Neuronal networks from Cortical human iPSCs for Machine Learning Processing- NEU-ChiP

Informacje na temat projektu

NEU-ChiP

Identyfikator umowy o grant: 964877

DOI

10.3030/964877

Projekt został zamknięty

Data podpisania przez KE 20 Stycznia 2021

Data rozpoczęcia 1 Września 2021

Data zakończenia 28 Lutego 2025

Finansowanie w ramach

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Koszt całkowity

€ 3 461 780,00

Wkład UE

€ 3 461 780,00

Koordynowany przez

ASTON UNIVERSITY
United Kingdom

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (12)

Developing a Computational model for NeuChiP-based neuromorphic circuits.
Engineering and stimulation parameters to shape specific hNN circuit architectures.
Emulator of small circuit with prescribed neural and synaptic characteristics.

Emulator of small circuit with prescribed neural and synaptic characteristics

Developing a Computational model for memristor-based neuromorphic circuits.

Developing a Computional model for memristor-based neuromorphic circuits.

Information content under various stimuli.
Conception and in silico tests of neural dynamical compiler.
Task processing/information flow in novel hNN circuits.
Final dissemination and exploitation plan
Dynamical visualisation and interpretation of the collective neuronal representations.
Development of genetically modified iPSCs.

iPSCs will be genetically modified to generate neuronglia lines expressing optogenetic actuator and calcium activity indicators M0112 AU UB LU

Comparison of NeuChiP/neuromorphic electronic circuits.
Production of defined functional neuronal & glial networks.

Production of defined functional neuronal and glial cell networks M12

Websites, patent fillings, videos etc. (2)

Dissemination and exploitation plan
Project website

Project website created

Open Research Data Pilot (1)

Data management plan.

Data management plan

Publikacje

Peer reviewed articles (24)

Engineering Coupled Consortia-Based Biosensors using Incoherent Feedforward Loops

Autorzy: Ramez Daniel, Rongying Huang, Valeriia Kravchik, Naama Geva-Zatorsky
Opublikowane w: Engineering Coupled Consortia-Based Biosensors for Diagnostic, 2024, ISSN 2693-5015
Wydawca: Research Square Platform LLC
DOI: 10.21203/rs.3.rs-4011356/v1

Real-time hardware emulation of neural cultures: A comparative study of in vitro, in silico and in duris silico models

Autorzy: Bernardo Vallejo-Mancero, Sergio Faci-Lázaro, Mireya Zapata, Jordi Soriano, Jordi Madrenas
Opublikowane w: Neural Networks, Numer 179, 2024, Strona(/y) 106593, ISSN 0893-6080
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.neunet.2024.106593

Analysis of Evolving Cortical Neuronal Networks Using Visual Informatics

Autorzy: Ho Fai Po, Akke Mats Houben, Anna-Christina Haeb, Yordan P. Raykov, Daniel Tornero, Jordi Soriano, David Saad
Opublikowane w: arXiv, 2025, ISSN 2331-8422
Wydawca: Cornell Univerity
DOI: 10.48550/arxiv.2502.20862

Complete realization of energy landscapes and non-equilibrium trapping dynamics in small spin glass and optimization problems

Autorzy: Ho Fai Po, Chi Ho Yeung
Opublikowane w: Scientific Reports, Numer 14, 2024, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-024-65493-4

Design, implementation, and functional validation of a new generation of microneedle 3D high-density CMOS multi-electrode array for brain tissue and spheroids

Autorzy: Lisa Mapelli, Olivier Dubochet, Mariateresa Tedesco, Giacomo Sciacca, Alessandra Ottaviani, Anita Monteverdi, Chiara Battaglia, Simona Tritto, Francis Cardot, Patrick Surbled, Jan Schildknecht, Mauro Gandolfo, Kilian Imfeld, Chiara Cervetto, Manuela Marcoli, Egidio D’Angelo, Alessandro Maccione
Opublikowane w: Frontiers in Neuroscience, 2022, ISSN 1662-453X
Wydawca: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.08.11.503595

Re-routing game: The inadequacy of mean-field approach in modeling the herd behavior in path switching

Autorzy: Ho Fai Po, Chi Ho Yeung
Opublikowane w: Physica A: Statistical Mechanics and its Applications, Numer 658, 2025, Strona(/y) 130266, ISSN 0378-4371
Wydawca: Elsevier BV
DOI: 10.1016/j.physa.2024.130266

Modular architecture facilitates noise-driven control of synchrony in neuronal networks

