RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Publications

Genomic and proteomic biomarker landscape in clinical trials

Auteurs: Piñero J, Rodriguez Fraga PS, Valls-Margarit J, Ronzano F, Accuosto P, Lambea
Publié dans: Computational and structural biotechnology journal, 2023, ISSN 2001-0370
Éditeur: Elsevier
DOI: 10.1016/j.csbj.2023.03.014

SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp® simulator

Auteurs: Khalidi H, Onasanwo A, Islam B, Jo H, Fisher C, Aidley R, Gardner I, Bois FY.
Publié dans: Frontiers in Pharmacology, Numéro 25 August 2022, 2022, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.929200

Acceptance criteria for new approach methods in toxicology and human health-relevant life science research – part I

Auteurs: Holzer, A.-K., Dreser, N., Pallocca, G., Mangerich, A., Stacey, G., Dipalo, M., van de Water, B., Rovida, C., Wirtz, P. H., van Vugt, B., Panzarella, G., Hartung, T., Terron, A., Mangas, I., Herzler, M., Marx-Stoelting, P., Coecke, S. and Leist, M.
Publié dans: ALTEX, 2023, ISSN 1868-596X
Éditeur: Springer
DOI: 10.14573/altex.2310021

An Adverse Outcome Pathway Network for Chemically Induced Oxidative Stress Leading to (Non)genotoxic Carcinogenesis

Auteurs: Christina H. J. Veltman; Jeroen L. A. Pennings; Bob van de Water; Mirjam Luijten
Publié dans: Chemical Research in Toxicology, Numéro 3, 2023, ISSN 0893-228X
Éditeur: American Chemical Society
DOI: 10.1021/acs.chemrestox.2c00396

Generation of Human Nociceptor-Enriched Sensory Neurons for the Study of Pain-Related Dysfunctions

Auteurs: Holzer, A. K., Karreman, C., Suciu, I., Furmanowsky, L. S., Wohlfarth, H., Loser, D., Dirks, W. G., Pardo González, E., and Leist, M.
Publié dans: Stem Cells Transl Med., Numéro 11(7), July 2022, 2022, Page(s) 727–741, ISSN 0029-3970
Éditeur: Oxford University Press
DOI: 10.1093/stcltm/szac031

A framework for chemical safety assessment incorporating new approach methodologies within REACH

Auteurs: Ball N, Bars R, Botham PA, Cuciureanu A, Cronin MTD, Doe JE, Dudzina T, Gant TW, Leist M, van Ravenzwaay B
Publié dans: Arch Toxicol., 2022, ISSN 2193-1801
Éditeur: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-021-03215-9

Preparation of Viable Human Neurites for Neurobiological and Neurodegeneration Studies

Auteurs: Brüll M, Geese N, CelardoI, Laumann M, Leist M
Publié dans: Cells, 2024, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells13030242

Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective

Auteurs: Pallocca G., Moné J. M., Kamp H., Luijten M., van de Water B., Leist M.
Publié dans: Altex, Numéro 39 (2), 7 April 2022, 2022, ISSN 2193-1801
Éditeur: Springer Science and Business Media Deutschland GmbH
DOI: 10.14573/altex.2204051

Modeling ferroptosis in human dopaminergic neurons: pitfalls and opportunities for neurodegeneration research

Auteurs: Renner N, Schöb F, Pape R, Suciu I, Spreng AS, Ückert AK, Cöllen E, Bovio F, Chilian B, Bauere J, Röpcke S, Bergemann J, Leist M, Schildknecht S
Publié dans: Redox Biology, 2024, ISSN 2213-2317
Éditeur: Elsevier BV
DOI: 10.1016/j.redox.2024.103165

Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays

Auteurs: Dolde X, Karreman C, Wiechers M, Schildknecht S, Leist M
Publié dans: International Journal of Molecular Sciences, Numéro 22(18):10079, 2021, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221810079

Bioactivity descriptors for in vivo toxicity prediction: now and the future

Auteurs: Helmke P, Füzi B, Ecker GF
Publié dans: Expert Opinion on Drug Metabolism & Toxicology, 2024, ISSN 1742-5255
Éditeur: Ashley Publications Ltd.
DOI: 10.1080/17425255.2024.2334308

Qualitative and quantitative concentration-response modelling of gene co-expression networks to unlock hepatotoxic mechanisms for next generation chemical safety assessment.

