RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Genomic and proteomic biomarker landscape in clinical trials

Autorzy: Piñero J, Rodriguez Fraga PS, Valls-Margarit J, Ronzano F, Accuosto P, Lambea
Opublikowane w: Computational and structural biotechnology journal, 2023, ISSN 2001-0370
Wydawca: Elsevier
DOI: 10.1016/j.csbj.2023.03.014

SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp® simulator

Autorzy: Khalidi H, Onasanwo A, Islam B, Jo H, Fisher C, Aidley R, Gardner I, Bois FY.
Opublikowane w: Frontiers in Pharmacology, Numer 25 August 2022, 2022, ISSN 1663-9812
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.929200

Acceptance criteria for new approach methods in toxicology and human health-relevant life science research – part I

Autorzy: Holzer, A.-K., Dreser, N., Pallocca, G., Mangerich, A., Stacey, G., Dipalo, M., van de Water, B., Rovida, C., Wirtz, P. H., van Vugt, B., Panzarella, G., Hartung, T., Terron, A., Mangas, I., Herzler, M., Marx-Stoelting, P., Coecke, S. and Leist, M.
Opublikowane w: ALTEX, 2023, ISSN 1868-596X
Wydawca: Springer
DOI: 10.14573/altex.2310021

Advancing transcriptomics-based mechanistic assessment of nephrotoxicity in vitro using the human RPTEC/TERT1 TXG-MAPr gene co-expression network

Autorzy: Hugo W van Kessel, Steven J Kunnen, Giulia Callegaro, Bob van de Water
Opublikowane w: Toxicological Sciences, Numer 209, 2026, ISSN 1096-6080
Wydawca: Oxford University Press
DOI: 10.1093/toxsci/kfaf159

AOP-informed qIVIVE modelling for liver steatosis using triazoles

Autorzy: A.M. Steinbach, C.T. Willenbockel, P. Marx-Stoelting, M.T.D. Cronin, V. Städele
Opublikowane w: Computational Toxicology, Numer 36, 2026, Strona(/y) 100382, ISSN 2468-1113
Wydawca: Elsevier BV
DOI: 10.1016/j.comtox.2025.100382

Computational Strategies for Assessing Adverse Outcome Pathways: Hepatic Steatosis as a Case Study

Autorzy: Ortega-Vallbona, R.; Palomino-Schätzlein, M.; Tolosa, L.; Benfenati, E.; Ecker, G.F.; Gozalbes, R.; Serrano-Candelas, E.
Opublikowane w: International Journal of Molecular Sciences, 2024, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)

Nutrient environment improves drug metabolic activity in human iPSC-derived hepatocytes and HepG2

Autorzy: Victoria Pozo Garcia, Tuğçe S. Çobanoğlu, Helen Sophie Hammer, Rita Carlota, Kasper Holm, Catherine Verfaillie, Oliver Poetz, Paul Jennings, Sofia Moco
Opublikowane w: Archives of Toxicology, Numer 99, 2025, Strona(/y) 4493-4511, ISSN 0340-5761
Wydawca: Springer Verlag
DOI: 10.1007/s00204-025-04139-4

Assessment of pulmonary fibrosis using weighted gene co-expression network analysis

Autorzy: Christina Drake, Walter Zobl, Sylvia E. Escher
Opublikowane w: Frontiers in Toxicology, Numer 6, 2024, ISSN 2673-3080
Wydawca: Frontiers Media SA
DOI: 10.3389/ftox.2024.1465704

Testing Strategies for Metabolite-Mediated Neurotoxicity

Autorzy: Julian Suess, Moritz Reinmoeller, Viktoria Magel, Baiba Gukalova, Edgars Liepinsh, Iain Gardner, Nadine Dreser, Anna-Katharina Holzer, Marcel Leist
Opublikowane w: International Journal of Molecular Sciences, Numer 26, 2025, Strona(/y) 8338, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26178338

Cell morphology and gene expression: tracking changes and complementarity across time and cell lines

Autorzy: Vanille Lejal, David Rouquié, Olivier Taboureau
Opublikowane w: Toxicology and Applied Pharmacology, Numer 504, 2025, Strona(/y) 117530, ISSN 0041-008X
Wydawca: Academic Press
DOI: 10.1016/j.taap.2025.117530

Utilizing rat kidney gene co-expression networks to enhance safety assessment biomarker identification and human translation

