European Clinical Research Alliance on Infectious Diseases

Informazioni relative al progetto

ECRAID-Base

ID dell’accordo di sovvenzione: 965313

DOI

10.3030/965313

Data della firma CE 29 Gennaio 2021

Data di avvio 1 Marzo 2021

Data di completamento 28 Febbraio 2026

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 29 969 875,00

Contributo UE

€ 29 969 875,00

Coordinato da

STICHTING EUROPEAN CLINICAL RESEARCH ALLIANCE ON INFECTIOUS DISEASES
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (2)

Updated ECRAID business plan

Updated ECRAID business plan month 12 annually updated

Virtual learning Platform

Updated Virtual learning Platform

Websites, patent fillings, videos etc. (1)

Project website and social media accounts

Project website and social media accounts month 3

Open Research Data Pilot (1)

Communications overview report

Communications overview report month 12 annually updated including overview of leaflets newsletters conferences brochures videos and other communications

Pubblicazioni

Peer reviewed articles (27)

Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19.

Autori: Ewan C. Goligher, MD, PhD; Patrick R. Lawler, MD, MPH; Thomas P. Jensen, MS; et al
Pubblicato in: JAMA, 2023, ISSN 1538-3598
Editore: American Medical Association
DOI: 10.1001/jama.2023.3651

Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial.

Autori: Writing Committee for the REMAP-CAP Investigators; Patrick R Lawler, Lennie P G Derde, Frank L van de Veerdonk, Bryan J McVerry, David T Huang, Lindsay R Berry, Elizabeth Lorenzi, Roland van Kimmenade, Frank Gommans, Muthiah Vaduganathan, David E Leaf, Rebecca M Baron, Edy Y Kim, Claudia Frankfurter, Slava Epelman, Yvonne Kwan, Richard Grieve, Stephen O'Neill, Zia Sadique, Michael Puskarich, John
Pubblicato in: JAMA, 2023, ISSN 1538-3598
Editore: American Medical Association
DOI: 10.1001/jama.2023.4480

How to: share and reuse data—challenges and solutions from predicting the impact of monoclonal antibodies & vaccines on antimicrobial resistance project

Autori: Mariana Guedes, Almudena de la Serna Bazan, Elena Rubio-Martín, Lydia Barrera Pulido, Virginia Palomo, Alen Piljić, Quentin J. Leclerc, Emmanuel Aris, Venanzio Vella, Asta Dambrauskienė, Julie V. Robotham, Astrid Pérez, Nasreen Hassoun-Kheir, Marlieke E.A. de Kraker, Fabiana Arieti, Ruth Joanna Davis, Evelina Tacconelli, Elena Salamanca-Rivera, Jesús Rodríguez-Baño
Pubblicato in: Clinical Microbiology and Infection, Numero 31, 2025, Pagina/e 753-760, ISSN 1198-743X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2025.01.024

Simvastatin in Critically Ill Patientswith Covid-19

Autori: The REMAP-CAP Investigators
Pubblicato in: The New England Journal of Medicine, 2023, ISSN 1533-4406
Editore: Massachusetts Medical Society
DOI: 10.1056/nejmoa2309995

Platform trials as the way forward in infectious disease' clinical research: the case of coronavirus disease 2019.

Autori: Juan M Pericàs, Lennie P G Derde, Scott M Berry; EU-PEARL and REMAP-CAP investigators
Pubblicato in: Clinical Microbiolology and Infection, 2023, ISSN 1469-0691
Editore: Elsevier
DOI: 10.1016/j.cmi.2022.11.022

Perpetual observational studies: new strategies to support efficient implementation of observational studies and randomized trials in infectious diseases

Autori: NasreenHassoun-Kheir1C. Henrivan Werkhoven2 JakeDunning3 ThomasJaenisch4 Jankovan Beek5 JuliaBielicki67 Christopher C.Butler8 BrunoFrancois9 StephanHarbarth1 Ana C.Hernandez Padilla9 PeterHorby3 MarionKoopmans510 JamesLee3 JesúsRodriguez-Baño1112 EvelinaTacconelli13 YreneThemistocleous3 Alike W.van der Velden2 MarcBonten2 HermanGoossens14 Marlieke E.A.de Kraker1 on behalf of ECRAID-Base consort
Pubblicato in: Clinical Microbiology and Infection, 2022, ISSN 1198-743X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2022.07.024

