RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs

Publikacje

SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp® simulator

Autorzy: Khalidi H, Onasanwo A, Islam B, Jo H, Fisher C, Aidley R, Gardner I, Bois FY.
Opublikowane w: Frontiers in Pharmacology, Numer 25 August 2022, 2022, ISSN 1663-9812
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.929200

Generation of Human Nociceptor-Enriched Sensory Neurons for the Study of Pain-Related Dysfunctions

Autorzy: Holzer, A. K., Karreman, C., Suciu, I., Furmanowsky, L. S., Wohlfarth, H., Loser, D., Dirks, W. G., Pardo González, E., and Leist, M.
Opublikowane w: Stem Cells Transl Med., Numer 11(7), July 2022, 2022, Strona(/y) 727–741, ISSN 0029-3970
Wydawca: Oxford University Press
DOI: 10.1093/stcltm/szac031

A framework for chemical safety assessment incorporating new approach methodologies within REACH

Autorzy: Ball N, Bars R, Botham PA, Cuciureanu A, Cronin MTD, Doe JE, Dudzina T, Gant TW, Leist M, van Ravenzwaay B
Opublikowane w: Arch Toxicol., 2022, ISSN 2193-1801
Wydawca: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-021-03215-9

Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective

Autorzy: Pallocca G., Moné J. M., Kamp H., Luijten M., van de Water B., Leist M.
Opublikowane w: Altex, Numer 39 (2), 7 April 2022, 2022, ISSN 2193-1801
Wydawca: Springer Science and Business Media Deutschland GmbH
DOI: 10.14573/altex.2204051

Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays

Autorzy: Dolde X, Karreman C, Wiechers M, Schildknecht S, Leist M
Opublikowane w: International Journal of Molecular Sciences, Numer 22(18):10079, 2021, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221810079

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

Autorzy: van der Stel W, Yang H, Vrijenhoek NG, Schimming JP, Callegaro G, Carta G, Darici S, Delp J, Forsby A, White A, le Dévédec S, Leist M, Jennings P, Beltman JB, van de Water B, Danen EHJ
Opublikowane w: Archives of Toxicology, Numer 96(1), January 2022, 2022, ISSN 1868-8551
Wydawca: Springer-Spektrum
DOI: 10.1007/s00204-021-03160-7

Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro

Autorzy: Holzer, Anna-Katharina, Ilinca Suciu, Christiaan Karreman, Thomas Goj, and Marcel Leist
Opublikowane w: International Journal of Molecular Sciences, Numer 23(7), 29 March 2022, 2022, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073734

Current Status and Challenges of Human Induced Pluripotent Stem Cell-Derived Liver Models in Drug Discovery

Autorzy: Tricot T, Verfaillie C, Kumar M
Opublikowane w: Cells, Numer january 27, 2022; 11: 442, 2022, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11030442

Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals

Autorzy: Blum J, Masjosthusmann S, Bartmann K, Bendt F, Dolde X, Dönmez A, Förster N, Holzer AK, Hübenthal U, Keßel HE, Kilic S, Klose J, Pahl M, Stürzl LC, Mangas I, Terron A, Crofton KM, Scholze M, Mosig A, Leist M, Fritsche E.
Opublikowane w: Chemosphere, Numer 31;311(Pt 2):137035, 2022, ISSN 1879-1298
Wydawca: Elsevier
DOI: 10.1016/j.chemosphere.2022.137035

Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment

Autorzy: Jaklin M, Zhang JD, Schäfer N, Clemann N, Barrow P, Küng E, Sach-Peltason L, McGinnis C, Leist M, Kustermann S.
Opublikowane w: Toxicological Sciences, Numer 188(1):17-33, 2022, ISSN 0029-3970
Wydawca: Oxford University Press
DOI: 10.1093/toxsci/kfac046

Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson’s Disease

Autorzy: Carecho R, Figueira I, Terrasso AP, Godinho-Pereira J, de Oliveira Sequeira C, Pereira SA, Milenkovic D, Leist M, Brito C, Nunes Dos Santos C.
Opublikowane w: Mol. Nutr. Food Res., Numer 29 December 2021, 2021, ISSN 1613-4125
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.202100959

Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses

Autorzy: Ter Braak B, Klip JE, Wink S, Hiemstra S, Cooper SL, Middleton A, White A, van de Water B
Opublikowane w: Toxicology In Vitro, 2022, ISSN 1879-1298
Wydawca: Elsevier
DOI: 10.1016/j.tiv.2022.105419

