Using real-world big data from eHealth, biobanks and national registries, integrated with clinical trial data to improve outcome of severe mental disorders

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Innovation, Intellectual Property (IP) and Knowledge Management Plan

Innovation Intellectual Property IP and Knowledge Management Plan

Risk Management Plan
Identification of relevant RWD sources in partner countries
Dissemination, Exploitation and Communication Plan yearly update M30

Dissemination, Exploitation and Communication Plan and yearly updates. Yearly updates shall include:- Newsletters- Updates of website- Report on scientific dissemination activities.- Report on public outreach.- Presentation of REALMENT findings to project stakeholders

An initial data freeze (Freeze 1) to be used for algorithm development
REALMENT Coordination team established
First Dissemination, Exploitation and Communication Plan done

First Dissemination Exploitation and Communication Plan done

Curated cross-border phenotypic data set
Minutes of the Annual Project Meeting Y3

Minutes of the Annual Project Meeting Y4

Quality Management Plan
Open access report on requirements for common data quality
Minutes of the Annual Project Meeting Y2
Replication of identified genotype-phenotype associations in an independent sample
Dissemination, Exploitation and Communication Plan yearly update M18

Dissemination Exploitation and Communication Plan and yearly updates Yearly updates shall include Newsletters Updates of website Report on scientific dissemination activities Report on public outreach Presentation of REALMENT findings to project stakeholders

Stakeholder input to design and user-friendly interface and clinical report design
Report of defined pharma trajectories
Tools and guidelines for data retrieval and sharing in place

Data Management Plan

REALMENT website and Social Media channels operational

Pubblicazioni

A novel framework for assessing causal effect of microbiome on health: long-term antibiotic usage as an instrument

Autori: Nele Taba, Krista Fischer, null Estonian Biobank Research Team, Elin Org, Oliver Aasmets
Pubblicato in: Gut Microbes, Numero 17, 2025, ISSN 1949-0976
Editore: Landes Bioscience
DOI: 10.1080/19490976.2025.2453616

Adolescent Psychedelic Use and Psychotic or Manic Symptoms

Autori: Otto Simonsson, Miriam A. Mosing, Walter Osika, Fredrik Ullén, Henrik Larsson, Yi Lu, Laura W. Wesseldijk
Pubblicato in: JAMA Psychiatry, Numero 81, 2024, Pagina/e 579, ISSN 2168-622X
Editore: American Medical Association
DOI: 10.1001/jamapsychiatry.2024.0047

Placental efflux transporters and antiseizure or antidepressant medication use impact birth weight in MoBa cohort

Autori: Marta H. Hernandez, Jacqueline M. Cohen, Karoline H. Skåra, Thea K. Grindstad, Yunsung Lee, Per Magnus, Pål R. Njølstad, Ole A. Andreassen, Elizabeth C. Corfield, Alexandra Havdahl, Espen Molden, Kari Furu, Maria C. Magnus, Alvaro Hernaez
Pubblicato in: iScience, Numero 27, 2025, Pagina/e 109285, ISSN 2589-0042
Editore: Elsevier BV
DOI: 10.1016/j.isci.2024.109285

COVID-19 illness severity and 2-year prevalence of physical symptoms: an observational study in Iceland, Sweden, Norway and Denmark

Autori: Qing Shen, Emily E. Joyce, Omid V. Ebrahimi, Maria Didriksen, Anikó Lovik, Karen Sól Sævarsdóttir, Ingibjörg Magnúsdóttir, Dorte Helenius Mikkelsen, Anna Bára Unnarsdóttir, Arna Hauksdóttir, Asle Hoffart, Anna K. Kähler, Edda Björk Thórdardóttir, Elías Eythórsson, Emma M. Frans, Gunnar Tómasson, Helga Ask, Hrönn Hardardóttir, Jóhanna Jakobsdóttir, Kelli Lehto, Li Lu, Ole A. An
Pubblicato in: The Lancet Regional Health - Europe, Numero 35, 2025, Pagina/e 100756, ISSN 2666-7762
Editore: Elsevier BV
DOI: 10.1016/j.lanepe.2023.100756

Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores

Autori: Djenifer B.KappelaSophie E.LeggeaLeonHubbardaIsabella R.WillcocksaKevin S.O’ConnelldRobert L.SmithdfEspenMoldenefOle A.AndreassendAdrianKingbJohnJansencMarinkaHelthuiscMichael J.OwenaMichael C.O’DonovanaJames T.R.WaltersaAntonio F.Pardiñasa
Pubblicato in: Biological Psychiatry, Numero Volume 93, Numero 2, 15 January 2023, 2023, Pagina/e 149-156, ISSN 0006-3223
Editore: Elsevier BV
DOI: 10.1016/j.biopsych.2022.07.014

Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy

Autori: Guy Hindley, Alexey A. Shadrin, Dennis van der Meer, Nadine Parker, Weiqiu Cheng, Kevin S. O’Connell, Shahram Bahrami, Aihua Lin, Naz Karadag, Børge Holen, Thomas Bjella, Ian J. Deary, Gail Davies, W. David Hill, Jan Bressler, Sudha Seshadri, Chun Chieh Fan, Torill Ueland, Srdjan Djurovic, Olav B. Smeland, Oleksandr Frei, Anders M. Dale, Ole A. Andreassen
Pubblicato in: Nature Human Behaviour, Numero 7, 2023, Pagina/e 1584-1600, ISSN 2397-3374
Editore: nature human behaviour
DOI: 10.1038/s41562-023-01630-9

Epidemiological overview of major depressive disorder in Scandinavia using nationwide registers

Autori: Joëlle A. Pasman, Joeri J. Meijsen, Marit Haram, Kaarina Kowalec, Arvid Harder, Ying Xiong, Thuy-Dung Nguyen, Andreas Jangmo, John R. Shorter, Jacob Bergstedt, Urmi Das, Richard Zetterberg, Ashley Tate, Paul Lichtenstein, Henrik Larsson, Ingvild Odsbu, Thomas Werge, Ted Reichborn-Kjennerud, Ole A. Andreassen, Patrick F. Sullivan, Alfonso Buil, Martin Tesli, Yi Lu
Pubblicato in: The Lancet Regional Health - Europe, Numero 29, 2023, Pagina/e 100621, ISSN 2666-7762
Editore: Lancet Regional Health Europe
DOI: 10.1016/j.lanepe.2023.100621