Hurdles for the Delivery of Multinational Randomized Clinical Trials

Autori: Denise van Hout, Paul Mouncey, David Harrison, Marc Bonten, Lennie Derde, null null, Derek C. Angus, Aisha Anjum, Djillali Annane, Janis Best-Lane, Frank Brunkhorst, Maurizio Cecconi, Stephan Ehrmann, Anthony Gordon, Leanne Marie Hays, Esmee Kester, Niamh Mahon, Colin McArthur, Alistair Nichol, Svenja Peters, Sara Pugliese, Kathryn Rowan, Julian Torre-Cisneros, Sebastian Weis
Pubblicato in: JAMA Network Open, Numero 8, 2025, Pagina/e e2518503, ISSN 2574-3805
Editore: American Medical Association (AMA)
DOI: 10.1001/jamanetworkopen.2025.18503

The Renin-Angiotensin System in Acute Lung Injury

Autori: Patrick R Lawler, Lennie P G Derde, Bryan J McVerry, James A Russell, Frank L van de Veerdonk
Pubblicato in: Critical Care Medicine, 2022, ISSN 1530-0293
Editore: Lippincott Williams & Wilkins on behalf of the Society of Critical Care Medicine
DOI: 10.1097/ccm.0000000000005567

EPI-Net One Health reporting guideline for antimicrobialconsumption and resistance surveillance data: a Delphi approach

Autori: Babu Rajendran N, Arieti F, Mena-Benítez CA, Galia L, Tebon M, Alvarez J, Gladstone BP, Collineau L, De Angelis G, Duro R, Gaze W, Göpel S, Kanj SS, Käsbohrer A, Limmathurotsakul D, Lopez de Abechuco E, Mazzolini E, Mutters NT, Pezzani MD, Presterl E, Renk H, Rodríguez-Baño J, Săndulescu O, Scali F, Skov R, Velavan TP, Vuong C, Tacconelli E; EPI-Net One Health consensus working group.
Pubblicato in: The Lancet Regional Health - Europe, 2023, ISSN 1474-547X
Editore: Elsevier
DOI: 10.1016/j.lanepe.2022.100563

Are monoclonals the way forward to prevent or to treat ventilator-associated pneumonia in the intensive care unit?

Autori: Ana Catalina Hernandez Padilla, Sylvain Meyer, CH Van Werkhoven, Marlieke EA de Kraker, Bruno François
Pubblicato in: Expert Opinion on Biological Therapy, 2023, ISSN 1744-7682
Editore: Taylor & Francis
DOI: 10.1080/14712598.2023.2240701

A comparison of frequentist and Bayesian approaches to the Personalised Randomised Controlled Trial (PRACTical)—design and analysis considerations

Autori: Holly Jackson, Yiyun Shou, Nur Amira Binte Mohamed Azad, Jing Wen Chua, Rebecca Lynn Perez, Xinru Wang, Marlieke E. A. de Kraker, Yin Mo
Pubblicato in: BMC Medical Research Methodology, Numero 25, 2025, Pagina/e 149, ISSN 1471-2288
Editore: BioMed Central
DOI: 10.1186/s12874-025-02537-x

Continuation of therapeutic dose heparin for critically ill patients with COVID-19.

Autori: Charlotte A. Bradbury, Patrick R. Lawler, Bryan J. McVerry & Ryan Zarychanski on behalf of the REMAP-C. A. P. Investigators
Pubblicato in: Intensive care medicine, 2023, ISSN 1432-1238
Editore: Springer Science+Business Media
DOI: 10.1007/s00134-023-07095-8

Case numbers of acute hepatitis of unknown aetiology among children in 24 countries up to 18 April 2022 compared to the previous 5 years

Autori: Janko van Beek Pieter LA Fraaij Carlo Giaquinto Delane Shingadia Peter Horby Giuseppe Indolfi Marion Koopmans Acute hepatitis study group
Pubblicato in: Eurosurveillance, 2022, ISSN 1025-496x
Editore: Centre Europeen pour la Surveillance Epidemiologique du SIDA
DOI: 10.2807/1560-7917.es.2022.27.19.2200370

Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms

Autori: Barbara Wanjiru Citarella, Christiana Kartsonaki, Elsa D. Ibáñez-Prada, Bronner P. Gonçalves, Joaquin Baruch, Martina Escher, Mark G. Pritchard, Jia Wei, Fred Philippy, Andrew Dagens, Matthew Hall, James Lee, Demetrios James Kutsogiannis, Evert-Jan Wils, Marília Andreia Fernandes, Bharath Kumar Tirupakuzhi Vijayaraghavan, Prasan Kumar Panda, Ignacio Martin-Loeches, Shinichiro Ohshimo, Arie Zai
Pubblicato in: Heliyon, Numero 10, 2025, Pagina/e e29591, ISSN 2405-8440
Editore: Elsevier BV
DOI: 10.1016/j.heliyon.2024.e29591

Low levels of monkeypox virus neutralizing antibodies after MVA-BN vaccination in healthy individuals

Autori: Luca M. Zaeck, Mart M. Lamers, Babs E. Verstrepen, Theo M. Bestebroer, Martin E. van Royen, Hannelore Götz, Marc C. Shamier, Leanne P.M. van Leeuwen, Katharina S. Schmitz, Kimberley Alblas, Suzanne van Efferen, Susanne Bogers, Sandra Scherbeijn, Guus F. Rimmelzwaan, Eric C.M. van Gorp, Marion P.G. Koopmans, Bart L. Haagmans, Corine H. GeurtsvanKessel, Rory D. de Vries
Pubblicato in: Nature Medicine, 2022, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1101/2022.08.31.22279414

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Autori: Munib Mesinovic, Xin Ci Wong, Giri Shan Rajahram, Barbara Wanjiru Citarella, Kalaiarasu M. Peariasamy, Frank van Someren Greve, Piero Olliaro, Laura Merson, Lei Clifton, Christiana Kartsonaki, null null, Sheryl Ann Abdukahil, Nurul Najmee Abdulkadir, Ryuzo Abe, Laurent Abel, Amal Abrous, Lara Absil, Andrew Acker, Shingo Adachi, Elisabeth Adam, Enrico Adriano, Diana Adrião, Saleh Al Ageel, Shakeel
Pubblicato in: Scientific Reports, Numero 14, 2024, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-024-63212-7

International platform trials: as diseases cross borders, so should trials.

Autori: Hiroki Saito on behalf of theRandomized, Embedded, Multifactorial Adaptive Platform trial for Community-Acquired Pneumonia (REMAP-CAP) investigators
Pubblicato in: The Lancet Infectious Diseases, 2023, ISSN 1474-547X
Editore: Elsevier
DOI: 10.1016/s1473-3099(23)00193-7

Coronavirus disease 2019 subphenotypes and differential treatment response to convalescent plasma in critically ill adults: secondary analyses of a randomized clinical trial.

Autori: M Fish, J Rynne, A Jennings, C Lam, A A Lamikanra, J Ratcliff, S Cellone-Trevelin, E Timms, J Jiriha, I Tosi, R Pramanik, P Simmonds, S Seth, J Williams, A C Gordon, J Knight, D J Smith, J Whalley, D Harrison, K Rowan, H Harvala, P Klenerman, L Estcourt, D K Menon, D Roberts, M Shankar-Hari; REMAP-CAP Immunoglobulin Domain UK Investigators
Pubblicato in: Intensive care medicine, 2022, ISSN 1432-1238
Editore: Springer Science+Business Media
DOI: 10.1007/s00134-022-06869-w

Enforcing surveillance of antimicrobial resistance and antibiotic use to drive stewardship: experience in a paediatric setting

Autori: Zaffagnini A, Rigotti E, Opri F, Opri R, Simiele G, Tebon M, Sibani M; ENSURE Working Group; Piacentini G, Tacconelli E, Carrara E
Pubblicato in: Journal of Hospital Infection, 2023, ISSN 1532-2939
Editore: Elsevier
DOI: 10.1016/j.jhin.2023.12.001

Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial

Autori: Authors/Members of the Writing Committee for the REMAP-CAP Investigators: Alisa M. Higgins, PhD; Lindsay R. Berry, PhD; Elizabeth Lorenzi, PhD; Srinivas Murthy, MD; Zoe McQuilten, PhD; Paul R. Mouncey, MSc; Farah Al-Beidh, PhD; Djillali Annane, MD, PhD; Yaseen M. Arabi, MD; Abi Beane, PhD; Wilma van Bentum-Puijk, MSc; Zahra Bhimani, MPH; Marc J. M. Bonten, MD, PhD; Charlotte A. Bradbury, MD, PhD;
Pubblicato in: JAMA, 2023, ISSN 1538-3598
Editore: American Medical Association
DOI: 10.1001/jama.2022.23257

