RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Publications

Genomic and proteomic biomarker landscape in clinical trials

Auteurs: Piñero J, Rodriguez Fraga PS, Valls-Margarit J, Ronzano F, Accuosto P, Lambea
Publié dans: Computational and structural biotechnology journal, 2023, ISSN 2001-0370
Éditeur: Elsevier
DOI: 10.1016/j.csbj.2023.03.014

SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp® simulator

Auteurs: Khalidi H, Onasanwo A, Islam B, Jo H, Fisher C, Aidley R, Gardner I, Bois FY.
Publié dans: Frontiers in Pharmacology, Numéro 25 August 2022, 2022, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.929200

Acceptance criteria for new approach methods in toxicology and human health-relevant life science research – part I

Auteurs: Holzer, A.-K., Dreser, N., Pallocca, G., Mangerich, A., Stacey, G., Dipalo, M., van de Water, B., Rovida, C., Wirtz, P. H., van Vugt, B., Panzarella, G., Hartung, T., Terron, A., Mangas, I., Herzler, M., Marx-Stoelting, P., Coecke, S. and Leist, M.
Publié dans: ALTEX, 2023, ISSN 1868-596X
Éditeur: Springer
DOI: 10.14573/altex.2310021

Advancing transcriptomics-based mechanistic assessment of nephrotoxicity in vitro using the human RPTEC/TERT1 TXG-MAPr gene co-expression network

Auteurs: Hugo W van Kessel, Steven J Kunnen, Giulia Callegaro, Bob van de Water
Publié dans: Toxicological Sciences, Numéro 209, 2026, ISSN 1096-6080
Éditeur: Oxford University Press
DOI: 10.1093/toxsci/kfaf159

AOP-informed qIVIVE modelling for liver steatosis using triazoles

Auteurs: A.M. Steinbach, C.T. Willenbockel, P. Marx-Stoelting, M.T.D. Cronin, V. Städele
Publié dans: Computational Toxicology, Numéro 36, 2026, Page(s) 100382, ISSN 2468-1113
Éditeur: Elsevier BV
DOI: 10.1016/j.comtox.2025.100382

Computational Strategies for Assessing Adverse Outcome Pathways: Hepatic Steatosis as a Case Study

Auteurs: Ortega-Vallbona, R.; Palomino-Schätzlein, M.; Tolosa, L.; Benfenati, E.; Ecker, G.F.; Gozalbes, R.; Serrano-Candelas, E.
Publié dans: International Journal of Molecular Sciences, 2024, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)

Nutrient environment improves drug metabolic activity in human iPSC-derived hepatocytes and HepG2

Auteurs: Victoria Pozo Garcia, Tuğçe S. Çobanoğlu, Helen Sophie Hammer, Rita Carlota, Kasper Holm, Catherine Verfaillie, Oliver Poetz, Paul Jennings, Sofia Moco
Publié dans: Archives of Toxicology, Numéro 99, 2025, Page(s) 4493-4511, ISSN 0340-5761
Éditeur: Springer Verlag
DOI: 10.1007/s00204-025-04139-4

Assessment of pulmonary fibrosis using weighted gene co-expression network analysis

Auteurs: Christina Drake, Walter Zobl, Sylvia E. Escher
Publié dans: Frontiers in Toxicology, Numéro 6, 2024, ISSN 2673-3080
Éditeur: Frontiers Media SA
DOI: 10.3389/ftox.2024.1465704

Testing Strategies for Metabolite-Mediated Neurotoxicity

Auteurs: Julian Suess, Moritz Reinmoeller, Viktoria Magel, Baiba Gukalova, Edgars Liepinsh, Iain Gardner, Nadine Dreser, Anna-Katharina Holzer, Marcel Leist
Publié dans: International Journal of Molecular Sciences, Numéro 26, 2025, Page(s) 8338, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26178338

Cell morphology and gene expression: tracking changes and complementarity across time and cell lines

Auteurs: Vanille Lejal, David Rouquié, Olivier Taboureau
Publié dans: Toxicology and Applied Pharmacology, Numéro 504, 2025, Page(s) 117530, ISSN 0041-008X
Éditeur: Academic Press
DOI: 10.1016/j.taap.2025.117530

Utilizing rat kidney gene co-expression networks to enhance safety assessment biomarker identification and human translation

Auteurs: Steven J. Kunnen, Giulia Callegaro, Jeffrey J. Sutherland, Panuwat Trairatphisan, Hugo W. van Kessel, Lukas S. Wijaya, Git Chung, Keith Pye, Keith M. Goldstein, Claire R. Teague, Ciaran P. Fisher, Julio Saez-Rodriguez, Colin Brown, Susan A. Elmore, Kathleen M. Heinz-Taheny, James L. Stevens, Bob van de Water
Publié dans: iScience, Numéro 28, 2025, Page(s) 112978, ISSN 2589-0042
Éditeur: Elsevier BV
DOI: 10.1016/j.isci.2025.112978

Interdependency of estradiol-mediated ERα activation and subsequent PR and GREB1 induction to control cell cycle progression

Auteurs: M.M. Heldring, B. Duijndam, A. Kyriakidou, O.M. van der Meer, M. Tedeschi, J.W. van der Laan, B. van de Water, J.B. Beltman
Publié dans: Heliyon, Numéro 10, 2025, Page(s) e38406, ISSN 2405-8440
Éditeur: Elsevier BV
DOI: 10.1016/j.heliyon.2024.e38406

Refining Drug-Induced Cholestasis Prediction: An Explainable Consensus Model Integrating Chemical and Biological Fingerprints

Auteurs: Palle S. Helmke, Gerhard F. Ecker
Publié dans: Journal of Chemical Information and Modeling, Numéro 65, 2025, Page(s) 5301-5316, ISSN 1549-9596
Éditeur: American Chemical Society
DOI: 10.1021/acs.jcim.4c02363

A perfused iPSC-derived proximal tubule model for predicting drug-induced kidney injury

Auteurs: Michelle Lechtenberg, Coraline Chéneau, Kevin Riquin, Leopold Koenig, Carlos Mota, Franck Halary, Eva-Maria Dehne
Publié dans: Toxicology in Vitro, Numéro 105, 2025, Page(s) 106038, ISSN 0887-2333
Éditeur: Elsevier BV
DOI: 10.1016/j.tiv.2025.106038