Genome-wide meta-analyses of non-response to antidepressants provide insights into underlying molecular genetics and suggest potential pharmacotherapies

Autori: Elise Koch, Tuuli Puusepp, Guðmundur Einarsson, Brittany L. Mitchell, Arvid Harder, Yuhao Lin, Luis M. García-Marín, Kristi Krebs, Alexey A. Shadrin, Ying Xiong, null null, Andres Metspalu, Tõnu Esko, Reedik Mägi, Mari Nelis, Georgi Hudjashov, Oleksandr Frei, Yi Lu, Sara Hägg, Miguel E. Rentería, Sarah E. Medland, Naomi R. Wray, Nicholas G. Martin, Christopher Hübel, Gerome Breen, Thorgeir
Pubblicato in: Molecular Psychiatry, 2025, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-025-03357-7

Charting the Landscape of Genetic Overlap Between Mental Disorders and Related Traits Beyond Genetic Correlation

Autori: Guy Hindley, Oleksandr Frei, Alexey A. Shadrin, Weiqiu Cheng, Kevin S. O’Connell, Romain Icick, Nadine Parker, Shahram Bahrami, Naz Karadag, Daniel Roelfs, Børge Holen, Aihua Lin, Chun C. Fan, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Ole A. Andreassen
Pubblicato in: American Journal of Psychiatry, Numero 179, 2024, Pagina/e 833-843, ISSN 0002-953X
Editore: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.21101051

Polygenic overlap with granulocyte counts identifies novel loci for clozapine metabolism and clozapine-induced agranulocytosis

Autori: Elise Koch, Alexey A. Shadrin, Nadine Parker, Siobhan K. Lock, Robert L. Smith, Oleksandr Frei, Anders M. Dale, Srdjan Djurovic, Espen Molden, Kevin S. O´Connell, Ole A. Andreassen
Pubblicato in: Neuropsychopharmacology, Numero 50, 2025, Pagina/e 947-955, ISSN 0893-133X
Editore: Nature Publishing Group
DOI: 10.1038/s41386-025-02054-x

Impact of NFIB and CYP1A variants on clozapine serum concentration—A retrospective naturalistic cohort study on 526 patients with known smoking habits

Autori: Hasan Çağın Lenk,Robert Løvsletten Smith,Kevin S. O'Connell,Marin M. Jukić,Marianne Kristiansen Kringen,Ole A. Andreassen,Magnus Ingelman-Sundberg,Espen Molden
Pubblicato in: Clin Transl Sci ., Numero 2023 Jan;16(1):62-72. doi: 10.1111/cts.13422. Epub 2022 Oct 7., 2023, Pagina/e 62-72, ISSN 1752-8062
Editore: Wiley
DOI: 10.1111/cts.13422

Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia

Autori: Kevin S. O'Connell, Elise Koch, Hasan Çağın Lenk, Ibrahim A Akkouh, Guy Hindley, Piotr Jaholkowski, Robert Løvsletten Smith, Børge Holen, Alexey A. Shadrin, Oleksandr Frei, Olav B. Smeland, Nils Eiel Steen, Anders M. Dale, Espen Molden, Srdjan Djurovic, Ole A. Andreassen
Pubblicato in: Psychiatry Research, Numero 325, 2023, Pagina/e 115217, ISSN 0165-1781
Editore: Elsevier BV
DOI: 10.1016/j.psychres.2023.115217

Distinct patterns of genetic overlap among multimorbidities revealed with trivariate MiXeR

Autori: Alexey A. Shadrin, Guy Hindley, Espen Hagen, Nadine Parker, Markos Tesfaye, Piotr Jaholkowski, Zillur Rahman, Gleda Kutrolli, Vera Fominykh, Srdjan Djurovic, Olav B. Smeland, Kevin S. O’Connell, Dennis van der Meer, Oleksandr Frei, Ole A. Andreassen, Anders M. Dale
Pubblicato in: Genome Medicine, Numero 17, 2025, ISSN 1756-994X
Editore: BioMed Central
DOI: 10.1186/s13073-025-01528-3

Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease

Autori: Jacob Bergstedt, Joëlle A. Pasman, Ziyan Ma, Arvid Harder, Shuyang Yao, Nadine Parker, Jorien L. Treur, Dirk J. A. Smit, Oleksandr Frei, Alexey A. Shadrin, Joeri J. Meijsen, Qing Shen, Sara Hägg, Per Tornvall, Alfonso Buil, Thomas Werge, Jens Hjerling-Leffler, Thomas D. Als, Anders D. Børglum, Cathryn M. Lewis, Andrew M. McIntosh, Unnur A. Valdimarsdóttir, Ole A. Andreassen, Patrick F. Sulliva
Pubblicato in: Nature Cardiovascular Research, Numero 3, 2024, Pagina/e 754-769, ISSN 2731-0590
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44161-024-00488-y

How Real-World Data Can Facilitate the Development of Precision Medicine Treatment in Psychiatry

Autori: Elise Koch, Antonio F. Pardiñas, Kevin S. O’Connell, Pierluigi Selvaggi, José Camacho Collados, Aleksandar Babic, Serena E. Marshall, Erik Van der Eycken, Cecilia Angulo, Yi Lu, Patrick F. Sullivan, Anders M. Dale, Espen Molden, Danielle Posthuma, Nathan White, Alexander Schubert, Srdjan Djurovic, Hakon Heimer, Hreinn Stefánsson, Kári Stefánsson, Thomas Werge, Ida Sønderby, Michael C. O’
Pubblicato in: Biological Psychiatry, 2024, ISSN 0006-3223
Editore: Elsevier BV
DOI: 10.1016/j.biopsych.2024.01.001

Prioritizing Parkinson’s disease risk genes in genome-wide association loci

Autori: Lara M. Lange, Catalina Cerquera-Cleves, Marijn Schipper, Georgia Panagiotaropoulou, Alice Braun, Julia Kraft, Swapnil Awasthi, Nathaniel Bell, Danielle Posthuma, Stephan Ripke, Cornelis Blauwendraat, Karl Heilbron
Pubblicato in: npj parkinson's disease, 2026, ISSN 2373-8057
Editore: npj Parkinson's Disease (npj Parkinsons Dis.)
DOI: 10.1101/2024.12.13.24318996

Psychiatric disorders and brain white matter exhibit genetic overlap implicating developmental and neural cell biology