Auteurs: Kunnen SJ, Arnesdotter E, Willenbockel CT, Vinken M, van de Water B
Publié dans: ALTEX, 2024, ISSN 1868-596X
Éditeur: Springer
DOI: 10.14573/altex.2309201

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

Auteurs: van der Stel W, Yang H, Vrijenhoek NG, Schimming JP, Callegaro G, Carta G, Darici S, Delp J, Forsby A, White A, le Dévédec S, Leist M, Jennings P, Beltman JB, van de Water B, Danen EHJ
Publié dans: Archives of Toxicology, Numéro 96(1), January 2022, 2022, ISSN 1868-8551
Éditeur: Springer-Spektrum
DOI: 10.1007/s00204-021-03160-7

Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro

Auteurs: Holzer, Anna-Katharina, Ilinca Suciu, Christiaan Karreman, Thomas Goj, and Marcel Leist
Publié dans: International Journal of Molecular Sciences, Numéro 23(7), 29 March 2022, 2022, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073734

New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project

Auteurs: Tal T, Myhre O, Fritsche E, Rüegg J, Craenen K, Aiello K, Agrillo C, Babin PJ, Escher BI, Dirven H, Hellsten K, Dolva K, Heusinkveld H, Hadzhiev Y, Hurem S, Jagiełło K, Judzinska B, Klüver N, Knoll-Gellida A, Kühne BA, Leist M, Lislien M, Lyche JL, Müller F, Neuhaus W, Pallocca G, Seeger B, Scharkin I, Scholz S, Spjuth O, Torres-Ruiz M, Bartmann K
Publié dans: Frontiers in Toxicology, 2024, ISSN 2673-3080
Éditeur: Frontiers
DOI: 10.3389/ftox.2024.1359507

A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury

Auteurs: Lukas S Wijaya, Attila Gabor, Iris E Pot, Luca van de Have, Julio Saez-Rodriguez, James L Stevens, Sylvia E Le Dévédec, Giulia Callegaro, Bob van de Water
Publié dans: Toxicological Sciences, Numéro 198, 2024, Page(s) 14-30, ISSN 1096-6080
Éditeur: Oxford University Press
DOI: 10.1093/toxsci/kfad121

Development of an adverse outcome pathway network for nephrotoxicity

Auteurs: Barnes DA, Firman JW, Belfield SJ, Cronin MTD, Vinken M, Janssen MJ, Masereeuw R
Publié dans: Archives of Toxicology, 2024, ISSN 0340-5761
Éditeur: Springer Verlag
DOI: 10.1007/s00204-023-03637-7

Current Status and Challenges of Human Induced Pluripotent Stem Cell-Derived Liver Models in Drug Discovery

Auteurs: Tricot T, Verfaillie C, Kumar M
Publié dans: Cells, Numéro january 27, 2022; 11: 442, 2022, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11030442

Definition of the Neurotoxicity-Associated Metabolic Signature Triggered by Berberine and Other Respiratory Chain Inhibitors

Auteurs: Suciu I, Delp J, Gutbier S, Suess J, Henschke L, Celardo I, Mayer TU, Amelio I, Leist M.
Publié dans: Antioxidants, 2023, ISSN 2076-3921
Éditeur: MPDI
DOI: 10.3390/antiox13010049

Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals

Auteurs: Blum J, Masjosthusmann S, Bartmann K, Bendt F, Dolde X, Dönmez A, Förster N, Holzer AK, Hübenthal U, Keßel HE, Kilic S, Klose J, Pahl M, Stürzl LC, Mangas I, Terron A, Crofton KM, Scholze M, Mosig A, Leist M, Fritsche E.
Publié dans: Chemosphere, Numéro 31;311(Pt 2):137035, 2022, ISSN 1879-1298
Éditeur: Elsevier
DOI: 10.1016/j.chemosphere.2022.137035

Recommendations on fit-for-purpose criteria to establish quality managementfor microphysiological systems and for monitoring their reproducibility

Auteurs: David Pamies,Jason Ekert,Marie-Gabrielle Zurich,Olivier Frey,Sophie Werner,Monica Piergiovanni,Benjamin S. Freedman,Adrian Kee Keong Teo,Hendrik Erfurth,Darwin R. Reyes,Peter Loskill,Pelin Candarlioglu,Laura Suter-Dick,Shan Wang,Thomas Hartung,Sandra Coecke,Glyn N. Stacey,Beren Atac Wagegg,Eva-Maria Dehne,Francesca Pistollato,Marcel Leist
Publié dans: Stem cell Reports, 2024, ISSN 2213-6711
Éditeur: Cell Press
DOI: 10.1016/j.stemcr.2024.03.009

Prediction of adverse drug reactions due to genetic predisposition using deep neural networks

Auteurs: Dafniet B & Taboureau O.
Publié dans: Molecular Informatics, 2024, ISSN 1868-1751
Éditeur: Wiley
DOI: 10.1002/minf.202400021

Elements and development processes for test methods in toxicology and human health-relevant life science research

Auteurs: Cöllen E, Tanaskov Y, Holzer AK, Dipalo M, Schäfer J, Kraushaar U, Leist M
Publié dans: ALTEX, 2024, ISSN 1868-596X
Éditeur: Springer
DOI: 10.14573/altex.2401041

Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment

Auteurs: Jaklin M, Zhang JD, Schäfer N, Clemann N, Barrow P, Küng E, Sach-Peltason L, McGinnis C, Leist M, Kustermann S.
Publié dans: Toxicological Sciences, Numéro 188(1):17-33, 2022, ISSN 0029-3970
Éditeur: Oxford University Press
DOI: 10.1093/toxsci/kfac046

Integrating Mechanistic and Toxicokinetic Information in Predictive Models of Cholestasis

Auteurs: Pablo Rodríguez-BelenguerVictor Mangas-SanjuanEmilio Soria-OlivasManuel Pastor*
Publié dans: Journal of Chemical Information and Modeling, 2023, ISSN 1549-9596
Éditeur: American Chemical Society
DOI: 10.1021/acs.jcim.3c00945

Usage of model combination in computational toxicology

Auteurs: Rodríguez-Belenguer, P., March-Vila, E., Pastor, M., Mangas-Sanjuan, V., & Soria-Olivas, E
Publié dans: Toxicology Letters, 2023, ISSN 0378-4274
Éditeur: Elsevier BV
DOI: 10.1016/j.toxlet.2023.10.013

Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson’s Disease

Auteurs: Carecho R, Figueira I, Terrasso AP, Godinho-Pereira J, de Oliveira Sequeira C, Pereira SA, Milenkovic D, Leist M, Brito C, Nunes Dos Santos C.
Publié dans: Mol. Nutr. Food Res., Numéro 29 December 2021, 2021, ISSN 1613-4125
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.202100959

The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability

Auteurs: Vlasveld M, Callegaro G, Fisher C, Eakins J, Walker P, Lok S, van Oost S, de Jong B, Pellegrino-Coppola D, Burger G, Wink S, van de Water B.
Publié dans: Liver International, 2024, ISSN 1478-3231
Éditeur: John Wiley & Sons
DOI: 10.1111/liv.15822

Trust your gut: Establishing confidence in gastrointestinal models - An overview of the state of the science and contexts of use

