Revolution of sleep diagnostics and personalized health care based on digital diagnostics and therapeutics with health data integration

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

"Data Management Plan generated for ""Pilot on Open Research Data""."

Data Management Plan generated for Pilot on Open Research Data from Task 11Health actions that participates in the ORDPThe Data Management Plan will be generated within 6 months after the project starts for participating in the H2020 Pilot on Open Research Data This plan will be included in the Project Management Plan which will be updated yearly

An interactive tool for projecting the burden of SDB and cost-benefits by the novel technology for treatment of SDB in different EU-countries

An interactive tool for projecting the burden of SDB and cost-benefits by the novel technology for treatment of SDB in different EU-countries from Task 11.3.In this deliverable ant an interactive tool is generated to produce projections for SDB-related disease burden and potential cost savings that can be obtained with the application of the novel technology in SDB management. These projections will include the history and current levels of health and its determinants within the populations as parameters that can be modified to fit for purposes of different countries. Novel and innovative techniques of data-driven Bayesian hierarchical models that allow a natural way to incorporate different sources of uncertainty in projections including the large proportion of missing data and expert knowledge on effects of interventions at the individual level will be used to provide robust and comparable estimates for projections.

SAS release as a medical device

SAS release as a medical device from Task 6.5.Using the ISO13485 certified medical device development processes, the SAS will be redesigned as a medical device and first released with CE labelling in the EU. As is with every Medical Device development activity, the applicable process will include all the necessary steps to provide evidence of safety and efficiency requested for medical products, including risk analysis, usability testing, clinical evaluation, clinical validation and proper documentation for compliant Technical File. This will include all available and validated SAS accessories, software, and analysis at the time of implementation.

Establishment of an ethical guardian at each study site.

Establishment of an ethical guardian at each study site from Task 13.2.Due to the complexity of the network involved in this study, an ethical guardian will be appointed to co-ordinate ethical approval application processes in each of the institutions and countries involved in the data collection.

Establishment of the External Ethics Advisory Board

Establishment of the External Ethics Advisory Board from Task 13.2.a one-person EEAB will be established at the beginning of the project and maintained until the end of the project.

First publication of SLEEP REVOLUTION project in JSR or other scientific journal, as deemed appropriate.

First publication of SLEEP REVOLUTION project in JSR or other scientific journal as deemed appropriate from Task 121The ESRS publishes one of the principle international scientific journals the Journal of Sleep Research JSR which with an impact factor of 34 is in the top 3 international scientific sleep journals publishing original research

First dissemination of findings from SLEEP REVOLUTION project.

First dissemination of findings from SLEEP REVOLUTION project from Task 122OSA is a multisystem disorder that has important cardiometabolic comorbidities which are often not well recognised by health professionals and patients within these disciplines ESRS will play a central role in dissemination of relevant findings from SLEEP REVOLUTION to professional organizations with many sleep apnoea patients cardiology neurology respiratory diabetes obesity within Europe to patient organizations as well as to European societies Such dissemination is facilitated by established intersociety links with other European Societies such as the European Society of Hypertension the ERS and the European Academy of Neurology that have already resulted in the publication of joint position papers on the association of sleep apnoea with important comorbidities such as hypertension 64 and stroke 65 A website for the SLEEP REVOLUTION project will also be setup and linked to the the wwwesrseu website

First project presentation at the ESRS Scientific Congresses.

First project presentation at the ESRS Scientific Congresses from Task 121The ESRS holds annual conferences relating to sleep research and medicine The biannual ESRS Congress is the premier scientific congress in Europe relating to sleep research The Sleep and Breathing Congress is a biannual conference held jointly with ERS that is especially focused on education and continuing professional development These events provide the optimum opportunity to present original data arising from research performed in the various WPs of SLEEP REVOLUTION

Translation to different languages

Translation to different languages from Task 74All applicable text and functions in the DMP as seen by healthcare professionals and research staff will be in English A part of the development strategy of the DMP will make the text easily translated to other languages The translation aspect will therefore be included from the start and translating the DMP to a new language will include the manual labour of working with structured files However for the research subjectpatient relevant text and functions in the DMP will need to be translated into the respective language of different countries participating in WP810 This includes the PROMs in the European Sleep Questionnaire and electronic sleep diary NEH which require translation with the assistance of experienced translators The visualizations of data from the wearables will need some translations for each country which this task will also cover If needed text and functions in relation to the mobile application program by SKH objective daytime testing wearables Withings and ES sleep studies NOX and overall platform will also be translated This may however not be needed in all countries depending on the English proficiency of the population eg not needed in Iceland and we will assess which languages are needed as a part of this task

Deep learning algorithm for automatic estimation of sleep microstructure.

