Neuronal networks from Cortical human iPSCs for Machine Learning Processing- NEU-ChiP

Información del proyecto

NEU-ChiP

Identificador del acuerdo de subvención: 964877

DOI

10.3030/964877

Proyecto cerrado

Fecha de la firma de la CE 20 Enero 2021

Fecha de inicio 1 Septiembre 2021

Fecha de finalización 28 Febrero 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coste total

€ 3 461 780,00

Aportación de la UE

€ 3 461 780,00

Coordinado por

ASTON UNIVERSITY
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (12)

Developing a Computational model for NeuChiP-based neuromorphic circuits.
Engineering and stimulation parameters to shape specific hNN circuit architectures.
Emulator of small circuit with prescribed neural and synaptic characteristics.

Emulator of small circuit with prescribed neural and synaptic characteristics

Developing a Computational model for memristor-based neuromorphic circuits.

Developing a Computional model for memristor-based neuromorphic circuits.

Information content under various stimuli.
Conception and in silico tests of neural dynamical compiler.
Task processing/information flow in novel hNN circuits.
Final dissemination and exploitation plan
Dynamical visualisation and interpretation of the collective neuronal representations.
Development of genetically modified iPSCs.

iPSCs will be genetically modified to generate neuronglia lines expressing optogenetic actuator and calcium activity indicators M0112 AU UB LU

Comparison of NeuChiP/neuromorphic electronic circuits.
Production of defined functional neuronal & glial networks.

Production of defined functional neuronal and glial cell networks M12

Websites, patent fillings, videos etc. (2)

Dissemination and exploitation plan
Project website

Project website created

Open Research Data Pilot (1)

Data management plan.

Data management plan

Publicaciones

Peer reviewed articles (24)

Engineering Coupled Consortia-Based Biosensors using Incoherent Feedforward Loops

Autores: Ramez Daniel, Rongying Huang, Valeriia Kravchik, Naama Geva-Zatorsky
Publicado en: Engineering Coupled Consortia-Based Biosensors for Diagnostic, 2024, ISSN 2693-5015
Editor: Research Square Platform LLC
DOI: 10.21203/rs.3.rs-4011356/v1

Real-time hardware emulation of neural cultures: A comparative study of in vitro, in silico and in duris silico models

Autores: Bernardo Vallejo-Mancero, Sergio Faci-Lázaro, Mireya Zapata, Jordi Soriano, Jordi Madrenas
Publicado en: Neural Networks, Edición 179, 2024, Página(s) 106593, ISSN 0893-6080
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.neunet.2024.106593

Analysis of Evolving Cortical Neuronal Networks Using Visual Informatics

Autores: Ho Fai Po, Akke Mats Houben, Anna-Christina Haeb, Yordan P. Raykov, Daniel Tornero, Jordi Soriano, David Saad
Publicado en: arXiv, 2025, ISSN 2331-8422
Editor: Cornell Univerity
DOI: 10.48550/arxiv.2502.20862

Complete realization of energy landscapes and non-equilibrium trapping dynamics in small spin glass and optimization problems

Autores: Ho Fai Po, Chi Ho Yeung
Publicado en: Scientific Reports, Edición 14, 2024, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-024-65493-4

Design, implementation, and functional validation of a new generation of microneedle 3D high-density CMOS multi-electrode array for brain tissue and spheroids

Autores: Lisa Mapelli, Olivier Dubochet, Mariateresa Tedesco, Giacomo Sciacca, Alessandra Ottaviani, Anita Monteverdi, Chiara Battaglia, Simona Tritto, Francis Cardot, Patrick Surbled, Jan Schildknecht, Mauro Gandolfo, Kilian Imfeld, Chiara Cervetto, Manuela Marcoli, Egidio D’Angelo, Alessandro Maccione
Publicado en: Frontiers in Neuroscience, 2022, ISSN 1662-453X
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.08.11.503595

Re-routing game: The inadequacy of mean-field approach in modeling the herd behavior in path switching

Autores: Ho Fai Po, Chi Ho Yeung
Publicado en: Physica A: Statistical Mechanics and its Applications, Edición 658, 2025, Página(s) 130266, ISSN 0378-4371
Editor: Elsevier BV
DOI: 10.1016/j.physa.2024.130266

Modular architecture facilitates noise-driven control of synchrony in neuronal networks

