Using real-world big data from eHealth, biobanks and national registries, integrated with clinical trial data to improve outcome of severe mental disorders

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Innovation, Intellectual Property (IP) and Knowledge Management Plan

Innovation Intellectual Property IP and Knowledge Management Plan

Risk Management Plan
Identification of relevant RWD sources in partner countries
Dissemination, Exploitation and Communication Plan yearly update M30

Dissemination, Exploitation and Communication Plan and yearly updates. Yearly updates shall include:- Newsletters- Updates of website- Report on scientific dissemination activities.- Report on public outreach.- Presentation of REALMENT findings to project stakeholders

An initial data freeze (Freeze 1) to be used for algorithm development
REALMENT Coordination team established
First Dissemination, Exploitation and Communication Plan done

First Dissemination Exploitation and Communication Plan done

Curated cross-border phenotypic data set
Minutes of the Annual Project Meeting Y3

Minutes of the Annual Project Meeting Y4

Quality Management Plan
Open access report on requirements for common data quality
Minutes of the Annual Project Meeting Y2
Replication of identified genotype-phenotype associations in an independent sample
Dissemination, Exploitation and Communication Plan yearly update M18

Dissemination Exploitation and Communication Plan and yearly updates Yearly updates shall include Newsletters Updates of website Report on scientific dissemination activities Report on public outreach Presentation of REALMENT findings to project stakeholders

Stakeholder input to design and user-friendly interface and clinical report design
Report of defined pharma trajectories
Tools and guidelines for data retrieval and sharing in place

Data Management Plan

REALMENT website and Social Media channels operational

Publikacje

A novel framework for assessing causal effect of microbiome on health: long-term antibiotic usage as an instrument

Autorzy: Nele Taba, Krista Fischer, null Estonian Biobank Research Team, Elin Org, Oliver Aasmets
Opublikowane w: Gut Microbes, Numer 17, 2025, ISSN 1949-0976
Wydawca: Landes Bioscience
DOI: 10.1080/19490976.2025.2453616

Adolescent Psychedelic Use and Psychotic or Manic Symptoms

Autorzy: Otto Simonsson, Miriam A. Mosing, Walter Osika, Fredrik Ullén, Henrik Larsson, Yi Lu, Laura W. Wesseldijk
Opublikowane w: JAMA Psychiatry, Numer 81, 2024, Strona(/y) 579, ISSN 2168-622X
Wydawca: American Medical Association
DOI: 10.1001/jamapsychiatry.2024.0047

Placental efflux transporters and antiseizure or antidepressant medication use impact birth weight in MoBa cohort

Autorzy: Marta H. Hernandez, Jacqueline M. Cohen, Karoline H. Skåra, Thea K. Grindstad, Yunsung Lee, Per Magnus, Pål R. Njølstad, Ole A. Andreassen, Elizabeth C. Corfield, Alexandra Havdahl, Espen Molden, Kari Furu, Maria C. Magnus, Alvaro Hernaez
Opublikowane w: iScience, Numer 27, 2025, Strona(/y) 109285, ISSN 2589-0042
Wydawca: Elsevier BV
DOI: 10.1016/j.isci.2024.109285

COVID-19 illness severity and 2-year prevalence of physical symptoms: an observational study in Iceland, Sweden, Norway and Denmark

Autorzy: Qing Shen, Emily E. Joyce, Omid V. Ebrahimi, Maria Didriksen, Anikó Lovik, Karen Sól Sævarsdóttir, Ingibjörg Magnúsdóttir, Dorte Helenius Mikkelsen, Anna Bára Unnarsdóttir, Arna Hauksdóttir, Asle Hoffart, Anna K. Kähler, Edda Björk Thórdardóttir, Elías Eythórsson, Emma M. Frans, Gunnar Tómasson, Helga Ask, Hrönn Hardardóttir, Jóhanna Jakobsdóttir, Kelli Lehto, Li Lu, Ole A. An
Opublikowane w: The Lancet Regional Health - Europe, Numer 35, 2025, Strona(/y) 100756, ISSN 2666-7762
Wydawca: Elsevier BV
DOI: 10.1016/j.lanepe.2023.100756

Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores

Autorzy: Djenifer B.KappelaSophie E.LeggeaLeonHubbardaIsabella R.WillcocksaKevin S.O’ConnelldRobert L.SmithdfEspenMoldenefOle A.AndreassendAdrianKingbJohnJansencMarinkaHelthuiscMichael J.OwenaMichael C.O’DonovanaJames T.R.WaltersaAntonio F.Pardiñasa
Opublikowane w: Biological Psychiatry, Numer Volume 93, Numer 2, 15 January 2023, 2023, Strona(/y) 149-156, ISSN 0006-3223
Wydawca: Elsevier BV
DOI: 10.1016/j.biopsych.2022.07.014

Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy

Autorzy: Guy Hindley, Alexey A. Shadrin, Dennis van der Meer, Nadine Parker, Weiqiu Cheng, Kevin S. O’Connell, Shahram Bahrami, Aihua Lin, Naz Karadag, Børge Holen, Thomas Bjella, Ian J. Deary, Gail Davies, W. David Hill, Jan Bressler, Sudha Seshadri, Chun Chieh Fan, Torill Ueland, Srdjan Djurovic, Olav B. Smeland, Oleksandr Frei, Anders M. Dale, Ole A. Andreassen
Opublikowane w: Nature Human Behaviour, Numer 7, 2023, Strona(/y) 1584-1600, ISSN 2397-3374
Wydawca: nature human behaviour
DOI: 10.1038/s41562-023-01630-9

Epidemiological overview of major depressive disorder in Scandinavia using nationwide registers

Autorzy: Joëlle A. Pasman, Joeri J. Meijsen, Marit Haram, Kaarina Kowalec, Arvid Harder, Ying Xiong, Thuy-Dung Nguyen, Andreas Jangmo, John R. Shorter, Jacob Bergstedt, Urmi Das, Richard Zetterberg, Ashley Tate, Paul Lichtenstein, Henrik Larsson, Ingvild Odsbu, Thomas Werge, Ted Reichborn-Kjennerud, Ole A. Andreassen, Patrick F. Sullivan, Alfonso Buil, Martin Tesli, Yi Lu
Opublikowane w: The Lancet Regional Health - Europe, Numer 29, 2023, Strona(/y) 100621, ISSN 2666-7762
Wydawca: Lancet Regional Health Europe
DOI: 10.1016/j.lanepe.2023.100621