Deep learning algorithm for automatic estimation of sleep microstructure from Task 32This deliverable includes the followingTo validate the stateoftheart deep learning methodologies currently being developed for automatic sleep staging by our team The detailed deep learningbased analysis will allow the assessment of a time series analysis of the continuity of sleep microstructure instead of sleep fragmentation definitions based on arbitrary and discrete 30 seconds epochs Finally novel arousal detection will be incorporated into the sleep staging and the effect of arousal length and magnitude to patients wellbeing will be investigated

Respiratory event quantification by an expanded number of potentially important clinical parameters.

Respiratory event quantification by an expanded number of potentially important clinical parameters from Task 31The deliverable includes the following quantificationTo quantify respiratory events A by different physiological parameters This includes parameters such as the traditional AHI apnoea and hypopnea length the individual role of apnoeas vs hypopneas snore percentage and duration of total sleep snore loudness flow limitation and breathing effort Different physiological parameters will be assessed to find the most clinically relevant methods of quantifying A

Recommendations for most relevant and information-rich signals to be measured in sleep studies.

Recommendations for most relevant and informationrich signals to be measured in sleep studies from Task 53Using the sophisticated deep neural networks for an accurate SDB diagnosis and severity assessment will guide us to select the most informationrich signals and determine the minimum sensor and sampling setups needed This is critically important to optimise the diagnostic sensitivity minimum sensor setup maximal patient comfort and automation of data processing and analysis This information will be used for the final design of the SAS system in WP6 and included in the stateoftheart scoring manual created in WP4 D44

Real-world estimates of long-term costs of OSA

Realworld estimates of longterm costs of OSA from Task 111This deliverable is to collect relevant data on longterm costs of SDB and OSA using the retrospective data collected in WP3 This data will be utilized to select the most relevant measures and outcomes As the outcomesmeasures are not specific to SDB alone SDBrelated contribution will be extracted by using population attributable factors based on the known prevalence of diseases and increased risks related to SDB and OSA Here the analysed datasets will include at least 1 a longitudinal Kuopio Osteoporosis Risk Factor and Prevention Study OSTPREstudy on more than 14000 aging females followed since 1989 with questionnaires health investigations and registerbased followup and 2 a registerbased Diabetes in Finland FinDMresearch dataset of about one million persons with diagnosed diabetes since 1964

Comparison of unsupervised and supervised learning outcomes for SDB-related co-morbidities.

Comparison of unsupervised and supervised learning outcomes for SDBrelated comorbidities from Task 52Here we will to use backpropagation to pinpoint the most relevant signal features utilised by the machine learning approach when predicting the probabilities for OSArelated comorbidities and compare unsupervised to supervised machine learning techniques

Guidelines / position papers arising from SLEEP REVOLUTION project.

Guidelines / position papers arising from SLEEP REVOLUTION project from Task 12.3.The ESRS is ideally positioned to lead the development of guidelines and other position papers relating to SLEEP REVOLUTION based on its established track record in this area.

Simulation-based estimates of cost benefits of novel technology in treatment and prevention of SDB and OSA

Simulation-based estimates of cost benefits of novel technology in treatment and prevention of SDB and OSA from Task 11.2.With the rapid ageing of the population in Europe, it is increasingly important to obtain also reliable estimates of the future development of the SDB-related comorbidities and disability burden, healthy and disease-free life years and costs for policy makers and other stakeholders. Therefore, the results of task D11.1-D.11.2 will be summarised to generate a simulation-based estimates of cost benefits of novel technology in treatment and prevention of SDB and OSA.

Reliability report on automatic and manual scorings.