Autorzy: Steven J. Kunnen, Giulia Callegaro, Jeffrey J. Sutherland, Panuwat Trairatphisan, Hugo W. van Kessel, Lukas S. Wijaya, Git Chung, Keith Pye, Keith M. Goldstein, Claire R. Teague, Ciaran P. Fisher, Julio Saez-Rodriguez, Colin Brown, Susan A. Elmore, Kathleen M. Heinz-Taheny, James L. Stevens, Bob van de Water
Opublikowane w: iScience, Numer 28, 2025, Strona(/y) 112978, ISSN 2589-0042
Wydawca: Elsevier BV
DOI: 10.1016/j.isci.2025.112978

Interdependency of estradiol-mediated ERα activation and subsequent PR and GREB1 induction to control cell cycle progression

Autorzy: M.M. Heldring, B. Duijndam, A. Kyriakidou, O.M. van der Meer, M. Tedeschi, J.W. van der Laan, B. van de Water, J.B. Beltman
Opublikowane w: Heliyon, Numer 10, 2025, Strona(/y) e38406, ISSN 2405-8440
Wydawca: Elsevier BV
DOI: 10.1016/j.heliyon.2024.e38406

Refining Drug-Induced Cholestasis Prediction: An Explainable Consensus Model Integrating Chemical and Biological Fingerprints

Autorzy: Palle S. Helmke, Gerhard F. Ecker
Opublikowane w: Journal of Chemical Information and Modeling, Numer 65, 2025, Strona(/y) 5301-5316, ISSN 1549-9596
Wydawca: American Chemical Society
DOI: 10.1021/acs.jcim.4c02363

A perfused iPSC-derived proximal tubule model for predicting drug-induced kidney injury

Autorzy: Michelle Lechtenberg, Coraline Chéneau, Kevin Riquin, Leopold Koenig, Carlos Mota, Franck Halary, Eva-Maria Dehne
Opublikowane w: Toxicology in Vitro, Numer 105, 2025, Strona(/y) 106038, ISSN 0887-2333
Wydawca: Elsevier BV
DOI: 10.1016/j.tiv.2025.106038

An Adverse Outcome Pathway Network for Chemically Induced Oxidative Stress Leading to (Non)genotoxic Carcinogenesis

Autorzy: Christina H. J. Veltman; Jeroen L. A. Pennings; Bob van de Water; Mirjam Luijten
Opublikowane w: Chemical Research in Toxicology, Numer 3, 2023, ISSN 0893-228X
Wydawca: American Chemical Society
DOI: 10.1021/acs.chemrestox.2c00396

Developmental neurotoxicity (DNT): A call for implementation of new approach methodologies for regulatory purposes: Summary of the 5th International Conference on DNT Testing

Autorzy: Ivana Celardo, Michael Aschner, Randolph S. Ashton, Kelly E. Carstens, Andrea Cediel-Ulloa, Eike Cöllen, Kevin M. Crofton, Susan J. Debad, Nadine Dreser, Suzanne Fitzpatrick, Ellen Fritsche, Sebastian Gutsfeld, Barry Hardy, Thomas Hartung, Ellen Hessel, Harm Heusinkveld, Helena T. Hogberg, Jui-Hua Hsieh, Yasunari Kanda, Gavin T. Knight, Thomas Knudsen, Katharina Koch, Eliska Kuchovska, Iris Manga
Opublikowane w: ALTEX, Numer 42, 2025, ISSN 1868-596X
Wydawca: ALTEX Edition
DOI: 10.14573/altex.2503191

Generation of Human Nociceptor-Enriched Sensory Neurons for the Study of Pain-Related Dysfunctions

Autorzy: Holzer, A. K., Karreman, C., Suciu, I., Furmanowsky, L. S., Wohlfarth, H., Loser, D., Dirks, W. G., Pardo González, E., and Leist, M.
Opublikowane w: Stem Cells Transl Med., Numer 11(7), July 2022, 2022, Strona(/y) 727–741, ISSN 0029-3970
Wydawca: Oxford University Press
DOI: 10.1093/stcltm/szac031

A framework for chemical safety assessment incorporating new approach methodologies within REACH

Autorzy: Ball N, Bars R, Botham PA, Cuciureanu A, Cronin MTD, Doe JE, Dudzina T, Gant TW, Leist M, van Ravenzwaay B
Opublikowane w: Arch Toxicol., 2022, ISSN 2193-1801
Wydawca: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-021-03215-9

Preparation of Viable Human Neurites for Neurobiological and Neurodegeneration Studies

