Neuronal networks from Cortical human iPSCs for Machine Learning Processing- NEU-ChiP

Project Information

NEU-ChiP

Grant agreement ID: 964877

DOI 10.3030/964877

Project closed

EC signature date 20 January 2021

Start date 1 September 2021

End date 28 February 2025

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost € 3 461 780,00

EU contribution € 3 461 780,00

Coordinated by

ASTON UNIVERSITY
United Kingdom

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (12)

Developing a Computational model for NeuChiP-based neuromorphic circuits.
Engineering and stimulation parameters to shape specific hNN circuit architectures.
Emulator of small circuit with prescribed neural and synaptic characteristics.

Emulator of small circuit with prescribed neural and synaptic characteristics

Developing a Computational model for memristor-based neuromorphic circuits.

Developing a Computional model for memristor-based neuromorphic circuits.

Information content under various stimuli.
Conception and in silico tests of neural dynamical compiler.
Task processing/information flow in novel hNN circuits.
Final dissemination and exploitation plan
Dynamical visualisation and interpretation of the collective neuronal representations.
Development of genetically modified iPSCs.

iPSCs will be genetically modified to generate neuronglia lines expressing optogenetic actuator and calcium activity indicators M0112 AU UB LU

Comparison of NeuChiP/neuromorphic electronic circuits.
Production of defined functional neuronal & glial networks.

Production of defined functional neuronal and glial cell networks M12

Websites, patent fillings, videos etc. (2)

Dissemination and exploitation plan
Project website

Project website created

Open Research Data Pilot (1)

Data management plan.

Data management plan

Publications

Peer reviewed articles (25)

Engineering Coupled Consortia-Based Biosensors using Incoherent Feedforward Loops

Author(s): Ramez Daniel, Rongying Huang, Valeriia Kravchik, Naama Geva-Zatorsky
Published in: Engineering Coupled Consortia-Based Biosensors for Diagnostic, 2024, ISSN 2693-5015
Publisher: Research Square Platform LLC
DOI: 10.21203/rs.3.rs-4011356/v1

Real-time hardware emulation of neural cultures: A comparative study of in vitro, in silico and in duris silico models

Author(s): Bernardo Vallejo-Mancero, Sergio Faci-Lázaro, Mireya Zapata, Jordi Soriano, Jordi Madrenas
Published in: Neural Networks, Issue 179, 2024, Page(s) 106593, ISSN 0893-6080
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neunet.2024.106593

Analysis of Evolving Cortical Neuronal Networks Using Visual Informatics

Author(s): Ho Fai Po, Akke Mats Houben, Anna-Christina Haeb, Yordan P. Raykov, Daniel Tornero, Jordi Soriano, David Saad
Published in: arXiv, 2025, ISSN 2331-8422
Publisher: Cornell Univerity
DOI: 10.48550/arxiv.2502.20862

Complete realization of energy landscapes and non-equilibrium trapping dynamics in small spin glass and optimization problems

Author(s): Ho Fai Po, Chi Ho Yeung
Published in: Scientific Reports, Issue 14, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-65493-4

Design, implementation, and functional validation of a new generation of microneedle 3D high-density CMOS multi-electrode array for brain tissue and spheroids

Author(s): Lisa Mapelli, Olivier Dubochet, Mariateresa Tedesco, Giacomo Sciacca, Alessandra Ottaviani, Anita Monteverdi, Chiara Battaglia, Simona Tritto, Francis Cardot, Patrick Surbled, Jan Schildknecht, Mauro Gandolfo, Kilian Imfeld, Chiara Cervetto, Manuela Marcoli, Egidio D’Angelo, Alessandro Maccione
Published in: Frontiers in Neuroscience, 2022, ISSN 1662-453X
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.08.11.503595

Re-routing game: The inadequacy of mean-field approach in modeling the herd behavior in path switching

Author(s): Ho Fai Po, Chi Ho Yeung
Published in: Physica A: Statistical Mechanics and its Applications, Issue 658, 2025, Page(s) 130266, ISSN 0378-4371
Publisher: Elsevier BV
DOI: 10.1016/j.physa.2024.130266

Modular architecture facilitates noise-driven control of synchrony in neuronal networks