Reliability report on automatic and manual scorings from Task 42The agreement between the automatic analysis approach D41 and manual scorers D42 will be evaluated and submitted in a report

Advisory and Oversight Role

Advisory and Oversight Role from Task 12.4The ESRS, through its membership and expert committees, is also well positioned to provide an advisory and oversight role in the project to ensure optimum efficiency and integration of the project. The ESRS is well positioned to provide expert panels of sleep professionals to advise on different aspects of the work, as needed. The availability of a methodologist will provide an additional advisory benefit to the project.

Creation of The European Sleep Scoring Manual

The results of Tasks 4.1, 4.2 and 5.2 will be exploited here to develop a standardised European Sleep Scoring Manual. This manual will take into account the structure of scoring rules needed for a reliable automatic analysis as well as improved accuracy between manual scorers. This includes updated scoring rules of sleep stages, respiratory events, and acute systemic events (arousal re-evaluation, SpO2, sympathetic and cardiovascular events) based on our findings in WP3-WP5 and minimum sensor and sampling setup quality from WP5.3.

Acute systemic effect quantification by an expanded number of potentially important clinical parameters.

Acute systemic effect quantification by an expanded number of potentially important clinical parameters from Task 33The deliverable includes the followingTo expand the selection of parameters for pulse oximetry and ECG data for evaluating the risk of the most common OSArelated comorbidities such as cardiovascular diseases cerebrovascular diseases and metabolic disorders

Pubblicazioni

Future Treatment of Sleep Disorders: Syndromic Approach Versus Management of Treatable Traits?

Autori: Dirk Pevernagie
Pubblicato in: Sleep Medicine Clinics, Numero vol 16 (3), 2021, Pagina/e 465-473, ISSN 1556-407X
Editore: Elsevier BV
DOI: 10.1016/j.jsmc.2021.05.005

VALID Care Pathways: A Framework for Meaningful Digital Platform Design

Autori: null null, Lisa Schmitz, Elena Richert, null null, Kamilla R. Jóhannsdóttir, null null, Erna S. Arnardottir, null null, Anna S. Islind, null null
Pubblicato in: Communications of the Association for Information Systems, Numero 56, 2025, Pagina/e 1077-1103, ISSN 1529-3181
Editore: Association for Computing Machinary, Inc.
DOI: 10.17705/1cais.05641

Deep Learning Enables Automatic Sleep Staging from Textile Electrode-Based Home Sleep Recordings

Autori: M. Rusanen, R. Huttunen, H. Korkalainen, J. Töyräs, S. Myllymaa, T. Leppänen, S. Sigurdardottir, E.S. Arnardottir, S. Kainulainen
Pubblicato in: Sleep Medicine, Numero 100, 2022, Pagina/e S294, ISSN 1389-9457
Editore: Elsevier BV
DOI: 10.1016/j.sleep.2022.05.795

Obstructive sleep apnea-related intermittent hypoxaemia is associated with impaired vigilance

Autori: Purbanka Pahari, Henri Korkalainen, Tuomas Karhu, Marika Rissanen, Erna Sif Arnardottir, Harald Hrubos-Strøm, Brett Duce, Juha Töyräs, Timo Leppänen, Sami Nikkonen
Pubblicato in: Journal of Sleep Research, 2022, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1111/jsr.13803

Anomaly Detection in Sleep: Detecting Mouth Breathing in Children

Autori: Biedebach, L., Óskarsdóttir, M., Arnardóttir, E.S. et al.
Pubblicato in: Data Min Knowl Disc, 2023, ISSN 2380-0577
Editore: Springer Link
DOI: 10.1007/s10618-023-00985-x

Acute Cardiorespiratory Coupling Impairment in Worsening Sleep Apnea-Related Intermittent Hypoxemia

Autori: Hietakoste, S. et al
Pubblicato in: IEEE Transactions on Biomedical Engineering, 2023, ISSN 0018-9294
Editore: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbme.2023.3300079

Machine Learning and Wearable Technology in Sleep Medicine

Autori: T. Leppänen, C. Varon, M.d. Zambotti, and S. Myllymaa
Pubblicato in: Front. Digit. Health, 2022, 4:845879, 2022, ISSN 2673-253X
Editore: Frontiers in digital health
DOI: 10.3389/fdgth.2022.845879

Obstructive Sleep Apnea Patients With AtrialArrhythmias Suffer From ProlongedRecovery From Desaturations

Autori: Rissanen, M. et al
Pubblicato in: IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2023, ISSN 0018-9294
Editore: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbme.2023.3236680