Autori: Nadine Parker, Weiqiu Cheng, Guy F. L. Hindley, Pravesh Parekh, Alexey A. Shadrin, Ivan I. Maximov, Olav B. Smeland, Srdjan Djurovic, Anders M. Dale, Lars T. Westlye, Oleksandr Frei, Ole A. Andreassen
Pubblicato in: Molecular Psychiatry, Numero 28, 2024, Pagina/e 4924-4932, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-023-02264-z

Effect of CYP2D6 and CYP2C19 genotypes on atomoxetine serum levels -- a study based on therapeutic drug monitoring data

Autori: Robert Smith, Espen Molden, Jean-Paul Bernard
Pubblicato in: British Journal of Clinical Pharmacology, 2022, ISSN 1365-2125
Editore: Willey
DOI: 10.22541/au.167050638.80828727/v1

Genetic insights into psychotic major depressive disorder: bridging the mood-psychotic disorder spectrum

Autori: Thuy-Dung Nguyen, Joeri J. Meijsen, Robert Sigström, Ralf Kuja-Halkola, Ying Xiong, Arvid Harder, Kaarina Kowalec, Joëlle A. Pasman, Carolina Scarpa, Elin Hörbeck, Lina Jonsson, Sara Hägg, Niamh Mullins, Kevin S. O’Connell, Christina Dalman, Dorte Helenius, Richard Zetterberg, Henrik Larsson, Paul Lichtenstein, Ole A. Andreassen, Thomas Werge, Alfonso Buil, Mikael Landén, Patrick F. Sulliva
Pubblicato in: eBioMedicine, Numero 112, 2025, Pagina/e 105576, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2025.105576

Effects of antipsychotics on human cognitive function: causal evidence from healthy volunteers following sustained D2/D3 antagonism, D2/D3 partial agonism and placebo

Autori: Martin Osugo, Uzma Zahid, Pierluigi Selvaggi, Alexandria Chilimidos, Valeria Finelli, George E. Chapman, Thomas Whitehurst, Ellis Chika Onwordi, Robin M. Murray, Matthew B. Wall, Tiago Reis Marques, Mitul A. Mehta, Oliver D. Howes
Pubblicato in: Molecular Psychiatry, Numero 30, 2025, Pagina/e 5315-5325, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-025-03116-8

Translational Psychiatry

Autori: Ying Xiong; Robert Karlsson; Jie Song; Kaarina Kowalec; Christian Rck; Robert Sigstrm; Lina Jonsson; Caitlin C. Clements; Evelyn Andersson; Julia Boberg; Cathryn M. Lewis; Patrick F. Sullivan; Mikael Landn; Yi Lu
Pubblicato in: Translational Psychiatry, Vol 13, Iss 1, Pp 1-7 (2023), Numero 23, 2023, ISSN 2158-3188
Editore: Nature Publishing Group

Antipsychotic and pharmacogenomic effects on cross-sectional symptom severity and cognitive ability in schizophrenia

Autori: Siobhan K. Lock, Djenifer B. Kappel, Michael J. Owen, James T.R. Walters, Michael C. O'Donovan, Antonio F. Pardiñas, Sophie E. Legge
Pubblicato in: eBioMedicine, Numero 116, 2025, Pagina/e 105745, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2025.105745

Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders

Autori: Guy Hindley, Ole Kristian Drange, Aihua Lin, Gleda Kutrolli, Alexey A. Shadrin, Nadine Parker, Kevin S. O’Connell, Linn Rødevand, Weiqiu Cheng, Shahram Bahrami, Naz Karadag, Børge Holen, Piotr Jaholkowski, Markos Tesfaye Woldeyohannes, Srdjan Djurovic, Anders M. Dale, Oleksandr Frei, Thor Ueland, Olav B. Smeland, Ole A. Andreassen
Pubblicato in: Psychoneuroendocrinology, Numero 157, 2024, Pagina/e 106368, ISSN 0306-4530
Editore: Pergamon Press
DOI: 10.1016/j.psyneuen.2023.106368

Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study

Autori: E. P. Tissink, A. A. Shadrin, D. van der Meer, N. Parker, G. Hindley, D. Roelfs, O. Frei, C. C. Fan, M. Nagel, T. Nærland, M. Budisteanu, S. Djurovic, L. T. Westlye, M. P. van den Heuvel, D. Posthuma, T. Kaufmann, A. M. Dale, O. A. Andreassen
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-46817-4

Genetic Overlap Between Global Cortical Brain Structure, C-Reactive Protein, and White Blood Cell Counts

Autori: Nadine Parker, Weiqiu Cheng, Guy F.L. Hindley, Kevin S. O’Connell, Sandeep Karthikeyan, Børge Holen, Alexey A. Shadrin, Zillur Rahman, Naz Karadag, Shahram Bahrami, Aihua Lin, Nils Eiel Steen, Thor Ueland, Pål Aukrust, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Oleksandr Frei, Ole A. Andreassen
Pubblicato in: Biological Psychiatry, Numero 95, 2024, Pagina/e 62-71, ISSN 0006-3223
Editore: Elsevier BV
DOI: 10.1016/j.biopsych.2023.06.008

Rapid Metabolism Underlying Subtherapeutic Serum Levels of Atypical Antipsychotics Preceding Clozapine Treatment: A Retrospective Analysis of Real-World Data

Autori: Hasan Çağın Lenk, Robert Løvsletten Smith, Kevin S. O’Connell, Ole A. Andreassen, Espen Molden
Pubblicato in: CNS Drugs, Numero 38, 2024, Pagina/e 473-480, ISSN 1172-7047
Editore: Adis International Ltd.
DOI: 10.1007/s40263-024-01079-y

Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression

Autori: Ying Xiong, Kristi Krebs, Bradley Jermy, Robert Karlsson, Joëlle A. Pasman, Thuy-Dung Nguyen, Tong Gong, Kaarina Kowalec, Christian Rück, Robert Sigström, Lina Jonsson, Caitlin C. Clements, Elin Hörbeck, Evelyn Andersson, Julia Bäckman, null null, null null, Andrea Ganna, Jakob German, Patrick F. Sullivan, Mikael Landén, Kelli Lehto, Yi Lu
Pubblicato in: Molecular Psychiatry, Numero 30, 2025, Pagina/e 5024-5033, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-025-03084-z

Polygenic liability for antipsychotic dosage and polypharmacy - a real-world registry and biobank study

