debad, David Allen, Omari Bandele, Colin Bishop, Michaela Blaylock, Paul Brown, Maureen K. Bunger, Julia Y. Co, Lynn Crosby, Amber B. Daniel, Steve S. Ferguson, Kevin Ford, Gonçalo Gamboa da Costa, Kristin H. Gilchrist, Matthew W. Grogg, Maureen Gwinn, Thomas Hartung , Simon P. Hogan, Ye Eun Jeong, George E. N. Kass, Elaina Kenyon, Nicole C. Kleinstreuer, Ville Kujala, Patrik Lundquist, Jo
Opublikowane w: ALTEX, 2024, ISSN 1868-596X
Wydawca: Springer
DOI: 10.14573/altex.2403261

Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses

Autorzy: Ter Braak B, Klip JE, Wink S, Hiemstra S, Cooper SL, Middleton A, White A, van de Water B
Opublikowane w: Toxicology In Vitro, 2022, ISSN 1879-1298
Wydawca: Elsevier
DOI: 10.1016/j.tiv.2022.105419

REACH out-numbered! The future of REACH and animal numbers.

Autorzy: Rovida C, Busquet F, Leist M, Hartung T.
Opublikowane w: ALTEX, 2023, ISSN 1868-8551
Wydawca: Springer
DOI: 10.14573/altex.2307121

Linking chemicals, genes and morphological perturbations to diseases

Autorzy: Cerisier N, Dafniet B, Badel A, Taboureau O.
Opublikowane w: Toxicology and Applied Pharmacology, 2023, ISSN 0041-008X
Wydawca: Academic Press
DOI: 10.1016/j.taap.2023.116407

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

Autorzy: Loser D, Grillberger K, Hinojosa MG, Blum J, Haufe Y, Danker T, Johansson Y, Möller C, Nicke A, Bennekou SH, Gardner I, Bauch C, Walker P, Forsby A, Ecker GF, Kraushaar U, Leist M.
Opublikowane w: Arch Toxicol, Numer 95(12).3695-3716, 2021, ISSN 2193-1801
Wydawca: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-021-03168-z

Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models

Autorzy: Capinha L, Zhang Y, Holzer AK, Ückert AK, Zana M, Carta G, Murphy C, Baldovini J, Mazidi Z, Grillari J, Dinnyes A, van de Water B, Leist M, Commandeur JNM, Jennings P
Opublikowane w: Archives of Toxicology, 2023, ISSN 2193-1801
Wydawca: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-022-03436-6

Studying Metabolism by NMR-Based Metabolomics

Autorzy: Sofia Moco
Opublikowane w: Frontiers Molecular Biosciences, Numer 9:882487, 2022, 2022, ISSN 1663-9812
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fmolb.2022.882487

Controversy on health-based guidance values for bisphenol A—the need of criteria for studies that serve as a basis for risk assessment.

Autorzy: Leist M, Buettner A, Diel P, Eisenbrand G, Epe B, Först P, Grune T, Haller D, Heinz V, Hellwig M, Humpf HU, Jäger H, Kulling SE, Mally A, Marko D, Nöthlings U, Röhrdanz E, Spranger J, Vieths S, Wätjen W, Hengstler JG.
Opublikowane w: Archives of Toxicology, 2024, ISSN 0340-5761
Wydawca: Springer Verlag
DOI: 10.1007/s00204-024-03778-3

Analysis of health concerns not addressed by REACH for low tonnage chemicals and opportunities for new approach methodology

Autorzy: Botham P, Cronin MTD, Currie R, et al.
Opublikowane w: Archives of Toxycology, 2023, ISSN 0340-5761
Wydawca: Springer Verlag
DOI: 10.1007/s00204-023-03601-5

Metabolic regulation by p53 prevents R-loop-associated genomic instability

Autorzy: Emanuele Panatta, Alessio Butera, Eleonora Mammarella, Consuelo Pitolli, Alessandro Mauriello, Marcel Leist, Richard A. Knight, Gerry Melino, Ivano Amelio
Opublikowane w: Cell Reports, Numer Volume 41, Numer 5, 1 November 2022, 2022, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2022.111568