An Adverse Outcome Pathway Network for Chemically Induced Oxidative Stress Leading to (Non)genotoxic Carcinogenesis

Auteurs: Christina H. J. Veltman; Jeroen L. A. Pennings; Bob van de Water; Mirjam Luijten
Publié dans: Chemical Research in Toxicology, Numéro 3, 2023, ISSN 0893-228X
Éditeur: American Chemical Society
DOI: 10.1021/acs.chemrestox.2c00396

Developmental neurotoxicity (DNT): A call for implementation of new approach methodologies for regulatory purposes: Summary of the 5th International Conference on DNT Testing

Auteurs: Ivana Celardo, Michael Aschner, Randolph S. Ashton, Kelly E. Carstens, Andrea Cediel-Ulloa, Eike Cöllen, Kevin M. Crofton, Susan J. Debad, Nadine Dreser, Suzanne Fitzpatrick, Ellen Fritsche, Sebastian Gutsfeld, Barry Hardy, Thomas Hartung, Ellen Hessel, Harm Heusinkveld, Helena T. Hogberg, Jui-Hua Hsieh, Yasunari Kanda, Gavin T. Knight, Thomas Knudsen, Katharina Koch, Eliska Kuchovska, Iris Manga
Publié dans: ALTEX, Numéro 42, 2025, ISSN 1868-596X
Éditeur: ALTEX Edition
DOI: 10.14573/altex.2503191

Generation of Human Nociceptor-Enriched Sensory Neurons for the Study of Pain-Related Dysfunctions

Auteurs: Holzer, A. K., Karreman, C., Suciu, I., Furmanowsky, L. S., Wohlfarth, H., Loser, D., Dirks, W. G., Pardo González, E., and Leist, M.
Publié dans: Stem Cells Transl Med., Numéro 11(7), July 2022, 2022, Page(s) 727–741, ISSN 0029-3970
Éditeur: Oxford University Press
DOI: 10.1093/stcltm/szac031

A framework for chemical safety assessment incorporating new approach methodologies within REACH

Auteurs: Ball N, Bars R, Botham PA, Cuciureanu A, Cronin MTD, Doe JE, Dudzina T, Gant TW, Leist M, van Ravenzwaay B
Publié dans: Arch Toxicol., 2022, ISSN 2193-1801
Éditeur: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-021-03215-9

Preparation of Viable Human Neurites for Neurobiological and Neurodegeneration Studies

Auteurs: Brüll M, Geese N, CelardoI, Laumann M, Leist M
Publié dans: Cells, 2024, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells13030242

Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective

Auteurs: Pallocca G., Moné J. M., Kamp H., Luijten M., van de Water B., Leist M.
Publié dans: Altex, Numéro 39 (2), 7 April 2022, 2022, ISSN 2193-1801
Éditeur: Springer Science and Business Media Deutschland GmbH
DOI: 10.14573/altex.2204051

Chemical and Biological Mechanisms Relevant to the Rescue of MG-132-Treated Neurons by Cysteine

Auteurs: Anna-Katharina Ückert, Ilinca Suciu, Anja Land, Anna-Sophie Spreng, Hannah Welte, Doreen Herzog, Michael Basler, Marcel Leist
Publié dans: Antioxidants, Numéro 14, 2025, Page(s) 128, ISSN 2076-3921
Éditeur: MDPI AG
DOI: 10.3390/antiox14020128

Modeling ferroptosis in human dopaminergic neurons: pitfalls and opportunities for neurodegeneration research

Auteurs: Renner N, Schöb F, Pape R, Suciu I, Spreng AS, Ückert AK, Cöllen E, Bovio F, Chilian B, Bauere J, Röpcke S, Bergemann J, Leist M, Schildknecht S
Publié dans: Redox Biology, 2024, ISSN 2213-2317
Éditeur: Elsevier BV
DOI: 10.1016/j.redox.2024.103165

Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays

Auteurs: Dolde X, Karreman C, Wiechers M, Schildknecht S, Leist M
Publié dans: International Journal of Molecular Sciences, Numéro 22(18):10079, 2021, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221810079

Bioactivity descriptors for in vivo toxicity prediction: now and the future

Auteurs: Helmke P, Füzi B, Ecker GF
Publié dans: Expert Opinion on Drug Metabolism & Toxicology, 2024, ISSN 1742-5255
Éditeur: Ashley Publications Ltd.
DOI: 10.1080/17425255.2024.2334308

Qualitative and quantitative concentration-response modelling of gene co-expression networks to unlock hepatotoxic mechanisms for next generation chemical safety assessment.

Auteurs: Kunnen SJ, Arnesdotter E, Willenbockel CT, Vinken M, van de Water B
Publié dans: ALTEX, 2024, ISSN 1868-596X
Éditeur: Springer
DOI: 10.14573/altex.2309201

Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing

Auteurs: Cöllen E, Bartmann K, Blum J, Carstens K, Celardo I, Chatterjee N, Corvaro M, Dreser N, Fritsche E, Hartung T, Hogberg HT, Knudsen T, Koch K, Kreutz A, Lislien M, Magel V, Marty MS, Pallocca G, Bal-Price A, Rovida C, Sachana M, Shafer TJ, Smirnova L, Suciu I, Tanaskov Y, Tangianu S, Wolfbeisz C, Leist M.
Publié dans: ALTEX, Numéro 42, 2025, ISSN 1868-596X
Éditeur: ALTEX Edition
DOI: 10.14573/altex.2501091

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

Auteurs: van der Stel W, Yang H, Vrijenhoek NG, Schimming JP, Callegaro G, Carta G, Darici S, Delp J, Forsby A, White A, le Dévédec S, Leist M, Jennings P, Beltman JB, van de Water B, Danen EHJ
Publié dans: Archives of Toxicology, Numéro 96(1), January 2022, 2022, ISSN 1868-8551
Éditeur: Springer-Spektrum
DOI: 10.1007/s00204-021-03160-7

Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro

Auteurs: Holzer, Anna-Katharina, Ilinca Suciu, Christiaan Karreman, Thomas Goj, and Marcel Leist
Publié dans: International Journal of Molecular Sciences, Numéro 23(7), 29 March 2022, 2022, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073734