To breathe, or not to breathe through the mouth: analysing mouth breathing in a pediatric sleep study

Autori: L. Biedebach, D. Gozal, E.S. Arnardóttir, S. Sigurðardóttir, A.S. Islind
Pubblicato in: Sleep Medicine, Numero 115, 2024, Pagina/e S286-S287, ISSN 1389-9457
Editore: Elsevier BV
DOI: 10.1016/j.sleep.2023.11.783

Optimal Electroencephalogram and Electrooculogram Signal Combination for Deep Learning-based Sleep Staging

Autori: Masoumeh Tashakori, Matias Rusanen, Tuomas Karhu, Riku Huttunen, Timo Leppänen, Sami Nikkonen
Pubblicato in: IEEE Journal of Biomedical and Health Informatics, 2025, Pagina/e 1-8, ISSN 2168-2194
Editore: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/jbhi.2025.3541453

The role of physical activity on obstructive sleep apneaseverity and hypoxic load, and the mismatch betweensubjective and objective physical activity assessments

Autori: Fridgeirsdottir, K. Y., Ólafsdottir, K. A.,Islind, A. S., Leppänen, T., Arnardottir, E. S., & Saavedra, J. M.
Pubblicato in: Journal of Sleep Research, 2024, ISSN 0962-1105
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jsr.14195

Development of a frequency-domain based automatic event detection algorithm for EDA sleep signals and comparison with manual scorings

Autori: J. Piccini, S.L.N. Aziz Hanna, E.S. Arnardóttir, E. August
Pubblicato in: Sleep Medicine, Numero 100, 2022, Pagina/e S295-S296, ISSN 1389-9457
Editore: Elsevier BV
DOI: 10.1016/j.sleep.2022.05.798

The interaction between comorbidities and sleep stages influences oxygen re‐saturation characteristics

Autori: Timothy P. Howarth, Salla Hietakoste, Serajeddin Ebrahimian, Marika Rissanen, Samu Kainulainen, Tuomas Karhu
Pubblicato in: Journal of Sleep Research, 2025, ISSN 0962-1105
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jsr.14459

Evaluating User Compliance in Mobile Health Apps: Insights from a 90-Day Study Using a Digital Sleep Diary

Autori: Hlín Kristbergsdottir; Lisa Schmitz; Erna Sif Arnardottir; Anna Sigridur Islind
Pubblicato in: Diagnostics, Vol 13, Iss 18, p 2883 (2023), Numero 5, 2023, ISSN 2075-4418
Editore: Basel: MDPI AG
DOI: 10.3390/diagnostics13182883

An algorithmic approach to identification of gray areas: Analysis of sleep scoring expert ensemble non agreement areas using a multinomial mixture model

Autori: Jouan, G., Arnardóttir, E.S., Islind, A.S., Óskarsdóttir, M.
Pubblicato in: European Journal of Operational Research, 2023, ISSN 0377-2217
Editore: Elsevier BV
DOI: 10.1016/j.ejor.2023.09.039

An In-Laboratory Comparison of FocusBand EEG Device and Textile Electrodes Against a Medical-Grade System and Wet Gel Electrodes

Autori: M. Rusanen, S. Myllymaa, L. Kalevo, K. Myllymaa, J. Töyräs, T. Leppänen, and S. Kainulainen
Pubblicato in: IEEE Access, 2021, 9:132580-132591, 2021, ISSN 2169-3536
Editore: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/access.2021.3113049

World of <scp>ScoreCraft</scp>: Novel Multi‐Scorer Experiment on the Impact of a Decision Support System in Sleep Staging

Autori: Benedikt Holm, Arnar Óskarsson, Björn Elvar Þorleifsson, Hörður Þór Hafsteinsson, Sigríður Sigurðardóttir, Heiður Grétarsdóttir, Kenan Hoelke, Gabriel Marc Marie Jouan, Thomas Penzel, Erna Sif Arnardottir, María Óskarsdóttir
Pubblicato in: Journal of Sleep Research, 2025, ISSN 0962-1105
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jsr.70113

Does Obstructive Sleep Apnea Lead to Progression of Chronic Obstructive Pulmonary Disease

