Using real-world big data from eHealth, biobanks and national registries, integrated with clinical trial data to improve outcome of severe mental disorders

Informacje na temat projektu

REALMENT

Identyfikator umowy o grant: 964874

DOI

10.3030/964874

Data podpisania przez KE 29 Stycznia 2021

Data rozpoczęcia 1 Czerwca 2021

Data zakończenia 30 Listopada 2025

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 6 000 000,00

Wkład UE

€ 6 000 000,00

Koordynowany przez

UNIVERSITETET I OSLO
Norway

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (17)

Innovation, Intellectual Property (IP) and Knowledge Management Plan

Innovation Intellectual Property IP and Knowledge Management Plan

Risk Management Plan
Identification of relevant RWD sources in partner countries
Dissemination, Exploitation and Communication Plan yearly update M30

Dissemination, Exploitation and Communication Plan and yearly updates. Yearly updates shall include:- Newsletters- Updates of website- Report on scientific dissemination activities.- Report on public outreach.- Presentation of REALMENT findings to project stakeholders

An initial data freeze (Freeze 1) to be used for algorithm development
REALMENT Coordination team established
First Dissemination, Exploitation and Communication Plan done

First Dissemination Exploitation and Communication Plan done

Curated cross-border phenotypic data set
Minutes of the Annual Project Meeting Y3

Minutes of the Annual Project Meeting Y4

Quality Management Plan
Open access report on requirements for common data quality
Minutes of the Annual Project Meeting Y2
Replication of identified genotype-phenotype associations in an independent sample
Dissemination, Exploitation and Communication Plan yearly update M18

Dissemination Exploitation and Communication Plan and yearly updates Yearly updates shall include Newsletters Updates of website Report on scientific dissemination activities Report on public outreach Presentation of REALMENT findings to project stakeholders

Stakeholder input to design and user-friendly interface and clinical report design
Report of defined pharma trajectories
Tools and guidelines for data retrieval and sharing in place

Open Research Data Pilot (1)

Data Management Plan

Websites, patent fillings, videos etc. (1)

REALMENT website and Social Media channels operational

Publikacje

Peer reviewed articles (22)

Adolescent Psychedelic Use and Psychotic or Manic Symptoms

Autorzy: Otto Simonsson, Miriam A. Mosing, Walter Osika, Fredrik Ullén, Henrik Larsson, Yi Lu, Laura W. Wesseldijk
Opublikowane w: JAMA Psychiatry, Numer 81, 2024, Strona(/y) 579, ISSN 2168-622X
Wydawca: American Medical Association
DOI: 10.1001/jamapsychiatry.2024.0047

Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores

Autorzy: Djenifer B.KappelaSophie E.LeggeaLeonHubbardaIsabella R.WillcocksaKevin S.O’ConnelldRobert L.SmithdfEspenMoldenefOle A.AndreassendAdrianKingbJohnJansencMarinkaHelthuiscMichael J.OwenaMichael C.O’DonovanaJames T.R.WaltersaAntonio F.Pardiñasa
Opublikowane w: Biological Psychiatry, Numer Volume 93, Numer 2, 15 January 2023, 2023, Strona(/y) 149-156, ISSN 0006-3223
Wydawca: Elsevier BV
DOI: 10.1016/j.biopsych.2022.07.014

Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy

Autorzy: Guy Hindley, Alexey A. Shadrin, Dennis van der Meer, Nadine Parker, Weiqiu Cheng, Kevin S. O’Connell, Shahram Bahrami, Aihua Lin, Naz Karadag, Børge Holen, Thomas Bjella, Ian J. Deary, Gail Davies, W. David Hill, Jan Bressler, Sudha Seshadri, Chun Chieh Fan, Torill Ueland, Srdjan Djurovic, Olav B. Smeland, Oleksandr Frei, Anders M. Dale, Ole A. Andreassen
Opublikowane w: Nature Human Behaviour, Numer 7, 2023, Strona(/y) 1584-1600, ISSN 2397-3374
Wydawca: nature human behaviour
DOI: 10.1038/s41562-023-01630-9

Epidemiological overview of major depressive disorder in Scandinavia using nationwide registers