Autori: Elise Koch, Anders Kämpe, Maris Alver, Sindri Sigurðarson, Guðmundur Einarsson, Juulia Partanen, Robert L. Smith, Piotr Jaholkowski, Heidi Taipale, Markku Lähteenvuo, Nils Eiel Steen, Olav B. Smeland, Srdjan Djurovic, Espen Molden, null null, null null, Engilbert Sigurdsson, Hreinn Stefánsson, Kári Stefánsson, Aarno Palotie, Lili Milani, Kevin S. O’Connell, Ole A. Andreassen
Pubblicato in: Neuropsychopharmacology, Numero 49, 2024, Pagina/e 1113-1119, ISSN 0893-133X
Editore: Nature Publishing Group
DOI: 10.1038/s41386-023-01792-0

Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry

Autori: Anna Gui, Anja Hollowell, Emilie M. Wigdor, Morgan J. Morgan, Laurie J. Hannigan, Elizabeth C. Corfield, Veronika Odintsova, Jouke-Jan Hottenga, Andrew Wong, René Pool, Harriet Cullen, Siân Wilson, Varun Warrier, Espen M. Eilertsen, Ole A. Andreassen, Christel M. Middeldorp, Beate St Pourcain, Meike Bartels, Dorret I. Boomsma, Catharina A. Hartman, Elise B. Robinson, Tomoki Arichi, Anthony D. Ed
Pubblicato in: Nature Human Behaviour, Numero 9, 2025, Pagina/e 1470-1487, ISSN 2397-3374
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41562-025-02145-1

A comprehensive map of genetic relationships among diagnostic categories based on 48.6 million relative pairs from the Danish genealogy

Autori: Georgios Athanasiadis, Joeri J. Meijsen, Dorte Helenius, Andrew J. Schork, Andrés Ingason, Wesley K. Thompson, Daniel H. Geschwind, Thomas Werge, Alfonso Buil
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 119, 2022, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2118688119

Genetic Contribution to the Heterogeneity of Major Depressive Disorder: Evidence From a Sibling-Based Design Using Swedish National Registers

Autori: Thuy-Dung Nguyen, Kaarina Kowalec, Joëlle Pasman, Henrik Larsson, Paul Lichtenstein, Christina Dalman, Patrick F. Sullivan, Ralf Kuja-Halkola, Yi Lu
Pubblicato in: American Journal of Psychiatry, Numero 180, 2024, Pagina/e 714-722, ISSN 0002-953X
Editore: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.20220906

Medical comorbidities in bipolar disorder (BIPCOM): clinical validation of risk factors and biomarkers to improve prevention and treatment. Study protocol

Autori: Giovanni de Girolamo, Ole A. Andreassen, Michael Bauer, Paolo Brambilla, Stefano Calza, Nicholas Citerà, Rosa Corcoy, Andrea Fagiolini, Miguel Garcia-Argibay, Ophélia Godin, Florian Klingler, Nene F. Kobayashi, Henrik Larsson, Marion Leboyer, Silke Matura, Alessandra Martinelli, Víctor De la Peña-Arteaga, Roberto Poli, Andreas Reif, Philipp Ritter, Linn N. Rødevand, Marta Magno, Elisa Caselan
Pubblicato in: International Journal of Bipolar Disorders, Numero 12, 2024, ISSN 2194-7511
Editore: Springer Science and Business Media LLC
DOI: 10.1186/s40345-024-00337-8

Associations Between Symptoms of Premenstrual Disorders and Polygenic Liability for Major Psychiatric Disorders

Autori: Piotr Jaholkowski, Alexey A. Shadrin, Andreas Jangmo, Evgeniia Frei, Markos Tesfaye, Guy F. L. Hindley, Marit Haram, Zillur Rahman, Lavinia Athanasiu, Nora Refsum Bakken, Børge Holen, Vera Fominykh, Gleda Kutrolli, Pravesh Parekh, Nadine Parker, Linn Rødevand, Viktoria Birkenæs, Srdjan Djurovic, Oleksandr Frei, Kevin S. O’Connell, Olav B. Smeland, Martin Tesli, Ole A. Andreassen
Pubblicato in: JAMA Psychiatry, Numero 80, 2023, Pagina/e 738, ISSN 2168-622X
Editore: American Medical Association
DOI: 10.1001/jamapsychiatry.2023.1137

Identification of risk variants and cross-disorder pleiotropy through multi-ancestry genome-wide analysis of alcohol use disorder

Autori: Romain Icick, Alexey Shadrin, Børge Holen, Naz Karadag, Nadine Parker, Kevin S. O’Connell, Oleksandr Frei, Shahram Bahrami, Margrethe Collier Høegh, Trine Vik Lagerberg, Weiqiu Cheng, Tyler M. Seibert, Srdjan Djurovic, Anders M. Dale, Hang Zhou, Howard J. Edenberg, Joel Gelernter, Olav B. Smeland, Guy Hindley, Ole A. Andreassen
Pubblicato in: Nature Mental Health, Numero 3, 2025, Pagina/e 253-265, ISSN 2731-6076
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44220-024-00353-8

The phenotypic and genetic relationship between adolescent mental health and time spent on social media, gaming, and TV

Autori: Evgeniia Frei, Oleksandr Frei, Piotr Jaholkowski, Nadine Parker, Pravesh Parekh, Alexey A. Shadrin, Espen Hagen, Nora R. Bakken, Viktoria Birkenæs, Helga Ask, Ole A. Andreassen, Olav B. Smeland
Pubblicato in: Psychiatry Research, Numero 353, 2026, Pagina/e 116761, ISSN 0165-1781
Editore: Elsevier BV
DOI: 10.1016/j.psychres.2025.116761

Genetic and Phenotypic Features of Schizophrenia in the UK Biobank

Autori: Sophie E. Legge, Antonio F. Pardiñas, Grace Woolway, Elliott Rees, Alastair G. Cardno, Valentina Escott-Price, Peter Holmans, George Kirov, Michael J. Owen, Michael C. O’Donovan, James T. R. Walters
Pubblicato in: JAMA Psychiatry, Numero 81, 2024, Pagina/e 681, ISSN 2168-622X
Editore: American Medical Association
DOI: 10.1001/jamapsychiatry.2024.0200

Identification and validation of postpartum depression subtypes: a population-based cohort study