Author(s): Hideaki Yamamoto, F. Paul Spitzner, Taiki Takemuro, Victor Buendía, Hakuba Murota, Carla Morante, Tomohiro Konno, Shigeo Sato, Ayumi Hirano-Iwata, Anna Levina, Viola Priesemann, Miguel A. Muñoz, Johannes Zierenberg, Jordi Soriano
Published in: Science Advances, Issue 9, 2024, ISSN 2375-2548
Publisher: Science Advances
DOI: 10.1126/sciadv.ade1755

First Organoid Intelligence (OI) workshop to form an OI community

Author(s): Itzy E. Morales Pantoja, Lena Smirnova, Alysson R. Muotri, Karl J. Wahlin, Jeffrey Kahn, J. Lomax Boyd, David H. Gracias, Timothy D. Harris, Tzahi Cohen-Karni, Brian S. Caffo, Alexander S. Szalay, Fang Han, Donald J. Zack, Ralph Etienne-Cummings, Akwasi Akwaboah, July Carolina Romero, Dowlette-Mary Alam El Din, Jesse D. Plotkin, Barton L. Paulhamus, Erik C. Johnson, Frederic Gilbert, J. Lowry Curl
Published in: Frontiers in Artificial Intelligence, Issue 6, 2023, ISSN 2624-8212
Publisher: Frontiers
DOI: 10.3389/frai.2023.1116870

The Baltimore declaration toward the exploration of organoid intelligence

Author(s): Thomas Hartung, Lena Smirnova, Itzy E. Morales Pantoja, Akwasi Akwaboah, Dowlette-Mary Alam El Din, Cynthia A. Berlinicke, J. Lomax Boyd, Brian S. Caffo, Ben Cappiello, Tzahi Cohen-Karni, J. Lowry Curley, Ralph Etienne-Cummings, Raha Dastgheyb, David H. Gracias, Frederic Gilbert, Christa Whelan Habela, Fang Han, Timothy D. Harris, Kathrin Herrmann, Eric J. Hill, Qi Huang, Rabih E. Jabbour, Erik C.
Published in: Frontiers in Science, Issue 1, 2023, ISSN 2813-6330
Publisher: Frontiers in Science
DOI: 10.3389/fsci.2023.1068159

Efficient Training of the Memristive Deep Belief Net Immune to Non‐Idealities of the Synaptic Devices

Author(s): Wei Wang, Barak Hoffer, Tzofnat Greenberg-Toledo, Yang Li, Minhui Zou, Eric Herbelin, Ronny Ronen, Xiaoxin Xu, Yulin Zhao, Jianguo Yang, Shahar Kvatinsky
Published in: Advanced Intelligent Systems, Issue 4, 2024, ISSN 2640-4567
Publisher: Wiley
DOI: 10.1002/aisy.202100249

Single-neuron deep generative model uncovers underlying physics of neuronal activity in Ca imaging data

Author(s): Jordi Abante, Angelo Piga, Berta Ros, Clara F López-León, Josep M Canals, Jordi Soriano
Published in: arXiv, 2025, ISSN 2331-8422
Publisher: Cornell University
DOI: 10.48550/arxiv.2501.14615

Review of security techniques for memristor computing systems

Author(s): Minhui Zou, Nan Du, Shahar Kvatinsky
Published in: Frontiers in Electronic Materials, Issue 2, 2022, ISSN 2673-9895
Publisher: Frontiers
DOI: 10.3389/femat.2022.1010613

Variability vs Phenotype: multimodal analysis of Dravet Syndrome Brain Organoids powered by Deep Learning

Author(s): Isabel Turpin, Adriana Modrego, Andrea Martí-Sarrias, Anna-Christina Haeb, Laura García-González, Jordi Soriano, Núria Ruiz, Irene Peñuelas-Haro, Elisa Espinet, Daniel Tornero, Oscar Lao, Sandra Acosta
Published in: bioRxiv, 2025, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.28.635291

Hyaluronic acid-based bioink improves the differentiation and network formation of neural progenitor cells

Author(s): Inês Pereira, Maria J. Lopez-Martinez, Aranzazu Villasante, Clelia Introna, Daniel Tornero, Josep M. Canals, Josep Samitier
Published in: Frontiers in Bioengineering and Biotechnology, Issue 11, 2023, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2023.1110547