Genome-wide meta-analyses of non-response to antidepressants provide insights into underlying molecular genetics and suggest potential pharmacotherapies

Autorzy: Elise Koch, Tuuli Puusepp, Guðmundur Einarsson, Brittany L. Mitchell, Arvid Harder, Yuhao Lin, Luis M. García-Marín, Kristi Krebs, Alexey A. Shadrin, Ying Xiong, null null, Andres Metspalu, Tõnu Esko, Reedik Mägi, Mari Nelis, Georgi Hudjashov, Oleksandr Frei, Yi Lu, Sara Hägg, Miguel E. Rentería, Sarah E. Medland, Naomi R. Wray, Nicholas G. Martin, Christopher Hübel, Gerome Breen, Thorgeir
Opublikowane w: Molecular Psychiatry, 2025, ISSN 1359-4184
Wydawca: Nature Publishing Group
DOI: 10.1038/s41380-025-03357-7

Charting the Landscape of Genetic Overlap Between Mental Disorders and Related Traits Beyond Genetic Correlation

Autorzy: Guy Hindley, Oleksandr Frei, Alexey A. Shadrin, Weiqiu Cheng, Kevin S. O’Connell, Romain Icick, Nadine Parker, Shahram Bahrami, Naz Karadag, Daniel Roelfs, Børge Holen, Aihua Lin, Chun C. Fan, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Ole A. Andreassen
Opublikowane w: American Journal of Psychiatry, Numer 179, 2024, Strona(/y) 833-843, ISSN 0002-953X
Wydawca: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.21101051

Polygenic overlap with granulocyte counts identifies novel loci for clozapine metabolism and clozapine-induced agranulocytosis

Autorzy: Elise Koch, Alexey A. Shadrin, Nadine Parker, Siobhan K. Lock, Robert L. Smith, Oleksandr Frei, Anders M. Dale, Srdjan Djurovic, Espen Molden, Kevin S. O´Connell, Ole A. Andreassen
Opublikowane w: Neuropsychopharmacology, Numer 50, 2025, Strona(/y) 947-955, ISSN 0893-133X
Wydawca: Nature Publishing Group
DOI: 10.1038/s41386-025-02054-x

Impact of NFIB and CYP1A variants on clozapine serum concentration—A retrospective naturalistic cohort study on 526 patients with known smoking habits

Autorzy: Hasan Çağın Lenk,Robert Løvsletten Smith,Kevin S. O'Connell,Marin M. Jukić,Marianne Kristiansen Kringen,Ole A. Andreassen,Magnus Ingelman-Sundberg,Espen Molden
Opublikowane w: Clin Transl Sci ., Numer 2023 Jan;16(1):62-72. doi: 10.1111/cts.13422. Epub 2022 Oct 7., 2023, Strona(/y) 62-72, ISSN 1752-8062
Wydawca: Wiley
DOI: 10.1111/cts.13422

Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia

Autorzy: Kevin S. O'Connell, Elise Koch, Hasan Çağın Lenk, Ibrahim A Akkouh, Guy Hindley, Piotr Jaholkowski, Robert Løvsletten Smith, Børge Holen, Alexey A. Shadrin, Oleksandr Frei, Olav B. Smeland, Nils Eiel Steen, Anders M. Dale, Espen Molden, Srdjan Djurovic, Ole A. Andreassen
Opublikowane w: Psychiatry Research, Numer 325, 2023, Strona(/y) 115217, ISSN 0165-1781
Wydawca: Elsevier BV
DOI: 10.1016/j.psychres.2023.115217

Distinct patterns of genetic overlap among multimorbidities revealed with trivariate MiXeR

Autorzy: Alexey A. Shadrin, Guy Hindley, Espen Hagen, Nadine Parker, Markos Tesfaye, Piotr Jaholkowski, Zillur Rahman, Gleda Kutrolli, Vera Fominykh, Srdjan Djurovic, Olav B. Smeland, Kevin S. O’Connell, Dennis van der Meer, Oleksandr Frei, Ole A. Andreassen, Anders M. Dale
Opublikowane w: Genome Medicine, Numer 17, 2025, ISSN 1756-994X
Wydawca: BioMed Central
DOI: 10.1186/s13073-025-01528-3

Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease

Autorzy: Jacob Bergstedt, Joëlle A. Pasman, Ziyan Ma, Arvid Harder, Shuyang Yao, Nadine Parker, Jorien L. Treur, Dirk J. A. Smit, Oleksandr Frei, Alexey A. Shadrin, Joeri J. Meijsen, Qing Shen, Sara Hägg, Per Tornvall, Alfonso Buil, Thomas Werge, Jens Hjerling-Leffler, Thomas D. Als, Anders D. Børglum, Cathryn M. Lewis, Andrew M. McIntosh, Unnur A. Valdimarsdóttir, Ole A. Andreassen, Patrick F. Sulliva
Opublikowane w: Nature Cardiovascular Research, Numer 3, 2024, Strona(/y) 754-769, ISSN 2731-0590
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s44161-024-00488-y

How Real-World Data Can Facilitate the Development of Precision Medicine Treatment in Psychiatry

Autorzy: Elise Koch, Antonio F. Pardiñas, Kevin S. O’Connell, Pierluigi Selvaggi, José Camacho Collados, Aleksandar Babic, Serena E. Marshall, Erik Van der Eycken, Cecilia Angulo, Yi Lu, Patrick F. Sullivan, Anders M. Dale, Espen Molden, Danielle Posthuma, Nathan White, Alexander Schubert, Srdjan Djurovic, Hakon Heimer, Hreinn Stefánsson, Kári Stefánsson, Thomas Werge, Ida Sønderby, Michael C. O’
Opublikowane w: Biological Psychiatry, 2024, ISSN 0006-3223
Wydawca: Elsevier BV
DOI: 10.1016/j.biopsych.2024.01.001

Prioritizing Parkinson’s disease risk genes in genome-wide association loci

Autorzy: Lara M. Lange, Catalina Cerquera-Cleves, Marijn Schipper, Georgia Panagiotaropoulou, Alice Braun, Julia Kraft, Swapnil Awasthi, Nathaniel Bell, Danielle Posthuma, Stephan Ripke, Cornelis Blauwendraat, Karl Heilbron
Opublikowane w: npj parkinson's disease, 2026, ISSN 2373-8057
Wydawca: npj Parkinson's Disease (npj Parkinsons Dis.)
DOI: 10.1101/2024.12.13.24318996