Auteurs: Susan Debad, David Allen, Omari Bandele, Colin Bishop, Michaela Blaylock, Paul Brown, Maureen K. Bunger, Julia Y. Co, Lynn Crosby, Amber B. Daniel, Steve S. Ferguson, Kevin Ford, Gonçalo Gamboa da Costa, Kristin H. Gilchrist, Matthew W. Grogg, Maureen Gwinn, Thomas Hartung , Simon P. Hogan, Ye Eun Jeong, George E. N. Kass, Elaina Kenyon, Nicole C. Kleinstreuer, Ville Kujala, Patrik Lundquist, Jo
Publié dans: ALTEX, 2024, ISSN 1868-596X
Éditeur: Springer
DOI: 10.14573/altex.2403261

Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses

Auteurs: Ter Braak B, Klip JE, Wink S, Hiemstra S, Cooper SL, Middleton A, White A, van de Water B
Publié dans: Toxicology In Vitro, 2022, ISSN 1879-1298
Éditeur: Elsevier
DOI: 10.1016/j.tiv.2022.105419

REACH out-numbered! The future of REACH and animal numbers.

Auteurs: Rovida C, Busquet F, Leist M, Hartung T.
Publié dans: ALTEX, 2023, ISSN 1868-8551
Éditeur: Springer
DOI: 10.14573/altex.2307121

Linking chemicals, genes and morphological perturbations to diseases

Auteurs: Cerisier N, Dafniet B, Badel A, Taboureau O.
Publié dans: Toxicology and Applied Pharmacology, 2023, ISSN 0041-008X
Éditeur: Academic Press
DOI: 10.1016/j.taap.2023.116407

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

Auteurs: Loser D, Grillberger K, Hinojosa MG, Blum J, Haufe Y, Danker T, Johansson Y, Möller C, Nicke A, Bennekou SH, Gardner I, Bauch C, Walker P, Forsby A, Ecker GF, Kraushaar U, Leist M.
Publié dans: Arch Toxicol, Numéro 95(12).3695-3716, 2021, ISSN 2193-1801
Éditeur: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-021-03168-z

Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models

Auteurs: Capinha L, Zhang Y, Holzer AK, Ückert AK, Zana M, Carta G, Murphy C, Baldovini J, Mazidi Z, Grillari J, Dinnyes A, van de Water B, Leist M, Commandeur JNM, Jennings P
Publié dans: Archives of Toxicology, 2023, ISSN 2193-1801
Éditeur: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-022-03436-6

Studying Metabolism by NMR-Based Metabolomics

Auteurs: Sofia Moco
Publié dans: Frontiers Molecular Biosciences, Numéro 9:882487, 2022, 2022, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fmolb.2022.882487

Controversy on health-based guidance values for bisphenol A—the need of criteria for studies that serve as a basis for risk assessment.

Auteurs: Leist M, Buettner A, Diel P, Eisenbrand G, Epe B, Först P, Grune T, Haller D, Heinz V, Hellwig M, Humpf HU, Jäger H, Kulling SE, Mally A, Marko D, Nöthlings U, Röhrdanz E, Spranger J, Vieths S, Wätjen W, Hengstler JG.
Publié dans: Archives of Toxicology, 2024, ISSN 0340-5761
Éditeur: Springer Verlag
DOI: 10.1007/s00204-024-03778-3

Analysis of health concerns not addressed by REACH for low tonnage chemicals and opportunities for new approach methodology

Auteurs: Botham P, Cronin MTD, Currie R, et al.
Publié dans: Archives of Toxycology, 2023, ISSN 0340-5761
Éditeur: Springer Verlag
DOI: 10.1007/s00204-023-03601-5

Metabolic regulation by p53 prevents R-loop-associated genomic instability

Auteurs: Emanuele Panatta, Alessio Butera, Eleonora Mammarella, Consuelo Pitolli, Alessandro Mauriello, Marcel Leist, Richard A. Knight, Gerry Melino, Ivano Amelio
Publié dans: Cell Reports, Numéro Volume 41, Numéro 5, 1 November 2022, 2022, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2022.111568