Autori: Anna E. Bauer, Piotr Jaholkowski, Yi Lu, Jerry Guintivano, Laurie J. Hannigan, Elizabeth C. Corfield, Martin Tesli, Ole A. Andreassen, Yun Li, Ted Reichborn-Kjennerud, Patrick F. Sullivan, Samantha Meltzer-Brody, Alexandra Havdahl, Helga Ask
Pubblicato in: eClinicalMedicine, Numero 89, 2025, Pagina/e 103540, ISSN 2589-5370
Editore: Elsevier BV
DOI: 10.1016/j.eclinm.2025.103540

Recommendations for defining treatment outcomes in major psychiatric disorders leveraging real-world data

Autori: Elise Koch, Sophie Elizabeth Smart, Guðmundur Einarsson, Anders Kämpe, Lina Jonsson, Maris Alver, Matthew Henry Iveson, Andreas Göteson, Antonio F Pardiñas, Ida E. Sønderby, Kevin O’Connell, Qingqin Li, Lu Yi, Hreinn Stefansson, Kári Stefánsson, Heather C Whalley, Mikael Landén, Michael C. O’Donovan, Knut T. Smerud, Gerard R. Dawson, Thomas Werge, Alfonso Buil, Andreas Reif, Lili Milan
Pubblicato in: Lancet Psychiatry, 2025, ISSN 2215-0366
Editore: Elsevier Limited
DOI: 10.31234/osf.io/kumea_v1

Improved functional mapping of complex trait heritability with GSA-MiXeR implicates biologically specific gene sets

Autori: Oleksandr Frei, Guy Hindley, Alexey A. Shadrin, Dennis van der Meer, Bayram C. Akdeniz, Espen Hagen, Weiqiu Cheng, Kevin S. O’Connell, Shahram Bahrami, Nadine Parker, Olav B. Smeland, Dominic Holland, null null, Christiaan de Leeuw, Danielle Posthuma, Ole A. Andreassen, Anders M. Dale
Pubblicato in: Nature Genetics, Numero 56, 2024, Pagina/e 1310-1318, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-024-01771-1

Striatal dopamine D2/D3 receptor regulation of human reward processing and behaviour

Autori: Martin Osugo, Matthew B. Wall, Pierluigi Selvaggi, Uzma Zahid, Valeria Finelli, George E. Chapman, Thomas Whitehurst, Ellis Chika Onwordi, Ben Statton, Robert A. McCutcheon, Robin M. Murray, Tiago Reis Marques, Mitul A. Mehta, Oliver D. Howes
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-56663-7

Impact of CYP1A , CYP2C19 , CYP2D6 , CYP3A4 , CYP3A5 , and NFIB genotypes on clozapine serum concentration in smokers and nonsmokers

Autori: Hasan Çağın Lenk, Line Skute Bråten, Ole A. Andreassen, Espen Molden
Pubblicato in: Therapeutic Advances in Psychopharmacology, Numero 15, 2025, ISSN 2045-1253
Editore: SAGE Publications
DOI: 10.1177/20451253251377183

Polygenic and pharmacogenomic contributions to medication dosing: a real-world longitudinal biobank study

Autori: Silva Kasela, Laura Birgit Luitva, Kristi Krebs, null null, Märt Möls, Lili Milani, Maris Alver
Pubblicato in: Journal of Translational Medicine, Numero 23, 2025, ISSN 1479-5876
Editore: BioMed Central
DOI: 10.1186/s12967-025-06782-y

A pattern-learning algorithm associates copy number variations with brain structure and behavioural variables in an adolescent population cohort

Autori: Jakub Kopal, Guillaume Huguet, Justin Marotta, Shambhavi Aggarwal, Nicole Osayande, Kuldeep Kumar, Zohra Saci, Martineau Jean-Louis, Xiaoqian J. Chai, Tian Ge, B. T. Thomas Yeo, Paul M. Thompson, Carrie E. Bearden, Ole A. Andreassen, Sébastien Jacquemont, Danilo Bzdok
Pubblicato in: Nature Biomedical Engineering, 2025, ISSN 2157-846X
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41551-025-01454-0

Associations of polygenic risk scores for major depression and depression severity: an investigation of 105 623 individuals with 16 years follow-up

Autori: Marit Haram, Andreas Jangmo, Piotr Jaholkowski, Joëlle Pasman, Joeri Meijsen, John R. Shorter, Elizabeth C. Corfield, Oleksandr Frei, Ted Reichborn-Kjennerud, Alfonso Buil, Yi Lu, Thomas Werge, Patrick Sullivan, Ole A. Andreassen, Martin Tesli
Pubblicato in: Molecular Psychiatry, 2025, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-025-03243-2

Genetic predisposition and antipsychotic treatment effect on metabolic syndrome in schizophrenia: a ten-year follow-up study using the Estonian Biobank

Autori: Maris Alver, Silva Kasela, Liina Haring, Laura Birgit Luitva, Krista Fischer, Märt Möls, Lili Milani
Pubblicato in: The Lancet Regional Health - Europe, Numero 41, 2024, Pagina/e 100914, ISSN 2666-7762
Editore: Lancet Regional Health Europe
DOI: 10.1016/j.lanepe.2024.100914

AI for Analyzing Mental Health Disorders Among Social Media Users: Quarter-Century Narrative Review of Progress and Challenges

Autori: David Owen, Amy J Lynham, Sophie E Smart, Antonio F Pardiñas, Jose Camacho Collados
Pubblicato in: Journal of Medical Internet Research, Numero 26, 2024, Pagina/e e59225, ISSN 1438-8871
Editore: Journal of medical Internet Research
DOI: 10.2196/59225

Socio-demographic and genetic risk factors for drug adherence and persistence across 5 common medication classes

Autori: Mattia Cordioli, Andrea Corbetta, Hanna Maria Kariis, Sakari Jukarainen, Pekka Vartiainen, Tuomo Kiiskinen, Matteo Ferro, null null, Markus Perola, Samuli Ripatti, Andrea Ganna, null null, Andres Metspalu, Lili Milani, Tõnu Esko, Reedik Mägi, Mari Nelis, Georgi Hudjashov, Markus Perola, Mikko Niemi, Samuli Ripatti, Kelli Lehto, Lili Milani, Andrea Ganna
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-53556-z

