Using real-world big data from eHealth, biobanks and national registries, integrated with clinical trial data to improve outcome of severe mental disorders

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Innovation, Intellectual Property (IP) and Knowledge Management Plan

Innovation Intellectual Property IP and Knowledge Management Plan

Risk Management Plan
Identification of relevant RWD sources in partner countries
Dissemination, Exploitation and Communication Plan yearly update M30

Dissemination, Exploitation and Communication Plan and yearly updates. Yearly updates shall include:- Newsletters- Updates of website- Report on scientific dissemination activities.- Report on public outreach.- Presentation of REALMENT findings to project stakeholders

An initial data freeze (Freeze 1) to be used for algorithm development
REALMENT Coordination team established
First Dissemination, Exploitation and Communication Plan done

First Dissemination Exploitation and Communication Plan done

Curated cross-border phenotypic data set
Minutes of the Annual Project Meeting Y3

Minutes of the Annual Project Meeting Y4

Quality Management Plan
Open access report on requirements for common data quality
Minutes of the Annual Project Meeting Y2
Replication of identified genotype-phenotype associations in an independent sample
Dissemination, Exploitation and Communication Plan yearly update M18

Dissemination Exploitation and Communication Plan and yearly updates Yearly updates shall include Newsletters Updates of website Report on scientific dissemination activities Report on public outreach Presentation of REALMENT findings to project stakeholders

Stakeholder input to design and user-friendly interface and clinical report design
Report of defined pharma trajectories
Tools and guidelines for data retrieval and sharing in place

Data Management Plan

REALMENT website and Social Media channels operational

Publicaciones

A novel framework for assessing causal effect of microbiome on health: long-term antibiotic usage as an instrument

Autores: Nele Taba, Krista Fischer, null Estonian Biobank Research Team, Elin Org, Oliver Aasmets
Publicado en: Gut Microbes, Edición 17, 2025, ISSN 1949-0976
Editor: Landes Bioscience
DOI: 10.1080/19490976.2025.2453616

Adolescent Psychedelic Use and Psychotic or Manic Symptoms

Autores: Otto Simonsson, Miriam A. Mosing, Walter Osika, Fredrik Ullén, Henrik Larsson, Yi Lu, Laura W. Wesseldijk
Publicado en: JAMA Psychiatry, Edición 81, 2024, Página(s) 579, ISSN 2168-622X
Editor: American Medical Association
DOI: 10.1001/jamapsychiatry.2024.0047

Placental efflux transporters and antiseizure or antidepressant medication use impact birth weight in MoBa cohort

Autores: Marta H. Hernandez, Jacqueline M. Cohen, Karoline H. Skåra, Thea K. Grindstad, Yunsung Lee, Per Magnus, Pål R. Njølstad, Ole A. Andreassen, Elizabeth C. Corfield, Alexandra Havdahl, Espen Molden, Kari Furu, Maria C. Magnus, Alvaro Hernaez
Publicado en: iScience, Edición 27, 2025, Página(s) 109285, ISSN 2589-0042
Editor: Elsevier BV
DOI: 10.1016/j.isci.2024.109285

COVID-19 illness severity and 2-year prevalence of physical symptoms: an observational study in Iceland, Sweden, Norway and Denmark

Autores: Qing Shen, Emily E. Joyce, Omid V. Ebrahimi, Maria Didriksen, Anikó Lovik, Karen Sól Sævarsdóttir, Ingibjörg Magnúsdóttir, Dorte Helenius Mikkelsen, Anna Bára Unnarsdóttir, Arna Hauksdóttir, Asle Hoffart, Anna K. Kähler, Edda Björk Thórdardóttir, Elías Eythórsson, Emma M. Frans, Gunnar Tómasson, Helga Ask, Hrönn Hardardóttir, Jóhanna Jakobsdóttir, Kelli Lehto, Li Lu, Ole A. An
Publicado en: The Lancet Regional Health - Europe, Edición 35, 2025, Página(s) 100756, ISSN 2666-7762
Editor: Elsevier BV
DOI: 10.1016/j.lanepe.2023.100756

Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores

Autores: Djenifer B.KappelaSophie E.LeggeaLeonHubbardaIsabella R.WillcocksaKevin S.O’ConnelldRobert L.SmithdfEspenMoldenefOle A.AndreassendAdrianKingbJohnJansencMarinkaHelthuiscMichael J.OwenaMichael C.O’DonovanaJames T.R.WaltersaAntonio F.Pardiñasa
Publicado en: Biological Psychiatry, Edición Volume 93, Edición 2, 15 January 2023, 2023, Página(s) 149-156, ISSN 0006-3223
Editor: Elsevier BV
DOI: 10.1016/j.biopsych.2022.07.014

Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy

Autores: Guy Hindley, Alexey A. Shadrin, Dennis van der Meer, Nadine Parker, Weiqiu Cheng, Kevin S. O’Connell, Shahram Bahrami, Aihua Lin, Naz Karadag, Børge Holen, Thomas Bjella, Ian J. Deary, Gail Davies, W. David Hill, Jan Bressler, Sudha Seshadri, Chun Chieh Fan, Torill Ueland, Srdjan Djurovic, Olav B. Smeland, Oleksandr Frei, Anders M. Dale, Ole A. Andreassen
Publicado en: Nature Human Behaviour, Edición 7, 2023, Página(s) 1584-1600, ISSN 2397-3374
Editor: nature human behaviour
DOI: 10.1038/s41562-023-01630-9

Epidemiological overview of major depressive disorder in Scandinavia using nationwide registers

Autores: Joëlle A. Pasman, Joeri J. Meijsen, Marit Haram, Kaarina Kowalec, Arvid Harder, Ying Xiong, Thuy-Dung Nguyen, Andreas Jangmo, John R. Shorter, Jacob Bergstedt, Urmi Das, Richard Zetterberg, Ashley Tate, Paul Lichtenstein, Henrik Larsson, Ingvild Odsbu, Thomas Werge, Ted Reichborn-Kjennerud, Ole A. Andreassen, Patrick F. Sullivan, Alfonso Buil, Martin Tesli, Yi Lu
Publicado en: The Lancet Regional Health - Europe, Edición 29, 2023, Página(s) 100621, ISSN 2666-7762
Editor: Lancet Regional Health Europe
DOI: 10.1016/j.lanepe.2023.100621