Autorzy: Brüll M, Geese N, CelardoI, Laumann M, Leist M
Opublikowane w: Cells, 2024, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells13030242

Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective

Autorzy: Pallocca G., Moné J. M., Kamp H., Luijten M., van de Water B., Leist M.
Opublikowane w: Altex, Numer 39 (2), 7 April 2022, 2022, ISSN 2193-1801
Wydawca: Springer Science and Business Media Deutschland GmbH
DOI: 10.14573/altex.2204051

Chemical and Biological Mechanisms Relevant to the Rescue of MG-132-Treated Neurons by Cysteine

Autorzy: Anna-Katharina Ückert, Ilinca Suciu, Anja Land, Anna-Sophie Spreng, Hannah Welte, Doreen Herzog, Michael Basler, Marcel Leist
Opublikowane w: Antioxidants, Numer 14, 2025, Strona(/y) 128, ISSN 2076-3921
Wydawca: MDPI AG
DOI: 10.3390/antiox14020128

Modeling ferroptosis in human dopaminergic neurons: pitfalls and opportunities for neurodegeneration research

Autorzy: Renner N, Schöb F, Pape R, Suciu I, Spreng AS, Ückert AK, Cöllen E, Bovio F, Chilian B, Bauere J, Röpcke S, Bergemann J, Leist M, Schildknecht S
Opublikowane w: Redox Biology, 2024, ISSN 2213-2317
Wydawca: Elsevier BV
DOI: 10.1016/j.redox.2024.103165

Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays

Autorzy: Dolde X, Karreman C, Wiechers M, Schildknecht S, Leist M
Opublikowane w: International Journal of Molecular Sciences, Numer 22(18):10079, 2021, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221810079

Bioactivity descriptors for in vivo toxicity prediction: now and the future

Autorzy: Helmke P, Füzi B, Ecker GF
Opublikowane w: Expert Opinion on Drug Metabolism & Toxicology, 2024, ISSN 1742-5255
Wydawca: Ashley Publications Ltd.
DOI: 10.1080/17425255.2024.2334308

Qualitative and quantitative concentration-response modelling of gene co-expression networks to unlock hepatotoxic mechanisms for next generation chemical safety assessment.

Autorzy: Kunnen SJ, Arnesdotter E, Willenbockel CT, Vinken M, van de Water B
Opublikowane w: ALTEX, 2024, ISSN 1868-596X
Wydawca: Springer
DOI: 10.14573/altex.2309201

Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing

Autorzy: Cöllen E, Bartmann K, Blum J, Carstens K, Celardo I, Chatterjee N, Corvaro M, Dreser N, Fritsche E, Hartung T, Hogberg HT, Knudsen T, Koch K, Kreutz A, Lislien M, Magel V, Marty MS, Pallocca G, Bal-Price A, Rovida C, Sachana M, Shafer TJ, Smirnova L, Suciu I, Tanaskov Y, Tangianu S, Wolfbeisz C, Leist M.
Opublikowane w: ALTEX, Numer 42, 2025, ISSN 1868-596X
Wydawca: ALTEX Edition
DOI: 10.14573/altex.2501091

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

Autorzy: van der Stel W, Yang H, Vrijenhoek NG, Schimming JP, Callegaro G, Carta G, Darici S, Delp J, Forsby A, White A, le Dévédec S, Leist M, Jennings P, Beltman JB, van de Water B, Danen EHJ
Opublikowane w: Archives of Toxicology, Numer 96(1), January 2022, 2022, ISSN 1868-8551
Wydawca: Springer-Spektrum
DOI: 10.1007/s00204-021-03160-7

Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro

Autorzy: Holzer, Anna-Katharina, Ilinca Suciu, Christiaan Karreman, Thomas Goj, and Marcel Leist
Opublikowane w: International Journal of Molecular Sciences, Numer 23(7), 29 March 2022, 2022, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073734

An Alternative Safety Profiling Algorithm (ASPA) to transform next generation risk assessment into a structured and transparent process

Autorzy: Leist M, Tangianu S, Affourtit F, Braakhuis H, Colbourne J, Cöllen E, Dreser N, Escher SE, Gardner I, Hahn S, Hardy B, Herzler M, Islam B, Kamp H, Magel V, Marx-Stoelting P, Moné MJ, Lundquist P, Ottenbros I, Ouedraogo G, Pallocca G, van de Water B, Vinken M, White A, Pastor M, Luijten M.
Opublikowane w: ALTEX, Numer 26, 2025, ISSN 1868-596X
Wydawca: ALTEX Edition
DOI: 10.14573/altex.2509081

