Neuronal networks from Cortical human iPSCs for Machine Learning Processing- NEU-ChiP

Informazioni relative al progetto

NEU-ChiP

ID dell’accordo di sovvenzione: 964877

DOI

10.3030/964877

Progetto chiuso

Data della firma CE 20 Gennaio 2021

Data di avvio 1 Settembre 2021

Data di completamento 28 Febbraio 2025

Finanziato da

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Costo totale

€ 3 461 780,00

Contributo UE

€ 3 461 780,00

Coordinato da

ASTON UNIVERSITY
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (12)

Developing a Computational model for NeuChiP-based neuromorphic circuits.
Engineering and stimulation parameters to shape specific hNN circuit architectures.
Emulator of small circuit with prescribed neural and synaptic characteristics.

Emulator of small circuit with prescribed neural and synaptic characteristics

Developing a Computational model for memristor-based neuromorphic circuits.

Developing a Computional model for memristor-based neuromorphic circuits.

Information content under various stimuli.
Conception and in silico tests of neural dynamical compiler.
Task processing/information flow in novel hNN circuits.
Final dissemination and exploitation plan
Dynamical visualisation and interpretation of the collective neuronal representations.
Development of genetically modified iPSCs.

iPSCs will be genetically modified to generate neuronglia lines expressing optogenetic actuator and calcium activity indicators M0112 AU UB LU

Comparison of NeuChiP/neuromorphic electronic circuits.
Production of defined functional neuronal & glial networks.

Production of defined functional neuronal and glial cell networks M12

Websites, patent fillings, videos etc. (2)

Dissemination and exploitation plan
Project website

Project website created

Open Research Data Pilot (1)

Data management plan.

Data management plan

Pubblicazioni

Peer reviewed articles (24)

Engineering Coupled Consortia-Based Biosensors using Incoherent Feedforward Loops

Autori: Ramez Daniel, Rongying Huang, Valeriia Kravchik, Naama Geva-Zatorsky
Pubblicato in: Engineering Coupled Consortia-Based Biosensors for Diagnostic, 2024, ISSN 2693-5015
Editore: Research Square Platform LLC
DOI: 10.21203/rs.3.rs-4011356/v1

Real-time hardware emulation of neural cultures: A comparative study of in vitro, in silico and in duris silico models

Autori: Bernardo Vallejo-Mancero, Sergio Faci-Lázaro, Mireya Zapata, Jordi Soriano, Jordi Madrenas
Pubblicato in: Neural Networks, Numero 179, 2024, Pagina/e 106593, ISSN 0893-6080
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.neunet.2024.106593

Analysis of Evolving Cortical Neuronal Networks Using Visual Informatics

Autori: Ho Fai Po, Akke Mats Houben, Anna-Christina Haeb, Yordan P. Raykov, Daniel Tornero, Jordi Soriano, David Saad
Pubblicato in: arXiv, 2025, ISSN 2331-8422
Editore: Cornell Univerity
DOI: 10.48550/arxiv.2502.20862

Complete realization of energy landscapes and non-equilibrium trapping dynamics in small spin glass and optimization problems

Autori: Ho Fai Po, Chi Ho Yeung
Pubblicato in: Scientific Reports, Numero 14, 2024, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-024-65493-4

Design, implementation, and functional validation of a new generation of microneedle 3D high-density CMOS multi-electrode array for brain tissue and spheroids

Autori: Lisa Mapelli, Olivier Dubochet, Mariateresa Tedesco, Giacomo Sciacca, Alessandra Ottaviani, Anita Monteverdi, Chiara Battaglia, Simona Tritto, Francis Cardot, Patrick Surbled, Jan Schildknecht, Mauro Gandolfo, Kilian Imfeld, Chiara Cervetto, Manuela Marcoli, Egidio D’Angelo, Alessandro Maccione
Pubblicato in: Frontiers in Neuroscience, 2022, ISSN 1662-453X
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.08.11.503595

Re-routing game: The inadequacy of mean-field approach in modeling the herd behavior in path switching

Autori: Ho Fai Po, Chi Ho Yeung
Pubblicato in: Physica A: Statistical Mechanics and its Applications, Numero 658, 2025, Pagina/e 130266, ISSN 0378-4371
Editore: Elsevier BV
DOI: 10.1016/j.physa.2024.130266

Modular architecture facilitates noise-driven control of synchrony in neuronal networks