Genome-wide meta-analyses of non-response to antidepressants provide insights into underlying molecular genetics and suggest potential pharmacotherapies

Autores: Elise Koch, Tuuli Puusepp, Guðmundur Einarsson, Brittany L. Mitchell, Arvid Harder, Yuhao Lin, Luis M. García-Marín, Kristi Krebs, Alexey A. Shadrin, Ying Xiong, null null, Andres Metspalu, Tõnu Esko, Reedik Mägi, Mari Nelis, Georgi Hudjashov, Oleksandr Frei, Yi Lu, Sara Hägg, Miguel E. Rentería, Sarah E. Medland, Naomi R. Wray, Nicholas G. Martin, Christopher Hübel, Gerome Breen, Thorgeir
Publicado en: Molecular Psychiatry, 2025, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-025-03357-7

Charting the Landscape of Genetic Overlap Between Mental Disorders and Related Traits Beyond Genetic Correlation

Autores: Guy Hindley, Oleksandr Frei, Alexey A. Shadrin, Weiqiu Cheng, Kevin S. O’Connell, Romain Icick, Nadine Parker, Shahram Bahrami, Naz Karadag, Daniel Roelfs, Børge Holen, Aihua Lin, Chun C. Fan, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Ole A. Andreassen
Publicado en: American Journal of Psychiatry, Edición 179, 2024, Página(s) 833-843, ISSN 0002-953X
Editor: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.21101051

Polygenic overlap with granulocyte counts identifies novel loci for clozapine metabolism and clozapine-induced agranulocytosis

Autores: Elise Koch, Alexey A. Shadrin, Nadine Parker, Siobhan K. Lock, Robert L. Smith, Oleksandr Frei, Anders M. Dale, Srdjan Djurovic, Espen Molden, Kevin S. O´Connell, Ole A. Andreassen
Publicado en: Neuropsychopharmacology, Edición 50, 2025, Página(s) 947-955, ISSN 0893-133X
Editor: Nature Publishing Group
DOI: 10.1038/s41386-025-02054-x

Impact of NFIB and CYP1A variants on clozapine serum concentration—A retrospective naturalistic cohort study on 526 patients with known smoking habits

Autores: Hasan Çağın Lenk,Robert Løvsletten Smith,Kevin S. O'Connell,Marin M. Jukić,Marianne Kristiansen Kringen,Ole A. Andreassen,Magnus Ingelman-Sundberg,Espen Molden
Publicado en: Clin Transl Sci ., Edición 2023 Jan;16(1):62-72. doi: 10.1111/cts.13422. Epub 2022 Oct 7., 2023, Página(s) 62-72, ISSN 1752-8062
Editor: Wiley
DOI: 10.1111/cts.13422

Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia

Autores: Kevin S. O'Connell, Elise Koch, Hasan Çağın Lenk, Ibrahim A Akkouh, Guy Hindley, Piotr Jaholkowski, Robert Løvsletten Smith, Børge Holen, Alexey A. Shadrin, Oleksandr Frei, Olav B. Smeland, Nils Eiel Steen, Anders M. Dale, Espen Molden, Srdjan Djurovic, Ole A. Andreassen
Publicado en: Psychiatry Research, Edición 325, 2023, Página(s) 115217, ISSN 0165-1781
Editor: Elsevier BV
DOI: 10.1016/j.psychres.2023.115217

Distinct patterns of genetic overlap among multimorbidities revealed with trivariate MiXeR

Autores: Alexey A. Shadrin, Guy Hindley, Espen Hagen, Nadine Parker, Markos Tesfaye, Piotr Jaholkowski, Zillur Rahman, Gleda Kutrolli, Vera Fominykh, Srdjan Djurovic, Olav B. Smeland, Kevin S. O’Connell, Dennis van der Meer, Oleksandr Frei, Ole A. Andreassen, Anders M. Dale
Publicado en: Genome Medicine, Edición 17, 2025, ISSN 1756-994X
Editor: BioMed Central
DOI: 10.1186/s13073-025-01528-3

Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease

Autores: Jacob Bergstedt, Joëlle A. Pasman, Ziyan Ma, Arvid Harder, Shuyang Yao, Nadine Parker, Jorien L. Treur, Dirk J. A. Smit, Oleksandr Frei, Alexey A. Shadrin, Joeri J. Meijsen, Qing Shen, Sara Hägg, Per Tornvall, Alfonso Buil, Thomas Werge, Jens Hjerling-Leffler, Thomas D. Als, Anders D. Børglum, Cathryn M. Lewis, Andrew M. McIntosh, Unnur A. Valdimarsdóttir, Ole A. Andreassen, Patrick F. Sulliva
Publicado en: Nature Cardiovascular Research, Edición 3, 2024, Página(s) 754-769, ISSN 2731-0590
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s44161-024-00488-y

How Real-World Data Can Facilitate the Development of Precision Medicine Treatment in Psychiatry

Autores: Elise Koch, Antonio F. Pardiñas, Kevin S. O’Connell, Pierluigi Selvaggi, José Camacho Collados, Aleksandar Babic, Serena E. Marshall, Erik Van der Eycken, Cecilia Angulo, Yi Lu, Patrick F. Sullivan, Anders M. Dale, Espen Molden, Danielle Posthuma, Nathan White, Alexander Schubert, Srdjan Djurovic, Hakon Heimer, Hreinn Stefánsson, Kári Stefánsson, Thomas Werge, Ida Sønderby, Michael C. O’
Publicado en: Biological Psychiatry, 2024, ISSN 0006-3223
Editor: Elsevier BV
DOI: 10.1016/j.biopsych.2024.01.001

Prioritizing Parkinson’s disease risk genes in genome-wide association loci

Autores: Lara M. Lange, Catalina Cerquera-Cleves, Marijn Schipper, Georgia Panagiotaropoulou, Alice Braun, Julia Kraft, Swapnil Awasthi, Nathaniel Bell, Danielle Posthuma, Stephan Ripke, Cornelis Blauwendraat, Karl Heilbron
Publicado en: npj parkinson's disease, 2026, ISSN 2373-8057
Editor: npj Parkinson's Disease (npj Parkinsons Dis.)
DOI: 10.1101/2024.12.13.24318996

Psychiatric disorders and brain white matter exhibit genetic overlap implicating developmental and neural cell biology