Autorzy: Joëlle A. Pasman, Joeri J. Meijsen, Marit Haram, Kaarina Kowalec, Arvid Harder, Ying Xiong, Thuy-Dung Nguyen, Andreas Jangmo, John R. Shorter, Jacob Bergstedt, Urmi Das, Richard Zetterberg, Ashley Tate, Paul Lichtenstein, Henrik Larsson, Ingvild Odsbu, Thomas Werge, Ted Reichborn-Kjennerud, Ole A. Andreassen, Patrick F. Sullivan, Alfonso Buil, Martin Tesli, Yi Lu
Opublikowane w: The Lancet Regional Health - Europe, Numer 29, 2023, Strona(/y) 100621, ISSN 2666-7762
Wydawca: Lancet Regional Health Europe
DOI: 10.1016/j.lanepe.2023.100621

Charting the Landscape of Genetic Overlap Between Mental Disorders and Related Traits Beyond Genetic Correlation

Autorzy: Guy Hindley, Oleksandr Frei, Alexey A. Shadrin, Weiqiu Cheng, Kevin S. O’Connell, Romain Icick, Nadine Parker, Shahram Bahrami, Naz Karadag, Daniel Roelfs, Børge Holen, Aihua Lin, Chun C. Fan, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Ole A. Andreassen
Opublikowane w: American Journal of Psychiatry, Numer 179, 2024, Strona(/y) 833-843, ISSN 0002-953X
Wydawca: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.21101051

Impact of NFIB and CYP1A variants on clozapine serum concentration—A retrospective naturalistic cohort study on 526 patients with known smoking habits

Autorzy: Hasan Çağın Lenk,Robert Løvsletten Smith,Kevin S. O'Connell,Marin M. Jukić,Marianne Kristiansen Kringen,Ole A. Andreassen,Magnus Ingelman-Sundberg,Espen Molden
Opublikowane w: Clin Transl Sci ., Numer 2023 Jan;16(1):62-72. doi: 10.1111/cts.13422. Epub 2022 Oct 7., 2023, Strona(/y) 62-72, ISSN 1752-8062
Wydawca: Wiley
DOI: 10.1111/cts.13422

Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia

Autorzy: Kevin S. O'Connell, Elise Koch, Hasan Çağın Lenk, Ibrahim A Akkouh, Guy Hindley, Piotr Jaholkowski, Robert Løvsletten Smith, Børge Holen, Alexey A. Shadrin, Oleksandr Frei, Olav B. Smeland, Nils Eiel Steen, Anders M. Dale, Espen Molden, Srdjan Djurovic, Ole A. Andreassen
Opublikowane w: Psychiatry Research, Numer 325, 2023, Strona(/y) 115217, ISSN 0165-1781
Wydawca: Elsevier BV
DOI: 10.1016/j.psychres.2023.115217

How Real-World Data Can Facilitate the Development of Precision Medicine Treatment in Psychiatry

Autorzy: Elise Koch, Antonio F. Pardiñas, Kevin S. O’Connell, Pierluigi Selvaggi, José Camacho Collados, Aleksandar Babic, Serena E. Marshall, Erik Van der Eycken, Cecilia Angulo, Yi Lu, Patrick F. Sullivan, Anders M. Dale, Espen Molden, Danielle Posthuma, Nathan White, Alexander Schubert, Srdjan Djurovic, Hakon Heimer, Hreinn Stefánsson, Kári Stefánsson, Thomas Werge, Ida Sønderby, Michael C. O’
Opublikowane w: Biological Psychiatry, 2024, ISSN 0006-3223
Wydawca: Elsevier BV
DOI: 10.1016/j.biopsych.2024.01.001

Genetic Overlap Between Global Cortical Brain Structure, C-Reactive Protein, and White Blood Cell Counts

Autorzy: Nadine Parker, Weiqiu Cheng, Guy F.L. Hindley, Kevin S. O’Connell, Sandeep Karthikeyan, Børge Holen, Alexey A. Shadrin, Zillur Rahman, Naz Karadag, Shahram Bahrami, Aihua Lin, Nils Eiel Steen, Thor Ueland, Pål Aukrust, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Oleksandr Frei, Ole A. Andreassen
Opublikowane w: Biological Psychiatry, Numer 95, 2024, Strona(/y) 62-71, ISSN 0006-3223
Wydawca: Elsevier BV
DOI: 10.1016/j.biopsych.2023.06.008

Polygenic liability for antipsychotic dosage and polypharmacy - a real-world registry and biobank study