Autores: Hideaki Yamamoto, F. Paul Spitzner, Taiki Takemuro, Victor Buendía, Hakuba Murota, Carla Morante, Tomohiro Konno, Shigeo Sato, Ayumi Hirano-Iwata, Anna Levina, Viola Priesemann, Miguel A. Muñoz, Johannes Zierenberg, Jordi Soriano
Publicado en: Science Advances, Edición 9, 2024, ISSN 2375-2548
Editor: Science Advances
DOI: 10.1126/sciadv.ade1755

First Organoid Intelligence (OI) workshop to form an OI community

Autores: Itzy E. Morales Pantoja, Lena Smirnova, Alysson R. Muotri, Karl J. Wahlin, Jeffrey Kahn, J. Lomax Boyd, David H. Gracias, Timothy D. Harris, Tzahi Cohen-Karni, Brian S. Caffo, Alexander S. Szalay, Fang Han, Donald J. Zack, Ralph Etienne-Cummings, Akwasi Akwaboah, July Carolina Romero, Dowlette-Mary Alam El Din, Jesse D. Plotkin, Barton L. Paulhamus, Erik C. Johnson, Frederic Gilbert, J. Lowry Curl
Publicado en: Frontiers in Artificial Intelligence, Edición 6, 2023, ISSN 2624-8212
Editor: Frontiers
DOI: 10.3389/frai.2023.1116870

The Baltimore declaration toward the exploration of organoid intelligence

Autores: Thomas Hartung, Lena Smirnova, Itzy E. Morales Pantoja, Akwasi Akwaboah, Dowlette-Mary Alam El Din, Cynthia A. Berlinicke, J. Lomax Boyd, Brian S. Caffo, Ben Cappiello, Tzahi Cohen-Karni, J. Lowry Curley, Ralph Etienne-Cummings, Raha Dastgheyb, David H. Gracias, Frederic Gilbert, Christa Whelan Habela, Fang Han, Timothy D. Harris, Kathrin Herrmann, Eric J. Hill, Qi Huang, Rabih E. Jabbour, Erik C.
Publicado en: Frontiers in Science, Edición 1, 2023, ISSN 2813-6330
Editor: Frontiers in Science
DOI: 10.3389/fsci.2023.1068159

Efficient Training of the Memristive Deep Belief Net Immune to Non‐Idealities of the Synaptic Devices

Autores: Wei Wang, Barak Hoffer, Tzofnat Greenberg-Toledo, Yang Li, Minhui Zou, Eric Herbelin, Ronny Ronen, Xiaoxin Xu, Yulin Zhao, Jianguo Yang, Shahar Kvatinsky
Publicado en: Advanced Intelligent Systems, Edición 4, 2024, ISSN 2640-4567
Editor: Wiley
DOI: 10.1002/aisy.202100249

Single-neuron deep generative model uncovers underlying physics of neuronal activity in Ca imaging data

Autores: Jordi Abante, Angelo Piga, Berta Ros, Clara F López-León, Josep M Canals, Jordi Soriano
Publicado en: arXiv, 2025, ISSN 2331-8422
Editor: Cornell University
DOI: 10.48550/arxiv.2501.14615

Review of security techniques for memristor computing systems

Autores: Minhui Zou, Nan Du, Shahar Kvatinsky
Publicado en: Frontiers in Electronic Materials, Edición 2, 2022, ISSN 2673-9895
Editor: Frontiers
DOI: 10.3389/femat.2022.1010613

Hyaluronic acid-based bioink improves the differentiation and network formation of neural progenitor cells

Autores: Inês Pereira, Maria J. Lopez-Martinez, Aranzazu Villasante, Clelia Introna, Daniel Tornero, Josep M. Canals, Josep Samitier
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 11, 2023, ISSN 2296-4185
Editor: Frontiers
DOI: 10.3389/fbioe.2023.1110547

Neuronal circuitry reconstruction after stem cell therapy in damaged brain

Autores: Daniel Tornero
Publicado en: Neural Regeneration Research, Edición 17, 2022, Página(s) 1959, ISSN 1673-5374
Editor: Neural Regeneration Research
DOI: 10.4103/1673-5374.335145

Role of connectivity anisotropies in the dynamics of cultured neuronal networks

Autores: Akke Mats Houben, Jordi Garcia-Ojalvo, Jordi Soriano
Publicado en: arXia, 2025, ISSN 2331-8422
Editor: Cornell University
DOI: 10.48550/arxiv.2501.04427