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications

Autori: Ole A. Andreassen, Guy F.L. Hindley, Oleksandr Frei, Olav B. Smeland
Pubblicato in: World Psychiatry, Numero 22, 2023, Pagina/e 4-24, ISSN 1723-8617
Editore: Masson Italia Periodici
DOI: 10.1002/wps.21034

Association between genetic liability to physical health conditions and comorbidities in individuals with severe mental illness: an analysis of two cross-sectional observational studies in the UK

Autori: Djenifer B Kappel, Sophie E Smart, Michael J Owen, Michael C O'Donovan, Antonio F Pardiñas, James T R Walters
Pubblicato in: The Lancet Psychiatry, Numero 12, 2025, Pagina/e 447-456, ISSN 2215-0366
Editore: Elsevier Limited
DOI: 10.1016/s2215-0366(25)00123-3

Effects of a Novel UGT2B Haplotype and UGT1A4*3 Allele Variants on Glucuronidation of Clozapine In vivo

Autori: Robert Løvsletten Smith; Birgit M. Wollmann; Marianne Kausberg; Sondre Mæland; Marit Tveito; Kevin O’Connell; Espen Molden; Marianne Kristiansen Kringen
Pubblicato in: Crossref, Numero 1, 2022, ISSN 1389-2002
Editore: Bentham Science Publishers
DOI: 10.2174/1389200223666220201152953

Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study

Autori: Álvaro Hernáez, Karoline H. Skåra, Christian M. Page, Vera R. Mitter, Marta H. Hernández, Per Magnus, Pål R. Njølstad, Ole A. Andreassen, Elizabeth C. Corfield, Alexandra Havdahl, Øyvind Næss, Ben Brumpton, Bjørn Olav Åsvold, Deborah A. Lawlor, Abigail Fraser, Maria Christine Magnus
Pubblicato in: BMC Medicine, Numero 22, 2024, ISSN 1741-7015
Editore: BioMed Central
DOI: 10.1186/s12916-023-03223-9

Polygenic risk scores of lithium response and treatment resistance in major depressive disorder

Autori: Ying Xiong, Robert Karlsson, Jie Song, Kaarina Kowalec, Christian Rück, Robert Sigström, Lina Jonsson, Caitlin C. Clements, Evelyn Andersson, Julia Boberg, Cathryn M. Lewis, Patrick F. Sullivan, Mikael Landén, Yi Lu
Pubblicato in: Translational Psychiatry, Numero 13, 2023, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-023-02602-3

Partitioning variance in cortical morphometry into genetic, environmental, and subject-specific components

Autori: Diana M Smith, Pravesh Parekh, Joseph Kennedy, Robert Loughnan, Oleksandr Frei, Thomas E Nichols, Ole A Andreassen, Terry L Jernigan, Anders M Dale
Pubblicato in: Cerebral Cortex, Numero 34, 2024, ISSN 1047-3211
Editore: Oxford University Press
DOI: 10.1093/cercor/bhae234

Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count

Autori: Siobhan K. Lock, Sophie E. Legge, Djenifer B. Kappel, Isabella R. Willcocks, Marinka Helthuis, John Jansen, James T. R. Walters, Michael J. Owen, Michael C. O’Donovan, Antonio F. Pardiñas
Pubblicato in: Schizophrenia, Numero 9, 2023, ISSN 2754-6993
Editore: Schizophrenia
DOI: 10.1038/s41537-023-00404-6

Finemap-MiXeR: A variational Bayesian approach for genetic finemapping

Autori: Bayram Cevdet Akdeniz, Oleksandr Frei, Alexey Shadrin, Dmitry Vetrov, Dmitry Kropotov, Eivind Hovig, Ole A. Andreassen, Anders M. Dale
Pubblicato in: PLOS Genetics, Numero 20, 2024, Pagina/e e1011372, ISSN 1553-7404
Editore: Public Library of Science (PLoS)
DOI: 10.1371/journal.pgen.1011372

Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis

Autori: Markos Tesfaye, Piotr Jaholkowski, Guy F. L. Hindley, Alexey A. Shadrin, Zillur Rahman, Shahram Bahrami, Aihua Lin, Børge Holen, Nadine Parker, Weiqiu Cheng, Linn Rødevand, Oleksandr Frei, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Kevin S. O’Connell, Ole A. Andreassen
Pubblicato in: Genome Medicine, Numero 15, 2023, ISSN 1756-994X
Editore: BioMed Central
DOI: 10.1186/s13073-023-01212-4

Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities

Autori: Nils Eiel Steen, Zillur Rahman, Attila Szabo, Guy F L Hindley, Nadine Parker, Weiqiu Cheng, Aihua Lin, Kevin S O’Connell, Mashhood A Sheikh, Alexey Shadrin, Shahram Bahrami, Sandeep Karthikeyan, Eva Z Hoseth, Anders M Dale, Pål Aukrust, Olav B Smeland, Thor Ueland, Oleksandr Frei, Srdjan Djurovic, Ole A Andreassen
Pubblicato in: Schizophrenia Bulletin, Numero 49, 2023, Pagina/e 1345-1354, ISSN 0586-7614
Editore: Oxford University Press
DOI: 10.1093/schbul/sbad082

Large Language Model–Supported Identification of Intellectual Disabilities in Clinical Free-Text Summaries: Mixed Methods Study

Autori: Aleksandra Edwards, Antonio F Pardiñas, George Kirov, Elliott Rees, Jose Camacho-Collados
Pubblicato in: JMIR AI, Numero 4, 2025, Pagina/e e72256-e72256, ISSN 2817-1705
Editore: JMIR Publications Inc.
DOI: 10.2196/72256

Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia

Autori: Djenifer B. Kappel, Elliott Rees, Eilidh Fenner, Adrian King, John Jansen, Marinka Helthuis, Michael J. Owen, Michael C. O'Donovan, James T.R. Walters, Antonio F. Pardiñas
Pubblicato in: European Neuropsychopharmacology, Numero 80, 2024, Pagina/e 47-54, ISSN 0924-977X
Editore: Elsevier BV
DOI: 10.1016/j.euroneuro.2023.12.007

Unraveling the shared genetics of common epilepsies and general cognitive ability

Autori: Naz Karadag, Espen Hagen, Alexey A. Shadrin, Dennis van der Meer, Kevin S. O'Connell, Zillur Rahman, Gleda Kutrolli, Nadine Parker, Shahram Bahrami, Vera Fominykh, Kjell Heuser, Erik Taubøll, Torill Ueland, Nils Eiel Steen, Srdjan Djurovic, Anders M. Dale, Oleksandr Frei, Ole A. Andreassen, Olav B. Smeland
Pubblicato in: Seizure: European Journal of Epilepsy, Numero 122, 2025, Pagina/e 105-112, ISSN 1059-1311
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.seizure.2024.09.016