Autori: Walter T. McNicholas
Pubblicato in: Sleep Medicine Clinics, Numero 19, 2024, Pagina/e 253-260, ISSN 1556-407X
Editore: Elsevier BV
DOI: 10.1016/j.jsmc.2024.02.005

Self-Applied Electrode Set Provides a Clinically Feasible Solution Enabling EEG Recording in Home Sleep Apnea Testing

Autori: LAURA KALEVO, TOMI MIETTINEN, AKSELI LEINO, SUSANNA WESTEREN-PUNNONEN, JOHANNA SAHLMAN, ESA MERVAALA, JUHA TÖYRÄS, TIMO LEPPÄNEN, SAMI MYLLYMAA, KATJA MYLLYMAA
Pubblicato in: IEEE Access, Numero vol 10, 2022, Pagina/e 60633-60642, ISSN 2169-3536
Editore: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/access.2022.3178189

Deep Learning Enables Accurate Automatic Sleep Staging Based on Ambulatory Forehead EEG

Autori: Akseli Leino; Henri Korkalainen; Laura Kalevo; Sami Nikkonen; Samu Kainulainen; Alexander Ryan; Brett Duce; Kirsi Sipila; Jari Ahlberg; Johanna Sahlman; Tomi Miettinen; Susanna Westeren-Punnonen; Esa Mervaala; Juha Toyras; Sami Myllymaa; Timo Leppanen; Katja Myllymaa
Pubblicato in: IEEE Access, Numero Vol 10, 2022, Pagina/e 26554 - 26566, ISSN 2169-3536
Editore: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/access.2022.3154899

The Sleep Revolution Platform: a Dynamic Data Source Pipeline and Digital Platform Architecture for Complex Sleep Data

Autori: Bjarki Freyr Sveinbjarnarson; Lisa Schmitz; Erna Sif Arnardottir; Anna Sigridur Islind
Pubblicato in: Current Sleep Medicine Reports, 2023, ISSN 2198-6401
Editore: Springer Nature
DOI: 10.1007/s40675-023-00252-x

ABOSA – Freely available automatic blood oxygen saturation signal analysis software: Structure and validation

Autori: Tuomas Karhu, Timo Leppänen, Juha Töyräs, Arie Oksenberg, Sami Myllymaa, Sami Nikkonen
Pubblicato in: Computer Methods and Programs in Biomedicine, Numero vol 226, 2022, ISSN 2169-3536
Editore: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1016/j.cmpb.2022.107120

What are the important risk factors for excessive daytime sleepiness in a population‐based cohort?

Autori: Jenny Theorell‐Haglöw, Martin Ulander, John Brandberg, Martin Claesson, Karl A. Franklin, Jan Hedner, Magnus Hultin, Fredrik Iredahl, Eva Lindberg, Mirjam Ljunggren, Andrei Malinovschi, Maria Mannila, Ida Pesonen, Anthony Prakash, Carin Sahlin, Magnus Sköld, Jonas Spaak, Hanan Tanash, Ding Zou, Ludger Grote
Pubblicato in: Journal of Sleep Research, 2025, ISSN 0962-1105
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jsr.14449

Generalizable Deep Learning-based Sleep Staging Approach for Ambulatory Textile Electrode Headband Recordings

Autori: M. Rusanen, R. Huttunen, H. Korkalainen, S. Myllymaa, J. Töyräs, K. Myllymaa, S. Sigurdardottir, K. A. Olafsdottir, T. Leppänen, E. S. Arnardottir, S. Kainulainen
Pubblicato in: IEEE Journal of Biomedical and Health Informatics, 2023, ISSN 2169-3536
Editore: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/jbhi.2023.3240437

The effect of orofacial myofunctional therapy with autofeedback in patients with mild or moderate obstructive sleep apnea

Autori: A. Köster, H. Vaher, D. Dobran Hansen, U. Tinbod, H. Mäkinen, H. Hrubos-Strøm, T. Jagomägi
Pubblicato in: Sleep Medicine, Numero 115, 2024, Pagina/e S392, ISSN 1389-9457
Editore: Elsevier BV
DOI: 10.1016/j.sleep.2023.11.1056

Deep learning-based algorithm accurately classifies sleep stages in preadolescent children with sleep-disordered breathing symptoms and age-matched controls

