Neuronal networks from Cortical human iPSCs for Machine Learning Processing- NEU-ChiP

Informations projet

NEU-ChiP

N° de convention de subvention: 964877

DOI

10.3030/964877

Projet clôturé

Date de signature de la CE 20 Janvier 2021

Date de début 1 Septembre 2021

Date de fin 28 Février 2025

Financé au titre de

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coût total

€ 3 461 780,00

Contribution de l’UE

€ 3 461 780,00

Coordonné par

ASTON UNIVERSITY
United Kingdom

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (12)

Developing a Computational model for NeuChiP-based neuromorphic circuits.
Engineering and stimulation parameters to shape specific hNN circuit architectures.
Emulator of small circuit with prescribed neural and synaptic characteristics.

Emulator of small circuit with prescribed neural and synaptic characteristics

Developing a Computational model for memristor-based neuromorphic circuits.

Developing a Computional model for memristor-based neuromorphic circuits.

Information content under various stimuli.
Conception and in silico tests of neural dynamical compiler.
Task processing/information flow in novel hNN circuits.
Final dissemination and exploitation plan
Dynamical visualisation and interpretation of the collective neuronal representations.
Development of genetically modified iPSCs.

iPSCs will be genetically modified to generate neuronglia lines expressing optogenetic actuator and calcium activity indicators M0112 AU UB LU

Comparison of NeuChiP/neuromorphic electronic circuits.
Production of defined functional neuronal & glial networks.

Production of defined functional neuronal and glial cell networks M12

Websites, patent fillings, videos etc. (2)

Dissemination and exploitation plan
Project website

Project website created

Open Research Data Pilot (1)

Data management plan.

Data management plan

Publications

Peer reviewed articles (24)

Engineering Coupled Consortia-Based Biosensors using Incoherent Feedforward Loops

Auteurs: Ramez Daniel, Rongying Huang, Valeriia Kravchik, Naama Geva-Zatorsky
Publié dans: Engineering Coupled Consortia-Based Biosensors for Diagnostic, 2024, ISSN 2693-5015
Éditeur: Research Square Platform LLC
DOI: 10.21203/rs.3.rs-4011356/v1

Real-time hardware emulation of neural cultures: A comparative study of in vitro, in silico and in duris silico models

Auteurs: Bernardo Vallejo-Mancero, Sergio Faci-Lázaro, Mireya Zapata, Jordi Soriano, Jordi Madrenas
Publié dans: Neural Networks, Numéro 179, 2024, Page(s) 106593, ISSN 0893-6080
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.neunet.2024.106593

Analysis of Evolving Cortical Neuronal Networks Using Visual Informatics

Auteurs: Ho Fai Po, Akke Mats Houben, Anna-Christina Haeb, Yordan P. Raykov, Daniel Tornero, Jordi Soriano, David Saad
Publié dans: arXiv, 2025, ISSN 2331-8422
Éditeur: Cornell Univerity
DOI: 10.48550/arxiv.2502.20862

Complete realization of energy landscapes and non-equilibrium trapping dynamics in small spin glass and optimization problems

Auteurs: Ho Fai Po, Chi Ho Yeung
Publié dans: Scientific Reports, Numéro 14, 2024, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-024-65493-4

Design, implementation, and functional validation of a new generation of microneedle 3D high-density CMOS multi-electrode array for brain tissue and spheroids

Auteurs: Lisa Mapelli, Olivier Dubochet, Mariateresa Tedesco, Giacomo Sciacca, Alessandra Ottaviani, Anita Monteverdi, Chiara Battaglia, Simona Tritto, Francis Cardot, Patrick Surbled, Jan Schildknecht, Mauro Gandolfo, Kilian Imfeld, Chiara Cervetto, Manuela Marcoli, Egidio D’Angelo, Alessandro Maccione
Publié dans: Frontiers in Neuroscience, 2022, ISSN 1662-453X
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.08.11.503595

Re-routing game: The inadequacy of mean-field approach in modeling the herd behavior in path switching

Auteurs: Ho Fai Po, Chi Ho Yeung
Publié dans: Physica A: Statistical Mechanics and its Applications, Numéro 658, 2025, Page(s) 130266, ISSN 0378-4371
Éditeur: Elsevier BV
DOI: 10.1016/j.physa.2024.130266

Modular architecture facilitates noise-driven control of synchrony in neuronal networks