Polygenic overlap of substance use behaviors and disorders with externalizing and internalizing problems independent of genetic correlations

Autori: Laila Al-Soufi, Guy Hindley, Linn Rødevand, Alexey A. Shadrin, Piotr Jaholkowski, Vera Fominykh, Romain Icick, Markos Tesfaye, Javier Costas, Ole A. Andreassen
Pubblicato in: Psychological Medicine, Numero 55, 2025, ISSN 0033-2917
Editore: Cambridge University Press
DOI: 10.1017/s0033291725000108

Telomere biology and its maintenance in schizophrenia spectrum disorders: Exploring links to cognition

Autori: Vid Mlakar, Ibrahim Akkouh, Els F. Halff, Deepak P. Srivastava, Viktoria Birkenæs, Torill Ueland, Daniel S. Quintana, Monica B.E.G. Ormerod, Nils Eiel Steen, Srdjan Djurovic, Ole A. Andreassen, Monica Aas
Pubblicato in: Schizophrenia Research, Numero 272, 2025, Pagina/e 89-95, ISSN 0920-9964
Editore: Elsevier BV
DOI: 10.1016/j.schres.2024.08.011

COSGAP: COntainerized Statistical Genetics Analysis Pipelines

Autori: Bayram Cevdet Akdeniz, Oleksandr Frei, Espen Hagen, Tahir Tekin Filiz, Sandeep Karthikeyan, Joëlle Pasman, Andreas Jangmo, Jacob Bergstedt, John R Shorter, Richard Zetterberg, Joeri Meijsen, Ida Elken Sønderby, Alfonso Buil, Martin Tesli, Yi Lu, Patrick Sullivan, Ole A Andreassen, Eivind Hovig
Pubblicato in: Bioinformatics Advances, Numero 4, 2024, ISSN 2635-0041
Editore: Oxford University Press (OUP)
DOI: 10.1093/bioadv/vbae067

Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research

Autori: Na Cai, Brad Verhulst, Ole A. Andreassen, Jan Buitelaar, Howard J. Edenberg, John M. Hettema, Michael Gandal, Andrew Grotzinger, Katherine Jonas, Phil Lee, Travis T. Mallard, Manuel Mattheisen, Michael C. Neale, John I. Nurnberger, Wouter J. Peyrot, Elliot M. Tucker-Drob, Jordan W. Smoller, Kenneth S. Kendler
Pubblicato in: Molecular Psychiatry, Numero 30, 2025, Pagina/e 1627-1638, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-024-02878-x

Genome-wide association analysis of treatment resistant schizophrenia for variant discovery and polygenic assessment

Autori: Hasan Çağın Lenk, Elise Koch, Kevin S. O’Connell, Robert Løvsletten Smith, Ibrahim A. Akkouh, Srdjan Djurovic, Ole A. Andreassen, Espen Molden
Pubblicato in: Human Genomics, Numero 18, 2024, ISSN 1479-7364
Editore: Springer Science and Business Media LLC
DOI: 10.1186/s40246-024-00673-x

Effect of the NFIB rs28379954 T>C polymorphism on <scp>CYP2D6</scp>‐catalyzed metabolism of solanidine

Autori: Robert Løvsletten Smith, Birgit M. Wollmann, Elisabet Størset, Hasan Çağın Lenk, Kevin S. O'Connell, Marianne Kringen Kristiansen, Magnus Ingelman‐Sundberg, Espen Molden
Pubblicato in: Clinical and Translational Science, Numero 17, 2024, ISSN 1752-8054
Editore: Wiley-Blackwell
DOI: 10.1111/cts.13743

Investigating genetic overlap between antidepressant and lithium response and treatment resistance in major depressive disorder

Autori: Yi Lu; Ying Xiong; Robert Karlsson; Jie Song; Kaarina Kowalec; Christian Rück; Robert Sigstrom; Lina Jonsson; Caitlin Clements; Evelyn Andersson; Julia Boberg; Cathryn Lewis; Patrick Sullivan; Mikael Landén
Pubblicato in: Crossref, Numero 17, 2023, ISSN 2693-5015
Editore: translational psychiatry
DOI: 10.21203/rs.3.rs-2556941/v1

Psychometric Properties and Diagnostic Associations of the Short-Form Community Assessment of Psychic Experiences in a Population-Based Sample of 29 021 Adult Men

Autori: Viktoria Birkenæs, Nora Refsum Bakken, Evgeniia Frei, Piotr Jaholkowski, Olav B Smeland, Markos Tesfaye, Ingrid Agartz, Ezra Susser, Michaeline Bresnahan, Espen Røysamb, Kjetil Nordbø Jørgensen, Ragnar Nesvåg, Alexandra Havdahl, Ole A Andreassen, Ida Elken Sønderby
Pubblicato in: Schizophrenia Bulletin, Numero 49, 2023, Pagina/e 1229-1238, ISSN 0586-7614
Editore: Oxford University Press
DOI: 10.1093/schbul/sbad074

Shared genetic loci between Alzheimer's disease and multiple sclerosis: Crossroads between neurodegeneration and immune system

Autori: Vera Fominykh, Alexey A. Shadrin, Piotr P. Jaholkowski, Shahram Bahrami, Lavinia Athanasiu, Douglas P. Wightman, Emil Uffelmann, Danielle Posthuma, Geir Selbæk, Anders M. Dale, Srdjan Djurovic, Oleksandr Frei, Ole A. Andreassen
Pubblicato in: Neurobiology of Disease, Numero 183, 2024, Pagina/e 106174, ISSN 0969-9961
Editore: Academic Press
DOI: 10.1016/j.nbd.2023.106174

Mapping the genetic landscape of immune-mediated disorders: potential implications for classification and therapeutic strategies

Autori: Vera Fominykh, Alexey A. Shadrin, Piotr Jaholkowski, Julian Fuhrer, Nadine Parker, Erik D. Wiström, Oleksandr Frei, Olav B. Smeland, Helga Sanner, Srdjan Djurovic, Ole A. Andreassen
Pubblicato in: Frontiers in Immunology, Numero 16, 2025, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1543781