Autori: Somaskandhan P, Leppänen T, Terrill PI, Sigurdardottir S, Arnardottir ES, Ólafsdóttir KA, Serwatko M, Sigurðardóttir SÞ, Clausen M, Töyräs J and Korkalainen H
Pubblicato in: Sleep Disorders, a section of the journal Frontiers in Neurology, 2023, ISSN 1664-2295
Editore: Frontiers Research Foundation
DOI: 10.3389/fneur.2023.1162998

The Role of Patient-Reported Outcomes in Sleep Measurements

Autori: Dirk Pevernagie, Fré A.Bauters, Katrien Hertegonne
Pubblicato in: Sleep Medicine Clinics, Numero vol 16 (4), 2021, Pagina/e 595-606, ISSN 1556-407X
Editore: Elsevier BV
DOI: 10.1016/j.jsmc.2021.07.001

Effects of Exercise and a Lifestyle App on Sleep-Disordered Breathing, Physical Health, and quality of Life

Autori: Katrin Y. Fridgeirsdottir, Conor J. Murphy, Anna Sigridur Islind, Birta S. Árnadóttir, Harald Hrubos-Strøm, Erna S. Arnardottir, Jose M. Saavedra
Pubblicato in: ERJ Open Research, 2025, Pagina/e 01134-2024, ISSN 2312-0541
Editore: European Respiratory Society (ERS)
DOI: 10.1183/23120541.01134-2024

The Future of Sleep Measurements: A Review and Perspective.

Autori: Erna Sif Arnardottir; Anna Sigridur Islind; María Óskarsdóttir
Pubblicato in: Sleep Medicine Clinics, Numero 16 (3), 2021, Pagina/e 447-464, ISSN 1556-407X
Editore: Elsevier BV
DOI: 10.1016/j.jsmc.2021.05.004

QTc prolongation is associated with severe desaturations in stroke patients with sleep apnea

Autori: S. Sillanmäki, J. Lipponen, H. Korkalainen, A. Kulkas, T. Leppänen, J. Töyräs, B. Duce, S. Kainulainen
Pubblicato in: BMC Pulmonary Medicine volume 22, Article number: 204 (2022), 2022, ISSN 1471-2466
Editore: BioMed Central
DOI: 10.1186/s12890-022-01996-y

A Fully Replicable Exercise Program for Individuals with Sleep-Disordered Breathing: Protocol Design and Training Load Monitoring

Autori: Jose M. Saavedra, Katrin Y. Fridgeirsdottir, Conor J. Murphy, Harald Hrubos-Strøm, Erna S. Arnardottir
Pubblicato in: Journal of Functional Morphology and Kinesiology, Numero 10, 2025, Pagina/e 311, ISSN 2411-5142
Editore: MDPI AG
DOI: 10.3390/jfmk10030311

Error Propagation from Sleep Stage Classification to Derived Sleep Parameters in Machine Learning on Data from Wearables

Autori: Emil Hardarson; Anna Sigridur Islind; Erna Sif Arnardottir; María Óskarsdóttir
Pubblicato in: Current Sleep Medicine Reports, Numero 2, 2023, ISSN 2198-6401
Editore: Springer Nature
DOI: 10.1007/s40675-023-00253-w

Multi-centre arousal scoring agreement in the Sleep Revolution

Autori: Pitkänen, H., Nikkonen, S., Rissanen,M., Islind, A. S., Gretarsdottir, H., Arnardottir, E. S., Leppänen,T., & Korkalainen, H.
Pubblicato in: Journal of Sleep Research, 2023, ISSN 0962-1105
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jsr.14127

Beyond the apnea–hypopnea index: alternative diagnostic parameters and machine learning solutions for estimation of sleep apnea severity

Autori: T. Leppänen, S. Myllymaa, A. Kulkas, and J. Töyräs
Pubblicato in: Sleep, Volume 44, Numero 9, September 2021, zsab134,, 2021, ISSN 0161-8105
Editore: The American Academy of Sleep Medicine
DOI: 10.1093/sleep/zsab134

Nocturnal short-term heart rate variability reflects impaired daytime vigilance better than overnight heart rate variability in suspected obstructive sleep apnea patients

