CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.
I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .
Risultati finali
Tumor size will be measured daily over a ten-days period after which tumors will be harvested and analyzed by multiplex immunohistochemistry coupled to high-dimensional flow cytometry to define the 3D spatial distribution of fibroblastic stromal and immune cells, and the extracellular matrix and to quantify their number variation and phenotype over time in the tumor microenvironment and draining lymph nodes.
We will set-up two melanoma mouse models, the transplantable B16F1 in C57Bl/6N mice and spontaneous HGF-CDK4 models for which the phenotype and transcriptomic profile of anti-tumor T cells have been characterised. Tumor cells will be injected subcutaneously and stem cell memory (potent anti-tumor T cells) or effector memory (dysfunctional anti-tumor T cells) Pmel-1 transgenic T cells will be injected intravenously 7-days post tumor take.
At project start, BCC will create a house-style to be used to set up the project website and create a project summary in text and visuals. Every partner commits to writing >2 blog-posts per year, according to the Dissemination and Exploitation Plan, ensuring a good timing and relevant spread of result posts throughout the project. The website text and visuals will be transferred to a regularly updated slide-deck for project presentations. A project brochure will be generated that includes project outcomes to provide stakeholders with an overview of the work done, and to generate impact after the project.
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