Characterization of Organic Anion and Cation Transport in Three Human Renal Proximal Tubular Epithelial Models

Autorzy: Meijer, T., da Costa Pereira, D., Klatt, O.C., Buitenhuis, J., Jennings, P., & Wilmes, A.
Opublikowane w: Cells, 2024, ISSN 2073-4409
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells13121008

Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells

Autorzy: Olivier J. M. BéquignonJose C. Gómez-TamayoEelke B. LenselinkSteven WinkSteven HiemstraChi Chung LamDomenico GadaletaAlessandra RoncaglioniUlf NorinderBob van de WaterManuel PastorGerard J. P. van Westen*
Opublikowane w: Journal of Chemical Information and Modeling, 2023, ISSN 1549-9596
Wydawca: American Chemical Society
DOI: 10.1021/acs.jcim.3c00220

Protectiveness of NAM-Based Hazard Assessment – Which Testing Scope is Required?

Autorzy: Zobl W, Bitsch A, Blum J, Boei JJWA, Capinha L, Carta G, Castell J, Davoli E, Drake C, Fisher CP, Heldring MM, Islam B, Jennings P, Leist M, Pellegrino-Coppola D, Schimming JP, Snijders KE, Tolosa L, van de Water B, van Vugt-Lussenburg BMA, Walker P, Wehr MM, Wijaya LS, Escher SE
Opublikowane w: ALTEX, 2024, ISSN 1868-596X
Wydawca: Springer
DOI: 10.14573/altex.2309081

4.2 million and counting… The animal toll for REACH systemic toxicity studies

Autorzy: Knight J, Hartung T, Rovida C.
Opublikowane w: ALTEX, 2023, ISSN 1868-596X
Wydawca: Springer
DOI: 10.14573/altex.2303201

Mapping Interindividual Variability of Toxicodynamics Using High-ThroughputTranscriptomics and Primary Human Hepatocytes from Fifty Donors

Autorzy: Niemeijer M, Więcek W, Fu S, Huppelschoten S, Bouwman P, Baze A, Parmentier C, Richert L, Paules RS, Bois FY, van de Water B
Opublikowane w: Environmental Health Perspectives, 2024, ISSN 0091-6765
Wydawca: US Department of Health and Human Services
DOI: 10.1289/ehp11891

Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis

Autorzy: Lambrecht R, Rudolf F, Ückert AK, Sladky VC, Phan TS, Jansen J, Naim S, Kaufmann T, Keogh A, Kirschnek S, Mangerich A, Stengel F, Leist M, Villunger A, Brunner T
Opublikowane w: Cell Death & Differentiation, 2024, ISSN 1350-9047
Wydawca: Nature Publishing Group
DOI: 10.1038/s41418-023-01245-7

Structural Insights into Neonicotinoids and N-Unsubstituted Metabolites on Human nAChRs by Molecular Docking, Dynamics Simulations, and Calcium Imaging

Autorzy: K. Grillberger, E. Cöllen, C. I. Trivisani, J. Blum, M. Leist, and G. F. Ecker
Opublikowane w: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241713170

PathwayNexus: a tool for interactive metabolic data analysis

Autorzy: Eberhard P, Aichem M, Kern M, Klein K, Delp J, Suciu I, Dietrich D, Leist M, Schreiber F
Opublikowane w: Bioinformatics, 2024, ISSN 1367-4803
Wydawca: Oxford University Press
DOI: 10.1093/bioinformatics/btae310

Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration

Autorzy: Anna-Katharina Ückert, Sina Rütschlin, Simon Gutbier, Nathalie Christine Wörz, Mahfuzur R. Miah, Airton C. Martins, Isa Hauer, Anna-Katharina Holzer, Birthe Meyburg, Ann-Kathrin Mix, Christof Hauck, Michael Aschner, Thomas Böttcher, Marcel Leist
Opublikowane w: Environment International, 2023, ISSN 0160-4120
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.108229