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

Autorzy: Loser D, Grillberger K, Hinojosa MG, Blum J, Haufe Y, Danker T, Johansson Y, Möller C, Nicke A, Bennekou SH, Gardner I, Bauch C, Walker P, Forsby A, Ecker GF, Kraushaar U, Leist M.
Opublikowane w: Arch Toxicol, Numer 95(12).3695-3716, 2021, ISSN 2193-1801
Wydawca: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-021-03168-z

Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models

Autorzy: Capinha L, Zhang Y, Holzer AK, Ückert AK, Zana M, Carta G, Murphy C, Baldovini J, Mazidi Z, Grillari J, Dinnyes A, van de Water B, Leist M, Commandeur JNM, Jennings P
Opublikowane w: Archives of Toxicology, 2023, ISSN 2193-1801
Wydawca: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-022-03436-6

Studying Metabolism by NMR-Based Metabolomics

Autorzy: Sofia Moco
Opublikowane w: Frontiers Molecular Biosciences, Numer 9:882487, 2022, 2022, ISSN 1663-9812
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fmolb.2022.882487

Metabolic regulation by p53 prevents R-loop-associated genomic instability

Autorzy: Emanuele Panatta, Alessio Butera, Eleonora Mammarella, Consuelo Pitolli, Alessandro Mauriello, Marcel Leist, Richard A. Knight, Gerry Melino, Ivano Amelio
Opublikowane w: Cell Reports, Numer Volume 41, Numer 5, 1 November 2022, 2022, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2022.111568

High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation

Autorzy: Seidel F, Cherianidou A, Kappenberg F, Marta M, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Scholtz-Illigens A, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG.
Opublikowane w: Cells, Numer 11(21):3404, 2022, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11213404

Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons

Autorzy: Suciu, I.; Delp, J.; Gutbier, S.; Ückert, A.-K.; Spreng, A.-S.; Eberhard, P.; Karreman, C.; Schreiber, F.; Madjar, K.; Rahnenführer, J.; Celardo, I.; Amelio, I.; Leist, M
Opublikowane w: Antioxidants, 2023, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/antiox12010164

Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation

Autorzy: Spreng AS, Brüll M, Leisner H, Suciu I, Leist M.
Opublikowane w: Human Stem Cells in Disease Modelling, Drug Discovery and Regenerative Medicine, Numer 11(17):2644, 25 August 2022, 2022, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11172644

Use of metabolic glycoengineering and pharmacological inhibitors to assess lipid and protein sialylation on cells.

Autorzy: Kranaster P, Blum J, Dold JEGA, Wittmann V, Leist M.
Opublikowane w: Neurochem, 2022, ISSN 1613-4125
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1111/jnc.15737

Large-scale perfused tissues via synthetic 3D soft microfluidics

Autorzy: Grebenyuk S, Abdel Fattah AR, Kumar M, Toprakhisar B, Rustandi G, Vananroye A, Salmon I, Verfaillie C, Grillo M, Ranga A
Opublikowane w: Nat Commun, 2023, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-022-35619-1

On the Usefulness of Animals as a Model System (Part II): Considering Benefits within Distinct Use Domains

Autorzy: G. Pallocca, M. Leist
Opublikowane w: ALTEX- Alternatives to Animal Experimentation, Numer 39(3), 20 July 2022, 2022, ISSN 1868-8551
Wydawca: Springer Spektrum
DOI: 10.14573/altex.2207111

Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation

Autorzy: Scheibe C, Karreman C, Schildknecht S, Leist M, Hauser K.
Opublikowane w: Biomolecules, Numer 11(8): 1067, Aug 2021, 2021, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom11081067

Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test

Autorzy: Cherianidou A, Seidel F, Kappenberg F, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG.
Opublikowane w: Chemical Research in Toxicology, 2022, ISSN 0002-7863
Wydawca: American Chemical Society
DOI: 10.1021/acs.chemrestox.1c00392

Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0

Autorzy: Pamies D, Leist M, Coecke S, Bowe G, Allen DG, Gstraunthaler G, Bal-Price A, Pistollato F, de Vries RBM, Hogberg HT, Hartung T, Stacey G.
Opublikowane w: ALTEX, Numer 39:30-70, 2022, ISSN 1868-8551
Wydawca: Springer Spektrum
DOI: 10.14573/altex.2111011

On the usefulness of animals as a model system (part I): Overview of criteria and focus on robustness

Autorzy: Pallocca G., Rovida C., Leist M
Opublikowane w: ALTEX, Numer 2022;39(2):347-353, 2022, ISSN 2193-1801
Wydawca: Springer Science and Business Media Deutschland GmbH
DOI: 10.14573/altex.2203291

Wyszukiwanie danych OpenAIRE...

Publikacje

Udostępnij tę stronę

Pobierz