Characterization of Organic Anion and Cation Transport in Three Human Renal Proximal Tubular Epithelial Models

Auteurs: Meijer, T., da Costa Pereira, D., Klatt, O.C., Buitenhuis, J., Jennings, P., & Wilmes, A.
Publié dans: Cells, 2024, ISSN 2073-4409
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells13121008

Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells

Auteurs: Olivier J. M. BéquignonJose C. Gómez-TamayoEelke B. LenselinkSteven WinkSteven HiemstraChi Chung LamDomenico GadaletaAlessandra RoncaglioniUlf NorinderBob van de WaterManuel PastorGerard J. P. van Westen*
Publié dans: Journal of Chemical Information and Modeling, 2023, ISSN 1549-9596
Éditeur: American Chemical Society
DOI: 10.1021/acs.jcim.3c00220

Protectiveness of NAM-Based Hazard Assessment – Which Testing Scope is Required?

Auteurs: Zobl W, Bitsch A, Blum J, Boei JJWA, Capinha L, Carta G, Castell J, Davoli E, Drake C, Fisher CP, Heldring MM, Islam B, Jennings P, Leist M, Pellegrino-Coppola D, Schimming JP, Snijders KE, Tolosa L, van de Water B, van Vugt-Lussenburg BMA, Walker P, Wehr MM, Wijaya LS, Escher SE
Publié dans: ALTEX, 2024, ISSN 1868-596X
Éditeur: Springer
DOI: 10.14573/altex.2309081

4.2 million and counting… The animal toll for REACH systemic toxicity studies

Auteurs: Knight J, Hartung T, Rovida C.
Publié dans: ALTEX, 2023, ISSN 1868-596X
Éditeur: Springer
DOI: 10.14573/altex.2303201

Mapping Interindividual Variability of Toxicodynamics Using High-ThroughputTranscriptomics and Primary Human Hepatocytes from Fifty Donors

Auteurs: Niemeijer M, Więcek W, Fu S, Huppelschoten S, Bouwman P, Baze A, Parmentier C, Richert L, Paules RS, Bois FY, van de Water B
Publié dans: Environmental Health Perspectives, 2024, ISSN 0091-6765
Éditeur: US Department of Health and Human Services
DOI: 10.1289/ehp11891

Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis

Auteurs: Lambrecht R, Rudolf F, Ückert AK, Sladky VC, Phan TS, Jansen J, Naim S, Kaufmann T, Keogh A, Kirschnek S, Mangerich A, Stengel F, Leist M, Villunger A, Brunner T
Publié dans: Cell Death & Differentiation, 2024, ISSN 1350-9047
Éditeur: Nature Publishing Group
DOI: 10.1038/s41418-023-01245-7

Structural Insights into Neonicotinoids and N-Unsubstituted Metabolites on Human nAChRs by Molecular Docking, Dynamics Simulations, and Calcium Imaging

Auteurs: K. Grillberger, E. Cöllen, C. I. Trivisani, J. Blum, M. Leist, and G. F. Ecker
Publié dans: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241713170

PathwayNexus: a tool for interactive metabolic data analysis

Auteurs: Eberhard P, Aichem M, Kern M, Klein K, Delp J, Suciu I, Dietrich D, Leist M, Schreiber F
Publié dans: Bioinformatics, 2024, ISSN 1367-4803
Éditeur: Oxford University Press
DOI: 10.1093/bioinformatics/btae310

Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration

Auteurs: Anna-Katharina Ückert, Sina Rütschlin, Simon Gutbier, Nathalie Christine Wörz, Mahfuzur R. Miah, Airton C. Martins, Isa Hauer, Anna-Katharina Holzer, Birthe Meyburg, Ann-Kathrin Mix, Christof Hauck, Michael Aschner, Thomas Böttcher, Marcel Leist
Publié dans: Environment International, 2023, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.108229