Psychiatric disorders and brain white matter exhibit genetic overlap implicating developmental and neural cell biology

Autorzy: Nadine Parker, Weiqiu Cheng, Guy F. L. Hindley, Pravesh Parekh, Alexey A. Shadrin, Ivan I. Maximov, Olav B. Smeland, Srdjan Djurovic, Anders M. Dale, Lars T. Westlye, Oleksandr Frei, Ole A. Andreassen
Opublikowane w: Molecular Psychiatry, Numer 28, 2024, Strona(/y) 4924-4932, ISSN 1359-4184
Wydawca: Nature Publishing Group
DOI: 10.1038/s41380-023-02264-z

Effect of CYP2D6 and CYP2C19 genotypes on atomoxetine serum levels -- a study based on therapeutic drug monitoring data

Autorzy: Robert Smith, Espen Molden, Jean-Paul Bernard
Opublikowane w: British Journal of Clinical Pharmacology, 2022, ISSN 1365-2125
Wydawca: Willey
DOI: 10.22541/au.167050638.80828727/v1

Genetic insights into psychotic major depressive disorder: bridging the mood-psychotic disorder spectrum

Autorzy: Thuy-Dung Nguyen, Joeri J. Meijsen, Robert Sigström, Ralf Kuja-Halkola, Ying Xiong, Arvid Harder, Kaarina Kowalec, Joëlle A. Pasman, Carolina Scarpa, Elin Hörbeck, Lina Jonsson, Sara Hägg, Niamh Mullins, Kevin S. O’Connell, Christina Dalman, Dorte Helenius, Richard Zetterberg, Henrik Larsson, Paul Lichtenstein, Ole A. Andreassen, Thomas Werge, Alfonso Buil, Mikael Landén, Patrick F. Sulliva
Opublikowane w: eBioMedicine, Numer 112, 2025, Strona(/y) 105576, ISSN 2352-3964
Wydawca: Elsevier BV
DOI: 10.1016/j.ebiom.2025.105576

Effects of antipsychotics on human cognitive function: causal evidence from healthy volunteers following sustained D2/D3 antagonism, D2/D3 partial agonism and placebo

Autorzy: Martin Osugo, Uzma Zahid, Pierluigi Selvaggi, Alexandria Chilimidos, Valeria Finelli, George E. Chapman, Thomas Whitehurst, Ellis Chika Onwordi, Robin M. Murray, Matthew B. Wall, Tiago Reis Marques, Mitul A. Mehta, Oliver D. Howes
Opublikowane w: Molecular Psychiatry, Numer 30, 2025, Strona(/y) 5315-5325, ISSN 1359-4184
Wydawca: Nature Publishing Group
DOI: 10.1038/s41380-025-03116-8

Translational Psychiatry

Autorzy: Ying Xiong; Robert Karlsson; Jie Song; Kaarina Kowalec; Christian Rck; Robert Sigstrm; Lina Jonsson; Caitlin C. Clements; Evelyn Andersson; Julia Boberg; Cathryn M. Lewis; Patrick F. Sullivan; Mikael Landn; Yi Lu
Opublikowane w: Translational Psychiatry, Vol 13, Iss 1, Pp 1-7 (2023), Numer 23, 2023, ISSN 2158-3188
Wydawca: Nature Publishing Group

Antipsychotic and pharmacogenomic effects on cross-sectional symptom severity and cognitive ability in schizophrenia

Autorzy: Siobhan K. Lock, Djenifer B. Kappel, Michael J. Owen, James T.R. Walters, Michael C. O'Donovan, Antonio F. Pardiñas, Sophie E. Legge
Opublikowane w: eBioMedicine, Numer 116, 2025, Strona(/y) 105745, ISSN 2352-3964
Wydawca: Elsevier BV
DOI: 10.1016/j.ebiom.2025.105745

Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders

Autorzy: Guy Hindley, Ole Kristian Drange, Aihua Lin, Gleda Kutrolli, Alexey A. Shadrin, Nadine Parker, Kevin S. O’Connell, Linn Rødevand, Weiqiu Cheng, Shahram Bahrami, Naz Karadag, Børge Holen, Piotr Jaholkowski, Markos Tesfaye Woldeyohannes, Srdjan Djurovic, Anders M. Dale, Oleksandr Frei, Thor Ueland, Olav B. Smeland, Ole A. Andreassen
Opublikowane w: Psychoneuroendocrinology, Numer 157, 2024, Strona(/y) 106368, ISSN 0306-4530
Wydawca: Pergamon Press
DOI: 10.1016/j.psyneuen.2023.106368

Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study

Autorzy: E. P. Tissink, A. A. Shadrin, D. van der Meer, N. Parker, G. Hindley, D. Roelfs, O. Frei, C. C. Fan, M. Nagel, T. Nærland, M. Budisteanu, S. Djurovic, L. T. Westlye, M. P. van den Heuvel, D. Posthuma, T. Kaufmann, A. M. Dale, O. A. Andreassen
Opublikowane w: Nature Communications, Numer 15, 2024, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-024-46817-4

Genetic Overlap Between Global Cortical Brain Structure, C-Reactive Protein, and White Blood Cell Counts

Autorzy: Nadine Parker, Weiqiu Cheng, Guy F.L. Hindley, Kevin S. O’Connell, Sandeep Karthikeyan, Børge Holen, Alexey A. Shadrin, Zillur Rahman, Naz Karadag, Shahram Bahrami, Aihua Lin, Nils Eiel Steen, Thor Ueland, Pål Aukrust, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Oleksandr Frei, Ole A. Andreassen
Opublikowane w: Biological Psychiatry, Numer 95, 2024, Strona(/y) 62-71, ISSN 0006-3223
Wydawca: Elsevier BV
DOI: 10.1016/j.biopsych.2023.06.008

Rapid Metabolism Underlying Subtherapeutic Serum Levels of Atypical Antipsychotics Preceding Clozapine Treatment: A Retrospective Analysis of Real-World Data

Autorzy: Hasan Çağın Lenk, Robert Løvsletten Smith, Kevin S. O’Connell, Ole A. Andreassen, Espen Molden
Opublikowane w: CNS Drugs, Numer 38, 2024, Strona(/y) 473-480, ISSN 1172-7047
Wydawca: Adis International Ltd.
DOI: 10.1007/s40263-024-01079-y

Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression

Autorzy: Ying Xiong, Kristi Krebs, Bradley Jermy, Robert Karlsson, Joëlle A. Pasman, Thuy-Dung Nguyen, Tong Gong, Kaarina Kowalec, Christian Rück, Robert Sigström, Lina Jonsson, Caitlin C. Clements, Elin Hörbeck, Evelyn Andersson, Julia Bäckman, null null, null null, Andrea Ganna, Jakob German, Patrick F. Sullivan, Mikael Landén, Kelli Lehto, Yi Lu
Opublikowane w: Molecular Psychiatry, Numer 30, 2025, Strona(/y) 5024-5033, ISSN 1359-4184
Wydawca: Nature Publishing Group
DOI: 10.1038/s41380-025-03084-z

Polygenic liability for antipsychotic dosage and polypharmacy - a real-world registry and biobank study

Autorzy: Elise Koch, Anders Kämpe, Maris Alver, Sindri Sigurðarson, Guðmundur Einarsson, Juulia Partanen, Robert L. Smith, Piotr Jaholkowski, Heidi Taipale, Markku Lähteenvuo, Nils Eiel Steen, Olav B. Smeland, Srdjan Djurovic, Espen Molden, null null, null null, Engilbert Sigurdsson, Hreinn Stefánsson, Kári Stefánsson, Aarno Palotie, Lili Milani, Kevin S. O’Connell, Ole A. Andreassen
Opublikowane w: Neuropsychopharmacology, Numer 49, 2024, Strona(/y) 1113-1119, ISSN 0893-133X
Wydawca: Nature Publishing Group
DOI: 10.1038/s41386-023-01792-0

Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry

Autorzy: Anna Gui, Anja Hollowell, Emilie M. Wigdor, Morgan J. Morgan, Laurie J. Hannigan, Elizabeth C. Corfield, Veronika Odintsova, Jouke-Jan Hottenga, Andrew Wong, René Pool, Harriet Cullen, Siân Wilson, Varun Warrier, Espen M. Eilertsen, Ole A. Andreassen, Christel M. Middeldorp, Beate St Pourcain, Meike Bartels, Dorret I. Boomsma, Catharina A. Hartman, Elise B. Robinson, Tomoki Arichi, Anthony D. Ed
Opublikowane w: Nature Human Behaviour, Numer 9, 2025, Strona(/y) 1470-1487, ISSN 2397-3374
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41562-025-02145-1

A comprehensive map of genetic relationships among diagnostic categories based on 48.6 million relative pairs from the Danish genealogy

Autorzy: Georgios Athanasiadis, Joeri J. Meijsen, Dorte Helenius, Andrew J. Schork, Andrés Ingason, Wesley K. Thompson, Daniel H. Geschwind, Thomas Werge, Alfonso Buil
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 119, 2022, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.2118688119

Genetic Contribution to the Heterogeneity of Major Depressive Disorder: Evidence From a Sibling-Based Design Using Swedish National Registers

Autorzy: Thuy-Dung Nguyen, Kaarina Kowalec, Joëlle Pasman, Henrik Larsson, Paul Lichtenstein, Christina Dalman, Patrick F. Sullivan, Ralf Kuja-Halkola, Yi Lu
Opublikowane w: American Journal of Psychiatry, Numer 180, 2024, Strona(/y) 714-722, ISSN 0002-953X
Wydawca: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.20220906

Medical comorbidities in bipolar disorder (BIPCOM): clinical validation of risk factors and biomarkers to improve prevention and treatment. Study protocol

Autorzy: Giovanni de Girolamo, Ole A. Andreassen, Michael Bauer, Paolo Brambilla, Stefano Calza, Nicholas Citerà, Rosa Corcoy, Andrea Fagiolini, Miguel Garcia-Argibay, Ophélia Godin, Florian Klingler, Nene F. Kobayashi, Henrik Larsson, Marion Leboyer, Silke Matura, Alessandra Martinelli, Víctor De la Peña-Arteaga, Roberto Poli, Andreas Reif, Philipp Ritter, Linn N. Rødevand, Marta Magno, Elisa Caselan
Opublikowane w: International Journal of Bipolar Disorders, Numer 12, 2024, ISSN 2194-7511
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/s40345-024-00337-8

Associations Between Symptoms of Premenstrual Disorders and Polygenic Liability for Major Psychiatric Disorders

Autorzy: Piotr Jaholkowski, Alexey A. Shadrin, Andreas Jangmo, Evgeniia Frei, Markos Tesfaye, Guy F. L. Hindley, Marit Haram, Zillur Rahman, Lavinia Athanasiu, Nora Refsum Bakken, Børge Holen, Vera Fominykh, Gleda Kutrolli, Pravesh Parekh, Nadine Parker, Linn Rødevand, Viktoria Birkenæs, Srdjan Djurovic, Oleksandr Frei, Kevin S. O’Connell, Olav B. Smeland, Martin Tesli, Ole A. Andreassen
Opublikowane w: JAMA Psychiatry, Numer 80, 2023, Strona(/y) 738, ISSN 2168-622X
Wydawca: American Medical Association
DOI: 10.1001/jamapsychiatry.2023.1137

Identification of risk variants and cross-disorder pleiotropy through multi-ancestry genome-wide analysis of alcohol use disorder

Autorzy: Romain Icick, Alexey Shadrin, Børge Holen, Naz Karadag, Nadine Parker, Kevin S. O’Connell, Oleksandr Frei, Shahram Bahrami, Margrethe Collier Høegh, Trine Vik Lagerberg, Weiqiu Cheng, Tyler M. Seibert, Srdjan Djurovic, Anders M. Dale, Hang Zhou, Howard J. Edenberg, Joel Gelernter, Olav B. Smeland, Guy Hindley, Ole A. Andreassen
Opublikowane w: Nature Mental Health, Numer 3, 2025, Strona(/y) 253-265, ISSN 2731-6076
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s44220-024-00353-8

The phenotypic and genetic relationship between adolescent mental health and time spent on social media, gaming, and TV

