Using real-world big data from eHealth, biobanks and national registries, integrated with clinical trial data to improve outcome of severe mental disorders

Livrables

Innovation, Intellectual Property (IP) and Knowledge Management Plan

Innovation Intellectual Property IP and Knowledge Management Plan

Risk Management Plan
Identification of relevant RWD sources in partner countries
REALMENT Coordination team established
First Dissemination, Exploitation and Communication Plan done

First Dissemination Exploitation and Communication Plan done

Quality Management Plan
Open access report on requirements for common data quality
Minutes of the Annual Project Meeting Y2
Dissemination, Exploitation and Communication Plan yearly update M18

Dissemination Exploitation and Communication Plan and yearly updates Yearly updates shall include Newsletters Updates of website Report on scientific dissemination activities Report on public outreach Presentation of REALMENT findings to project stakeholders

Tools and guidelines for data retrieval and sharing in place

Data Management Plan

REALMENT website and Social Media channels operational

Publications

Adolescent Psychedelic Use and Psychotic or Manic Symptoms

Auteurs: Otto Simonsson, Miriam A. Mosing, Walter Osika, Fredrik Ullén, Henrik Larsson, Yi Lu, Laura W. Wesseldijk
Publié dans: JAMA Psychiatry, Numéro 81, 2024, Page(s) 579, ISSN 2168-622X
Éditeur: American Medical Association
DOI: 10.1001/jamapsychiatry.2024.0047

Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores

Auteurs: Djenifer B.KappelaSophie E.LeggeaLeonHubbardaIsabella R.WillcocksaKevin S.O’ConnelldRobert L.SmithdfEspenMoldenefOle A.AndreassendAdrianKingbJohnJansencMarinkaHelthuiscMichael J.OwenaMichael C.O’DonovanaJames T.R.WaltersaAntonio F.Pardiñasa
Publié dans: Biological Psychiatry, Numéro Volume 93, Numéro 2, 15 January 2023, 2023, Page(s) 149-156, ISSN 0006-3223
Éditeur: Elsevier BV
DOI: 10.1016/j.biopsych.2022.07.014

Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy

Auteurs: Guy Hindley, Alexey A. Shadrin, Dennis van der Meer, Nadine Parker, Weiqiu Cheng, Kevin S. O’Connell, Shahram Bahrami, Aihua Lin, Naz Karadag, Børge Holen, Thomas Bjella, Ian J. Deary, Gail Davies, W. David Hill, Jan Bressler, Sudha Seshadri, Chun Chieh Fan, Torill Ueland, Srdjan Djurovic, Olav B. Smeland, Oleksandr Frei, Anders M. Dale, Ole A. Andreassen
Publié dans: Nature Human Behaviour, Numéro 7, 2023, Page(s) 1584-1600, ISSN 2397-3374
Éditeur: nature human behaviour
DOI: 10.1038/s41562-023-01630-9

Epidemiological overview of major depressive disorder in Scandinavia using nationwide registers

Auteurs: Joëlle A. Pasman, Joeri J. Meijsen, Marit Haram, Kaarina Kowalec, Arvid Harder, Ying Xiong, Thuy-Dung Nguyen, Andreas Jangmo, John R. Shorter, Jacob Bergstedt, Urmi Das, Richard Zetterberg, Ashley Tate, Paul Lichtenstein, Henrik Larsson, Ingvild Odsbu, Thomas Werge, Ted Reichborn-Kjennerud, Ole A. Andreassen, Patrick F. Sullivan, Alfonso Buil, Martin Tesli, Yi Lu
Publié dans: The Lancet Regional Health - Europe, Numéro 29, 2023, Page(s) 100621, ISSN 2666-7762
Éditeur: Lancet Regional Health Europe
DOI: 10.1016/j.lanepe.2023.100621

Charting the Landscape of Genetic Overlap Between Mental Disorders and Related Traits Beyond Genetic Correlation

Auteurs: Guy Hindley, Oleksandr Frei, Alexey A. Shadrin, Weiqiu Cheng, Kevin S. O’Connell, Romain Icick, Nadine Parker, Shahram Bahrami, Naz Karadag, Daniel Roelfs, Børge Holen, Aihua Lin, Chun C. Fan, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Ole A. Andreassen
Publié dans: American Journal of Psychiatry, Numéro 179, 2024, Page(s) 833-843, ISSN 0002-953X
Éditeur: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.21101051

Impact of NFIB and CYP1A variants on clozapine serum concentration—A retrospective naturalistic cohort study on 526 patients with known smoking habits

Auteurs: Hasan Çağın Lenk,Robert Løvsletten Smith,Kevin S. O'Connell,Marin M. Jukić,Marianne Kristiansen Kringen,Ole A. Andreassen,Magnus Ingelman-Sundberg,Espen Molden
Publié dans: Clin Transl Sci ., Numéro 2023 Jan;16(1):62-72. doi: 10.1111/cts.13422. Epub 2022 Oct 7., 2023, Page(s) 62-72, ISSN 1752-8062
Éditeur: Wiley
DOI: 10.1111/cts.13422

Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia

Auteurs: Kevin S. O'Connell, Elise Koch, Hasan Çağın Lenk, Ibrahim A Akkouh, Guy Hindley, Piotr Jaholkowski, Robert Løvsletten Smith, Børge Holen, Alexey A. Shadrin, Oleksandr Frei, Olav B. Smeland, Nils Eiel Steen, Anders M. Dale, Espen Molden, Srdjan Djurovic, Ole A. Andreassen
Publié dans: Psychiatry Research, Numéro 325, 2023, Page(s) 115217, ISSN 0165-1781
Éditeur: Elsevier BV
DOI: 10.1016/j.psychres.2023.115217

Genetic Overlap Between Global Cortical Brain Structure, C-Reactive Protein, and White Blood Cell Counts

Auteurs: Nadine Parker, Weiqiu Cheng, Guy F.L. Hindley, Kevin S. O’Connell, Sandeep Karthikeyan, Børge Holen, Alexey A. Shadrin, Zillur Rahman, Naz Karadag, Shahram Bahrami, Aihua Lin, Nils Eiel Steen, Thor Ueland, Pål Aukrust, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Oleksandr Frei, Ole A. Andreassen
Publié dans: Biological Psychiatry, Numéro 95, 2024, Page(s) 62-71, ISSN 0006-3223
Éditeur: Elsevier BV
DOI: 10.1016/j.biopsych.2023.06.008

Polygenic liability for antipsychotic dosage and polypharmacy - a real-world registry and biobank study

Auteurs: Elise Koch, Anders Kämpe, Maris Alver, Sindri Sigurðarson, Guðmundur Einarsson, Juulia Partanen, Robert L. Smith, Piotr Jaholkowski, Heidi Taipale, Markku Lähteenvuo, Nils Eiel Steen, Olav B. Smeland, Srdjan Djurovic, Espen Molden, null null, null null, Engilbert Sigurdsson, Hreinn Stefánsson, Kári Stefánsson, Aarno Palotie, Lili Milani, Kevin S. O’Connell, Ole A. Andreassen
Publié dans: Neuropsychopharmacology, Numéro 49, 2024, Page(s) 1113-1119, ISSN 0893-133X
Éditeur: Nature Publishing Group
DOI: 10.1038/s41386-023-01792-0

A comprehensive map of genetic relationships among diagnostic categories based on 48.6 million relative pairs from the Danish genealogy

Auteurs: Georgios Athanasiadis, Joeri J. Meijsen, Dorte Helenius, Andrew J. Schork, Andrés Ingason, Wesley K. Thompson, Daniel H. Geschwind, Thomas Werge, Alfonso Buil
Publié dans: Proceedings of the National Academy of Sciences, Numéro 119, 2022, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.2118688119

Genetic Contribution to the Heterogeneity of Major Depressive Disorder: Evidence From a Sibling-Based Design Using Swedish National Registers

Auteurs: Thuy-Dung Nguyen, Kaarina Kowalec, Joëlle Pasman, Henrik Larsson, Paul Lichtenstein, Christina Dalman, Patrick F. Sullivan, Ralf Kuja-Halkola, Yi Lu
Publié dans: American Journal of Psychiatry, Numéro 180, 2024, Page(s) 714-722, ISSN 0002-953X
Éditeur: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.20220906

Associations Between Symptoms of Premenstrual Disorders and Polygenic Liability for Major Psychiatric Disorders

Auteurs: Piotr Jaholkowski, Alexey A. Shadrin, Andreas Jangmo, Evgeniia Frei, Markos Tesfaye, Guy F. L. Hindley, Marit Haram, Zillur Rahman, Lavinia Athanasiu, Nora Refsum Bakken, Børge Holen, Vera Fominykh, Gleda Kutrolli, Pravesh Parekh, Nadine Parker, Linn Rødevand, Viktoria Birkenæs, Srdjan Djurovic, Oleksandr Frei, Kevin S. O’Connell, Olav B. Smeland, Martin Tesli, Ole A. Andreassen
Publié dans: JAMA Psychiatry, Numéro 80, 2023, Page(s) 738, ISSN 2168-622X
Éditeur: American Medical Association
DOI: 10.1001/jamapsychiatry.2023.1137

Genetic predisposition and antipsychotic treatment effect on metabolic syndrome in schizophrenia: a ten-year follow-up study using the Estonian Biobank

Auteurs: Maris Alver, Silva Kasela, Liina Haring, Laura Birgit Luitva, Krista Fischer, Märt Möls, Lili Milani
Publié dans: The Lancet Regional Health - Europe, Numéro 41, 2024, Page(s) 100914, ISSN 2666-7762
Éditeur: Lancet Regional Health Europe
DOI: 10.1016/j.lanepe.2024.100914

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications

Auteurs: Ole A. Andreassen, Guy F.L. Hindley, Oleksandr Frei, Olav B. Smeland
Publié dans: World Psychiatry, Numéro 22, 2023, Page(s) 4-24, ISSN 1723-8617
Éditeur: Masson Italia Periodici
DOI: 10.1002/wps.21034