Autori: Hideaki Yamamoto, F. Paul Spitzner, Taiki Takemuro, Victor Buendía, Hakuba Murota, Carla Morante, Tomohiro Konno, Shigeo Sato, Ayumi Hirano-Iwata, Anna Levina, Viola Priesemann, Miguel A. Muñoz, Johannes Zierenberg, Jordi Soriano
Pubblicato in: Science Advances, Numero 9, 2024, ISSN 2375-2548
Editore: Science Advances
DOI: 10.1126/sciadv.ade1755

First Organoid Intelligence (OI) workshop to form an OI community

Autori: Itzy E. Morales Pantoja, Lena Smirnova, Alysson R. Muotri, Karl J. Wahlin, Jeffrey Kahn, J. Lomax Boyd, David H. Gracias, Timothy D. Harris, Tzahi Cohen-Karni, Brian S. Caffo, Alexander S. Szalay, Fang Han, Donald J. Zack, Ralph Etienne-Cummings, Akwasi Akwaboah, July Carolina Romero, Dowlette-Mary Alam El Din, Jesse D. Plotkin, Barton L. Paulhamus, Erik C. Johnson, Frederic Gilbert, J. Lowry Curl
Pubblicato in: Frontiers in Artificial Intelligence, Numero 6, 2023, ISSN 2624-8212
Editore: Frontiers
DOI: 10.3389/frai.2023.1116870

The Baltimore declaration toward the exploration of organoid intelligence

Autori: Thomas Hartung, Lena Smirnova, Itzy E. Morales Pantoja, Akwasi Akwaboah, Dowlette-Mary Alam El Din, Cynthia A. Berlinicke, J. Lomax Boyd, Brian S. Caffo, Ben Cappiello, Tzahi Cohen-Karni, J. Lowry Curley, Ralph Etienne-Cummings, Raha Dastgheyb, David H. Gracias, Frederic Gilbert, Christa Whelan Habela, Fang Han, Timothy D. Harris, Kathrin Herrmann, Eric J. Hill, Qi Huang, Rabih E. Jabbour, Erik C.
Pubblicato in: Frontiers in Science, Numero 1, 2023, ISSN 2813-6330
Editore: Frontiers in Science
DOI: 10.3389/fsci.2023.1068159

Efficient Training of the Memristive Deep Belief Net Immune to Non‐Idealities of the Synaptic Devices

Autori: Wei Wang, Barak Hoffer, Tzofnat Greenberg-Toledo, Yang Li, Minhui Zou, Eric Herbelin, Ronny Ronen, Xiaoxin Xu, Yulin Zhao, Jianguo Yang, Shahar Kvatinsky
Pubblicato in: Advanced Intelligent Systems, Numero 4, 2024, ISSN 2640-4567
Editore: Wiley
DOI: 10.1002/aisy.202100249

Single-neuron deep generative model uncovers underlying physics of neuronal activity in Ca imaging data

Autori: Jordi Abante, Angelo Piga, Berta Ros, Clara F López-León, Josep M Canals, Jordi Soriano
Pubblicato in: arXiv, 2025, ISSN 2331-8422
Editore: Cornell University
DOI: 10.48550/arxiv.2501.14615

Review of security techniques for memristor computing systems

Autori: Minhui Zou, Nan Du, Shahar Kvatinsky
Pubblicato in: Frontiers in Electronic Materials, Numero 2, 2022, ISSN 2673-9895
Editore: Frontiers
DOI: 10.3389/femat.2022.1010613

Hyaluronic acid-based bioink improves the differentiation and network formation of neural progenitor cells

Autori: Inês Pereira, Maria J. Lopez-Martinez, Aranzazu Villasante, Clelia Introna, Daniel Tornero, Josep M. Canals, Josep Samitier
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 11, 2023, ISSN 2296-4185
Editore: Frontiers
DOI: 10.3389/fbioe.2023.1110547

Neuronal circuitry reconstruction after stem cell therapy in damaged brain

Autori: Daniel Tornero
Pubblicato in: Neural Regeneration Research, Numero 17, 2022, Pagina/e 1959, ISSN 1673-5374
Editore: Neural Regeneration Research
DOI: 10.4103/1673-5374.335145

Role of connectivity anisotropies in the dynamics of cultured neuronal networks

Autori: Akke Mats Houben, Jordi Garcia-Ojalvo, Jordi Soriano
Pubblicato in: arXia, 2025, ISSN 2331-8422
Editore: Cornell University
DOI: 10.48550/arxiv.2501.04427