Autorzy: Hideaki Yamamoto, F. Paul Spitzner, Taiki Takemuro, Victor Buendía, Hakuba Murota, Carla Morante, Tomohiro Konno, Shigeo Sato, Ayumi Hirano-Iwata, Anna Levina, Viola Priesemann, Miguel A. Muñoz, Johannes Zierenberg, Jordi Soriano
Opublikowane w: Science Advances, Numer 9, 2024, ISSN 2375-2548
Wydawca: Science Advances
DOI: 10.1126/sciadv.ade1755

First Organoid Intelligence (OI) workshop to form an OI community

Autorzy: Itzy E. Morales Pantoja, Lena Smirnova, Alysson R. Muotri, Karl J. Wahlin, Jeffrey Kahn, J. Lomax Boyd, David H. Gracias, Timothy D. Harris, Tzahi Cohen-Karni, Brian S. Caffo, Alexander S. Szalay, Fang Han, Donald J. Zack, Ralph Etienne-Cummings, Akwasi Akwaboah, July Carolina Romero, Dowlette-Mary Alam El Din, Jesse D. Plotkin, Barton L. Paulhamus, Erik C. Johnson, Frederic Gilbert, J. Lowry Curl
Opublikowane w: Frontiers in Artificial Intelligence, Numer 6, 2023, ISSN 2624-8212
Wydawca: Frontiers
DOI: 10.3389/frai.2023.1116870

The Baltimore declaration toward the exploration of organoid intelligence

Autorzy: Thomas Hartung, Lena Smirnova, Itzy E. Morales Pantoja, Akwasi Akwaboah, Dowlette-Mary Alam El Din, Cynthia A. Berlinicke, J. Lomax Boyd, Brian S. Caffo, Ben Cappiello, Tzahi Cohen-Karni, J. Lowry Curley, Ralph Etienne-Cummings, Raha Dastgheyb, David H. Gracias, Frederic Gilbert, Christa Whelan Habela, Fang Han, Timothy D. Harris, Kathrin Herrmann, Eric J. Hill, Qi Huang, Rabih E. Jabbour, Erik C.
Opublikowane w: Frontiers in Science, Numer 1, 2023, ISSN 2813-6330
Wydawca: Frontiers in Science
DOI: 10.3389/fsci.2023.1068159

Efficient Training of the Memristive Deep Belief Net Immune to Non‐Idealities of the Synaptic Devices

Autorzy: Wei Wang, Barak Hoffer, Tzofnat Greenberg-Toledo, Yang Li, Minhui Zou, Eric Herbelin, Ronny Ronen, Xiaoxin Xu, Yulin Zhao, Jianguo Yang, Shahar Kvatinsky
Opublikowane w: Advanced Intelligent Systems, Numer 4, 2024, ISSN 2640-4567
Wydawca: Wiley
DOI: 10.1002/aisy.202100249

Single-neuron deep generative model uncovers underlying physics of neuronal activity in Ca imaging data

Autorzy: Jordi Abante, Angelo Piga, Berta Ros, Clara F López-León, Josep M Canals, Jordi Soriano
Opublikowane w: arXiv, 2025, ISSN 2331-8422
Wydawca: Cornell University
DOI: 10.48550/arxiv.2501.14615

Review of security techniques for memristor computing systems

Autorzy: Minhui Zou, Nan Du, Shahar Kvatinsky
Opublikowane w: Frontiers in Electronic Materials, Numer 2, 2022, ISSN 2673-9895
Wydawca: Frontiers
DOI: 10.3389/femat.2022.1010613

Hyaluronic acid-based bioink improves the differentiation and network formation of neural progenitor cells

Autorzy: Inês Pereira, Maria J. Lopez-Martinez, Aranzazu Villasante, Clelia Introna, Daniel Tornero, Josep M. Canals, Josep Samitier
Opublikowane w: Frontiers in Bioengineering and Biotechnology, Numer 11, 2023, ISSN 2296-4185
Wydawca: Frontiers
DOI: 10.3389/fbioe.2023.1110547

Neuronal circuitry reconstruction after stem cell therapy in damaged brain

Autorzy: Daniel Tornero
Opublikowane w: Neural Regeneration Research, Numer 17, 2022, Strona(/y) 1959, ISSN 1673-5374
Wydawca: Neural Regeneration Research
DOI: 10.4103/1673-5374.335145

Role of connectivity anisotropies in the dynamics of cultured neuronal networks

Autorzy: Akke Mats Houben, Jordi Garcia-Ojalvo, Jordi Soriano
Opublikowane w: arXia, 2025, ISSN 2331-8422
Wydawca: Cornell University
DOI: 10.48550/arxiv.2501.04427

