RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs

Publications

SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp® simulator

Auteurs: Khalidi H, Onasanwo A, Islam B, Jo H, Fisher C, Aidley R, Gardner I, Bois FY.
Publié dans: Frontiers in Pharmacology, Numéro 25 August 2022, 2022, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.929200

Generation of Human Nociceptor-Enriched Sensory Neurons for the Study of Pain-Related Dysfunctions

Auteurs: Holzer, A. K., Karreman, C., Suciu, I., Furmanowsky, L. S., Wohlfarth, H., Loser, D., Dirks, W. G., Pardo González, E., and Leist, M.
Publié dans: Stem Cells Transl Med., Numéro 11(7), July 2022, 2022, Page(s) 727–741, ISSN 0029-3970
Éditeur: Oxford University Press
DOI: 10.1093/stcltm/szac031

A framework for chemical safety assessment incorporating new approach methodologies within REACH

Auteurs: Ball N, Bars R, Botham PA, Cuciureanu A, Cronin MTD, Doe JE, Dudzina T, Gant TW, Leist M, van Ravenzwaay B
Publié dans: Arch Toxicol., 2022, ISSN 2193-1801
Éditeur: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-021-03215-9

Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective

Auteurs: Pallocca G., Moné J. M., Kamp H., Luijten M., van de Water B., Leist M.
Publié dans: Altex, Numéro 39 (2), 7 April 2022, 2022, ISSN 2193-1801
Éditeur: Springer Science and Business Media Deutschland GmbH
DOI: 10.14573/altex.2204051

Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays

Auteurs: Dolde X, Karreman C, Wiechers M, Schildknecht S, Leist M
Publié dans: International Journal of Molecular Sciences, Numéro 22(18):10079, 2021, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221810079

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

Auteurs: van der Stel W, Yang H, Vrijenhoek NG, Schimming JP, Callegaro G, Carta G, Darici S, Delp J, Forsby A, White A, le Dévédec S, Leist M, Jennings P, Beltman JB, van de Water B, Danen EHJ
Publié dans: Archives of Toxicology, Numéro 96(1), January 2022, 2022, ISSN 1868-8551
Éditeur: Springer-Spektrum
DOI: 10.1007/s00204-021-03160-7

Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro

Auteurs: Holzer, Anna-Katharina, Ilinca Suciu, Christiaan Karreman, Thomas Goj, and Marcel Leist
Publié dans: International Journal of Molecular Sciences, Numéro 23(7), 29 March 2022, 2022, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073734

Current Status and Challenges of Human Induced Pluripotent Stem Cell-Derived Liver Models in Drug Discovery

Auteurs: Tricot T, Verfaillie C, Kumar M
Publié dans: Cells, Numéro january 27, 2022; 11: 442, 2022, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11030442

Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals

Auteurs: Blum J, Masjosthusmann S, Bartmann K, Bendt F, Dolde X, Dönmez A, Förster N, Holzer AK, Hübenthal U, Keßel HE, Kilic S, Klose J, Pahl M, Stürzl LC, Mangas I, Terron A, Crofton KM, Scholze M, Mosig A, Leist M, Fritsche E.
Publié dans: Chemosphere, Numéro 31;311(Pt 2):137035, 2022, ISSN 1879-1298
Éditeur: Elsevier
DOI: 10.1016/j.chemosphere.2022.137035

Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment

Auteurs: Jaklin M, Zhang JD, Schäfer N, Clemann N, Barrow P, Küng E, Sach-Peltason L, McGinnis C, Leist M, Kustermann S.
Publié dans: Toxicological Sciences, Numéro 188(1):17-33, 2022, ISSN 0029-3970
Éditeur: Oxford University Press
DOI: 10.1093/toxsci/kfac046

Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson’s Disease

Auteurs: Carecho R, Figueira I, Terrasso AP, Godinho-Pereira J, de Oliveira Sequeira C, Pereira SA, Milenkovic D, Leist M, Brito C, Nunes Dos Santos C.
Publié dans: Mol. Nutr. Food Res., Numéro 29 December 2021, 2021, ISSN 1613-4125
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.202100959

Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses

Auteurs: Ter Braak B, Klip JE, Wink S, Hiemstra S, Cooper SL, Middleton A, White A, van de Water B
Publié dans: Toxicology In Vitro, 2022, ISSN 1879-1298
Éditeur: Elsevier
DOI: 10.1016/j.tiv.2022.105419