An Alternative Safety Profiling Algorithm (ASPA) to transform next generation risk assessment into a structured and transparent process

Auteurs: Leist M, Tangianu S, Affourtit F, Braakhuis H, Colbourne J, Cöllen E, Dreser N, Escher SE, Gardner I, Hahn S, Hardy B, Herzler M, Islam B, Kamp H, Magel V, Marx-Stoelting P, Moné MJ, Lundquist P, Ottenbros I, Ouedraogo G, Pallocca G, van de Water B, Vinken M, White A, Pastor M, Luijten M.
Publié dans: ALTEX, Numéro 26, 2025, ISSN 1868-596X
Éditeur: ALTEX Edition
DOI: 10.14573/altex.2509081

New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project

Auteurs: Tal T, Myhre O, Fritsche E, Rüegg J, Craenen K, Aiello K, Agrillo C, Babin PJ, Escher BI, Dirven H, Hellsten K, Dolva K, Heusinkveld H, Hadzhiev Y, Hurem S, Jagiełło K, Judzinska B, Klüver N, Knoll-Gellida A, Kühne BA, Leist M, Lislien M, Lyche JL, Müller F, Neuhaus W, Pallocca G, Seeger B, Scharkin I, Scholz S, Spjuth O, Torres-Ruiz M, Bartmann K
Publié dans: Frontiers in Toxicology, 2024, ISSN 2673-3080
Éditeur: Frontiers
DOI: 10.3389/ftox.2024.1359507

A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury

Auteurs: Lukas S Wijaya, Attila Gabor, Iris E Pot, Luca van de Have, Julio Saez-Rodriguez, James L Stevens, Sylvia E Le Dévédec, Giulia Callegaro, Bob van de Water
Publié dans: Toxicological Sciences, Numéro 198, 2024, Page(s) 14-30, ISSN 1096-6080
Éditeur: Oxford University Press
DOI: 10.1093/toxsci/kfad121

Development of an adverse outcome pathway network for nephrotoxicity

Auteurs: Barnes DA, Firman JW, Belfield SJ, Cronin MTD, Vinken M, Janssen MJ, Masereeuw R
Publié dans: Archives of Toxicology, 2024, ISSN 0340-5761
Éditeur: Springer Verlag
DOI: 10.1007/s00204-023-03637-7

Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare

Auteurs: Marx U, Beken S, Chen Z, Dehne EM, Doherty A, Ewart L, Fitzpatrick SC, Griffith LG, Gu Z, Hartung T, Hickman J, Ingber DE, Ishida S, Jeong J, Leist M, Levin L, Mendrick DL, Pallocca G, Platz S, Raschke M, Smirnova L, Tagle DA, Trapecar M, van Balkom BWM, van den Eijnden-van Raaij J, van der Meer A, Roth A.
Publié dans: ALTEX, Numéro 42, 2025, ISSN 1868-596X
Éditeur: ALTEX Edition
DOI: 10.14573/altex.2410112

Current Status and Challenges of Human Induced Pluripotent Stem Cell-Derived Liver Models in Drug Discovery

Auteurs: Tricot T, Verfaillie C, Kumar M
Publié dans: Cells, Numéro january 27, 2022; 11: 442, 2022, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11030442

Inhibition of Neural Crest Cell Migration by Strobilurin Fungicides and Other Mitochondrial Toxicants

Auteurs: Viktoria Magel, Jonathan Blum, Xenia Dolde, Heidrun Leisner, Karin Grillberger, Hiba Khalidi, Iain Gardner, Gerhard F. Ecker, Giorgia Pallocca, Nadine Dreser, Marcel Leist
Publié dans: Cells, Numéro 13, 2025, Page(s) 2057, ISSN 2073-4409
Éditeur: MDPI AG
DOI: 10.3390/cells13242057

Interdisciplinary risks – a delicate balance between trust and critical review

Auteurs: Ullrika Sahlin, Henrik Thorén
Publié dans: Journal of Risk Research, Numéro 28, 2025, Page(s) 197-202, ISSN 1366-9877
Éditeur: Carfax Publishing Ltd.
DOI: 10.1080/13669877.2025.2526473

Differential Responses of Human iPSC-Derived Microglia to Stimulation with Diverse Inflammogens

Auteurs: Chiara Wolfbeisz, Julian Suess, Nadine Dreser, Heidrun Leisner, Markus Brüll, Madeleine Fandrich, Nicole Schneiderhan-Marra, Oliver Poetz, Thomas Hartung, Marcel Leist
Publié dans: Cells, Numéro 14, 2025, Page(s) 1687, ISSN 2073-4409
Éditeur: MDPI AG
DOI: 10.3390/cells14211687

Definition of the Neurotoxicity-Associated Metabolic Signature Triggered by Berberine and Other Respiratory Chain Inhibitors

Auteurs: Suciu I, Delp J, Gutbier S, Suess J, Henschke L, Celardo I, Mayer TU, Amelio I, Leist M.
Publié dans: Antioxidants, 2023, ISSN 2076-3921
Éditeur: MPDI
DOI: 10.3390/antiox13010049

Computational Strategies for Assessing Adverse Outcome Pathways: Hepatic Steatosis as a Case Study

Auteurs: Rita Ortega-Vallbona, Martina Palomino-Schätzlein, Laia Tolosa, Emilio Benfenati, Gerhard F. Ecker, Rafael Gozalbes, Eva Serrano-Candelas
Publié dans: International Journal of Molecular Sciences, Numéro 25, 2025, Page(s) 11154, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms252011154

Integrating human exposome data into next-generation risk assessment: a systematic framework to infer real-life exposure levels and prioritize chemical compounds for testing

Auteurs: Yifeng Dai, Bob van de Water, Jaione Telleria, Laura I. Furlong, Roel C.H. Vermeulen, Jelle Vlaanderen
Publié dans: Environment International, Numéro 208, 2026, Page(s) 110110, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2026.110110

Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals

Auteurs: Blum J, Masjosthusmann S, Bartmann K, Bendt F, Dolde X, Dönmez A, Förster N, Holzer AK, Hübenthal U, Keßel HE, Kilic S, Klose J, Pahl M, Stürzl LC, Mangas I, Terron A, Crofton KM, Scholze M, Mosig A, Leist M, Fritsche E.
Publié dans: Chemosphere, Numéro 31;311(Pt 2):137035, 2022, ISSN 1879-1298
Éditeur: Elsevier
DOI: 10.1016/j.chemosphere.2022.137035

MolCompass: multi-tool for the navigation in chemical space and visual validation of QSAR/QSPR models

Auteurs: Sergey Sosnin
Publié dans: Journal of Cheminformatics, 2024, ISSN 1758-2946
Éditeur: Chemistry Central

Organobodies: A robust and size-controllable system for generating scalable hiPSC-derived liver organoids for drug toxicity screening

Auteurs: Mostafa Kiamehr, Stefano Manzini, Burak Toprakhisar, Rodrigo F. Madeiro da Costa, Guillem García-Llorens, Birhanu Belay, Mustapha Najimi, José V Castell, Wolfgang Moritz, Giulia Chiesa, Katriina Aalto-Setälä, Catherine Verfaillie
Publié dans: Bioarchives, 2026, ISSN 2692-8205
Éditeur: openRxiv
DOI: 10.1101/2025.10.20.683433

Recommendations on fit-for-purpose criteria to establish quality managementfor microphysiological systems and for monitoring their reproducibility

Auteurs: David Pamies,Jason Ekert,Marie-Gabrielle Zurich,Olivier Frey,Sophie Werner,Monica Piergiovanni,Benjamin S. Freedman,Adrian Kee Keong Teo,Hendrik Erfurth,Darwin R. Reyes,Peter Loskill,Pelin Candarlioglu,Laura Suter-Dick,Shan Wang,Thomas Hartung,Sandra Coecke,Glyn N. Stacey,Beren Atac Wagegg,Eva-Maria Dehne,Francesca Pistollato,Marcel Leist
Publié dans: Stem cell Reports, 2024, ISSN 2213-6711
Éditeur: Cell Press
DOI: 10.1016/j.stemcr.2024.03.009

The predictivity of QSARs for toxicity: Recommendations for improving model performance

Auteurs: Mark T.D. Cronin, Homa Basiri, Georgios Chrysochoou, Steven J. Enoch, James W. Firman, Nicoleta Spînu, Judith C. Madden
Publié dans: Computational Toxicology, Numéro 33, 2025, Page(s) 100338, ISSN 2468-1113
Éditeur: Elsevier BV
DOI: 10.1016/j.comtox.2024.100338

Prediction of adverse drug reactions due to genetic predisposition using deep neural networks

Auteurs: Dafniet B & Taboureau O.
Publié dans: Molecular Informatics, 2024, ISSN 1868-1751
Éditeur: Wiley
DOI: 10.1002/minf.202400021

Elements and development processes for test methods in toxicology and human health-relevant life science research

Auteurs: Cöllen E, Tanaskov Y, Holzer AK, Dipalo M, Schäfer J, Kraushaar U, Leist M
Publié dans: ALTEX, 2024, ISSN 1868-596X
Éditeur: Springer
DOI: 10.14573/altex.2401041

Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment

Auteurs: Jaklin M, Zhang JD, Schäfer N, Clemann N, Barrow P, Küng E, Sach-Peltason L, McGinnis C, Leist M, Kustermann S.
Publié dans: Toxicological Sciences, Numéro 188(1):17-33, 2022, ISSN 0029-3970
Éditeur: Oxford University Press
DOI: 10.1093/toxsci/kfac046

Identifying human toxicodynamic variability: A systematic evidence map of the current knowledge

Auteurs: Annika Boye Petersen, Lea Bredsdorff, Natasha Tahir, Marije Niemeijer, George E.N. Kass, Aiste Vitkauskaite, Matthijs Moerland, Frederic Y. Bois, Nadia Quignot, Bob van de Water, Susanne Hougaard Bennekou
Publié dans: Regulatory Toxicology and Pharmacology, Numéro 161, 2025, Page(s) 105842, ISSN 0273-2300
Éditeur: Academic Press
DOI: 10.1016/j.yrtph.2025.105842

Integrating Mechanistic and Toxicokinetic Information in Predictive Models of Cholestasis

Auteurs: Pablo Rodríguez-BelenguerVictor Mangas-SanjuanEmilio Soria-OlivasManuel Pastor*
Publié dans: Journal of Chemical Information and Modeling, 2023, ISSN 1549-9596
Éditeur: American Chemical Society
DOI: 10.1021/acs.jcim.3c00945

Usage of model combination in computational toxicology

Auteurs: Rodríguez-Belenguer, P., March-Vila, E., Pastor, M., Mangas-Sanjuan, V., & Soria-Olivas, E
Publié dans: Toxicology Letters, 2023, ISSN 0378-4274
Éditeur: Elsevier BV
DOI: 10.1016/j.toxlet.2023.10.013

Moving towards making (quantitative) structure-activity relationships ((Q)SARs) for toxicity-related endpoints findable, accessible, interoperable and reusable (FAIR)

Auteurs: Belfield SJ, Basiri H, Swapnil C, Chrysochoou G, Enoch SJ, Firman JW, Gomatam A, Hardy B, Helmke PS, Madden JC, Maran U, March-Vila E, Nikolov NG, Pastor M, Piir G, Sild S, Smajić A, Spînu N, Wedebye EB, Cronin MTD
Publié dans: ALTEX, 2025, ISSN 1868-596X
Éditeur: ALTEX Edition
DOI: 10.14573/altex.2411161

Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson’s Disease

Auteurs: Carecho R, Figueira I, Terrasso AP, Godinho-Pereira J, de Oliveira Sequeira C, Pereira SA, Milenkovic D, Leist M, Brito C, Nunes Dos Santos C.
Publié dans: Mol. Nutr. Food Res., Numéro 29 December 2021, 2021, ISSN 1613-4125
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.202100959

The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability

Auteurs: Vlasveld M, Callegaro G, Fisher C, Eakins J, Walker P, Lok S, van Oost S, de Jong B, Pellegrino-Coppola D, Burger G, Wink S, van de Water B.
Publié dans: Liver International, 2024, ISSN 1478-3231
Éditeur: John Wiley & Sons
DOI: 10.1111/liv.15822