Effects of a Novel UGT2B Haplotype and UGT1A4*3 Allele Variants on Glucuronidation of Clozapine In vivo

Auteurs: Robert Løvsletten Smith; Birgit M. Wollmann; Marianne Kausberg; Sondre Mæland; Marit Tveito; Kevin O’Connell; Espen Molden; Marianne Kristiansen Kringen
Publié dans: Crossref, Numéro 1, 2022, ISSN 1389-2002
Éditeur: Bentham Science Publishers
DOI: 10.2174/1389200223666220201152953

Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study

Auteurs: Álvaro Hernáez, Karoline H. Skåra, Christian M. Page, Vera R. Mitter, Marta H. Hernández, Per Magnus, Pål R. Njølstad, Ole A. Andreassen, Elizabeth C. Corfield, Alexandra Havdahl, Øyvind Næss, Ben Brumpton, Bjørn Olav Åsvold, Deborah A. Lawlor, Abigail Fraser, Maria Christine Magnus
Publié dans: BMC Medicine, Numéro 22, 2024, ISSN 1741-7015
Éditeur: BioMed Central
DOI: 10.1186/s12916-023-03223-9

Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count

Auteurs: Siobhan K. Lock, Sophie E. Legge, Djenifer B. Kappel, Isabella R. Willcocks, Marinka Helthuis, John Jansen, James T. R. Walters, Michael J. Owen, Michael C. O’Donovan, Antonio F. Pardiñas
Publié dans: Schizophrenia, Numéro 9, 2023, ISSN 2754-6993
Éditeur: Schizophrenia
DOI: 10.1038/s41537-023-00404-6

Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities

Auteurs: Nils Eiel Steen, Zillur Rahman, Attila Szabo, Guy F L Hindley, Nadine Parker, Weiqiu Cheng, Aihua Lin, Kevin S O’Connell, Mashhood A Sheikh, Alexey Shadrin, Shahram Bahrami, Sandeep Karthikeyan, Eva Z Hoseth, Anders M Dale, Pål Aukrust, Olav B Smeland, Thor Ueland, Oleksandr Frei, Srdjan Djurovic, Ole A Andreassen
Publié dans: Schizophrenia Bulletin, Numéro 49, 2023, Page(s) 1345-1354, ISSN 0586-7614
Éditeur: Oxford University Press
DOI: 10.1093/schbul/sbad082

Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia

Auteurs: Djenifer B. Kappel, Elliott Rees, Eilidh Fenner, Adrian King, John Jansen, Marinka Helthuis, Michael J. Owen, Michael C. O'Donovan, James T.R. Walters, Antonio F. Pardiñas
Publié dans: European Neuropsychopharmacology, Numéro 80, 2024, Page(s) 47-54, ISSN 0924-977X
Éditeur: Elsevier BV
DOI: 10.1016/j.euroneuro.2023.12.007

Investigating genetic overlap between antidepressant and lithium response and treatment resistance in major depressive disorder

Auteurs: Yi Lu; Ying Xiong; Robert Karlsson; Jie Song; Kaarina Kowalec; Christian Rück; Robert Sigstrom; Lina Jonsson; Caitlin Clements; Evelyn Andersson; Julia Boberg; Cathryn Lewis; Patrick Sullivan; Mikael Landén
Publié dans: Crossref, Numéro 17, 2023, ISSN 2693-5015
Éditeur: translational psychiatry
DOI: 10.21203/rs.3.rs-2556941/v1

Psychometric Properties and Diagnostic Associations of the Short-Form Community Assessment of Psychic Experiences in a Population-Based Sample of 29 021 Adult Men

Auteurs: Viktoria Birkenæs, Nora Refsum Bakken, Evgeniia Frei, Piotr Jaholkowski, Olav B Smeland, Markos Tesfaye, Ingrid Agartz, Ezra Susser, Michaeline Bresnahan, Espen Røysamb, Kjetil Nordbø Jørgensen, Ragnar Nesvåg, Alexandra Havdahl, Ole A Andreassen, Ida Elken Sønderby
Publié dans: Schizophrenia Bulletin, Numéro 49, 2023, Page(s) 1229-1238, ISSN 0586-7614
Éditeur: Oxford University Press
DOI: 10.1093/schbul/sbad074

Genome-wide analyses reveal widespread genetic overlap between neurological and psychiatric disorders and a convergence of biological associations related to the brain

Auteurs: Smeland, Olav B.; Kutrolli, Gleda; Bahrami, Shahram; Fominykh, Vera; Parker, Nadine; Hindley, Guy F. L.; Rødevand, Linn; Jaholkowski, Piotr; Tesfaye, Markos; Parekh, Pravesh; Elvsåshagen, Torbjørn; Grotzinger, Andrew D.; Steen, Nils Eiel; van der Meer, Dennis; O’Connell, Kevin S.; Djurovic, Srdjan; Dale, Anders M.; Shadrin, Alexey A.; Frei, Oleksandr; Andreassen, Ole A.
Publié dans: medRxiv, Numéro 28, 2023, Page(s) 37503175
Éditeur: Europe PMC

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