Autorzy: Evgeniia Frei, Oleksandr Frei, Piotr Jaholkowski, Nadine Parker, Pravesh Parekh, Alexey A. Shadrin, Espen Hagen, Nora R. Bakken, Viktoria Birkenæs, Helga Ask, Ole A. Andreassen, Olav B. Smeland
Opublikowane w: Psychiatry Research, Numer 353, 2026, Strona(/y) 116761, ISSN 0165-1781
Wydawca: Elsevier BV
DOI: 10.1016/j.psychres.2025.116761

Genetic and Phenotypic Features of Schizophrenia in the UK Biobank

Autorzy: Sophie E. Legge, Antonio F. Pardiñas, Grace Woolway, Elliott Rees, Alastair G. Cardno, Valentina Escott-Price, Peter Holmans, George Kirov, Michael J. Owen, Michael C. O’Donovan, James T. R. Walters
Opublikowane w: JAMA Psychiatry, Numer 81, 2024, Strona(/y) 681, ISSN 2168-622X
Wydawca: American Medical Association
DOI: 10.1001/jamapsychiatry.2024.0200

Identification and validation of postpartum depression subtypes: a population-based cohort study

Autorzy: Anna E. Bauer, Piotr Jaholkowski, Yi Lu, Jerry Guintivano, Laurie J. Hannigan, Elizabeth C. Corfield, Martin Tesli, Ole A. Andreassen, Yun Li, Ted Reichborn-Kjennerud, Patrick F. Sullivan, Samantha Meltzer-Brody, Alexandra Havdahl, Helga Ask
Opublikowane w: eClinicalMedicine, Numer 89, 2025, Strona(/y) 103540, ISSN 2589-5370
Wydawca: Elsevier BV
DOI: 10.1016/j.eclinm.2025.103540

Recommendations for defining treatment outcomes in major psychiatric disorders leveraging real-world data

Autorzy: Elise Koch, Sophie Elizabeth Smart, Guðmundur Einarsson, Anders Kämpe, Lina Jonsson, Maris Alver, Matthew Henry Iveson, Andreas Göteson, Antonio F Pardiñas, Ida E. Sønderby, Kevin O’Connell, Qingqin Li, Lu Yi, Hreinn Stefansson, Kári Stefánsson, Heather C Whalley, Mikael Landén, Michael C. O’Donovan, Knut T. Smerud, Gerard R. Dawson, Thomas Werge, Alfonso Buil, Andreas Reif, Lili Milan
Opublikowane w: Lancet Psychiatry, 2025, ISSN 2215-0366
Wydawca: Elsevier Limited
DOI: 10.31234/osf.io/kumea_v1

Improved functional mapping of complex trait heritability with GSA-MiXeR implicates biologically specific gene sets

Autorzy: Oleksandr Frei, Guy Hindley, Alexey A. Shadrin, Dennis van der Meer, Bayram C. Akdeniz, Espen Hagen, Weiqiu Cheng, Kevin S. O’Connell, Shahram Bahrami, Nadine Parker, Olav B. Smeland, Dominic Holland, null null, Christiaan de Leeuw, Danielle Posthuma, Ole A. Andreassen, Anders M. Dale
Opublikowane w: Nature Genetics, Numer 56, 2024, Strona(/y) 1310-1318, ISSN 1061-4036
Wydawca: Nature Publishing Group
DOI: 10.1038/s41588-024-01771-1

Striatal dopamine D2/D3 receptor regulation of human reward processing and behaviour

Autorzy: Martin Osugo, Matthew B. Wall, Pierluigi Selvaggi, Uzma Zahid, Valeria Finelli, George E. Chapman, Thomas Whitehurst, Ellis Chika Onwordi, Ben Statton, Robert A. McCutcheon, Robin M. Murray, Tiago Reis Marques, Mitul A. Mehta, Oliver D. Howes
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Impact of CYP1A , CYP2C19 , CYP2D6 , CYP3A4 , CYP3A5 , and NFIB genotypes on clozapine serum concentration in smokers and nonsmokers

Autorzy: Hasan Çağın Lenk, Line Skute Bråten, Ole A. Andreassen, Espen Molden
Opublikowane w: Therapeutic Advances in Psychopharmacology, Numer 15, 2025, ISSN 2045-1253
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Polygenic and pharmacogenomic contributions to medication dosing: a real-world longitudinal biobank study

Autorzy: Silva Kasela, Laura Birgit Luitva, Kristi Krebs, null null, Märt Möls, Lili Milani, Maris Alver
Opublikowane w: Journal of Translational Medicine, Numer 23, 2025, ISSN 1479-5876
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A pattern-learning algorithm associates copy number variations with brain structure and behavioural variables in an adolescent population cohort

Autorzy: Jakub Kopal, Guillaume Huguet, Justin Marotta, Shambhavi Aggarwal, Nicole Osayande, Kuldeep Kumar, Zohra Saci, Martineau Jean-Louis, Xiaoqian J. Chai, Tian Ge, B. T. Thomas Yeo, Paul M. Thompson, Carrie E. Bearden, Ole A. Andreassen, Sébastien Jacquemont, Danilo Bzdok
Opublikowane w: Nature Biomedical Engineering, 2025, ISSN 2157-846X
Wydawca: Springer Science and Business Media LLC
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Associations of polygenic risk scores for major depression and depression severity: an investigation of 105 623 individuals with 16 years follow-up

Autorzy: Marit Haram, Andreas Jangmo, Piotr Jaholkowski, Joëlle Pasman, Joeri Meijsen, John R. Shorter, Elizabeth C. Corfield, Oleksandr Frei, Ted Reichborn-Kjennerud, Alfonso Buil, Yi Lu, Thomas Werge, Patrick Sullivan, Ole A. Andreassen, Martin Tesli
Opublikowane w: Molecular Psychiatry, 2025, ISSN 1359-4184
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Genetic predisposition and antipsychotic treatment effect on metabolic syndrome in schizophrenia: a ten-year follow-up study using the Estonian Biobank

Autorzy: Maris Alver, Silva Kasela, Liina Haring, Laura Birgit Luitva, Krista Fischer, Märt Möls, Lili Milani
Opublikowane w: The Lancet Regional Health - Europe, Numer 41, 2024, Strona(/y) 100914, ISSN 2666-7762
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AI for Analyzing Mental Health Disorders Among Social Media Users: Quarter-Century Narrative Review of Progress and Challenges

Autorzy: David Owen, Amy J Lynham, Sophie E Smart, Antonio F Pardiñas, Jose Camacho Collados
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Socio-demographic and genetic risk factors for drug adherence and persistence across 5 common medication classes