Trust your gut: Establishing confidence in gastrointestinal models - An overview of the state of the science and contexts of use

Auteurs: Susan Debad, David Allen, Omari Bandele, Colin Bishop, Michaela Blaylock, Paul Brown, Maureen K. Bunger, Julia Y. Co, Lynn Crosby, Amber B. Daniel, Steve S. Ferguson, Kevin Ford, Gonçalo Gamboa da Costa, Kristin H. Gilchrist, Matthew W. Grogg, Maureen Gwinn, Thomas Hartung , Simon P. Hogan, Ye Eun Jeong, George E. N. Kass, Elaina Kenyon, Nicole C. Kleinstreuer, Ville Kujala, Patrik Lundquist, Jo
Publié dans: ALTEX, 2024, ISSN 1868-596X
Éditeur: Springer
DOI: 10.14573/altex.2403261

Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses

Auteurs: Ter Braak B, Klip JE, Wink S, Hiemstra S, Cooper SL, Middleton A, White A, van de Water B
Publié dans: Toxicology In Vitro, 2022, ISSN 1879-1298
Éditeur: Elsevier
DOI: 10.1016/j.tiv.2022.105419

REACH out-numbered! The future of REACH and animal numbers.

Auteurs: Rovida C, Busquet F, Leist M, Hartung T.
Publié dans: ALTEX, 2023, ISSN 1868-8551
Éditeur: Springer
DOI: 10.14573/altex.2307121

Linking chemicals, genes and morphological perturbations to diseases

Auteurs: Cerisier N, Dafniet B, Badel A, Taboureau O.
Publié dans: Toxicology and Applied Pharmacology, 2023, ISSN 0041-008X
Éditeur: Academic Press
DOI: 10.1016/j.taap.2023.116407

9-cis-Retinoic Acid Improves Disease Modelling in iPSC-Derived Liver Organoids

Auteurs: Mina Kazemzadeh Dastjerd, Vincent Merens, Ayla Smout, Rebeca De Wolf, Christophe Chesné, Catherine Verfaillie, Stefaan Verhulst, Leo A. van Grunsven
Publié dans: Cells, Numéro 14, 2025, Page(s) 983, ISSN 2073-4409
Éditeur: MDPI AG
DOI: 10.3390/cells14130983

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

Auteurs: Loser D, Grillberger K, Hinojosa MG, Blum J, Haufe Y, Danker T, Johansson Y, Möller C, Nicke A, Bennekou SH, Gardner I, Bauch C, Walker P, Forsby A, Ecker GF, Kraushaar U, Leist M.
Publié dans: Arch Toxicol, Numéro 95(12).3695-3716, 2021, ISSN 2193-1801
Éditeur: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-021-03168-z

Leveraging Consensus Docking Approaches for Human Mitochondrial Complexes I and III

Auteurs: Karin Grillberger, Viktoria Magel, Marcel Leist, Gerhard F. Ecker
Publié dans: Chemical Research in Toxicology, Numéro 39, 2026, Page(s) 79-94, ISSN 0893-228X
Éditeur: American Chemical Society
DOI: 10.1021/acs.chemrestox.5c00348

Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models

Auteurs: Capinha L, Zhang Y, Holzer AK, Ückert AK, Zana M, Carta G, Murphy C, Baldovini J, Mazidi Z, Grillari J, Dinnyes A, van de Water B, Leist M, Commandeur JNM, Jennings P
Publié dans: Archives of Toxicology, 2023, ISSN 2193-1801
Éditeur: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s00204-022-03436-6

Studying Metabolism by NMR-Based Metabolomics

Auteurs: Sofia Moco
Publié dans: Frontiers Molecular Biosciences, Numéro 9:882487, 2022, 2022, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fmolb.2022.882487

TOXTRUST: a tool leveraging the Dempster-Shafer Theory for robust integration of NAM results in decision-making considering uncertainty

Auteurs: Karolina Kopańska, Adrian Cabrera, Manuel Pastor
Publié dans: NAM Journal, Numéro 1, 2025, Page(s) 100043, ISSN 3050-6204
Éditeur: Elsevier BV
DOI: 10.1016/j.namjnl.2025.100043

Cell Painting PLUS: expanding the multiplexing capacity of Cell Painting-based phenotypic profiling using iterative staining-elution cycles

Auteurs: Elena von Coburg, Marlene Wedler, Jose M. Muino, Christopher Wolff, Nils Körber, Sebastian Dunst, Shu Liu
Publié dans: Nature Communications, Numéro 16, 2025, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-025-58765-8

Controversy on health-based guidance values for bisphenol A—the need of criteria for studies that serve as a basis for risk assessment.

Auteurs: Leist M, Buettner A, Diel P, Eisenbrand G, Epe B, Först P, Grune T, Haller D, Heinz V, Hellwig M, Humpf HU, Jäger H, Kulling SE, Mally A, Marko D, Nöthlings U, Röhrdanz E, Spranger J, Vieths S, Wätjen W, Hengstler JG.
Publié dans: Archives of Toxicology, 2024, ISSN 0340-5761
Éditeur: Springer Verlag
DOI: 10.1007/s00204-024-03778-3

Analysis of health concerns not addressed by REACH for low tonnage chemicals and opportunities for new approach methodology

Auteurs: Botham P, Cronin MTD, Currie R, et al.
Publié dans: Archives of Toxycology, 2023, ISSN 0340-5761
Éditeur: Springer Verlag
DOI: 10.1007/s00204-023-03601-5

Predicting xenobiotic metabolism: a computational approach mining LC–MS/MS data with SIRIUS and BioTransformer

Auteurs: Victoria Pozo Garcia, Mengqiu Zhang, Tuğçe S. Çobanoğlu, Kasper Holm, Paul Jennings, David A. Poole, Sofia Moco
Publié dans: Archives of Toxicology, 2025, ISSN 0340-5761
Éditeur: Springer Verlag
DOI: 10.1007/s00204-025-04248-0

Mechanism-based drug safety testing using innovative <i>in vitro</i> liver models: from DILI prediction to idiosyncratic DILI liability assessment