Autorzy: Elise Koch, Anders Kämpe, Maris Alver, Sindri Sigurðarson, Guðmundur Einarsson, Juulia Partanen, Robert L. Smith, Piotr Jaholkowski, Heidi Taipale, Markku Lähteenvuo, Nils Eiel Steen, Olav B. Smeland, Srdjan Djurovic, Espen Molden, null null, null null, Engilbert Sigurdsson, Hreinn Stefánsson, Kári Stefánsson, Aarno Palotie, Lili Milani, Kevin S. O’Connell, Ole A. Andreassen
Opublikowane w: Neuropsychopharmacology, Numer 49, 2024, Strona(/y) 1113-1119, ISSN 0893-133X
Wydawca: Nature Publishing Group
DOI: 10.1038/s41386-023-01792-0

A comprehensive map of genetic relationships among diagnostic categories based on 48.6 million relative pairs from the Danish genealogy

Autorzy: Georgios Athanasiadis, Joeri J. Meijsen, Dorte Helenius, Andrew J. Schork, Andrés Ingason, Wesley K. Thompson, Daniel H. Geschwind, Thomas Werge, Alfonso Buil
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 119, 2022, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.2118688119

Genetic Contribution to the Heterogeneity of Major Depressive Disorder: Evidence From a Sibling-Based Design Using Swedish National Registers

Autorzy: Thuy-Dung Nguyen, Kaarina Kowalec, Joëlle Pasman, Henrik Larsson, Paul Lichtenstein, Christina Dalman, Patrick F. Sullivan, Ralf Kuja-Halkola, Yi Lu
Opublikowane w: American Journal of Psychiatry, Numer 180, 2024, Strona(/y) 714-722, ISSN 0002-953X
Wydawca: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.20220906

Associations Between Symptoms of Premenstrual Disorders and Polygenic Liability for Major Psychiatric Disorders

Autorzy: Piotr Jaholkowski, Alexey A. Shadrin, Andreas Jangmo, Evgeniia Frei, Markos Tesfaye, Guy F. L. Hindley, Marit Haram, Zillur Rahman, Lavinia Athanasiu, Nora Refsum Bakken, Børge Holen, Vera Fominykh, Gleda Kutrolli, Pravesh Parekh, Nadine Parker, Linn Rødevand, Viktoria Birkenæs, Srdjan Djurovic, Oleksandr Frei, Kevin S. O’Connell, Olav B. Smeland, Martin Tesli, Ole A. Andreassen
Opublikowane w: JAMA Psychiatry, Numer 80, 2023, Strona(/y) 738, ISSN 2168-622X
Wydawca: American Medical Association
DOI: 10.1001/jamapsychiatry.2023.1137

Genetic predisposition and antipsychotic treatment effect on metabolic syndrome in schizophrenia: a ten-year follow-up study using the Estonian Biobank

Autorzy: Maris Alver, Silva Kasela, Liina Haring, Laura Birgit Luitva, Krista Fischer, Märt Möls, Lili Milani
Opublikowane w: The Lancet Regional Health - Europe, Numer 41, 2024, Strona(/y) 100914, ISSN 2666-7762
Wydawca: Lancet Regional Health Europe
DOI: 10.1016/j.lanepe.2024.100914

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications

Autorzy: Ole A. Andreassen, Guy F.L. Hindley, Oleksandr Frei, Olav B. Smeland
Opublikowane w: World Psychiatry, Numer 22, 2023, Strona(/y) 4-24, ISSN 1723-8617
Wydawca: Masson Italia Periodici
DOI: 10.1002/wps.21034

Effects of a Novel UGT2B Haplotype and UGT1A4*3 Allele Variants on Glucuronidation of Clozapine In vivo

Autorzy: Robert Løvsletten Smith; Birgit M. Wollmann; Marianne Kausberg; Sondre Mæland; Marit Tveito; Kevin O’Connell; Espen Molden; Marianne Kristiansen Kringen
Opublikowane w: Crossref, Numer 1, 2022, ISSN 1389-2002
Wydawca: Bentham Science Publishers
DOI: 10.2174/1389200223666220201152953

Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study

Autorzy: Álvaro Hernáez, Karoline H. Skåra, Christian M. Page, Vera R. Mitter, Marta H. Hernández, Per Magnus, Pål R. Njølstad, Ole A. Andreassen, Elizabeth C. Corfield, Alexandra Havdahl, Øyvind Næss, Ben Brumpton, Bjørn Olav Åsvold, Deborah A. Lawlor, Abigail Fraser, Maria Christine Magnus
Opublikowane w: BMC Medicine, Numer 22, 2024, ISSN 1741-7015
Wydawca: BioMed Central
DOI: 10.1186/s12916-023-03223-9

Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count

Autorzy: Siobhan K. Lock, Sophie E. Legge, Djenifer B. Kappel, Isabella R. Willcocks, Marinka Helthuis, John Jansen, James T. R. Walters, Michael J. Owen, Michael C. O’Donovan, Antonio F. Pardiñas
Opublikowane w: Schizophrenia, Numer 9, 2023, ISSN 2754-6993
Wydawca: Schizophrenia
DOI: 10.1038/s41537-023-00404-6

Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities

Autorzy: Nils Eiel Steen, Zillur Rahman, Attila Szabo, Guy F L Hindley, Nadine Parker, Weiqiu Cheng, Aihua Lin, Kevin S O’Connell, Mashhood A Sheikh, Alexey Shadrin, Shahram Bahrami, Sandeep Karthikeyan, Eva Z Hoseth, Anders M Dale, Pål Aukrust, Olav B Smeland, Thor Ueland, Oleksandr Frei, Srdjan Djurovic, Ole A Andreassen
Opublikowane w: Schizophrenia Bulletin, Numer 49, 2023, Strona(/y) 1345-1354, ISSN 0586-7614
Wydawca: Oxford University Press
DOI: 10.1093/schbul/sbad082

Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia

Autorzy: Djenifer B. Kappel, Elliott Rees, Eilidh Fenner, Adrian King, John Jansen, Marinka Helthuis, Michael J. Owen, Michael C. O'Donovan, James T.R. Walters, Antonio F. Pardiñas
Opublikowane w: European Neuropsychopharmacology, Numer 80, 2024, Strona(/y) 47-54, ISSN 0924-977X
Wydawca: Elsevier BV
DOI: 10.1016/j.euroneuro.2023.12.007

Investigating genetic overlap between antidepressant and lithium response and treatment resistance in major depressive disorder

Autorzy: Yi Lu; Ying Xiong; Robert Karlsson; Jie Song; Kaarina Kowalec; Christian Rück; Robert Sigstrom; Lina Jonsson; Caitlin Clements; Evelyn Andersson; Julia Boberg; Cathryn Lewis; Patrick Sullivan; Mikael Landén
Opublikowane w: Crossref, Numer 17, 2023, ISSN 2693-5015
Wydawca: translational psychiatry
DOI: 10.21203/rs.3.rs-2556941/v1

Psychometric Properties and Diagnostic Associations of the Short-Form Community Assessment of Psychic Experiences in a Population-Based Sample of 29 021 Adult Men

Autorzy: Viktoria Birkenæs, Nora Refsum Bakken, Evgeniia Frei, Piotr Jaholkowski, Olav B Smeland, Markos Tesfaye, Ingrid Agartz, Ezra Susser, Michaeline Bresnahan, Espen Røysamb, Kjetil Nordbø Jørgensen, Ragnar Nesvåg, Alexandra Havdahl, Ole A Andreassen, Ida Elken Sønderby
Opublikowane w: Schizophrenia Bulletin, Numer 49, 2023, Strona(/y) 1229-1238, ISSN 0586-7614
Wydawca: Oxford University Press
DOI: 10.1093/schbul/sbad074

Conference proceedings (1)

Genome-wide analyses reveal widespread genetic overlap between neurological and psychiatric disorders and a convergence of biological associations related to the brain

Autorzy: Smeland, Olav B.; Kutrolli, Gleda; Bahrami, Shahram; Fominykh, Vera; Parker, Nadine; Hindley, Guy F. L.; Rødevand, Linn; Jaholkowski, Piotr; Tesfaye, Markos; Parekh, Pravesh; Elvsåshagen, Torbjørn; Grotzinger, Andrew D.; Steen, Nils Eiel; van der Meer, Dennis; O’Connell, Kevin S.; Djurovic, Srdjan; Dale, Anders M.; Shadrin, Alexey A.; Frei, Oleksandr; Andreassen, Ole A.
Opublikowane w: medRxiv, Numer 28, 2023, Strona(/y) 37503175
Wydawca: Europe PMC