Autores: Nadine Parker, Weiqiu Cheng, Guy F. L. Hindley, Pravesh Parekh, Alexey A. Shadrin, Ivan I. Maximov, Olav B. Smeland, Srdjan Djurovic, Anders M. Dale, Lars T. Westlye, Oleksandr Frei, Ole A. Andreassen
Publicado en: Molecular Psychiatry, Edición 28, 2024, Página(s) 4924-4932, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-023-02264-z

Effect of CYP2D6 and CYP2C19 genotypes on atomoxetine serum levels -- a study based on therapeutic drug monitoring data

Autores: Robert Smith, Espen Molden, Jean-Paul Bernard
Publicado en: British Journal of Clinical Pharmacology, 2022, ISSN 1365-2125
Editor: Willey
DOI: 10.22541/au.167050638.80828727/v1

Genetic insights into psychotic major depressive disorder: bridging the mood-psychotic disorder spectrum

Autores: Thuy-Dung Nguyen, Joeri J. Meijsen, Robert Sigström, Ralf Kuja-Halkola, Ying Xiong, Arvid Harder, Kaarina Kowalec, Joëlle A. Pasman, Carolina Scarpa, Elin Hörbeck, Lina Jonsson, Sara Hägg, Niamh Mullins, Kevin S. O’Connell, Christina Dalman, Dorte Helenius, Richard Zetterberg, Henrik Larsson, Paul Lichtenstein, Ole A. Andreassen, Thomas Werge, Alfonso Buil, Mikael Landén, Patrick F. Sulliva
Publicado en: eBioMedicine, Edición 112, 2025, Página(s) 105576, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2025.105576

Effects of antipsychotics on human cognitive function: causal evidence from healthy volunteers following sustained D2/D3 antagonism, D2/D3 partial agonism and placebo

Autores: Martin Osugo, Uzma Zahid, Pierluigi Selvaggi, Alexandria Chilimidos, Valeria Finelli, George E. Chapman, Thomas Whitehurst, Ellis Chika Onwordi, Robin M. Murray, Matthew B. Wall, Tiago Reis Marques, Mitul A. Mehta, Oliver D. Howes
Publicado en: Molecular Psychiatry, Edición 30, 2025, Página(s) 5315-5325, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-025-03116-8

Translational Psychiatry

Autores: Ying Xiong; Robert Karlsson; Jie Song; Kaarina Kowalec; Christian Rck; Robert Sigstrm; Lina Jonsson; Caitlin C. Clements; Evelyn Andersson; Julia Boberg; Cathryn M. Lewis; Patrick F. Sullivan; Mikael Landn; Yi Lu
Publicado en: Translational Psychiatry, Vol 13, Iss 1, Pp 1-7 (2023), Edición 23, 2023, ISSN 2158-3188
Editor: Nature Publishing Group

Antipsychotic and pharmacogenomic effects on cross-sectional symptom severity and cognitive ability in schizophrenia

Autores: Siobhan K. Lock, Djenifer B. Kappel, Michael J. Owen, James T.R. Walters, Michael C. O'Donovan, Antonio F. Pardiñas, Sophie E. Legge
Publicado en: eBioMedicine, Edición 116, 2025, Página(s) 105745, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2025.105745

Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders

Autores: Guy Hindley, Ole Kristian Drange, Aihua Lin, Gleda Kutrolli, Alexey A. Shadrin, Nadine Parker, Kevin S. O’Connell, Linn Rødevand, Weiqiu Cheng, Shahram Bahrami, Naz Karadag, Børge Holen, Piotr Jaholkowski, Markos Tesfaye Woldeyohannes, Srdjan Djurovic, Anders M. Dale, Oleksandr Frei, Thor Ueland, Olav B. Smeland, Ole A. Andreassen
Publicado en: Psychoneuroendocrinology, Edición 157, 2024, Página(s) 106368, ISSN 0306-4530
Editor: Pergamon Press
DOI: 10.1016/j.psyneuen.2023.106368

Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study

Autores: E. P. Tissink, A. A. Shadrin, D. van der Meer, N. Parker, G. Hindley, D. Roelfs, O. Frei, C. C. Fan, M. Nagel, T. Nærland, M. Budisteanu, S. Djurovic, L. T. Westlye, M. P. van den Heuvel, D. Posthuma, T. Kaufmann, A. M. Dale, O. A. Andreassen
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-46817-4

Genetic Overlap Between Global Cortical Brain Structure, C-Reactive Protein, and White Blood Cell Counts

Autores: Nadine Parker, Weiqiu Cheng, Guy F.L. Hindley, Kevin S. O’Connell, Sandeep Karthikeyan, Børge Holen, Alexey A. Shadrin, Zillur Rahman, Naz Karadag, Shahram Bahrami, Aihua Lin, Nils Eiel Steen, Thor Ueland, Pål Aukrust, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Oleksandr Frei, Ole A. Andreassen
Publicado en: Biological Psychiatry, Edición 95, 2024, Página(s) 62-71, ISSN 0006-3223
Editor: Elsevier BV
DOI: 10.1016/j.biopsych.2023.06.008

Rapid Metabolism Underlying Subtherapeutic Serum Levels of Atypical Antipsychotics Preceding Clozapine Treatment: A Retrospective Analysis of Real-World Data

Autores: Hasan Çağın Lenk, Robert Løvsletten Smith, Kevin S. O’Connell, Ole A. Andreassen, Espen Molden
Publicado en: CNS Drugs, Edición 38, 2024, Página(s) 473-480, ISSN 1172-7047
Editor: Adis International Ltd.
DOI: 10.1007/s40263-024-01079-y

Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression

Autores: Ying Xiong, Kristi Krebs, Bradley Jermy, Robert Karlsson, Joëlle A. Pasman, Thuy-Dung Nguyen, Tong Gong, Kaarina Kowalec, Christian Rück, Robert Sigström, Lina Jonsson, Caitlin C. Clements, Elin Hörbeck, Evelyn Andersson, Julia Bäckman, null null, null null, Andrea Ganna, Jakob German, Patrick F. Sullivan, Mikael Landén, Kelli Lehto, Yi Lu
Publicado en: Molecular Psychiatry, Edición 30, 2025, Página(s) 5024-5033, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-025-03084-z

Polygenic liability for antipsychotic dosage and polypharmacy - a real-world registry and biobank study