Autori: Salla Hietakoste, Tuomas Karhu, Carolina Lombardi, Pablo Armañac-Julián, Raquel Bailón, Brett Duce, Saara Sillanmäki, Juha Töyräs, Timo Leppänen, Sami Myllymaa, Samu Kainulainen
Pubblicato in: SLEEP, Numero 48, 2025, ISSN 0161-8105
Editore: The American Academy of Sleep Medicine
DOI: 10.1093/sleep/zsae282

An optimized framework for processing multicentric polysomnographic data incorporating expert human oversight

Autori: Benedikt Holm, Gabriel Jouan, Emil Hardarson, Sigríður Sigurðardottir, Kenan Hoelke, Conor Murphy, Erna Sif Arnardóttir, María Óskarsdóttir, Anna Sigríður Islind
Pubblicato in: Frontiers in Neuroinformatics, Numero 18, 2024, ISSN 1662-5196
Editore: Frontiers Research Foundation
DOI: 10.3389/fninf.2024.1379932

Deep learning for sleep analysis on children with sleep-disordered breathing: Automatic detection of mouth breathing events.

Autori: Sturludóttir Jóna Elísabet, Sigurðardóttir Sigríður, Serwatko Marta, Arnardóttir Erna S., Hrubos-Strøm Harald, Clausen Michael Valur, Sigurðardóttir Sigurveig, Óskarsdóttir María, Islind Anna Sigridur
Pubblicato in: Frontiers in Sleep, Numero Vol 2, 2023, ISSN 2813-2890
Editore: Frontiers Media SA
DOI: 10.3389/frsle.2023.1082996

The influence of diabetes on sleep-derived cardiorespiratory features of the finger pulse wave signal – The population-based SCAPIS study

Autori: Christian Strassberger, Jan Hedner, Dirk Sommermeyer, Ding Zou, Ludger Grote
Pubblicato in: Sleep Medicine, Numero 122, 2024, Pagina/e 245-252, ISSN 1389-9457
Editore: Elsevier BV
DOI: 10.1016/j.sleep.2024.08.016

Explaining cognitive complaints in obstructive sleep apnea (OSA) with OSA severity, depression symptoms, and sleep architecture: a path model analysis

Autori: B. Gailer; E. Richert; E.S. Arnardóttir; K.R. Jóhannsdóttir
Pubblicato in: Neuroscience Applied, Numero 1, 2023, ISSN 2772-4085
Editore: Amsterdam Elsevier B.V.
DOI: 10.1016/j.nsa.2023.103833

Feasibility and usability of three consecutive nights with self‐applied, home polysomnography

Autori: Dimitri Ferretti, Anna S. Islind, Kristín A. Ólafsdóttir, Sigridur Sigurdardottir, Kamilla R. Jóhannsdóttir, Jan Hedner, Ludger Grote, Erna Sif Arnardottir
Pubblicato in: Journal of Sleep Research, Numero 34, 2025, ISSN 0962-1105
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jsr.14286

A-phase index: an alternative view for sleep stability analysis based on automatic detection of the A-phases from the cyclic alternating pattern

Autori: Fábio Mendonça, Sheikh Shanawaz Mostafa, Ankit Gupta, Erna Sif Arnardottir, Timo Leppänen, Fernando Morgado-Dias, Antonio G Ravelo-García
Pubblicato in: Sleep, 2022;, zsac217, 2022, ISSN 0161-8105
Editore: The American Academy of Sleep Medicine
DOI: 10.1093/sleep/zsac217

Driving restrictions in patients with obstructive sleep apnoea: who, how and are they effective?

Autori: Walter T. McNicholas
Pubblicato in: ERJ Open Research, Numero 10, 2025, Pagina/e 00634-2024, ISSN 2312-0541
Editore: European Respiratory Society (ERS)
DOI: 10.1183/23120541.00634-2024

Verbal memory is linked to average oxygen saturation during sleep, not the apnea-hypopnea index nor novel hypoxic load variables

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The economic cost of obstructive sleep apnea: A systematic review

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Sleep stage continuity is associated with objective daytime sleepiness in patients with suspected obstructive sleep apnea

Autori: Xin Chen, Timo Leppänen, Samu Kainulainen, Timothy P. Howarth, Arie Oksenberg, Juha Töyräs, Philip I. Terrill, Henri Korkalainen
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Gamma Power of ElectroencephalogramArousal Is Modulated by Respiratory EventType and Severity in Obstructive Sleep Apnea