Task Learning through Stimulation-Induced Plasticity in Neural Networks

Autori: Francesco Borra, Simona Cocco, Rémi Monasson
Pubblicato in: PRX Life, Numero 2, 2024, ISSN 2835-8279
Editore: PRX Liw
DOI: 10.1103/prxlife.2.043014

Dynamic and Functional Alterations of Neuronal Networks In Vitro upon Physical Damage: A Proof of Concept

Autori: Sàlem Ayasreh, Imanol Jurado, Clara López-León, Marc Montalà-Flaquer, Jordi Soriano
Pubblicato in: Micromachines, Numero 13, 2025, Pagina/e 2259, ISSN 2072-666X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi13122259

Inferring structure of cortical neuronal networks from activity data: A statistical physics approach

Autori: Ho Fai Po, Akke Mats Houben, Anna-Christina Haeb, David Rhys Jenkins, Eric J Hill, H Rheinallt Parri, Jordi Soriano, David Saad
Pubblicato in: PNAS Nexus, Numero 4, 2025, ISSN 2752-6542
Editore: PNAS NEXUS
DOI: 10.1093/pnasnexus/pgae565

Integrated information decomposition unveils major structural traits of <i>in silico</i> and <i>in vitro</i> neuronal networks

Autori: Gustavo Menesse, Akke Mats Houben, Jordi Soriano, Joaquín J. Torres
Pubblicato in: Chaos: An Interdisciplinary Journal of Nonlinear Science, Numero 34, 2024, ISSN 1054-1500
Editore: American Institute of Physics
DOI: 10.1063/5.0201454

A memristive deep belief neural network based on silicon synapses

Autori: Wei Wang, Loai Danial, Yang Li, Eric Herbelin, Evgeny Pikhay, Yakov Roizin, Barak Hoffer, Zhongrui Wang, Shahar Kvatinsky
Pubblicato in: Nature Electronics, Numero 5, 2024, Pagina/e 870-880, ISSN 2520-1131
Editore: Nature Electronics
DOI: 10.1038/s41928-022-00878-9

Long-term calcium imaging reveals functional development in hiPSC-derived cultures comparable to human but not rat primary cultures

Autori: Estefanía Estévez-Priego, Martina Moreno-Fina, Emanuela Monni, Zaal Kokaia, Jordi Soriano, Daniel Tornero
Pubblicato in: Stem Cell Reports, Numero 18, 2024, Pagina/e 205-219, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2022.11.014

Rich dynamics and functional organization on topographically designed neuronal networks in vitro

Autori: Marc Montalà-Flaquer, Clara F. López-León, Daniel Tornero, Akke Mats Houben, Tanguy Fardet, Pascal Monceau, Samuel Bottani, Jordi Soriano
Pubblicato in: iScience, Numero 25, 2024, Pagina/e 105680, ISSN 2589-0042
Editore: Elsevier
DOI: 10.1016/j.isci.2022.105680

Neuronal Cultures: Exploring Biophysics, Complex Systems, and Medicine in a Dish

Autori: Jordi Soriano
Pubblicato in: Biophysica, Numero 3, 2025, Pagina/e 181-202, ISSN 2673-4125
Editore: Biophysica
DOI: 10.3390/biophysica3010012

TDPP: 2-D Permutation-Based Protection of Memristive Deep Neural Networks

Autori: Minhui Zou, Zhenhua Zhu, Tzofnat Greenberg-Toledo, Orian Leitersdorf, Jiang Li, Junlong Zhou, Yu Wang, Nan Du, Shahar Kvatinsky
Pubblicato in: IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, Numero 43, 2024, Pagina/e 742-755, ISSN 0278-0070
Editore: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tcad.2023.3322351

Non-peer reviewed articles (1)

Variability vs Phenotype: multimodal analysis of Dravet Syndrome Brain Organoids powered by Deep Learning

Autori: Isabel Turpin, Adriana Modrego, Andrea Martí-Sarrias, Anna-Christina Haeb, Laura García-González, Jordi Soriano, Núria Ruiz, Irene Peñuelas-Haro, Elisa Espinet, Daniel Tornero, Oscar Lao, Sandra Acosta
Pubblicato in: bioRxiv, 2025, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.28.635291