Task Learning through Stimulation-Induced Plasticity in Neural Networks

Autores: Francesco Borra, Simona Cocco, Rémi Monasson
Publicado en: PRX Life, Edición 2, 2024, ISSN 2835-8279
Editor: PRX Liw
DOI: 10.1103/prxlife.2.043014

Dynamic and Functional Alterations of Neuronal Networks In Vitro upon Physical Damage: A Proof of Concept

Autores: Sàlem Ayasreh, Imanol Jurado, Clara López-León, Marc Montalà-Flaquer, Jordi Soriano
Publicado en: Micromachines, Edición 13, 2025, Página(s) 2259, ISSN 2072-666X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi13122259

Inferring structure of cortical neuronal networks from activity data: A statistical physics approach

Autores: Ho Fai Po, Akke Mats Houben, Anna-Christina Haeb, David Rhys Jenkins, Eric J Hill, H Rheinallt Parri, Jordi Soriano, David Saad
Publicado en: PNAS Nexus, Edición 4, 2025, ISSN 2752-6542
Editor: PNAS NEXUS
DOI: 10.1093/pnasnexus/pgae565

Integrated information decomposition unveils major structural traits of <i>in silico</i> and <i>in vitro</i> neuronal networks

Autores: Gustavo Menesse, Akke Mats Houben, Jordi Soriano, Joaquín J. Torres
Publicado en: Chaos: An Interdisciplinary Journal of Nonlinear Science, Edición 34, 2024, ISSN 1054-1500
Editor: American Institute of Physics
DOI: 10.1063/5.0201454

A memristive deep belief neural network based on silicon synapses

Autores: Wei Wang, Loai Danial, Yang Li, Eric Herbelin, Evgeny Pikhay, Yakov Roizin, Barak Hoffer, Zhongrui Wang, Shahar Kvatinsky
Publicado en: Nature Electronics, Edición 5, 2024, Página(s) 870-880, ISSN 2520-1131
Editor: Nature Electronics
DOI: 10.1038/s41928-022-00878-9

Long-term calcium imaging reveals functional development in hiPSC-derived cultures comparable to human but not rat primary cultures

Autores: Estefanía Estévez-Priego, Martina Moreno-Fina, Emanuela Monni, Zaal Kokaia, Jordi Soriano, Daniel Tornero
Publicado en: Stem Cell Reports, Edición 18, 2024, Página(s) 205-219, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2022.11.014

Rich dynamics and functional organization on topographically designed neuronal networks in vitro

Autores: Marc Montalà-Flaquer, Clara F. López-León, Daniel Tornero, Akke Mats Houben, Tanguy Fardet, Pascal Monceau, Samuel Bottani, Jordi Soriano
Publicado en: iScience, Edición 25, 2024, Página(s) 105680, ISSN 2589-0042
Editor: Elsevier
DOI: 10.1016/j.isci.2022.105680

Neuronal Cultures: Exploring Biophysics, Complex Systems, and Medicine in a Dish

Autores: Jordi Soriano
Publicado en: Biophysica, Edición 3, 2025, Página(s) 181-202, ISSN 2673-4125
Editor: Biophysica
DOI: 10.3390/biophysica3010012

TDPP: 2-D Permutation-Based Protection of Memristive Deep Neural Networks

Autores: Minhui Zou, Zhenhua Zhu, Tzofnat Greenberg-Toledo, Orian Leitersdorf, Jiang Li, Junlong Zhou, Yu Wang, Nan Du, Shahar Kvatinsky
Publicado en: IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, Edición 43, 2024, Página(s) 742-755, ISSN 0278-0070
Editor: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tcad.2023.3322351

Non-peer reviewed articles (1)

Variability vs Phenotype: multimodal analysis of Dravet Syndrome Brain Organoids powered by Deep Learning

Autores: Isabel Turpin, Adriana Modrego, Andrea Martí-Sarrias, Anna-Christina Haeb, Laura García-González, Jordi Soriano, Núria Ruiz, Irene Peñuelas-Haro, Elisa Espinet, Daniel Tornero, Oscar Lao, Sandra Acosta
Publicado en: bioRxiv, 2025, ISSN 2692-8205
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.28.635291