Auteurs: Hideaki Yamamoto, F. Paul Spitzner, Taiki Takemuro, Victor Buendía, Hakuba Murota, Carla Morante, Tomohiro Konno, Shigeo Sato, Ayumi Hirano-Iwata, Anna Levina, Viola Priesemann, Miguel A. Muñoz, Johannes Zierenberg, Jordi Soriano
Publié dans: Science Advances, Numéro 9, 2024, ISSN 2375-2548
Éditeur: Science Advances
DOI: 10.1126/sciadv.ade1755

First Organoid Intelligence (OI) workshop to form an OI community

Auteurs: Itzy E. Morales Pantoja, Lena Smirnova, Alysson R. Muotri, Karl J. Wahlin, Jeffrey Kahn, J. Lomax Boyd, David H. Gracias, Timothy D. Harris, Tzahi Cohen-Karni, Brian S. Caffo, Alexander S. Szalay, Fang Han, Donald J. Zack, Ralph Etienne-Cummings, Akwasi Akwaboah, July Carolina Romero, Dowlette-Mary Alam El Din, Jesse D. Plotkin, Barton L. Paulhamus, Erik C. Johnson, Frederic Gilbert, J. Lowry Curl
Publié dans: Frontiers in Artificial Intelligence, Numéro 6, 2023, ISSN 2624-8212
Éditeur: Frontiers
DOI: 10.3389/frai.2023.1116870

The Baltimore declaration toward the exploration of organoid intelligence

Auteurs: Thomas Hartung, Lena Smirnova, Itzy E. Morales Pantoja, Akwasi Akwaboah, Dowlette-Mary Alam El Din, Cynthia A. Berlinicke, J. Lomax Boyd, Brian S. Caffo, Ben Cappiello, Tzahi Cohen-Karni, J. Lowry Curley, Ralph Etienne-Cummings, Raha Dastgheyb, David H. Gracias, Frederic Gilbert, Christa Whelan Habela, Fang Han, Timothy D. Harris, Kathrin Herrmann, Eric J. Hill, Qi Huang, Rabih E. Jabbour, Erik C.
Publié dans: Frontiers in Science, Numéro 1, 2023, ISSN 2813-6330
Éditeur: Frontiers in Science
DOI: 10.3389/fsci.2023.1068159

Efficient Training of the Memristive Deep Belief Net Immune to Non‐Idealities of the Synaptic Devices

Auteurs: Wei Wang, Barak Hoffer, Tzofnat Greenberg-Toledo, Yang Li, Minhui Zou, Eric Herbelin, Ronny Ronen, Xiaoxin Xu, Yulin Zhao, Jianguo Yang, Shahar Kvatinsky
Publié dans: Advanced Intelligent Systems, Numéro 4, 2024, ISSN 2640-4567
Éditeur: Wiley
DOI: 10.1002/aisy.202100249

Single-neuron deep generative model uncovers underlying physics of neuronal activity in Ca imaging data

Auteurs: Jordi Abante, Angelo Piga, Berta Ros, Clara F López-León, Josep M Canals, Jordi Soriano
Publié dans: arXiv, 2025, ISSN 2331-8422
Éditeur: Cornell University
DOI: 10.48550/arxiv.2501.14615

Review of security techniques for memristor computing systems

Auteurs: Minhui Zou, Nan Du, Shahar Kvatinsky
Publié dans: Frontiers in Electronic Materials, Numéro 2, 2022, ISSN 2673-9895
Éditeur: Frontiers
DOI: 10.3389/femat.2022.1010613

Hyaluronic acid-based bioink improves the differentiation and network formation of neural progenitor cells

Auteurs: Inês Pereira, Maria J. Lopez-Martinez, Aranzazu Villasante, Clelia Introna, Daniel Tornero, Josep M. Canals, Josep Samitier
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 11, 2023, ISSN 2296-4185
Éditeur: Frontiers
DOI: 10.3389/fbioe.2023.1110547

Neuronal circuitry reconstruction after stem cell therapy in damaged brain

Auteurs: Daniel Tornero
Publié dans: Neural Regeneration Research, Numéro 17, 2022, Page(s) 1959, ISSN 1673-5374
Éditeur: Neural Regeneration Research
DOI: 10.4103/1673-5374.335145

Role of connectivity anisotropies in the dynamics of cultured neuronal networks

Auteurs: Akke Mats Houben, Jordi Garcia-Ojalvo, Jordi Soriano
Publié dans: arXia, 2025, ISSN 2331-8422
Éditeur: Cornell University
DOI: 10.48550/arxiv.2501.04427