Neuronal circuitry reconstruction after stem cell therapy in damaged brain

Author(s): Daniel Tornero
Published in: Neural Regeneration Research, Issue 17, 2022, Page(s) 1959, ISSN 1673-5374
Publisher: Neural Regeneration Research
DOI: 10.4103/1673-5374.335145

Role of connectivity anisotropies in the dynamics of cultured neuronal networks

Author(s): Akke Mats Houben, Jordi Garcia-Ojalvo, Jordi Soriano
Published in: arXia, 2025, ISSN 2331-8422
Publisher: Cornell University
DOI: 10.48550/arxiv.2501.04427

Task Learning through Stimulation-Induced Plasticity in Neural Networks

Author(s): Francesco Borra, Simona Cocco, Rémi Monasson
Published in: PRX Life, Issue 2, 2024, ISSN 2835-8279
Publisher: PRX Liw
DOI: 10.1103/prxlife.2.043014

Dynamic and Functional Alterations of Neuronal Networks In Vitro upon Physical Damage: A Proof of Concept

Author(s): Sàlem Ayasreh, Imanol Jurado, Clara López-León, Marc Montalà-Flaquer, Jordi Soriano
Published in: Micromachines, Issue 13, 2025, Page(s) 2259, ISSN 2072-666X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi13122259

Inferring structure of cortical neuronal networks from activity data: A statistical physics approach

Author(s): Ho Fai Po, Akke Mats Houben, Anna-Christina Haeb, David Rhys Jenkins, Eric J Hill, H Rheinallt Parri, Jordi Soriano, David Saad
Published in: PNAS Nexus, Issue 4, 2025, ISSN 2752-6542
Publisher: PNAS NEXUS
DOI: 10.1093/pnasnexus/pgae565

Integrated information decomposition unveils major structural traits of <i>in silico</i> and <i>in vitro</i> neuronal networks

Author(s): Gustavo Menesse, Akke Mats Houben, Jordi Soriano, Joaquín J. Torres
Published in: Chaos: An Interdisciplinary Journal of Nonlinear Science, Issue 34, 2024, ISSN 1054-1500
Publisher: American Institute of Physics
DOI: 10.1063/5.0201454

A memristive deep belief neural network based on silicon synapses

Author(s): Wei Wang, Loai Danial, Yang Li, Eric Herbelin, Evgeny Pikhay, Yakov Roizin, Barak Hoffer, Zhongrui Wang, Shahar Kvatinsky
Published in: Nature Electronics, Issue 5, 2024, Page(s) 870-880, ISSN 2520-1131
Publisher: Nature Electronics
DOI: 10.1038/s41928-022-00878-9

Long-term calcium imaging reveals functional development in hiPSC-derived cultures comparable to human but not rat primary cultures

Author(s): Estefanía Estévez-Priego, Martina Moreno-Fina, Emanuela Monni, Zaal Kokaia, Jordi Soriano, Daniel Tornero
Published in: Stem Cell Reports, Issue 18, 2024, Page(s) 205-219, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2022.11.014

Rich dynamics and functional organization on topographically designed neuronal networks in vitro

Author(s): Marc Montalà-Flaquer, Clara F. López-León, Daniel Tornero, Akke Mats Houben, Tanguy Fardet, Pascal Monceau, Samuel Bottani, Jordi Soriano
Published in: iScience, Issue 25, 2024, Page(s) 105680, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2022.105680

Neuronal Cultures: Exploring Biophysics, Complex Systems, and Medicine in a Dish

Author(s): Jordi Soriano
Published in: Biophysica, Issue 3, 2025, Page(s) 181-202, ISSN 2673-4125
Publisher: Biophysica
DOI: 10.3390/biophysica3010012

TDPP: 2-D Permutation-Based Protection of Memristive Deep Neural Networks

Author(s): Minhui Zou, Zhenhua Zhu, Tzofnat Greenberg-Toledo, Orian Leitersdorf, Jiang Li, Junlong Zhou, Yu Wang, Nan Du, Shahar Kvatinsky
Published in: IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, Issue 43, 2024, Page(s) 742-755, ISSN 0278-0070
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tcad.2023.3322351