Autorzy: Mattia Cordioli, Andrea Corbetta, Hanna Maria Kariis, Sakari Jukarainen, Pekka Vartiainen, Tuomo Kiiskinen, Matteo Ferro, null null, Markus Perola, Samuli Ripatti, Andrea Ganna, null null, Andres Metspalu, Lili Milani, Tõnu Esko, Reedik Mägi, Mari Nelis, Georgi Hudjashov, Markus Perola, Mikko Niemi, Samuli Ripatti, Kelli Lehto, Lili Milani, Andrea Ganna
Opublikowane w: Nature Communications, Numer 15, 2024, ISSN 2041-1723
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New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications

Autorzy: Ole A. Andreassen, Guy F.L. Hindley, Oleksandr Frei, Olav B. Smeland
Opublikowane w: World Psychiatry, Numer 22, 2023, Strona(/y) 4-24, ISSN 1723-8617
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Association between genetic liability to physical health conditions and comorbidities in individuals with severe mental illness: an analysis of two cross-sectional observational studies in the UK

Autorzy: Djenifer B Kappel, Sophie E Smart, Michael J Owen, Michael C O'Donovan, Antonio F Pardiñas, James T R Walters
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Effects of a Novel UGT2B Haplotype and UGT1A4*3 Allele Variants on Glucuronidation of Clozapine In vivo

Autorzy: Robert Løvsletten Smith; Birgit M. Wollmann; Marianne Kausberg; Sondre Mæland; Marit Tveito; Kevin O’Connell; Espen Molden; Marianne Kristiansen Kringen
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Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study

Autorzy: Álvaro Hernáez, Karoline H. Skåra, Christian M. Page, Vera R. Mitter, Marta H. Hernández, Per Magnus, Pål R. Njølstad, Ole A. Andreassen, Elizabeth C. Corfield, Alexandra Havdahl, Øyvind Næss, Ben Brumpton, Bjørn Olav Åsvold, Deborah A. Lawlor, Abigail Fraser, Maria Christine Magnus
Opublikowane w: BMC Medicine, Numer 22, 2024, ISSN 1741-7015
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Polygenic risk scores of lithium response and treatment resistance in major depressive disorder

Autorzy: Ying Xiong, Robert Karlsson, Jie Song, Kaarina Kowalec, Christian Rück, Robert Sigström, Lina Jonsson, Caitlin C. Clements, Evelyn Andersson, Julia Boberg, Cathryn M. Lewis, Patrick F. Sullivan, Mikael Landén, Yi Lu
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Partitioning variance in cortical morphometry into genetic, environmental, and subject-specific components

Autorzy: Diana M Smith, Pravesh Parekh, Joseph Kennedy, Robert Loughnan, Oleksandr Frei, Thomas E Nichols, Ole A Andreassen, Terry L Jernigan, Anders M Dale
Opublikowane w: Cerebral Cortex, Numer 34, 2024, ISSN 1047-3211
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DOI: 10.1093/cercor/bhae234

Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count

Autorzy: Siobhan K. Lock, Sophie E. Legge, Djenifer B. Kappel, Isabella R. Willcocks, Marinka Helthuis, John Jansen, James T. R. Walters, Michael J. Owen, Michael C. O’Donovan, Antonio F. Pardiñas
Opublikowane w: Schizophrenia, Numer 9, 2023, ISSN 2754-6993
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Finemap-MiXeR: A variational Bayesian approach for genetic finemapping

Autorzy: Bayram Cevdet Akdeniz, Oleksandr Frei, Alexey Shadrin, Dmitry Vetrov, Dmitry Kropotov, Eivind Hovig, Ole A. Andreassen, Anders M. Dale
Opublikowane w: PLOS Genetics, Numer 20, 2024, Strona(/y) e1011372, ISSN 1553-7404
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Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis

Autorzy: Markos Tesfaye, Piotr Jaholkowski, Guy F. L. Hindley, Alexey A. Shadrin, Zillur Rahman, Shahram Bahrami, Aihua Lin, Børge Holen, Nadine Parker, Weiqiu Cheng, Linn Rødevand, Oleksandr Frei, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Kevin S. O’Connell, Ole A. Andreassen
Opublikowane w: Genome Medicine, Numer 15, 2023, ISSN 1756-994X
Wydawca: BioMed Central
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Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities

Autorzy: Nils Eiel Steen, Zillur Rahman, Attila Szabo, Guy F L Hindley, Nadine Parker, Weiqiu Cheng, Aihua Lin, Kevin S O’Connell, Mashhood A Sheikh, Alexey Shadrin, Shahram Bahrami, Sandeep Karthikeyan, Eva Z Hoseth, Anders M Dale, Pål Aukrust, Olav B Smeland, Thor Ueland, Oleksandr Frei, Srdjan Djurovic, Ole A Andreassen
Opublikowane w: Schizophrenia Bulletin, Numer 49, 2023, Strona(/y) 1345-1354, ISSN 0586-7614
Wydawca: Oxford University Press
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Large Language Model–Supported Identification of Intellectual Disabilities in Clinical Free-Text Summaries: Mixed Methods Study

Autorzy: Aleksandra Edwards, Antonio F Pardiñas, George Kirov, Elliott Rees, Jose Camacho-Collados
Opublikowane w: JMIR AI, Numer 4, 2025, Strona(/y) e72256-e72256, ISSN 2817-1705
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Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia

Autorzy: Djenifer B. Kappel, Elliott Rees, Eilidh Fenner, Adrian King, John Jansen, Marinka Helthuis, Michael J. Owen, Michael C. O'Donovan, James T.R. Walters, Antonio F. Pardiñas
Opublikowane w: European Neuropsychopharmacology, Numer 80, 2024, Strona(/y) 47-54, ISSN 0924-977X
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Unraveling the shared genetics of common epilepsies and general cognitive ability

Autorzy: Naz Karadag, Espen Hagen, Alexey A. Shadrin, Dennis van der Meer, Kevin S. O'Connell, Zillur Rahman, Gleda Kutrolli, Nadine Parker, Shahram Bahrami, Vera Fominykh, Kjell Heuser, Erik Taubøll, Torill Ueland, Nils Eiel Steen, Srdjan Djurovic, Anders M. Dale, Oleksandr Frei, Ole A. Andreassen, Olav B. Smeland
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Polygenic overlap of substance use behaviors and disorders with externalizing and internalizing problems independent of genetic correlations