Autores: Elise Koch, Anders Kämpe, Maris Alver, Sindri Sigurðarson, Guðmundur Einarsson, Juulia Partanen, Robert L. Smith, Piotr Jaholkowski, Heidi Taipale, Markku Lähteenvuo, Nils Eiel Steen, Olav B. Smeland, Srdjan Djurovic, Espen Molden, null null, null null, Engilbert Sigurdsson, Hreinn Stefánsson, Kári Stefánsson, Aarno Palotie, Lili Milani, Kevin S. O’Connell, Ole A. Andreassen
Publicado en: Neuropsychopharmacology, Edición 49, 2024, Página(s) 1113-1119, ISSN 0893-133X
Editor: Nature Publishing Group
DOI: 10.1038/s41386-023-01792-0

Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry

Autores: Anna Gui, Anja Hollowell, Emilie M. Wigdor, Morgan J. Morgan, Laurie J. Hannigan, Elizabeth C. Corfield, Veronika Odintsova, Jouke-Jan Hottenga, Andrew Wong, René Pool, Harriet Cullen, Siân Wilson, Varun Warrier, Espen M. Eilertsen, Ole A. Andreassen, Christel M. Middeldorp, Beate St Pourcain, Meike Bartels, Dorret I. Boomsma, Catharina A. Hartman, Elise B. Robinson, Tomoki Arichi, Anthony D. Ed
Publicado en: Nature Human Behaviour, Edición 9, 2025, Página(s) 1470-1487, ISSN 2397-3374
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41562-025-02145-1

A comprehensive map of genetic relationships among diagnostic categories based on 48.6 million relative pairs from the Danish genealogy

Autores: Georgios Athanasiadis, Joeri J. Meijsen, Dorte Helenius, Andrew J. Schork, Andrés Ingason, Wesley K. Thompson, Daniel H. Geschwind, Thomas Werge, Alfonso Buil
Publicado en: Proceedings of the National Academy of Sciences, Edición 119, 2022, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2118688119

Genetic Contribution to the Heterogeneity of Major Depressive Disorder: Evidence From a Sibling-Based Design Using Swedish National Registers

Autores: Thuy-Dung Nguyen, Kaarina Kowalec, Joëlle Pasman, Henrik Larsson, Paul Lichtenstein, Christina Dalman, Patrick F. Sullivan, Ralf Kuja-Halkola, Yi Lu
Publicado en: American Journal of Psychiatry, Edición 180, 2024, Página(s) 714-722, ISSN 0002-953X
Editor: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.20220906

Medical comorbidities in bipolar disorder (BIPCOM): clinical validation of risk factors and biomarkers to improve prevention and treatment. Study protocol

Autores: Giovanni de Girolamo, Ole A. Andreassen, Michael Bauer, Paolo Brambilla, Stefano Calza, Nicholas Citerà, Rosa Corcoy, Andrea Fagiolini, Miguel Garcia-Argibay, Ophélia Godin, Florian Klingler, Nene F. Kobayashi, Henrik Larsson, Marion Leboyer, Silke Matura, Alessandra Martinelli, Víctor De la Peña-Arteaga, Roberto Poli, Andreas Reif, Philipp Ritter, Linn N. Rødevand, Marta Magno, Elisa Caselan
Publicado en: International Journal of Bipolar Disorders, Edición 12, 2024, ISSN 2194-7511
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s40345-024-00337-8

Associations Between Symptoms of Premenstrual Disorders and Polygenic Liability for Major Psychiatric Disorders

Autores: Piotr Jaholkowski, Alexey A. Shadrin, Andreas Jangmo, Evgeniia Frei, Markos Tesfaye, Guy F. L. Hindley, Marit Haram, Zillur Rahman, Lavinia Athanasiu, Nora Refsum Bakken, Børge Holen, Vera Fominykh, Gleda Kutrolli, Pravesh Parekh, Nadine Parker, Linn Rødevand, Viktoria Birkenæs, Srdjan Djurovic, Oleksandr Frei, Kevin S. O’Connell, Olav B. Smeland, Martin Tesli, Ole A. Andreassen
Publicado en: JAMA Psychiatry, Edición 80, 2023, Página(s) 738, ISSN 2168-622X
Editor: American Medical Association
DOI: 10.1001/jamapsychiatry.2023.1137

Identification of risk variants and cross-disorder pleiotropy through multi-ancestry genome-wide analysis of alcohol use disorder

Autores: Romain Icick, Alexey Shadrin, Børge Holen, Naz Karadag, Nadine Parker, Kevin S. O’Connell, Oleksandr Frei, Shahram Bahrami, Margrethe Collier Høegh, Trine Vik Lagerberg, Weiqiu Cheng, Tyler M. Seibert, Srdjan Djurovic, Anders M. Dale, Hang Zhou, Howard J. Edenberg, Joel Gelernter, Olav B. Smeland, Guy Hindley, Ole A. Andreassen
Publicado en: Nature Mental Health, Edición 3, 2025, Página(s) 253-265, ISSN 2731-6076
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s44220-024-00353-8

The phenotypic and genetic relationship between adolescent mental health and time spent on social media, gaming, and TV

Autores: Evgeniia Frei, Oleksandr Frei, Piotr Jaholkowski, Nadine Parker, Pravesh Parekh, Alexey A. Shadrin, Espen Hagen, Nora R. Bakken, Viktoria Birkenæs, Helga Ask, Ole A. Andreassen, Olav B. Smeland
Publicado en: Psychiatry Research, Edición 353, 2026, Página(s) 116761, ISSN 0165-1781
Editor: Elsevier BV
DOI: 10.1016/j.psychres.2025.116761

Genetic and Phenotypic Features of Schizophrenia in the UK Biobank

Autores: Sophie E. Legge, Antonio F. Pardiñas, Grace Woolway, Elliott Rees, Alastair G. Cardno, Valentina Escott-Price, Peter Holmans, George Kirov, Michael J. Owen, Michael C. O’Donovan, James T. R. Walters
Publicado en: JAMA Psychiatry, Edición 81, 2024, Página(s) 681, ISSN 2168-622X
Editor: American Medical Association
DOI: 10.1001/jamapsychiatry.2024.0200

Identification and validation of postpartum depression subtypes: a population-based cohort study