Task Learning through Stimulation-Induced Plasticity in Neural Networks

Autorzy: Francesco Borra, Simona Cocco, Rémi Monasson
Opublikowane w: PRX Life, Numer 2, 2024, ISSN 2835-8279
Wydawca: PRX Liw
DOI: 10.1103/prxlife.2.043014

Dynamic and Functional Alterations of Neuronal Networks In Vitro upon Physical Damage: A Proof of Concept

Autorzy: Sàlem Ayasreh, Imanol Jurado, Clara López-León, Marc Montalà-Flaquer, Jordi Soriano
Opublikowane w: Micromachines, Numer 13, 2025, Strona(/y) 2259, ISSN 2072-666X
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi13122259

Inferring structure of cortical neuronal networks from activity data: A statistical physics approach

Autorzy: Ho Fai Po, Akke Mats Houben, Anna-Christina Haeb, David Rhys Jenkins, Eric J Hill, H Rheinallt Parri, Jordi Soriano, David Saad
Opublikowane w: PNAS Nexus, Numer 4, 2025, ISSN 2752-6542
Wydawca: PNAS NEXUS
DOI: 10.1093/pnasnexus/pgae565

Integrated information decomposition unveils major structural traits of <i>in silico</i> and <i>in vitro</i> neuronal networks

Autorzy: Gustavo Menesse, Akke Mats Houben, Jordi Soriano, Joaquín J. Torres
Opublikowane w: Chaos: An Interdisciplinary Journal of Nonlinear Science, Numer 34, 2024, ISSN 1054-1500
Wydawca: American Institute of Physics
DOI: 10.1063/5.0201454

A memristive deep belief neural network based on silicon synapses

Autorzy: Wei Wang, Loai Danial, Yang Li, Eric Herbelin, Evgeny Pikhay, Yakov Roizin, Barak Hoffer, Zhongrui Wang, Shahar Kvatinsky
Opublikowane w: Nature Electronics, Numer 5, 2024, Strona(/y) 870-880, ISSN 2520-1131
Wydawca: Nature Electronics
DOI: 10.1038/s41928-022-00878-9

Long-term calcium imaging reveals functional development in hiPSC-derived cultures comparable to human but not rat primary cultures

Autorzy: Estefanía Estévez-Priego, Martina Moreno-Fina, Emanuela Monni, Zaal Kokaia, Jordi Soriano, Daniel Tornero
Opublikowane w: Stem Cell Reports, Numer 18, 2024, Strona(/y) 205-219, ISSN 2213-6711
Wydawca: Cell Press
DOI: 10.1016/j.stemcr.2022.11.014

Rich dynamics and functional organization on topographically designed neuronal networks in vitro

Autorzy: Marc Montalà-Flaquer, Clara F. López-León, Daniel Tornero, Akke Mats Houben, Tanguy Fardet, Pascal Monceau, Samuel Bottani, Jordi Soriano
Opublikowane w: iScience, Numer 25, 2024, Strona(/y) 105680, ISSN 2589-0042
Wydawca: Elsevier
DOI: 10.1016/j.isci.2022.105680

Neuronal Cultures: Exploring Biophysics, Complex Systems, and Medicine in a Dish

Autorzy: Jordi Soriano
Opublikowane w: Biophysica, Numer 3, 2025, Strona(/y) 181-202, ISSN 2673-4125
Wydawca: Biophysica
DOI: 10.3390/biophysica3010012

TDPP: 2-D Permutation-Based Protection of Memristive Deep Neural Networks

Autorzy: Minhui Zou, Zhenhua Zhu, Tzofnat Greenberg-Toledo, Orian Leitersdorf, Jiang Li, Junlong Zhou, Yu Wang, Nan Du, Shahar Kvatinsky
Opublikowane w: IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, Numer 43, 2024, Strona(/y) 742-755, ISSN 0278-0070
Wydawca: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tcad.2023.3322351

Non-peer reviewed articles (1)

Variability vs Phenotype: multimodal analysis of Dravet Syndrome Brain Organoids powered by Deep Learning

Autorzy: Isabel Turpin, Adriana Modrego, Andrea Martí-Sarrias, Anna-Christina Haeb, Laura García-González, Jordi Soriano, Núria Ruiz, Irene Peñuelas-Haro, Elisa Espinet, Daniel Tornero, Oscar Lao, Sandra Acosta
Opublikowane w: bioRxiv, 2025, ISSN 2692-8205
Wydawca: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.28.635291