Autorzy: Laila Al-Soufi, Guy Hindley, Linn Rødevand, Alexey A. Shadrin, Piotr Jaholkowski, Vera Fominykh, Romain Icick, Markos Tesfaye, Javier Costas, Ole A. Andreassen
Opublikowane w: Psychological Medicine, Numer 55, 2025, ISSN 0033-2917
Wydawca: Cambridge University Press
DOI: 10.1017/s0033291725000108

Telomere biology and its maintenance in schizophrenia spectrum disorders: Exploring links to cognition

Autorzy: Vid Mlakar, Ibrahim Akkouh, Els F. Halff, Deepak P. Srivastava, Viktoria Birkenæs, Torill Ueland, Daniel S. Quintana, Monica B.E.G. Ormerod, Nils Eiel Steen, Srdjan Djurovic, Ole A. Andreassen, Monica Aas
Opublikowane w: Schizophrenia Research, Numer 272, 2025, Strona(/y) 89-95, ISSN 0920-9964
Wydawca: Elsevier BV
DOI: 10.1016/j.schres.2024.08.011

COSGAP: COntainerized Statistical Genetics Analysis Pipelines

Autorzy: Bayram Cevdet Akdeniz, Oleksandr Frei, Espen Hagen, Tahir Tekin Filiz, Sandeep Karthikeyan, Joëlle Pasman, Andreas Jangmo, Jacob Bergstedt, John R Shorter, Richard Zetterberg, Joeri Meijsen, Ida Elken Sønderby, Alfonso Buil, Martin Tesli, Yi Lu, Patrick Sullivan, Ole A Andreassen, Eivind Hovig
Opublikowane w: Bioinformatics Advances, Numer 4, 2024, ISSN 2635-0041
Wydawca: Oxford University Press (OUP)
DOI: 10.1093/bioadv/vbae067

Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research

Autorzy: Na Cai, Brad Verhulst, Ole A. Andreassen, Jan Buitelaar, Howard J. Edenberg, John M. Hettema, Michael Gandal, Andrew Grotzinger, Katherine Jonas, Phil Lee, Travis T. Mallard, Manuel Mattheisen, Michael C. Neale, John I. Nurnberger, Wouter J. Peyrot, Elliot M. Tucker-Drob, Jordan W. Smoller, Kenneth S. Kendler
Opublikowane w: Molecular Psychiatry, Numer 30, 2025, Strona(/y) 1627-1638, ISSN 1359-4184
Wydawca: Nature Publishing Group
DOI: 10.1038/s41380-024-02878-x

Genome-wide association analysis of treatment resistant schizophrenia for variant discovery and polygenic assessment

Autorzy: Hasan Çağın Lenk, Elise Koch, Kevin S. O’Connell, Robert Løvsletten Smith, Ibrahim A. Akkouh, Srdjan Djurovic, Ole A. Andreassen, Espen Molden
Opublikowane w: Human Genomics, Numer 18, 2024, ISSN 1479-7364
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/s40246-024-00673-x

Effect of the NFIB rs28379954 T>C polymorphism on <scp>CYP2D6</scp>‐catalyzed metabolism of solanidine

Autorzy: Robert Løvsletten Smith, Birgit M. Wollmann, Elisabet Størset, Hasan Çağın Lenk, Kevin S. O'Connell, Marianne Kringen Kristiansen, Magnus Ingelman‐Sundberg, Espen Molden
Opublikowane w: Clinical and Translational Science, Numer 17, 2024, ISSN 1752-8054
Wydawca: Wiley-Blackwell
DOI: 10.1111/cts.13743

Investigating genetic overlap between antidepressant and lithium response and treatment resistance in major depressive disorder

Autorzy: Yi Lu; Ying Xiong; Robert Karlsson; Jie Song; Kaarina Kowalec; Christian Rück; Robert Sigstrom; Lina Jonsson; Caitlin Clements; Evelyn Andersson; Julia Boberg; Cathryn Lewis; Patrick Sullivan; Mikael Landén
Opublikowane w: Crossref, Numer 17, 2023, ISSN 2693-5015
Wydawca: translational psychiatry
DOI: 10.21203/rs.3.rs-2556941/v1

Psychometric Properties and Diagnostic Associations of the Short-Form Community Assessment of Psychic Experiences in a Population-Based Sample of 29 021 Adult Men

Autorzy: Viktoria Birkenæs, Nora Refsum Bakken, Evgeniia Frei, Piotr Jaholkowski, Olav B Smeland, Markos Tesfaye, Ingrid Agartz, Ezra Susser, Michaeline Bresnahan, Espen Røysamb, Kjetil Nordbø Jørgensen, Ragnar Nesvåg, Alexandra Havdahl, Ole A Andreassen, Ida Elken Sønderby
Opublikowane w: Schizophrenia Bulletin, Numer 49, 2023, Strona(/y) 1229-1238, ISSN 0586-7614
Wydawca: Oxford University Press
DOI: 10.1093/schbul/sbad074

Shared genetic loci between Alzheimer's disease and multiple sclerosis: Crossroads between neurodegeneration and immune system

Autorzy: Vera Fominykh, Alexey A. Shadrin, Piotr P. Jaholkowski, Shahram Bahrami, Lavinia Athanasiu, Douglas P. Wightman, Emil Uffelmann, Danielle Posthuma, Geir Selbæk, Anders M. Dale, Srdjan Djurovic, Oleksandr Frei, Ole A. Andreassen
Opublikowane w: Neurobiology of Disease, Numer 183, 2024, Strona(/y) 106174, ISSN 0969-9961
Wydawca: Academic Press
DOI: 10.1016/j.nbd.2023.106174

Mapping the genetic landscape of immune-mediated disorders: potential implications for classification and therapeutic strategies

Autorzy: Vera Fominykh, Alexey A. Shadrin, Piotr Jaholkowski, Julian Fuhrer, Nadine Parker, Erik D. Wiström, Oleksandr Frei, Olav B. Smeland, Helga Sanner, Srdjan Djurovic, Ole A. Andreassen
Opublikowane w: Frontiers in Immunology, Numer 16, 2025, ISSN 1664-3224
Wydawca: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1543781