Autores: Anna E. Bauer, Piotr Jaholkowski, Yi Lu, Jerry Guintivano, Laurie J. Hannigan, Elizabeth C. Corfield, Martin Tesli, Ole A. Andreassen, Yun Li, Ted Reichborn-Kjennerud, Patrick F. Sullivan, Samantha Meltzer-Brody, Alexandra Havdahl, Helga Ask
Publicado en: eClinicalMedicine, Edición 89, 2025, Página(s) 103540, ISSN 2589-5370
Editor: Elsevier BV
DOI: 10.1016/j.eclinm.2025.103540

Recommendations for defining treatment outcomes in major psychiatric disorders leveraging real-world data

Autores: Elise Koch, Sophie Elizabeth Smart, Guðmundur Einarsson, Anders Kämpe, Lina Jonsson, Maris Alver, Matthew Henry Iveson, Andreas Göteson, Antonio F Pardiñas, Ida E. Sønderby, Kevin O’Connell, Qingqin Li, Lu Yi, Hreinn Stefansson, Kári Stefánsson, Heather C Whalley, Mikael Landén, Michael C. O’Donovan, Knut T. Smerud, Gerard R. Dawson, Thomas Werge, Alfonso Buil, Andreas Reif, Lili Milan
Publicado en: Lancet Psychiatry, 2025, ISSN 2215-0366
Editor: Elsevier Limited
DOI: 10.31234/osf.io/kumea_v1

Improved functional mapping of complex trait heritability with GSA-MiXeR implicates biologically specific gene sets

Autores: Oleksandr Frei, Guy Hindley, Alexey A. Shadrin, Dennis van der Meer, Bayram C. Akdeniz, Espen Hagen, Weiqiu Cheng, Kevin S. O’Connell, Shahram Bahrami, Nadine Parker, Olav B. Smeland, Dominic Holland, null null, Christiaan de Leeuw, Danielle Posthuma, Ole A. Andreassen, Anders M. Dale
Publicado en: Nature Genetics, Edición 56, 2024, Página(s) 1310-1318, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-024-01771-1

Striatal dopamine D2/D3 receptor regulation of human reward processing and behaviour

Autores: Martin Osugo, Matthew B. Wall, Pierluigi Selvaggi, Uzma Zahid, Valeria Finelli, George E. Chapman, Thomas Whitehurst, Ellis Chika Onwordi, Ben Statton, Robert A. McCutcheon, Robin M. Murray, Tiago Reis Marques, Mitul A. Mehta, Oliver D. Howes
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-025-56663-7

Impact of CYP1A , CYP2C19 , CYP2D6 , CYP3A4 , CYP3A5 , and NFIB genotypes on clozapine serum concentration in smokers and nonsmokers

Autores: Hasan Çağın Lenk, Line Skute Bråten, Ole A. Andreassen, Espen Molden
Publicado en: Therapeutic Advances in Psychopharmacology, Edición 15, 2025, ISSN 2045-1253
Editor: SAGE Publications
DOI: 10.1177/20451253251377183

Polygenic and pharmacogenomic contributions to medication dosing: a real-world longitudinal biobank study

Autores: Silva Kasela, Laura Birgit Luitva, Kristi Krebs, null null, Märt Möls, Lili Milani, Maris Alver
Publicado en: Journal of Translational Medicine, Edición 23, 2025, ISSN 1479-5876
Editor: BioMed Central
DOI: 10.1186/s12967-025-06782-y

A pattern-learning algorithm associates copy number variations with brain structure and behavioural variables in an adolescent population cohort

Autores: Jakub Kopal, Guillaume Huguet, Justin Marotta, Shambhavi Aggarwal, Nicole Osayande, Kuldeep Kumar, Zohra Saci, Martineau Jean-Louis, Xiaoqian J. Chai, Tian Ge, B. T. Thomas Yeo, Paul M. Thompson, Carrie E. Bearden, Ole A. Andreassen, Sébastien Jacquemont, Danilo Bzdok
Publicado en: Nature Biomedical Engineering, 2025, ISSN 2157-846X
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41551-025-01454-0

Associations of polygenic risk scores for major depression and depression severity: an investigation of 105 623 individuals with 16 years follow-up

Autores: Marit Haram, Andreas Jangmo, Piotr Jaholkowski, Joëlle Pasman, Joeri Meijsen, John R. Shorter, Elizabeth C. Corfield, Oleksandr Frei, Ted Reichborn-Kjennerud, Alfonso Buil, Yi Lu, Thomas Werge, Patrick Sullivan, Ole A. Andreassen, Martin Tesli
Publicado en: Molecular Psychiatry, 2025, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-025-03243-2

Genetic predisposition and antipsychotic treatment effect on metabolic syndrome in schizophrenia: a ten-year follow-up study using the Estonian Biobank

Autores: Maris Alver, Silva Kasela, Liina Haring, Laura Birgit Luitva, Krista Fischer, Märt Möls, Lili Milani
Publicado en: The Lancet Regional Health - Europe, Edición 41, 2024, Página(s) 100914, ISSN 2666-7762
Editor: Lancet Regional Health Europe
DOI: 10.1016/j.lanepe.2024.100914

AI for Analyzing Mental Health Disorders Among Social Media Users: Quarter-Century Narrative Review of Progress and Challenges

Autores: David Owen, Amy J Lynham, Sophie E Smart, Antonio F Pardiñas, Jose Camacho Collados
Publicado en: Journal of Medical Internet Research, Edición 26, 2024, Página(s) e59225, ISSN 1438-8871
Editor: Journal of medical Internet Research
DOI: 10.2196/59225

Socio-demographic and genetic risk factors for drug adherence and persistence across 5 common medication classes

Autores: Mattia Cordioli, Andrea Corbetta, Hanna Maria Kariis, Sakari Jukarainen, Pekka Vartiainen, Tuomo Kiiskinen, Matteo Ferro, null null, Markus Perola, Samuli Ripatti, Andrea Ganna, null null, Andres Metspalu, Lili Milani, Tõnu Esko, Reedik Mägi, Mari Nelis, Georgi Hudjashov, Markus Perola, Mikko Niemi, Samuli Ripatti, Kelli Lehto, Lili Milani, Andrea Ganna
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-53556-z