High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation

Auteurs: Seidel F, Cherianidou A, Kappenberg F, Marta M, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Scholtz-Illigens A, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG.
Publié dans: Cells, Numéro 11(21):3404, 2022, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11213404

Making in silico predictive models for toxicology FAIR

Auteurs: Cronin MTD, Belfield SJ, Briggs KA, Enoch SJ, Firman JW, Frericks M, Garrard C, Maccallum PH, Madden JC, Pastor M, Sanz F, Soininen I, Sousoni D.
Publié dans: Regulatory Toxicology and Pharmacology, 2023, ISSN 0273-2300
Éditeur: Academic Press
DOI: 10.1016/j.yrtph.2023.105385

Knowledge infrastructure for integrated data management and analysis supporting new approach methods in predictive toxicology and risk assessment

Auteurs: Barry Hardy, Tomaz Mohoric,Thomas Exner, Joh Dokler, Maja Brajnik, Daniel Bachler, Ody Mbegbu, Nora Kleisli, Lucian Farcal, Krzysztof Maciejczuk, Haris Rašidagić, Ghada Tagorti, Pascal Ankli, Daniel Burgwinkel, Divanshu Anand, Ugis Sarkans, Awais Athar
Publié dans: Toxicology in Vitro, 2024, ISSN 0887-2333
Éditeur: Elsevier BV
DOI: 10.1016/j.tiv.2024.105903

Deconvoluting gene and environmentinteractions to develop an “epigeneticscore meter” of disease

Auteurs: Butera, A, Smirnova, L., Ferrando-May, E., Hartung, T., Brunner, T., Leist, M., Amelio, I.
Publié dans: EMBO Molecular Medicine, 2023, ISSN 1757-4676
Éditeur: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202318208

Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons

Auteurs: Suciu, I.; Delp, J.; Gutbier, S.; Ückert, A.-K.; Spreng, A.-S.; Eberhard, P.; Karreman, C.; Schreiber, F.; Madjar, K.; Rahnenführer, J.; Celardo, I.; Amelio, I.; Leist, M
Publié dans: Antioxidants, 2023, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/antiox12010164

Assessing network-based methods in the context of system toxicology

Auteurs: Valls-Margarit J, Piñero J, Füzi B, Cerisier N, Taboureau O, Furlong LI
Publié dans: Frontiers in Pharmacology, 2023, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1225697

Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation

Auteurs: Spreng AS, Brüll M, Leisner H, Suciu I, Leist M.
Publié dans: Human Stem Cells in Disease Modelling, Drug Discovery and Regenerative Medicine, Numéro 11(17):2644, 25 August 2022, 2022, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11172644

Use of metabolic glycoengineering and pharmacological inhibitors to assess lipid and protein sialylation on cells.

Auteurs: Kranaster P, Blum J, Dold JEGA, Wittmann V, Leist M.
Publié dans: Neurochem, 2022, ISSN 1613-4125
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1111/jnc.15737

Osmolar Modulation Drives Reversible Cell Cycle Exit and Human Pluripotent Cell Differentiation via NF-κВ and WNT Signaling

Auteurs: Jonathan Sai-Hong Chui , Teresa Izuel-Idoype , Alessandra Qualizza , Rita Pires de Almeida , Lindsey Piessens , Bernard K van der Veer , Gert Vanmarcke , Aneta Malesa , Paraskevi Athanasouli , Ruben Boon , Joris Vriens , Leo van Grunsven , Kian Peng Koh , Catherine M Verfaillie , Frederic Lluis
Publié dans: Advanced Science, 2024, ISSN 2198-3844
Éditeur: Wiley Online Library
DOI: 10.1002/advs.202307554

Uncertainty assessment of proarrhythmia predictions derived from multi‑level in silico models