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

Auteurs: Loser D, Grillberger K, Hinojosa MG, Blum J, Haufe Y, Danker T, Johansson Y, Möller C, Nicke A, Bennekou SH, Gardner I, Bauch C, Walker P, Forsby A, Ecker GF, Kraushaar U, Leist M.
Publié dans: Arch Toxicol, Numéro 95(12).3695-3716, 2021, ISSN 2193-1801
Éditeur: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-021-03168-z

Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models

Auteurs: Capinha L, Zhang Y, Holzer AK, Ückert AK, Zana M, Carta G, Murphy C, Baldovini J, Mazidi Z, Grillari J, Dinnyes A, van de Water B, Leist M, Commandeur JNM, Jennings P
Publié dans: Archives of Toxicology, 2023, ISSN 2193-1801
Éditeur: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-022-03436-6

Studying Metabolism by NMR-Based Metabolomics

Auteurs: Sofia Moco
Publié dans: Frontiers Molecular Biosciences, Numéro 9:882487, 2022, 2022, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fmolb.2022.882487

Metabolic regulation by p53 prevents R-loop-associated genomic instability

Auteurs: Emanuele Panatta, Alessio Butera, Eleonora Mammarella, Consuelo Pitolli, Alessandro Mauriello, Marcel Leist, Richard A. Knight, Gerry Melino, Ivano Amelio
Publié dans: Cell Reports, Numéro Volume 41, Numéro 5, 1 November 2022, 2022, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2022.111568

High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation

Auteurs: Seidel F, Cherianidou A, Kappenberg F, Marta M, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Scholtz-Illigens A, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG.
Publié dans: Cells, Numéro 11(21):3404, 2022, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11213404

Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons

Auteurs: Suciu, I.; Delp, J.; Gutbier, S.; Ückert, A.-K.; Spreng, A.-S.; Eberhard, P.; Karreman, C.; Schreiber, F.; Madjar, K.; Rahnenführer, J.; Celardo, I.; Amelio, I.; Leist, M
Publié dans: Antioxidants, 2023, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/antiox12010164

Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation

Auteurs: Spreng AS, Brüll M, Leisner H, Suciu I, Leist M.
Publié dans: Human Stem Cells in Disease Modelling, Drug Discovery and Regenerative Medicine, Numéro 11(17):2644, 25 August 2022, 2022, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11172644

Use of metabolic glycoengineering and pharmacological inhibitors to assess lipid and protein sialylation on cells.

Auteurs: Kranaster P, Blum J, Dold JEGA, Wittmann V, Leist M.
Publié dans: Neurochem, 2022, ISSN 1613-4125
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1111/jnc.15737

Large-scale perfused tissues via synthetic 3D soft microfluidics

Auteurs: Grebenyuk S, Abdel Fattah AR, Kumar M, Toprakhisar B, Rustandi G, Vananroye A, Salmon I, Verfaillie C, Grillo M, Ranga A
Publié dans: Nat Commun, 2023, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-35619-1

On the Usefulness of Animals as a Model System (Part II): Considering Benefits within Distinct Use Domains

Auteurs: G. Pallocca, M. Leist
Publié dans: ALTEX- Alternatives to Animal Experimentation, Numéro 39(3), 20 July 2022, 2022, ISSN 1868-8551
Éditeur: Springer Spektrum
DOI: 10.14573/altex.2207111

Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation

Auteurs: Scheibe C, Karreman C, Schildknecht S, Leist M, Hauser K.
Publié dans: Biomolecules, Numéro 11(8): 1067, Aug 2021, 2021, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom11081067

Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test

Auteurs: Cherianidou A, Seidel F, Kappenberg F, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG.
Publié dans: Chemical Research in Toxicology, 2022, ISSN 0002-7863
Éditeur: American Chemical Society
DOI: 10.1021/acs.chemrestox.1c00392

Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0

Auteurs: Pamies D, Leist M, Coecke S, Bowe G, Allen DG, Gstraunthaler G, Bal-Price A, Pistollato F, de Vries RBM, Hogberg HT, Hartung T, Stacey G.
Publié dans: ALTEX, Numéro 39:30-70, 2022, ISSN 1868-8551
Éditeur: Springer Spektrum
DOI: 10.14573/altex.2111011

On the usefulness of animals as a model system (part I): Overview of criteria and focus on robustness

Auteurs: Pallocca G., Rovida C., Leist M
Publié dans: ALTEX, Numéro 2022;39(2):347-353, 2022, ISSN 2193-1801
Éditeur: Springer Science and Business Media Deutschland GmbH
DOI: 10.14573/altex.2203291

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