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications

Autores: Ole A. Andreassen, Guy F.L. Hindley, Oleksandr Frei, Olav B. Smeland
Publicado en: World Psychiatry, Edición 22, 2023, Página(s) 4-24, ISSN 1723-8617
Editor: Masson Italia Periodici
DOI: 10.1002/wps.21034

Association between genetic liability to physical health conditions and comorbidities in individuals with severe mental illness: an analysis of two cross-sectional observational studies in the UK

Autores: Djenifer B Kappel, Sophie E Smart, Michael J Owen, Michael C O'Donovan, Antonio F Pardiñas, James T R Walters
Publicado en: The Lancet Psychiatry, Edición 12, 2025, Página(s) 447-456, ISSN 2215-0366
Editor: Elsevier Limited
DOI: 10.1016/s2215-0366(25)00123-3

Effects of a Novel UGT2B Haplotype and UGT1A4*3 Allele Variants on Glucuronidation of Clozapine In vivo

Autores: Robert Løvsletten Smith; Birgit M. Wollmann; Marianne Kausberg; Sondre Mæland; Marit Tveito; Kevin O’Connell; Espen Molden; Marianne Kristiansen Kringen
Publicado en: Crossref, Edición 1, 2022, ISSN 1389-2002
Editor: Bentham Science Publishers
DOI: 10.2174/1389200223666220201152953

Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study

Autores: Álvaro Hernáez, Karoline H. Skåra, Christian M. Page, Vera R. Mitter, Marta H. Hernández, Per Magnus, Pål R. Njølstad, Ole A. Andreassen, Elizabeth C. Corfield, Alexandra Havdahl, Øyvind Næss, Ben Brumpton, Bjørn Olav Åsvold, Deborah A. Lawlor, Abigail Fraser, Maria Christine Magnus
Publicado en: BMC Medicine, Edición 22, 2024, ISSN 1741-7015
Editor: BioMed Central
DOI: 10.1186/s12916-023-03223-9

Polygenic risk scores of lithium response and treatment resistance in major depressive disorder

Autores: Ying Xiong, Robert Karlsson, Jie Song, Kaarina Kowalec, Christian Rück, Robert Sigström, Lina Jonsson, Caitlin C. Clements, Evelyn Andersson, Julia Boberg, Cathryn M. Lewis, Patrick F. Sullivan, Mikael Landén, Yi Lu
Publicado en: Translational Psychiatry, Edición 13, 2023, ISSN 2158-3188
Editor: Nature Publishing Group
DOI: 10.1038/s41398-023-02602-3

Partitioning variance in cortical morphometry into genetic, environmental, and subject-specific components

Autores: Diana M Smith, Pravesh Parekh, Joseph Kennedy, Robert Loughnan, Oleksandr Frei, Thomas E Nichols, Ole A Andreassen, Terry L Jernigan, Anders M Dale
Publicado en: Cerebral Cortex, Edición 34, 2024, ISSN 1047-3211
Editor: Oxford University Press
DOI: 10.1093/cercor/bhae234

Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count

Autores: Siobhan K. Lock, Sophie E. Legge, Djenifer B. Kappel, Isabella R. Willcocks, Marinka Helthuis, John Jansen, James T. R. Walters, Michael J. Owen, Michael C. O’Donovan, Antonio F. Pardiñas
Publicado en: Schizophrenia, Edición 9, 2023, ISSN 2754-6993
Editor: Schizophrenia
DOI: 10.1038/s41537-023-00404-6

Finemap-MiXeR: A variational Bayesian approach for genetic finemapping

Autores: Bayram Cevdet Akdeniz, Oleksandr Frei, Alexey Shadrin, Dmitry Vetrov, Dmitry Kropotov, Eivind Hovig, Ole A. Andreassen, Anders M. Dale
Publicado en: PLOS Genetics, Edición 20, 2024, Página(s) e1011372, ISSN 1553-7404
Editor: Public Library of Science (PLoS)
DOI: 10.1371/journal.pgen.1011372

Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis

Autores: Markos Tesfaye, Piotr Jaholkowski, Guy F. L. Hindley, Alexey A. Shadrin, Zillur Rahman, Shahram Bahrami, Aihua Lin, Børge Holen, Nadine Parker, Weiqiu Cheng, Linn Rødevand, Oleksandr Frei, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Kevin S. O’Connell, Ole A. Andreassen
Publicado en: Genome Medicine, Edición 15, 2023, ISSN 1756-994X
Editor: BioMed Central
DOI: 10.1186/s13073-023-01212-4

Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities

Autores: Nils Eiel Steen, Zillur Rahman, Attila Szabo, Guy F L Hindley, Nadine Parker, Weiqiu Cheng, Aihua Lin, Kevin S O’Connell, Mashhood A Sheikh, Alexey Shadrin, Shahram Bahrami, Sandeep Karthikeyan, Eva Z Hoseth, Anders M Dale, Pål Aukrust, Olav B Smeland, Thor Ueland, Oleksandr Frei, Srdjan Djurovic, Ole A Andreassen
Publicado en: Schizophrenia Bulletin, Edición 49, 2023, Página(s) 1345-1354, ISSN 0586-7614
Editor: Oxford University Press
DOI: 10.1093/schbul/sbad082

Large Language Model–Supported Identification of Intellectual Disabilities in Clinical Free-Text Summaries: Mixed Methods Study

Autores: Aleksandra Edwards, Antonio F Pardiñas, George Kirov, Elliott Rees, Jose Camacho-Collados
Publicado en: JMIR AI, Edición 4, 2025, Página(s) e72256-e72256, ISSN 2817-1705
Editor: JMIR Publications Inc.
DOI: 10.2196/72256

Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia

Autores: Djenifer B. Kappel, Elliott Rees, Eilidh Fenner, Adrian King, John Jansen, Marinka Helthuis, Michael J. Owen, Michael C. O'Donovan, James T.R. Walters, Antonio F. Pardiñas
Publicado en: European Neuropsychopharmacology, Edición 80, 2024, Página(s) 47-54, ISSN 0924-977X
Editor: Elsevier BV
DOI: 10.1016/j.euroneuro.2023.12.007

Unraveling the shared genetics of common epilepsies and general cognitive ability