Auteurs: Sibel Bahtiri, Tessa M. S. Hagens, Bob van de Water, Marije Niemeijer
Publié dans: Expert Opinion on Drug Metabolism & Toxicology, Numéro 21, 2025, Page(s) 769-787, ISSN 1742-5255
Éditeur: Ashley Publications Ltd.
DOI: 10.1080/17425255.2025.2516051

Metabolic regulation by p53 prevents R-loop-associated genomic instability

Auteurs: Emanuele Panatta, Alessio Butera, Eleonora Mammarella, Consuelo Pitolli, Alessandro Mauriello, Marcel Leist, Richard A. Knight, Gerry Melino, Ivano Amelio
Publié dans: Cell Reports, Numéro Volume 41, Numéro 5, 1 November 2022, 2022, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2022.111568

Characterization of Organic Anion and Cation Transport in Three Human Renal Proximal Tubular Epithelial Models

Auteurs: Meijer, T., da Costa Pereira, D., Klatt, O.C., Buitenhuis, J., Jennings, P., & Wilmes, A.
Publié dans: Cells, 2024, ISSN 2073-4409
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells13121008

Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells

Auteurs: Olivier J. M. BéquignonJose C. Gómez-TamayoEelke B. LenselinkSteven WinkSteven HiemstraChi Chung LamDomenico GadaletaAlessandra RoncaglioniUlf NorinderBob van de WaterManuel PastorGerard J. P. van Westen*
Publié dans: Journal of Chemical Information and Modeling, 2023, ISSN 1549-9596
Éditeur: American Chemical Society
DOI: 10.1021/acs.jcim.3c00220

Challenges and opportunities of read-across for the tumor promotion effects of microcystins

Auteurs: Cynthia B. Pestana, Daniela Morais Leme, Enzo Zini Moreira Silva, Sahra Kiessig, James W. Firman, Carsten Kneuer, Philip Marx-Stoelting, Mark T.D. Cronin
Publié dans: Regulatory Toxicology and Pharmacology, Numéro 163, 2026, Page(s) 105938, ISSN 0273-2300
Éditeur: Academic Press
DOI: 10.1016/j.yrtph.2025.105938

The long way from raw data to NAM-based information: Overview on data layers and processing steps

Auteurs: Blum J, Brüll M, Hengstler JG, Dietrich DR, Gruber AJ, Dipalo M, Kraushaar U, Mangas I, Terron A, Fritsche E, Marx-Stoelting P, Hardy B, Schepky A, Escher S, Hartung T, Landsiedel R, Odermatt A, Sachana M, Koch K, Dönmez A, Masjosthusmann S, Bothe K, Schildknecht S, Beilmann M, Beltman JB, Fitzpatrick S, Mangerich A, Rehm M, Tangianu S, Zickgraf FM, Kamp H, Burger G, van de Water B, Kleinstreuer
Publié dans: ALTEX, Numéro 42, 2025, ISSN 1868-596X
Éditeur: ALTEX Edition
DOI: 10.14573/altex.2412171

Protectiveness of NAM-Based Hazard Assessment – Which Testing Scope is Required?

Auteurs: Zobl W, Bitsch A, Blum J, Boei JJWA, Capinha L, Carta G, Castell J, Davoli E, Drake C, Fisher CP, Heldring MM, Islam B, Jennings P, Leist M, Pellegrino-Coppola D, Schimming JP, Snijders KE, Tolosa L, van de Water B, van Vugt-Lussenburg BMA, Walker P, Wehr MM, Wijaya LS, Escher SE
Publié dans: ALTEX, 2024, ISSN 1868-596X
Éditeur: Springer
DOI: 10.14573/altex.2309081

Towards a quantitative adverse outcome pathway for liver carcinogenesis: From proliferation to prediction

Auteurs: Christina H.J. Veltman, Hiba Khalidi, Elias Zgheib, Bob van de Water, Mirjam Luijten, Jeroen L.A. Pennings
Publié dans: Computational Toxicology, Numéro 34, 2025, Page(s) 100359, ISSN 2468-1113
Éditeur: Elsevier BV
DOI: 10.1016/j.comtox.2025.100359

A broad kinase inhibitor library live cell imaging screen using liver, kidney and cardiac hiPSC-ICAM1-eGFP reporter lineages identifies liabilities for TNFα pathway modulation

Auteurs: Matthijs Vlasveld, Linda van den Berk, Janet Piñero, Palle S. Helmke, Gerhard F. Ecker, Rob van Rossom, Bela Z. Schmidt, Catherine Verfaillie, Konstantinos Tassis, Giulia Callegaro, Peter Bouwman, Bob van de Water
Publié dans: Archives of Toxicology, Numéro 100, 2026, Page(s) 585-601, ISSN 0340-5761
Éditeur: Springer Verlag
DOI: 10.1007/s00204-025-04226-6

Cell type heterogeneity in gene co-expression networks: implications for toxicological research

Auteurs: Imke B Bruns, Yingxue Li, James L Stevens, Bob van de Water, Giulia Callegaro
Publié dans: Briefings in Bioinformatics, Numéro 26, 2025, ISSN 1467-5463
Éditeur: Oxford University Press
DOI: 10.1093/bib/bbaf421

The intracellular free concentration of endocrine disrupting chemicals enables translation between cell-free and cell-based estrogenic activity assays

Auteurs: Vesna Munic Kos, Staffan Arvidsson, Barira Islam, Violetta Nikiforova, Evgeniya Mickols, Alina Meyer, Richard Svensson, Ummu Gulsum Boztepe, Eirini Banti, Patrik Lundquist, Hiba Khalidi, Iain Gardner, Ola Spjuth, Ian Cotgreave, Per Artursson
Publié dans: Environmental Toxicology and Pharmacology, Numéro 117, 2025, Page(s) 104750, ISSN 1382-6689
Éditeur: Elsevier BV
DOI: 10.1016/j.etap.2025.104750

4.2 million and counting… The animal toll for REACH systemic toxicity studies

Auteurs: Knight J, Hartung T, Rovida C.
Publié dans: ALTEX, 2023, ISSN 1868-596X
Éditeur: Springer
DOI: 10.14573/altex.2303201

Mapping Interindividual Variability of Toxicodynamics Using High-ThroughputTranscriptomics and Primary Human Hepatocytes from Fifty Donors