Multimodal Prediction of Psychosis in the Prospective MoBa Birth Cohort

Autori: Viktoria Birkenæs, Pravesh Parekh, Alexey Shadrin, Piotr Jaholkowski, Lars A. R. Ystaas, Carolina Makowski, Nora R. Bakken, Espen Hagen, Evgeniia Frei, Dominic Oliver, Paolo Fusar-Poli, Anders Dale, John P. John, Alexandra Havdahl, Ida E. Sønderby, Ole A. Andreassen
Pubblicato in: Preprint in Research Square, 2025
Editore: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-6783339/v1

Associations of Genetic Liability to Six Psychiatric Disorders With Cardiometabolic Diseases

Autori: Jacob Bergstedt, Kadri Kõiv, Andreas Jangmo, Marit Haram, Piotr P. Jaholkowski, Jorien L. Treur, Isabell Brikell, Zheng Chang, Henrik Larsson, Patrik K. E. Magnusson, Andrew M. McIntosh, Cathryn M. Lewis, Brian K. Lee, Ida E. Sønderby, Yi Lu, Patrick F. Sullivan, Unnur A. Valdimarsdóttir, Ole Andreassen, Martin Tesli, Kelli Lehto, Fang Fang, null null, null null
Pubblicato in: 2026
Editore: openRxiv
DOI: 10.1101/2025.03.11.25323757

Genome-wide meta-analyses of non-response to antidepressants identify novel loci and potential drugs

Autori: Elise Koch, Tuuli Jurgenson, Gudmundur Einarsson, Brittany Mitchell, Arvid Harder, Luis M Garcia-Marin, Kristi Krebs, Yuhao Lin, Ying Xiong, Estonian Biobank Research Team, Yi Lu, Sara Hagg, Miguel E Renteria, Sarah E Medland, Naomi R Wray, Nicholas G Martin, Christopher Huebel, Gerome Breen, Thorgeir Thorgeirsson, Hreinn Stefansson, Kari Stefansson, Lili Milani, Ole A Andreassen, Kevin S O'Connel
Pubblicato in: 2026
Editore: openRxiv
DOI: 10.1101/2024.07.13.24310361

SLC39A8.p.(Ala391Thr) is associated with poorer cognitive ability: a cross-sectional study of schizophrenia and the general UK population

Autori: Sophie E Smart, Sophie E. Legge, Eilidh Fenner, Antonio F. Pardiñas, Grace Woolway, Amy J. Lynham, Valentina Escott-Price, Jeremy Hall, Lawrence Wilkinson, Peter Holmans, Michael C. O’Donovan, Michael J. Owen, James T.R. Walters
Pubblicato in: Preprint in medRxiv, 2026
Editore: openRxiv
DOI: 10.1101/2024.09.18.24313865

Youth Psychotic Experiences: Diagnostic Associations and Evaluation of the CAPE-16

Autori: Viktoria Birkenæs, Pravesh Parekh, Laura Hegemann, Nora R. Bakken, Evgeniia Frei, Piotr Jaholkowski, Olav B. Smeland, Ezra Susser, Katrina M. Rodriguez, Markos Tesfaye, Ole A. Andreassen, Alexandra Havdahl, Ida E. Sønderby
Pubblicato in: Preprint in MedRxiv, 2026
Editore: openRxiv
DOI: 10.1101/2024.04.18.24306017

Simplifying causal gene identification in GWAS loci

Autori: Marijn Schipper, Jacob Ulirsch, Danielle Posthuma, Stephan Ripke, Karl Heilbron
Pubblicato in: Preprint in medRxiv, 2026
Editore: openRxiv
DOI: 10.1101/2024.07.26.24311057

Interpreting artificial neural networks to detect genome-wide association signals for complex traits

Autori: Yelmen, Burak; Alver, Maris; Güler, Merve Nur; Team, Estonian Biobank Research; Jay, Flora; Milani, Lili
Pubblicato in: Preprint in Arxiv, Numero 1, 2024
Editore: Arxiv
DOI: 10.48550/arxiv.2407.18811

Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer’s Disease in European Populations: Development and Validation

Autori: Bayram Cevdet Akdeniz, Shahram Bahrami, Espen Hagen, Julian Fuhrer, Vera Fominykh, Alexey Shadrin, Tahir Tekin Filiz, Lavinia Athanasiu, Benjamin Grenier-Boley, Céline Bellenguez, Itziar de Rojas, Fahri Küçükali, Anja Schneider, Luca Kleineidam, Dan Rujescu, Norbert Scherbaum, Jürgen Deckert, Steffi Riedel-Heller, Lucrezia Hausner, Laura Molina-Porcel, Timo Grimmer, Stefanie Heilmann-Heimbach
Pubblicato in: Preprint in Medrxiv, 2026
Editore: Medrxiv
DOI: 10.1101/2025.07.28.25332293

Identification of Novel Loci and Cross-Disorder Pleiotropy Through Multi-Ancestry Genome-Wide Analysis of Alcohol Use Disorder in Over One Million Individuals

Autori: Romain Icick, Alexey Shadrin, Børge Holen, Naz Karadag, Nadine Parker, Kevin O'Connell, Oleksandr Frei, Shahram Bahrami, Margrethe Høegh, Trine Lagerberg, Weiqiu Cheng, Tyler Seibert, Srdjan Djurovic, Anders Dale, Hang Zhou, Howard Edenberg, Joel Gelernter, Olav Smeland, Guy Hindley, Ole Andreassen
Pubblicato in: Preprint NLM, 2025
Editore: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-3755915/v1

Genome-wide analyses reveal widespread genetic overlap between neurological and psychiatric disorders and a convergence of biological associations related to the brain

Autori: Smeland, Olav B.; Kutrolli, Gleda; Bahrami, Shahram; Fominykh, Vera; Parker, Nadine; Hindley, Guy F. L.; Rødevand, Linn; Jaholkowski, Piotr; Tesfaye, Markos; Parekh, Pravesh; Elvsåshagen, Torbjørn; Grotzinger, Andrew D.; Steen, Nils Eiel; van der Meer, Dennis; O’Connell, Kevin S.; Djurovic, Srdjan; Dale, Anders M.; Shadrin, Alexey A.; Frei, Oleksandr; Andreassen, Ole A.
Pubblicato in: medRxiv, Numero 28, 2023, Pagina/e 37503175
Editore: Europe PMC

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