Autores: Naz Karadag, Espen Hagen, Alexey A. Shadrin, Dennis van der Meer, Kevin S. O'Connell, Zillur Rahman, Gleda Kutrolli, Nadine Parker, Shahram Bahrami, Vera Fominykh, Kjell Heuser, Erik Taubøll, Torill Ueland, Nils Eiel Steen, Srdjan Djurovic, Anders M. Dale, Oleksandr Frei, Ole A. Andreassen, Olav B. Smeland
Publicado en: Seizure: European Journal of Epilepsy, Edición 122, 2025, Página(s) 105-112, ISSN 1059-1311
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.seizure.2024.09.016

Polygenic overlap of substance use behaviors and disorders with externalizing and internalizing problems independent of genetic correlations

Autores: Laila Al-Soufi, Guy Hindley, Linn Rødevand, Alexey A. Shadrin, Piotr Jaholkowski, Vera Fominykh, Romain Icick, Markos Tesfaye, Javier Costas, Ole A. Andreassen
Publicado en: Psychological Medicine, Edición 55, 2025, ISSN 0033-2917
Editor: Cambridge University Press
DOI: 10.1017/s0033291725000108

Telomere biology and its maintenance in schizophrenia spectrum disorders: Exploring links to cognition

Autores: Vid Mlakar, Ibrahim Akkouh, Els F. Halff, Deepak P. Srivastava, Viktoria Birkenæs, Torill Ueland, Daniel S. Quintana, Monica B.E.G. Ormerod, Nils Eiel Steen, Srdjan Djurovic, Ole A. Andreassen, Monica Aas
Publicado en: Schizophrenia Research, Edición 272, 2025, Página(s) 89-95, ISSN 0920-9964
Editor: Elsevier BV
DOI: 10.1016/j.schres.2024.08.011

COSGAP: COntainerized Statistical Genetics Analysis Pipelines

Autores: Bayram Cevdet Akdeniz, Oleksandr Frei, Espen Hagen, Tahir Tekin Filiz, Sandeep Karthikeyan, Joëlle Pasman, Andreas Jangmo, Jacob Bergstedt, John R Shorter, Richard Zetterberg, Joeri Meijsen, Ida Elken Sønderby, Alfonso Buil, Martin Tesli, Yi Lu, Patrick Sullivan, Ole A Andreassen, Eivind Hovig
Publicado en: Bioinformatics Advances, Edición 4, 2024, ISSN 2635-0041
Editor: Oxford University Press (OUP)
DOI: 10.1093/bioadv/vbae067

Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research

Autores: Na Cai, Brad Verhulst, Ole A. Andreassen, Jan Buitelaar, Howard J. Edenberg, John M. Hettema, Michael Gandal, Andrew Grotzinger, Katherine Jonas, Phil Lee, Travis T. Mallard, Manuel Mattheisen, Michael C. Neale, John I. Nurnberger, Wouter J. Peyrot, Elliot M. Tucker-Drob, Jordan W. Smoller, Kenneth S. Kendler
Publicado en: Molecular Psychiatry, Edición 30, 2025, Página(s) 1627-1638, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-024-02878-x

Genome-wide association analysis of treatment resistant schizophrenia for variant discovery and polygenic assessment

Autores: Hasan Çağın Lenk, Elise Koch, Kevin S. O’Connell, Robert Løvsletten Smith, Ibrahim A. Akkouh, Srdjan Djurovic, Ole A. Andreassen, Espen Molden
Publicado en: Human Genomics, Edición 18, 2024, ISSN 1479-7364
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s40246-024-00673-x

Effect of the NFIB rs28379954 T>C polymorphism on <scp>CYP2D6</scp>‐catalyzed metabolism of solanidine

Autores: Robert Løvsletten Smith, Birgit M. Wollmann, Elisabet Størset, Hasan Çağın Lenk, Kevin S. O'Connell, Marianne Kringen Kristiansen, Magnus Ingelman‐Sundberg, Espen Molden
Publicado en: Clinical and Translational Science, Edición 17, 2024, ISSN 1752-8054
Editor: Wiley-Blackwell
DOI: 10.1111/cts.13743

Investigating genetic overlap between antidepressant and lithium response and treatment resistance in major depressive disorder

Autores: Yi Lu; Ying Xiong; Robert Karlsson; Jie Song; Kaarina Kowalec; Christian Rück; Robert Sigstrom; Lina Jonsson; Caitlin Clements; Evelyn Andersson; Julia Boberg; Cathryn Lewis; Patrick Sullivan; Mikael Landén
Publicado en: Crossref, Edición 17, 2023, ISSN 2693-5015
Editor: translational psychiatry
DOI: 10.21203/rs.3.rs-2556941/v1

Psychometric Properties and Diagnostic Associations of the Short-Form Community Assessment of Psychic Experiences in a Population-Based Sample of 29 021 Adult Men

Autores: Viktoria Birkenæs, Nora Refsum Bakken, Evgeniia Frei, Piotr Jaholkowski, Olav B Smeland, Markos Tesfaye, Ingrid Agartz, Ezra Susser, Michaeline Bresnahan, Espen Røysamb, Kjetil Nordbø Jørgensen, Ragnar Nesvåg, Alexandra Havdahl, Ole A Andreassen, Ida Elken Sønderby
Publicado en: Schizophrenia Bulletin, Edición 49, 2023, Página(s) 1229-1238, ISSN 0586-7614
Editor: Oxford University Press
DOI: 10.1093/schbul/sbad074

Shared genetic loci between Alzheimer's disease and multiple sclerosis: Crossroads between neurodegeneration and immune system

Autores: Vera Fominykh, Alexey A. Shadrin, Piotr P. Jaholkowski, Shahram Bahrami, Lavinia Athanasiu, Douglas P. Wightman, Emil Uffelmann, Danielle Posthuma, Geir Selbæk, Anders M. Dale, Srdjan Djurovic, Oleksandr Frei, Ole A. Andreassen
Publicado en: Neurobiology of Disease, Edición 183, 2024, Página(s) 106174, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2023.106174

Mapping the genetic landscape of immune-mediated disorders: potential implications for classification and therapeutic strategies

Autores: Vera Fominykh, Alexey A. Shadrin, Piotr Jaholkowski, Julian Fuhrer, Nadine Parker, Erik D. Wiström, Oleksandr Frei, Olav B. Smeland, Helga Sanner, Srdjan Djurovic, Ole A. Andreassen
Publicado en: Frontiers in Immunology, Edición 16, 2025, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1543781