Task Learning through Stimulation-Induced Plasticity in Neural Networks

Auteurs: Francesco Borra, Simona Cocco, Rémi Monasson
Publié dans: PRX Life, Numéro 2, 2024, ISSN 2835-8279
Éditeur: PRX Liw
DOI: 10.1103/prxlife.2.043014

Dynamic and Functional Alterations of Neuronal Networks In Vitro upon Physical Damage: A Proof of Concept

Auteurs: Sàlem Ayasreh, Imanol Jurado, Clara López-León, Marc Montalà-Flaquer, Jordi Soriano
Publié dans: Micromachines, Numéro 13, 2025, Page(s) 2259, ISSN 2072-666X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi13122259

Inferring structure of cortical neuronal networks from activity data: A statistical physics approach

Auteurs: Ho Fai Po, Akke Mats Houben, Anna-Christina Haeb, David Rhys Jenkins, Eric J Hill, H Rheinallt Parri, Jordi Soriano, David Saad
Publié dans: PNAS Nexus, Numéro 4, 2025, ISSN 2752-6542
Éditeur: PNAS NEXUS
DOI: 10.1093/pnasnexus/pgae565

Integrated information decomposition unveils major structural traits of <i>in silico</i> and <i>in vitro</i> neuronal networks

Auteurs: Gustavo Menesse, Akke Mats Houben, Jordi Soriano, Joaquín J. Torres
Publié dans: Chaos: An Interdisciplinary Journal of Nonlinear Science, Numéro 34, 2024, ISSN 1054-1500
Éditeur: American Institute of Physics
DOI: 10.1063/5.0201454

A memristive deep belief neural network based on silicon synapses

Auteurs: Wei Wang, Loai Danial, Yang Li, Eric Herbelin, Evgeny Pikhay, Yakov Roizin, Barak Hoffer, Zhongrui Wang, Shahar Kvatinsky
Publié dans: Nature Electronics, Numéro 5, 2024, Page(s) 870-880, ISSN 2520-1131
Éditeur: Nature Electronics
DOI: 10.1038/s41928-022-00878-9

Long-term calcium imaging reveals functional development in hiPSC-derived cultures comparable to human but not rat primary cultures

Auteurs: Estefanía Estévez-Priego, Martina Moreno-Fina, Emanuela Monni, Zaal Kokaia, Jordi Soriano, Daniel Tornero
Publié dans: Stem Cell Reports, Numéro 18, 2024, Page(s) 205-219, ISSN 2213-6711
Éditeur: Cell Press
DOI: 10.1016/j.stemcr.2022.11.014

Rich dynamics and functional organization on topographically designed neuronal networks in vitro

Auteurs: Marc Montalà-Flaquer, Clara F. López-León, Daniel Tornero, Akke Mats Houben, Tanguy Fardet, Pascal Monceau, Samuel Bottani, Jordi Soriano
Publié dans: iScience, Numéro 25, 2024, Page(s) 105680, ISSN 2589-0042
Éditeur: Elsevier
DOI: 10.1016/j.isci.2022.105680

Neuronal Cultures: Exploring Biophysics, Complex Systems, and Medicine in a Dish

Auteurs: Jordi Soriano
Publié dans: Biophysica, Numéro 3, 2025, Page(s) 181-202, ISSN 2673-4125
Éditeur: Biophysica
DOI: 10.3390/biophysica3010012

TDPP: 2-D Permutation-Based Protection of Memristive Deep Neural Networks

Auteurs: Minhui Zou, Zhenhua Zhu, Tzofnat Greenberg-Toledo, Orian Leitersdorf, Jiang Li, Junlong Zhou, Yu Wang, Nan Du, Shahar Kvatinsky
Publié dans: IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, Numéro 43, 2024, Page(s) 742-755, ISSN 0278-0070
Éditeur: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tcad.2023.3322351

Non-peer reviewed articles (1)

Variability vs Phenotype: multimodal analysis of Dravet Syndrome Brain Organoids powered by Deep Learning

Auteurs: Isabel Turpin, Adriana Modrego, Andrea Martí-Sarrias, Anna-Christina Haeb, Laura García-González, Jordi Soriano, Núria Ruiz, Irene Peñuelas-Haro, Elisa Espinet, Daniel Tornero, Oscar Lao, Sandra Acosta
Publié dans: bioRxiv, 2025, ISSN 2692-8205
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.28.635291