Mycoplasma pneumoniae re-emergence in 2023 causes disease in adults in Europe

Autori: Bianca M. M. Streng, Louis J. Bont, Patrick M. Meyer Sauteur, Marc J. M. Bonten, Annemarie M.C. van Rossum, Cristina Prat Aymerich
Pubblicato in: ERJ Open Research, 2025, Pagina/e 00585-2025, ISSN 2312-0541
Editore: European Respiratory Society (ERS)
DOI: 10.1183/23120541.00585-2025

Intravenous Vitamin C for Patients Hospitalized With COVID-19Two Harmonized Randomized Clinical Trials

Autori: The LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators
Pubblicato in: JAMA, 2023, ISSN 1538-3598
Editore: American Medical Association
DOI: 10.1001/jama.2023.21407

Tracking Candidemia Trends and Antifungal Resistance Patterns across Europe: An In-Depth Analysis of Surveillance Systems and Surveillance Studies

Autori: Karin Odoj, Jacopo Garlasco, Maria Diletta Pezzani, Cristina Magnabosco, Diego Ortiz, Federica Manco, Liliana Galia, Sarah K. Foster, Fabiana Arieti, Evelina Tacconelli
Pubblicato in: Journal of Fungi, Numero 10, 2025, Pagina/e 685, ISSN 2309-608X
Editore: MDPI AG
DOI: 10.3390/jof10100685

Tocilizumab, sarilumab and anakinra in critically ill patients with COVID-19: a randomised, controlled, open-label, adaptive platform trial

Autori: Lennie Derde, Anthony C Gordon, Paul R Mouncey, Farah Al-Beidh, Kathryn M Rowan, Alistair D Nichol, Yaseen M Arabi, Djillali Annane, Abigail Beane, Richard Beasley, Marc J M Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Adrian Buzgau, Meredith Buxton, Allen C Cheng, Nicola Cooper, Matthew Cove, Olaf L Cremer, Michelle A Detry, Eamon J Duffy, Lise J Estcourt, Mark Fitzgerald, James Galea, Herma
Pubblicato in: Thorax, Numero 80, 2025, Pagina/e 530-539, ISSN 0040-6376
Editore: BMJ Publishing Group
DOI: 10.1136/thorax-2024-222488

Modelling antimicrobial resistance transmission to guide personalized antimicrobial stewardship interventions and infection control policies in healthcare setting: a pilot study

Autori: Durazzi F, Pezzani MD, Arieti F, Simonetti O, Canziani LM, Carrara E, Barbato L, Onorati F, Remondini D, Tacconelli E
Pubblicato in: Scientific Reports, 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-51051-x

Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia

Autori: null null, Nicholas Heming, Lindsay Berry, Elizabeth Lorenzi, Thomas E. Hills, Alisa M. Higgins, Yaseen Arabi, Diptesh Aryal, Abigail Beane, Janis Best-Lane, Marc Bonten, Charlotte Bradbury, Frank Brunkhorst, Aidan Burrell, Meredith Buxton, Maurizio Cecconi, James D. Chalmers, Allen C. Cheng, Graham Cooke, Matthew E. Cove, Paul Dark, Lennie Derde, Michelle A. Detry, Lise J. Estcourt, Mark Fitzgera
Pubblicato in: Intensive Care Medicine, Numero 51, 2025, Pagina/e 665-680, ISSN 0342-4642
Editore: Springer Verlag
DOI: 10.1007/s00134-025-07861-w

Modelling antimicrobial resistance transmission to guide personalized antimicrobial stewardship interventions and infection control policies in healthcare setting: a pilot study

Autori: Francesco Durazzi, Maria Diletta Pezzani, Fabiana Arieti, Omar Simonetti, Lorenzo Maria Canziani, Elena Carrara, Lorenzo Barbato, Francesco Onorati, Daniel Remondini, Evelina Tacconelli
Pubblicato in: Scientific Reports, Numero 13, 2024, Pagina/e Italy, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-42511-5