New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project

Autorzy: Tal T, Myhre O, Fritsche E, Rüegg J, Craenen K, Aiello K, Agrillo C, Babin PJ, Escher BI, Dirven H, Hellsten K, Dolva K, Heusinkveld H, Hadzhiev Y, Hurem S, Jagiełło K, Judzinska B, Klüver N, Knoll-Gellida A, Kühne BA, Leist M, Lislien M, Lyche JL, Müller F, Neuhaus W, Pallocca G, Seeger B, Scharkin I, Scholz S, Spjuth O, Torres-Ruiz M, Bartmann K
Opublikowane w: Frontiers in Toxicology, 2024, ISSN 2673-3080
Wydawca: Frontiers
DOI: 10.3389/ftox.2024.1359507

A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury

Autorzy: Lukas S Wijaya, Attila Gabor, Iris E Pot, Luca van de Have, Julio Saez-Rodriguez, James L Stevens, Sylvia E Le Dévédec, Giulia Callegaro, Bob van de Water
Opublikowane w: Toxicological Sciences, Numer 198, 2024, Strona(/y) 14-30, ISSN 1096-6080
Wydawca: Oxford University Press
DOI: 10.1093/toxsci/kfad121

Development of an adverse outcome pathway network for nephrotoxicity

Autorzy: Barnes DA, Firman JW, Belfield SJ, Cronin MTD, Vinken M, Janssen MJ, Masereeuw R
Opublikowane w: Archives of Toxicology, 2024, ISSN 0340-5761
Wydawca: Springer Verlag
DOI: 10.1007/s00204-023-03637-7

Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare

Autorzy: Marx U, Beken S, Chen Z, Dehne EM, Doherty A, Ewart L, Fitzpatrick SC, Griffith LG, Gu Z, Hartung T, Hickman J, Ingber DE, Ishida S, Jeong J, Leist M, Levin L, Mendrick DL, Pallocca G, Platz S, Raschke M, Smirnova L, Tagle DA, Trapecar M, van Balkom BWM, van den Eijnden-van Raaij J, van der Meer A, Roth A.
Opublikowane w: ALTEX, Numer 42, 2025, ISSN 1868-596X
Wydawca: ALTEX Edition
DOI: 10.14573/altex.2410112

Current Status and Challenges of Human Induced Pluripotent Stem Cell-Derived Liver Models in Drug Discovery

Autorzy: Tricot T, Verfaillie C, Kumar M
Opublikowane w: Cells, Numer january 27, 2022; 11: 442, 2022, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11030442

Inhibition of Neural Crest Cell Migration by Strobilurin Fungicides and Other Mitochondrial Toxicants

Autorzy: Viktoria Magel, Jonathan Blum, Xenia Dolde, Heidrun Leisner, Karin Grillberger, Hiba Khalidi, Iain Gardner, Gerhard F. Ecker, Giorgia Pallocca, Nadine Dreser, Marcel Leist
Opublikowane w: Cells, Numer 13, 2025, Strona(/y) 2057, ISSN 2073-4409
Wydawca: MDPI AG
DOI: 10.3390/cells13242057

Interdisciplinary risks – a delicate balance between trust and critical review

Autorzy: Ullrika Sahlin, Henrik Thorén
Opublikowane w: Journal of Risk Research, Numer 28, 2025, Strona(/y) 197-202, ISSN 1366-9877
Wydawca: Carfax Publishing Ltd.
DOI: 10.1080/13669877.2025.2526473

Differential Responses of Human iPSC-Derived Microglia to Stimulation with Diverse Inflammogens

Autorzy: Chiara Wolfbeisz, Julian Suess, Nadine Dreser, Heidrun Leisner, Markus Brüll, Madeleine Fandrich, Nicole Schneiderhan-Marra, Oliver Poetz, Thomas Hartung, Marcel Leist
Opublikowane w: Cells, Numer 14, 2025, Strona(/y) 1687, ISSN 2073-4409
Wydawca: MDPI AG
DOI: 10.3390/cells14211687

Definition of the Neurotoxicity-Associated Metabolic Signature Triggered by Berberine and Other Respiratory Chain Inhibitors

Autorzy: Suciu I, Delp J, Gutbier S, Suess J, Henschke L, Celardo I, Mayer TU, Amelio I, Leist M.
Opublikowane w: Antioxidants, 2023, ISSN 2076-3921
Wydawca: MPDI
DOI: 10.3390/antiox13010049