Multimodal Prediction of Psychosis in the Prospective MoBa Birth Cohort

Autores: Viktoria Birkenæs, Pravesh Parekh, Alexey Shadrin, Piotr Jaholkowski, Lars A. R. Ystaas, Carolina Makowski, Nora R. Bakken, Espen Hagen, Evgeniia Frei, Dominic Oliver, Paolo Fusar-Poli, Anders Dale, John P. John, Alexandra Havdahl, Ida E. Sønderby, Ole A. Andreassen
Publicado en: Preprint in Research Square, 2025
Editor: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-6783339/v1

Associations of Genetic Liability to Six Psychiatric Disorders With Cardiometabolic Diseases

Autores: Jacob Bergstedt, Kadri Kõiv, Andreas Jangmo, Marit Haram, Piotr P. Jaholkowski, Jorien L. Treur, Isabell Brikell, Zheng Chang, Henrik Larsson, Patrik K. E. Magnusson, Andrew M. McIntosh, Cathryn M. Lewis, Brian K. Lee, Ida E. Sønderby, Yi Lu, Patrick F. Sullivan, Unnur A. Valdimarsdóttir, Ole Andreassen, Martin Tesli, Kelli Lehto, Fang Fang, null null, null null
Publicado en: 2026
Editor: openRxiv
DOI: 10.1101/2025.03.11.25323757

Genome-wide meta-analyses of non-response to antidepressants identify novel loci and potential drugs

Autores: Elise Koch, Tuuli Jurgenson, Gudmundur Einarsson, Brittany Mitchell, Arvid Harder, Luis M Garcia-Marin, Kristi Krebs, Yuhao Lin, Ying Xiong, Estonian Biobank Research Team, Yi Lu, Sara Hagg, Miguel E Renteria, Sarah E Medland, Naomi R Wray, Nicholas G Martin, Christopher Huebel, Gerome Breen, Thorgeir Thorgeirsson, Hreinn Stefansson, Kari Stefansson, Lili Milani, Ole A Andreassen, Kevin S O'Connel
Publicado en: 2026
Editor: openRxiv
DOI: 10.1101/2024.07.13.24310361

SLC39A8.p.(Ala391Thr) is associated with poorer cognitive ability: a cross-sectional study of schizophrenia and the general UK population

Autores: Sophie E Smart, Sophie E. Legge, Eilidh Fenner, Antonio F. Pardiñas, Grace Woolway, Amy J. Lynham, Valentina Escott-Price, Jeremy Hall, Lawrence Wilkinson, Peter Holmans, Michael C. O’Donovan, Michael J. Owen, James T.R. Walters
Publicado en: Preprint in medRxiv, 2026
Editor: openRxiv
DOI: 10.1101/2024.09.18.24313865

Youth Psychotic Experiences: Diagnostic Associations and Evaluation of the CAPE-16

Autores: Viktoria Birkenæs, Pravesh Parekh, Laura Hegemann, Nora R. Bakken, Evgeniia Frei, Piotr Jaholkowski, Olav B. Smeland, Ezra Susser, Katrina M. Rodriguez, Markos Tesfaye, Ole A. Andreassen, Alexandra Havdahl, Ida E. Sønderby
Publicado en: Preprint in MedRxiv, 2026
Editor: openRxiv
DOI: 10.1101/2024.04.18.24306017

Simplifying causal gene identification in GWAS loci

Autores: Marijn Schipper, Jacob Ulirsch, Danielle Posthuma, Stephan Ripke, Karl Heilbron
Publicado en: Preprint in medRxiv, 2026
Editor: openRxiv
DOI: 10.1101/2024.07.26.24311057

Interpreting artificial neural networks to detect genome-wide association signals for complex traits

Autores: Yelmen, Burak; Alver, Maris; Güler, Merve Nur; Team, Estonian Biobank Research; Jay, Flora; Milani, Lili
Publicado en: Preprint in Arxiv, Edición 1, 2024
Editor: Arxiv
DOI: 10.48550/arxiv.2407.18811

Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer’s Disease in European Populations: Development and Validation

Autores: Bayram Cevdet Akdeniz, Shahram Bahrami, Espen Hagen, Julian Fuhrer, Vera Fominykh, Alexey Shadrin, Tahir Tekin Filiz, Lavinia Athanasiu, Benjamin Grenier-Boley, Céline Bellenguez, Itziar de Rojas, Fahri Küçükali, Anja Schneider, Luca Kleineidam, Dan Rujescu, Norbert Scherbaum, Jürgen Deckert, Steffi Riedel-Heller, Lucrezia Hausner, Laura Molina-Porcel, Timo Grimmer, Stefanie Heilmann-Heimbach
Publicado en: Preprint in Medrxiv, 2026
Editor: Medrxiv
DOI: 10.1101/2025.07.28.25332293

Identification of Novel Loci and Cross-Disorder Pleiotropy Through Multi-Ancestry Genome-Wide Analysis of Alcohol Use Disorder in Over One Million Individuals

Autores: Romain Icick, Alexey Shadrin, Børge Holen, Naz Karadag, Nadine Parker, Kevin O'Connell, Oleksandr Frei, Shahram Bahrami, Margrethe Høegh, Trine Lagerberg, Weiqiu Cheng, Tyler Seibert, Srdjan Djurovic, Anders Dale, Hang Zhou, Howard Edenberg, Joel Gelernter, Olav Smeland, Guy Hindley, Ole Andreassen
Publicado en: Preprint NLM, 2025
Editor: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-3755915/v1

Genome-wide analyses reveal widespread genetic overlap between neurological and psychiatric disorders and a convergence of biological associations related to the brain

Autores: Smeland, Olav B.; Kutrolli, Gleda; Bahrami, Shahram; Fominykh, Vera; Parker, Nadine; Hindley, Guy F. L.; Rødevand, Linn; Jaholkowski, Piotr; Tesfaye, Markos; Parekh, Pravesh; Elvsåshagen, Torbjørn; Grotzinger, Andrew D.; Steen, Nils Eiel; van der Meer, Dennis; O’Connell, Kevin S.; Djurovic, Srdjan; Dale, Anders M.; Shadrin, Alexey A.; Frei, Oleksandr; Andreassen, Ole A.
Publicado en: medRxiv, Edición 28, 2023, Página(s) 37503175
Editor: Europe PMC

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