Multimodal Prediction of Psychosis in the Prospective MoBa Birth Cohort

Autorzy: Viktoria Birkenæs, Pravesh Parekh, Alexey Shadrin, Piotr Jaholkowski, Lars A. R. Ystaas, Carolina Makowski, Nora R. Bakken, Espen Hagen, Evgeniia Frei, Dominic Oliver, Paolo Fusar-Poli, Anders Dale, John P. John, Alexandra Havdahl, Ida E. Sønderby, Ole A. Andreassen
Opublikowane w: Preprint in Research Square, 2025
Wydawca: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-6783339/v1

Associations of Genetic Liability to Six Psychiatric Disorders With Cardiometabolic Diseases

Autorzy: Jacob Bergstedt, Kadri Kõiv, Andreas Jangmo, Marit Haram, Piotr P. Jaholkowski, Jorien L. Treur, Isabell Brikell, Zheng Chang, Henrik Larsson, Patrik K. E. Magnusson, Andrew M. McIntosh, Cathryn M. Lewis, Brian K. Lee, Ida E. Sønderby, Yi Lu, Patrick F. Sullivan, Unnur A. Valdimarsdóttir, Ole Andreassen, Martin Tesli, Kelli Lehto, Fang Fang, null null, null null
Opublikowane w: 2026
Wydawca: openRxiv
DOI: 10.1101/2025.03.11.25323757

Genome-wide meta-analyses of non-response to antidepressants identify novel loci and potential drugs

Autorzy: Elise Koch, Tuuli Jurgenson, Gudmundur Einarsson, Brittany Mitchell, Arvid Harder, Luis M Garcia-Marin, Kristi Krebs, Yuhao Lin, Ying Xiong, Estonian Biobank Research Team, Yi Lu, Sara Hagg, Miguel E Renteria, Sarah E Medland, Naomi R Wray, Nicholas G Martin, Christopher Huebel, Gerome Breen, Thorgeir Thorgeirsson, Hreinn Stefansson, Kari Stefansson, Lili Milani, Ole A Andreassen, Kevin S O'Connel
Opublikowane w: 2026
Wydawca: openRxiv
DOI: 10.1101/2024.07.13.24310361

SLC39A8.p.(Ala391Thr) is associated with poorer cognitive ability: a cross-sectional study of schizophrenia and the general UK population

Autorzy: Sophie E Smart, Sophie E. Legge, Eilidh Fenner, Antonio F. Pardiñas, Grace Woolway, Amy J. Lynham, Valentina Escott-Price, Jeremy Hall, Lawrence Wilkinson, Peter Holmans, Michael C. O’Donovan, Michael J. Owen, James T.R. Walters
Opublikowane w: Preprint in medRxiv, 2026
Wydawca: openRxiv
DOI: 10.1101/2024.09.18.24313865

Youth Psychotic Experiences: Diagnostic Associations and Evaluation of the CAPE-16

Autorzy: Viktoria Birkenæs, Pravesh Parekh, Laura Hegemann, Nora R. Bakken, Evgeniia Frei, Piotr Jaholkowski, Olav B. Smeland, Ezra Susser, Katrina M. Rodriguez, Markos Tesfaye, Ole A. Andreassen, Alexandra Havdahl, Ida E. Sønderby
Opublikowane w: Preprint in MedRxiv, 2026
Wydawca: openRxiv
DOI: 10.1101/2024.04.18.24306017

Simplifying causal gene identification in GWAS loci

Autorzy: Marijn Schipper, Jacob Ulirsch, Danielle Posthuma, Stephan Ripke, Karl Heilbron
Opublikowane w: Preprint in medRxiv, 2026
Wydawca: openRxiv
DOI: 10.1101/2024.07.26.24311057

Interpreting artificial neural networks to detect genome-wide association signals for complex traits

Autorzy: Yelmen, Burak; Alver, Maris; Güler, Merve Nur; Team, Estonian Biobank Research; Jay, Flora; Milani, Lili
Opublikowane w: Preprint in Arxiv, Numer 1, 2024
Wydawca: Arxiv
DOI: 10.48550/arxiv.2407.18811

Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer’s Disease in European Populations: Development and Validation

Autorzy: Bayram Cevdet Akdeniz, Shahram Bahrami, Espen Hagen, Julian Fuhrer, Vera Fominykh, Alexey Shadrin, Tahir Tekin Filiz, Lavinia Athanasiu, Benjamin Grenier-Boley, Céline Bellenguez, Itziar de Rojas, Fahri Küçükali, Anja Schneider, Luca Kleineidam, Dan Rujescu, Norbert Scherbaum, Jürgen Deckert, Steffi Riedel-Heller, Lucrezia Hausner, Laura Molina-Porcel, Timo Grimmer, Stefanie Heilmann-Heimbach
Opublikowane w: Preprint in Medrxiv, 2026
Wydawca: Medrxiv
DOI: 10.1101/2025.07.28.25332293

Identification of Novel Loci and Cross-Disorder Pleiotropy Through Multi-Ancestry Genome-Wide Analysis of Alcohol Use Disorder in Over One Million Individuals

Autorzy: Romain Icick, Alexey Shadrin, Børge Holen, Naz Karadag, Nadine Parker, Kevin O'Connell, Oleksandr Frei, Shahram Bahrami, Margrethe Høegh, Trine Lagerberg, Weiqiu Cheng, Tyler Seibert, Srdjan Djurovic, Anders Dale, Hang Zhou, Howard Edenberg, Joel Gelernter, Olav Smeland, Guy Hindley, Ole Andreassen
Opublikowane w: Preprint NLM, 2025
Wydawca: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-3755915/v1

Genome-wide analyses reveal widespread genetic overlap between neurological and psychiatric disorders and a convergence of biological associations related to the brain

Autorzy: Smeland, Olav B.; Kutrolli, Gleda; Bahrami, Shahram; Fominykh, Vera; Parker, Nadine; Hindley, Guy F. L.; Rødevand, Linn; Jaholkowski, Piotr; Tesfaye, Markos; Parekh, Pravesh; Elvsåshagen, Torbjørn; Grotzinger, Andrew D.; Steen, Nils Eiel; van der Meer, Dennis; O’Connell, Kevin S.; Djurovic, Srdjan; Dale, Anders M.; Shadrin, Alexey A.; Frei, Oleksandr; Andreassen, Ole A.
Opublikowane w: medRxiv, Numer 28, 2023, Strona(/y) 37503175
Wydawca: Europe PMC

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