Auteurs: Kopańska K, Rodríguez-Belenguer P, Llopis-Lorente J, Trenor B, Saiz J, Pastor M.
Publié dans: Archives of Toxicology, 2023, ISSN 0340-5761
Éditeur: Springer Verlag
DOI: 10.1007/s00204-023-03557-6

Assessment of Drug-Induced Liver Injury through Cell Morphology and Gene Expression Analysisand Gene Expression Analysis

Auteurs: Lejal V, Cerisier N, Rouquié D, Taboureau O.
Publié dans: Chemical Research in Toxicology, 2023, ISSN 0893-228X
Éditeur: American Chemical Society
DOI: 10.1021/acs.chemrestox.2c00381

On the Usefulness of Animals as a Model System (Part II): Considering Benefits within Distinct Use Domains

Auteurs: G. Pallocca, M. Leist
Publié dans: ALTEX- Alternatives to Animal Experimentation, Numéro 39(3), 20 July 2022, 2022, ISSN 1868-8551
Éditeur: Springer Spektrum
DOI: 10.14573/altex.2207111

Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation

Auteurs: Scheibe C, Karreman C, Schildknecht S, Leist M, Hauser K.
Publié dans: Biomolecules, Numéro 11(8): 1067, Aug 2021, 2021, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom11081067

G × E interactions as a basis for toxicological uncertainty

Auteurs: Suciu I, Pamies D, Peruzzo R, Wirtz PH, Smirnova L, Pallocca G, Hauck C, Cronin MTD, Hengstler JG, Brunner T, Hartung T, Amelio I, Leist M.
Publié dans: Archives of Toxicology, 2023, ISSN 0340-5761
Éditeur: Springer Verlag
DOI: 10.1007/s00204-023-03500-9

Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test

Auteurs: Cherianidou A, Seidel F, Kappenberg F, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG.
Publié dans: Chemical Research in Toxicology, 2022, ISSN 0002-7863
Éditeur: American Chemical Society
DOI: 10.1021/acs.chemrestox.1c00392

Revolutionizing Developmental Neurotoxicity Testing – A Journey from Animal Models to Advanced In Vitro Systems

Auteurs: Smirnova L, Hogberg HT, Leist M, Hartung T
Publié dans: ALTEX, 2024, ISSN 1868-596X
Éditeur: Springer
DOI: 10.14573/altex.2403281

A continuous in silico learning strategy to identify safety liabilities in compounds used in the leather and textile industry

Auteurs: March-Vila E, Ferretti G, Terricabras E, Ardao I, Brea JM, Varela MJ, Arana Á, Rubiolo JA, Sanz F, Loza MI, Sánchez L, Alonso H, Pastor M
Publié dans: Archives of Toxicology, 2023, ISSN 1432-0738
Éditeur: Springer
DOI: 10.1007/s00204-023-03459-7

Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0

Auteurs: Pamies D, Leist M, Coecke S, Bowe G, Allen DG, Gstraunthaler G, Bal-Price A, Pistollato F, de Vries RBM, Hogberg HT, Hartung T, Stacey G.
Publié dans: ALTEX, Numéro 39:30-70, 2022, ISSN 1868-8551
Éditeur: Springer Spektrum
DOI: 10.14573/altex.2111011

On the usefulness of animals as a model system (part I): Overview of criteria and focus on robustness

Auteurs: Pallocca G., Rovida C., Leist M
Publié dans: ALTEX, Numéro 2022;39(2):347-353, 2022, ISSN 2193-1801
Éditeur: Springer Science and Business Media Deutschland GmbH
DOI: 10.14573/altex.2203291

Status of quantifying adverse outcome pathways to support next generation risk assessment

Auteurs: M Cronin, S Belfield, S Enoch, J Firman, Judith Madden, N Spinu
Publié dans: Altex Proceedings, 2023, ISSN 2194-0479
Éditeur: Springer Spektrum
DOI: 10.58847/ap.2302

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