Auteurs: Niemeijer M, Więcek W, Fu S, Huppelschoten S, Bouwman P, Baze A, Parmentier C, Richert L, Paules RS, Bois FY, van de Water B
Publié dans: Environmental Health Perspectives, 2024, ISSN 0091-6765
Éditeur: US Department of Health and Human Services
DOI: 10.1289/ehp11891

StreamChol: a web-based application for predicting cholestasis

Auteurs: Pablo Rodríguez-Belenguer, Emilio Soria-Olivas, Manuel Pastor
Publié dans: Journal of Cheminformatics, Numéro 17, 2025, ISSN 1758-2946
Éditeur: Chemistry Central
DOI: 10.1186/s13321-024-00943-9

Computational prediction of mutagenicity through comprehensive cell painting analysis

Auteurs: Natacha Cerisier, Emily Truong, Taku Watanabe, Taro Oshiro, Tomohiro Takahashi, Shigeaki Ito, Olivier Taboureau
Publié dans: Mutagenesis, Numéro 40, 2025, Page(s) 560-574, ISSN 0267-8357
Éditeur: Oxford University Press
DOI: 10.1093/mutage/geaf014

Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis

Auteurs: Lambrecht R, Rudolf F, Ückert AK, Sladky VC, Phan TS, Jansen J, Naim S, Kaufmann T, Keogh A, Kirschnek S, Mangerich A, Stengel F, Leist M, Villunger A, Brunner T
Publié dans: Cell Death & Differentiation, 2024, ISSN 1350-9047
Éditeur: Nature Publishing Group
DOI: 10.1038/s41418-023-01245-7

Structural Insights into Neonicotinoids and N-Unsubstituted Metabolites on Human nAChRs by Molecular Docking, Dynamics Simulations, and Calcium Imaging

Auteurs: K. Grillberger, E. Cöllen, C. I. Trivisani, J. Blum, M. Leist, and G. F. Ecker
Publié dans: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241713170

PathwayNexus: a tool for interactive metabolic data analysis

Auteurs: Eberhard P, Aichem M, Kern M, Klein K, Delp J, Suciu I, Dietrich D, Leist M, Schreiber F
Publié dans: Bioinformatics, 2024, ISSN 1367-4803
Éditeur: Oxford University Press
DOI: 10.1093/bioinformatics/btae310

Causal, Predictive or Observational? Different Understandings of Key Event Relationships for Adverse Outcome Pathways and their implications on practice

Auteurs: Zheng Zhou, Jeroen L.A. Pennings, Ullrika Sahlin
Publié dans: Environmental Toxicology and Pharmacology, 2024, ISSN 1382-6689
Éditeur: Elsevier BV

Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration

Auteurs: Anna-Katharina Ückert, Sina Rütschlin, Simon Gutbier, Nathalie Christine Wörz, Mahfuzur R. Miah, Airton C. Martins, Isa Hauer, Anna-Katharina Holzer, Birthe Meyburg, Ann-Kathrin Mix, Christof Hauck, Michael Aschner, Thomas Böttcher, Marcel Leist
Publié dans: Environment International, 2023, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.108229

Cell viability imaging in tumor spheroids <i>via</i> DNA binding of a ruthenium(<scp>ii</scp>) light-switch complex

Auteurs: Vadde Ramu, Lukas S. Wijaya, Nataliia Beztsinna, Corjan Van de Griend, Bob van de Water, Sylvestre Bonnet, Sylvia E. Le Dévédec
Publié dans: Chemical Communications, Numéro 60, 2024, Page(s) 6308-6311, ISSN 1359-7345
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d4cc01425a

High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation

Auteurs: Seidel F, Cherianidou A, Kappenberg F, Marta M, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Scholtz-Illigens A, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG.
Publié dans: Cells, Numéro 11(21):3404, 2022, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11213404

Making in silico predictive models for toxicology FAIR

Auteurs: Cronin MTD, Belfield SJ, Briggs KA, Enoch SJ, Firman JW, Frericks M, Garrard C, Maccallum PH, Madden JC, Pastor M, Sanz F, Soininen I, Sousoni D.
Publié dans: Regulatory Toxicology and Pharmacology, 2023, ISSN 0273-2300
Éditeur: Academic Press
DOI: 10.1016/j.yrtph.2023.105385

Knowledge infrastructure for integrated data management and analysis supporting new approach methods in predictive toxicology and risk assessment

Auteurs: Barry Hardy, Tomaz Mohoric,Thomas Exner, Joh Dokler, Maja Brajnik, Daniel Bachler, Ody Mbegbu, Nora Kleisli, Lucian Farcal, Krzysztof Maciejczuk, Haris Rašidagić, Ghada Tagorti, Pascal Ankli, Daniel Burgwinkel, Divanshu Anand, Ugis Sarkans, Awais Athar
Publié dans: Toxicology in Vitro, 2024, ISSN 0887-2333
Éditeur: Elsevier BV
DOI: 10.1016/j.tiv.2024.105903

Deconvoluting gene and environmentinteractions to develop an “epigeneticscore meter” of disease

Auteurs: Butera, A, Smirnova, L., Ferrando-May, E., Hartung, T., Brunner, T., Leist, M., Amelio, I.
Publié dans: EMBO Molecular Medicine, 2023, ISSN 1757-4676
Éditeur: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202318208

Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons

Auteurs: Suciu, I.; Delp, J.; Gutbier, S.; Ückert, A.-K.; Spreng, A.-S.; Eberhard, P.; Karreman, C.; Schreiber, F.; Madjar, K.; Rahnenführer, J.; Celardo, I.; Amelio, I.; Leist, M
Publié dans: Antioxidants, 2023, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/antiox12010164

Assessing network-based methods in the context of system toxicology

Auteurs: Valls-Margarit J, Piñero J, Füzi B, Cerisier N, Taboureau O, Furlong LI
Publié dans: Frontiers in Pharmacology, 2023, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1225697

Transcriptomic changes and mitochondrial toxicity in response to acute and repeat dose treatment with brequinar in human liver and kidney in vitro models

Auteurs: Tamara Meijer, Bas ter Braak, Liesanne Loonstra-Wolters, Steven J. Kunnen, Barira Islam, Ilinca Suciu, Iain Gardner, Oliver Hatley, Richard Currie, Barry Hardy, Marcel Leist, Bob van de Water, Paul Jennings, Anja Wilmes
Publié dans: Toxicology in Vitro, Numéro 104, 2025, Page(s) 106010, ISSN 0887-2333
Éditeur: Elsevier BV
DOI: 10.1016/j.tiv.2025.106010

Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation

Auteurs: Spreng AS, Brüll M, Leisner H, Suciu I, Leist M.
Publié dans: Human Stem Cells in Disease Modelling, Drug Discovery and Regenerative Medicine, Numéro 11(17):2644, 25 August 2022, 2022, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11172644

Use of metabolic glycoengineering and pharmacological inhibitors to assess lipid and protein sialylation on cells.