High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation

Autorzy: Seidel F, Cherianidou A, Kappenberg F, Marta M, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Scholtz-Illigens A, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG.
Opublikowane w: Cells, Numer 11(21):3404, 2022, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11213404

Making in silico predictive models for toxicology FAIR

Autorzy: Cronin MTD, Belfield SJ, Briggs KA, Enoch SJ, Firman JW, Frericks M, Garrard C, Maccallum PH, Madden JC, Pastor M, Sanz F, Soininen I, Sousoni D.
Opublikowane w: Regulatory Toxicology and Pharmacology, 2023, ISSN 0273-2300
Wydawca: Academic Press
DOI: 10.1016/j.yrtph.2023.105385

Knowledge infrastructure for integrated data management and analysis supporting new approach methods in predictive toxicology and risk assessment

Autorzy: Barry Hardy, Tomaz Mohoric,Thomas Exner, Joh Dokler, Maja Brajnik, Daniel Bachler, Ody Mbegbu, Nora Kleisli, Lucian Farcal, Krzysztof Maciejczuk, Haris Rašidagić, Ghada Tagorti, Pascal Ankli, Daniel Burgwinkel, Divanshu Anand, Ugis Sarkans, Awais Athar
Opublikowane w: Toxicology in Vitro, 2024, ISSN 0887-2333
Wydawca: Elsevier BV
DOI: 10.1016/j.tiv.2024.105903

Deconvoluting gene and environmentinteractions to develop an “epigeneticscore meter” of disease

Autorzy: Butera, A, Smirnova, L., Ferrando-May, E., Hartung, T., Brunner, T., Leist, M., Amelio, I.
Opublikowane w: EMBO Molecular Medicine, 2023, ISSN 1757-4676
Wydawca: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202318208

Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons

Autorzy: Suciu, I.; Delp, J.; Gutbier, S.; Ückert, A.-K.; Spreng, A.-S.; Eberhard, P.; Karreman, C.; Schreiber, F.; Madjar, K.; Rahnenführer, J.; Celardo, I.; Amelio, I.; Leist, M
Opublikowane w: Antioxidants, 2023, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/antiox12010164

Assessing network-based methods in the context of system toxicology

Autorzy: Valls-Margarit J, Piñero J, Füzi B, Cerisier N, Taboureau O, Furlong LI
Opublikowane w: Frontiers in Pharmacology, 2023, ISSN 1663-9812
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1225697

Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation

Autorzy: Spreng AS, Brüll M, Leisner H, Suciu I, Leist M.
Opublikowane w: Human Stem Cells in Disease Modelling, Drug Discovery and Regenerative Medicine, Numer 11(17):2644, 25 August 2022, 2022, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11172644

Use of metabolic glycoengineering and pharmacological inhibitors to assess lipid and protein sialylation on cells.

Autorzy: Kranaster P, Blum J, Dold JEGA, Wittmann V, Leist M.
Opublikowane w: Neurochem, 2022, ISSN 1613-4125
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1111/jnc.15737

Osmolar Modulation Drives Reversible Cell Cycle Exit and Human Pluripotent Cell Differentiation via NF-κВ and WNT Signaling

Autorzy: Jonathan Sai-Hong Chui , Teresa Izuel-Idoype , Alessandra Qualizza , Rita Pires de Almeida , Lindsey Piessens , Bernard K van der Veer , Gert Vanmarcke , Aneta Malesa , Paraskevi Athanasouli , Ruben Boon , Joris Vriens , Leo van Grunsven , Kian Peng Koh , Catherine M Verfaillie , Frederic Lluis
Opublikowane w: Advanced Science, 2024, ISSN 2198-3844
Wydawca: Wiley Online Library
DOI: 10.1002/advs.202307554

Uncertainty assessment of proarrhythmia predictions derived from multi‑level in silico models