Computational Strategies for Assessing Adverse Outcome Pathways: Hepatic Steatosis as a Case Study

Autorzy: Rita Ortega-Vallbona, Martina Palomino-Schätzlein, Laia Tolosa, Emilio Benfenati, Gerhard F. Ecker, Rafael Gozalbes, Eva Serrano-Candelas
Opublikowane w: International Journal of Molecular Sciences, Numer 25, 2025, Strona(/y) 11154, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms252011154

Integrating human exposome data into next-generation risk assessment: a systematic framework to infer real-life exposure levels and prioritize chemical compounds for testing

Autorzy: Yifeng Dai, Bob van de Water, Jaione Telleria, Laura I. Furlong, Roel C.H. Vermeulen, Jelle Vlaanderen
Opublikowane w: Environment International, Numer 208, 2026, Strona(/y) 110110, ISSN 0160-4120
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2026.110110

Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals

Autorzy: Blum J, Masjosthusmann S, Bartmann K, Bendt F, Dolde X, Dönmez A, Förster N, Holzer AK, Hübenthal U, Keßel HE, Kilic S, Klose J, Pahl M, Stürzl LC, Mangas I, Terron A, Crofton KM, Scholze M, Mosig A, Leist M, Fritsche E.
Opublikowane w: Chemosphere, Numer 31;311(Pt 2):137035, 2022, ISSN 1879-1298
Wydawca: Elsevier
DOI: 10.1016/j.chemosphere.2022.137035

MolCompass: multi-tool for the navigation in chemical space and visual validation of QSAR/QSPR models

Autorzy: Sergey Sosnin
Opublikowane w: Journal of Cheminformatics, 2024, ISSN 1758-2946
Wydawca: Chemistry Central

Organobodies: A robust and size-controllable system for generating scalable hiPSC-derived liver organoids for drug toxicity screening

Autorzy: Mostafa Kiamehr, Stefano Manzini, Burak Toprakhisar, Rodrigo F. Madeiro da Costa, Guillem García-Llorens, Birhanu Belay, Mustapha Najimi, José V Castell, Wolfgang Moritz, Giulia Chiesa, Katriina Aalto-Setälä, Catherine Verfaillie
Opublikowane w: Bioarchives, 2026, ISSN 2692-8205
Wydawca: openRxiv
DOI: 10.1101/2025.10.20.683433

Recommendations on fit-for-purpose criteria to establish quality managementfor microphysiological systems and for monitoring their reproducibility

Autorzy: David Pamies,Jason Ekert,Marie-Gabrielle Zurich,Olivier Frey,Sophie Werner,Monica Piergiovanni,Benjamin S. Freedman,Adrian Kee Keong Teo,Hendrik Erfurth,Darwin R. Reyes,Peter Loskill,Pelin Candarlioglu,Laura Suter-Dick,Shan Wang,Thomas Hartung,Sandra Coecke,Glyn N. Stacey,Beren Atac Wagegg,Eva-Maria Dehne,Francesca Pistollato,Marcel Leist
Opublikowane w: Stem cell Reports, 2024, ISSN 2213-6711
Wydawca: Cell Press
DOI: 10.1016/j.stemcr.2024.03.009

The predictivity of QSARs for toxicity: Recommendations for improving model performance

Autorzy: Mark T.D. Cronin, Homa Basiri, Georgios Chrysochoou, Steven J. Enoch, James W. Firman, Nicoleta Spînu, Judith C. Madden
Opublikowane w: Computational Toxicology, Numer 33, 2025, Strona(/y) 100338, ISSN 2468-1113
Wydawca: Elsevier BV
DOI: 10.1016/j.comtox.2024.100338

Prediction of adverse drug reactions due to genetic predisposition using deep neural networks

Autorzy: Dafniet B & Taboureau O.
Opublikowane w: Molecular Informatics, 2024, ISSN 1868-1751
Wydawca: Wiley
DOI: 10.1002/minf.202400021

Elements and development processes for test methods in toxicology and human health-relevant life science research

Autorzy: Cöllen E, Tanaskov Y, Holzer AK, Dipalo M, Schäfer J, Kraushaar U, Leist M
Opublikowane w: ALTEX, 2024, ISSN 1868-596X
Wydawca: Springer
DOI: 10.14573/altex.2401041

Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment

Autorzy: Jaklin M, Zhang JD, Schäfer N, Clemann N, Barrow P, Küng E, Sach-Peltason L, McGinnis C, Leist M, Kustermann S.
Opublikowane w: Toxicological Sciences, Numer 188(1):17-33, 2022, ISSN 0029-3970
Wydawca: Oxford University Press
DOI: 10.1093/toxsci/kfac046

Identifying human toxicodynamic variability: A systematic evidence map of the current knowledge

Autorzy: Annika Boye Petersen, Lea Bredsdorff, Natasha Tahir, Marije Niemeijer, George E.N. Kass, Aiste Vitkauskaite, Matthijs Moerland, Frederic Y. Bois, Nadia Quignot, Bob van de Water, Susanne Hougaard Bennekou
Opublikowane w: Regulatory Toxicology and Pharmacology, Numer 161, 2025, Strona(/y) 105842, ISSN 0273-2300
Wydawca: Academic Press
DOI: 10.1016/j.yrtph.2025.105842

Integrating Mechanistic and Toxicokinetic Information in Predictive Models of Cholestasis

Autorzy: Pablo Rodríguez-BelenguerVictor Mangas-SanjuanEmilio Soria-OlivasManuel Pastor*
Opublikowane w: Journal of Chemical Information and Modeling, 2023, ISSN 1549-9596
Wydawca: American Chemical Society
DOI: 10.1021/acs.jcim.3c00945

Usage of model combination in computational toxicology

Autorzy: Rodríguez-Belenguer, P., March-Vila, E., Pastor, M., Mangas-Sanjuan, V., & Soria-Olivas, E
Opublikowane w: Toxicology Letters, 2023, ISSN 0378-4274
Wydawca: Elsevier BV
DOI: 10.1016/j.toxlet.2023.10.013

Moving towards making (quantitative) structure-activity relationships ((Q)SARs) for toxicity-related endpoints findable, accessible, interoperable and reusable (FAIR)

Autorzy: Belfield SJ, Basiri H, Swapnil C, Chrysochoou G, Enoch SJ, Firman JW, Gomatam A, Hardy B, Helmke PS, Madden JC, Maran U, March-Vila E, Nikolov NG, Pastor M, Piir G, Sild S, Smajić A, Spînu N, Wedebye EB, Cronin MTD
Opublikowane w: ALTEX, 2025, ISSN 1868-596X
Wydawca: ALTEX Edition
DOI: 10.14573/altex.2411161

Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson’s Disease

Autorzy: Carecho R, Figueira I, Terrasso AP, Godinho-Pereira J, de Oliveira Sequeira C, Pereira SA, Milenkovic D, Leist M, Brito C, Nunes Dos Santos C.
Opublikowane w: Mol. Nutr. Food Res., Numer 29 December 2021, 2021, ISSN 1613-4125
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.202100959

The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability

Autorzy: Vlasveld M, Callegaro G, Fisher C, Eakins J, Walker P, Lok S, van Oost S, de Jong B, Pellegrino-Coppola D, Burger G, Wink S, van de Water B.
Opublikowane w: Liver International, 2024, ISSN 1478-3231
Wydawca: John Wiley & Sons
DOI: 10.1111/liv.15822

Trust your gut: Establishing confidence in gastrointestinal models - An overview of the state of the science and contexts of use

Autorzy: Susan Debad, David Allen, Omari Bandele, Colin Bishop, Michaela Blaylock, Paul Brown, Maureen K. Bunger, Julia Y. Co, Lynn Crosby, Amber B. Daniel, Steve S. Ferguson, Kevin Ford, Gonçalo Gamboa da Costa, Kristin H. Gilchrist, Matthew W. Grogg, Maureen Gwinn, Thomas Hartung , Simon P. Hogan, Ye Eun Jeong, George E. N. Kass, Elaina Kenyon, Nicole C. Kleinstreuer, Ville Kujala, Patrik Lundquist, Jo
Opublikowane w: ALTEX, 2024, ISSN 1868-596X
Wydawca: Springer
DOI: 10.14573/altex.2403261

Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses

Autorzy: Ter Braak B, Klip JE, Wink S, Hiemstra S, Cooper SL, Middleton A, White A, van de Water B
Opublikowane w: Toxicology In Vitro, 2022, ISSN 1879-1298
Wydawca: Elsevier
DOI: 10.1016/j.tiv.2022.105419

REACH out-numbered! The future of REACH and animal numbers.

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Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation

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