Auteurs: Kranaster P, Blum J, Dold JEGA, Wittmann V, Leist M.
Publié dans: Neurochem, 2022, ISSN 1613-4125
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1111/jnc.15737

Osmolar Modulation Drives Reversible Cell Cycle Exit and Human Pluripotent Cell Differentiation via NF-κВ and WNT Signaling

Auteurs: Jonathan Sai-Hong Chui , Teresa Izuel-Idoype , Alessandra Qualizza , Rita Pires de Almeida , Lindsey Piessens , Bernard K van der Veer , Gert Vanmarcke , Aneta Malesa , Paraskevi Athanasouli , Ruben Boon , Joris Vriens , Leo van Grunsven , Kian Peng Koh , Catherine M Verfaillie , Frederic Lluis
Publié dans: Advanced Science, 2024, ISSN 2198-3844
Éditeur: Wiley Online Library
DOI: 10.1002/advs.202307554

Uncertainty assessment of proarrhythmia predictions derived from multi‑level in silico models

Auteurs: Kopańska K, Rodríguez-Belenguer P, Llopis-Lorente J, Trenor B, Saiz J, Pastor M.
Publié dans: Archives of Toxicology, 2023, ISSN 0340-5761
Éditeur: Springer Verlag
DOI: 10.1007/s00204-023-03557-6

Assessment of Drug-Induced Liver Injury through Cell Morphology and Gene Expression Analysisand Gene Expression Analysis

Auteurs: Lejal V, Cerisier N, Rouquié D, Taboureau O.
Publié dans: Chemical Research in Toxicology, 2023, ISSN 0893-228X
Éditeur: American Chemical Society
DOI: 10.1021/acs.chemrestox.2c00381

On the Usefulness of Animals as a Model System (Part II): Considering Benefits within Distinct Use Domains

Auteurs: G. Pallocca, M. Leist
Publié dans: ALTEX- Alternatives to Animal Experimentation, Numéro 39(3), 20 July 2022, 2022, ISSN 1868-8551
Éditeur: Springer Spektrum
DOI: 10.14573/altex.2207111

Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation

Auteurs: Scheibe C, Karreman C, Schildknecht S, Leist M, Hauser K.
Publié dans: Biomolecules, Numéro 11(8): 1067, Aug 2021, 2021, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom11081067

G × E interactions as a basis for toxicological uncertainty

Auteurs: Suciu I, Pamies D, Peruzzo R, Wirtz PH, Smirnova L, Pallocca G, Hauck C, Cronin MTD, Hengstler JG, Brunner T, Hartung T, Amelio I, Leist M.
Publié dans: Archives of Toxicology, 2023, ISSN 0340-5761
Éditeur: Springer Verlag
DOI: 10.1007/s00204-023-03500-9

Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test

Auteurs: Cherianidou A, Seidel F, Kappenberg F, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG.
Publié dans: Chemical Research in Toxicology, 2022, ISSN 0002-7863
Éditeur: American Chemical Society
DOI: 10.1021/acs.chemrestox.1c00392

Gap Junctional Communication Required for the Establishment of Long-Term Robust Ca2+ Oscillations Across Human Neuronal Spheroids and Extended 2D Cultures

Auteurs: Jasmin Kormann, Eike Cöllen, Ayla Aksoy-Aksel, Jana Schneider, Yaroslav Tanaskov, Kevin Wulkesch, Marcel Leist, Udo Kraushaar
Publié dans: Cells, Numéro 14, 2025, Page(s) 1744, ISSN 2073-4409
Éditeur: MDPI AG
DOI: 10.3390/cells14211744

Revolutionizing Developmental Neurotoxicity Testing – A Journey from Animal Models to Advanced In Vitro Systems

Auteurs: Smirnova L, Hogberg HT, Leist M, Hartung T
Publié dans: ALTEX, 2024, ISSN 1868-596X
Éditeur: Springer
DOI: 10.14573/altex.2403281

A continuous in silico learning strategy to identify safety liabilities in compounds used in the leather and textile industry

Auteurs: March-Vila E, Ferretti G, Terricabras E, Ardao I, Brea JM, Varela MJ, Arana Á, Rubiolo JA, Sanz F, Loza MI, Sánchez L, Alonso H, Pastor M
Publié dans: Archives of Toxicology, 2023, ISSN 1432-0738
Éditeur: Springer
DOI: 10.1007/s00204-023-03459-7

Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0

Auteurs: Pamies D, Leist M, Coecke S, Bowe G, Allen DG, Gstraunthaler G, Bal-Price A, Pistollato F, de Vries RBM, Hogberg HT, Hartung T, Stacey G.
Publié dans: ALTEX, Numéro 39:30-70, 2022, ISSN 1868-8551
Éditeur: Springer Spektrum
DOI: 10.14573/altex.2111011

On the usefulness of animals as a model system (part I): Overview of criteria and focus on robustness

Auteurs: Pallocca G., Rovida C., Leist M
Publié dans: ALTEX, Numéro 2022;39(2):347-353, 2022, ISSN 2193-1801
Éditeur: Springer Science and Business Media Deutschland GmbH
DOI: 10.14573/altex.2203291

Status of quantifying adverse outcome pathways to support next generation risk assessment

Auteurs: M Cronin, S Belfield, S Enoch, J Firman, Judith Madden, N Spinu
Publié dans: Altex Proceedings, 2023, ISSN 2194-0479
Éditeur: Springer Spektrum
DOI: 10.58847/ap.2302

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