Autorzy: Kopańska K, Rodríguez-Belenguer P, Llopis-Lorente J, Trenor B, Saiz J, Pastor M.
Opublikowane w: Archives of Toxicology, 2023, ISSN 0340-5761
Wydawca: Springer Verlag
DOI: 10.1007/s00204-023-03557-6

Assessment of Drug-Induced Liver Injury through Cell Morphology and Gene Expression Analysisand Gene Expression Analysis

Autorzy: Lejal V, Cerisier N, Rouquié D, Taboureau O.
Opublikowane w: Chemical Research in Toxicology, 2023, ISSN 0893-228X
Wydawca: American Chemical Society
DOI: 10.1021/acs.chemrestox.2c00381

On the Usefulness of Animals as a Model System (Part II): Considering Benefits within Distinct Use Domains

Autorzy: G. Pallocca, M. Leist
Opublikowane w: ALTEX- Alternatives to Animal Experimentation, Numer 39(3), 20 July 2022, 2022, ISSN 1868-8551
Wydawca: Springer Spektrum
DOI: 10.14573/altex.2207111

Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation

Autorzy: Scheibe C, Karreman C, Schildknecht S, Leist M, Hauser K.
Opublikowane w: Biomolecules, Numer 11(8): 1067, Aug 2021, 2021, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom11081067

G × E interactions as a basis for toxicological uncertainty

Autorzy: Suciu I, Pamies D, Peruzzo R, Wirtz PH, Smirnova L, Pallocca G, Hauck C, Cronin MTD, Hengstler JG, Brunner T, Hartung T, Amelio I, Leist M.
Opublikowane w: Archives of Toxicology, 2023, ISSN 0340-5761
Wydawca: Springer Verlag
DOI: 10.1007/s00204-023-03500-9

Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test

Autorzy: Cherianidou A, Seidel F, Kappenberg F, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG.
Opublikowane w: Chemical Research in Toxicology, 2022, ISSN 0002-7863
Wydawca: American Chemical Society
DOI: 10.1021/acs.chemrestox.1c00392

Revolutionizing Developmental Neurotoxicity Testing – A Journey from Animal Models to Advanced In Vitro Systems

Autorzy: Smirnova L, Hogberg HT, Leist M, Hartung T
Opublikowane w: ALTEX, 2024, ISSN 1868-596X
Wydawca: Springer
DOI: 10.14573/altex.2403281

A continuous in silico learning strategy to identify safety liabilities in compounds used in the leather and textile industry

Autorzy: March-Vila E, Ferretti G, Terricabras E, Ardao I, Brea JM, Varela MJ, Arana Á, Rubiolo JA, Sanz F, Loza MI, Sánchez L, Alonso H, Pastor M
Opublikowane w: Archives of Toxicology, 2023, ISSN 1432-0738
Wydawca: Springer
DOI: 10.1007/s00204-023-03459-7

Non-peer reviewed articles (2)

Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0

Autorzy: Pamies D, Leist M, Coecke S, Bowe G, Allen DG, Gstraunthaler G, Bal-Price A, Pistollato F, de Vries RBM, Hogberg HT, Hartung T, Stacey G.
Opublikowane w: ALTEX, Numer 39:30-70, 2022, ISSN 1868-8551
Wydawca: Springer Spektrum
DOI: 10.14573/altex.2111011

On the usefulness of animals as a model system (part I): Overview of criteria and focus on robustness

Autorzy: Pallocca G., Rovida C., Leist M
Opublikowane w: ALTEX, Numer 2022;39(2):347-353, 2022, ISSN 2193-1801
Wydawca: Springer Science and Business Media Deutschland GmbH
DOI: 10.14573/altex.2203291

Conference proceedings (1)

Status of quantifying adverse outcome pathways to support next generation risk assessment

Autorzy: M Cronin, S Belfield, S Enoch, J Firman, Judith Madden, N Spinu
Opublikowane w: Altex Proceedings, 2023, ISSN 2194-0479
Wydawca: Springer Spektrum
DOI: 10.58847/ap.2302