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Respiratory event index underestimates severity of sleep apnea compared to apnea-hypopnea index

Autori: Minna Pitkänen, Rajdeep Kumar Nath, Henri Korkalainen, Sami Nikkonen, Alaa Mahamid, Arie Oksenberg, Brett Duce, Juha Töyräs, Samu Kainulainen, Timo Leppänen
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Hypoxic Load and Average Oxygen‐Saturation During Sleep and Wake Are Associated With Cognitive Function in Obstructive Sleep Apnea

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Variation in the Photoplethysmogram Response to Arousal From Sleep Depending on the Cause of Arousal and the Presence of Desaturation

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Reaction time in psychomotor vigilance task is related to hypoxic load in males with sleep apnea

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Translation of obstructive sleep apnea pathophysiology and phenotypes to personalized treatment: a narrative review

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Utilizing Envelope Analysis of a Nasal Pressure Signal for Sleep Apnea Severity Estimation

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Morbid obesity influences the nocturnal electrocardiogram wave and interval durations among suspected sleep apnea patients

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The Sleep Revolution: the concept and objectives

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Oxygen resaturation rate is significantly associated with objectively assessed excessive daytime sleepiness in suspected obstructive sleep apnoea patients

Autori: Timothy P. Howarth; Tuomas Karhu; Samu Kainulainen; Xin Chen; Alaa Mahamid; Juha Töyräs; Timo Leppänen
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Duration of respiratory events in obstructive sleep apnea: Factors influencing the duration of respiratory events

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Search filters for systematic reviews and meta-analyses in sleep medicine

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BreathFinder: A Method for Non-Invasive Isolation of Respiratory Cycles Utilizing the Thoracic Respiratory Inductance Plethysmography Signal

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Implementation of European National Driving Regulations for Obstructive Sleep Apnoea: challenges and recommendations

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Guidelines for the development, performance evaluation and validation of new sleep technologies (DEVSleepTech guidelines) - a protocol for a Delphi consensus study

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Inter-sleep stage variations in corrected QT interval differ between obstructive sleep apnea patients with and without stroke history

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Ambulatory diagnosis of sleep-disordered breathing: Pushing out the boundaries

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Increased Flow Limitation During Sleep Is Associated With Increased Psychomotor Vigilance Task Lapses in Individuals With Suspected OSA

Autori: Eric Staykov, Dwayne L. Mann, Brett Duce, Samu Kainulainen, Timo Leppänen, Juha Töyräs, Ali Azarbarzin, Thomas Georgeson, Scott A. Sands, Philip I. Terrill,
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STAR sleep recording export software for automatic export and anonymization of sleep studies

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CPAP therapy for obstructive sleep apnoea: persisting challenges in outcome assessment

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Temporal and sleep stage‐dependent agreement in manual scoring of respiratory events

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Unsupervised Machine Learning in Sleep Research: A Scoping Review

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Multi-Level Classification of Driver Drowsiness by Simultaneous Analysis of ECG and Respiration Signals Using Deep Neural Networks

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Automatic Detection of Electrodermal Activity Events during Sleep

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Self-Applied Home Sleep Recordings: The Future of Sleep Medicine

Autori: Henri Korkalainen, Sami Nikkonen, Samu Kainulainen, Amit Krishna Dwivedi, Sami Myllymaa, Timo Leppänen, Juha Töyräs
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Objective Measures of Cognitive Performance in Sleep Disorder Research.

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Novel oxygen desaturation parameters are associated with cardiac troponin I: Data from the Akershus Sleep Apnea Project

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Advancements in vigilance monitoring: addressing fatigue and sleepiness in driving

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Obstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac response

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Self-applied somnography: technical feasibility of electroencephalography and electro-oculography signal characteristics in sleep staging of suspected sleep-disordered adults

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Automatic Non-Invasive Isolation of Respiratory Cycles

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Beat-to-beat cardiac repolarization lability increases during hypoxemia and arousals in obstructive sleep apnea patients

Autori: Serajeddin Ebrahimian, Saara Sillanmäki, Salla Hietakoste, Antti Kulkas, Juha Töyräs, Raquel Bailón, David Hernando, Carolina Lombardi, Ludger Grote, Maria R. Bonsignore, Tarja Saaresranta, Jean-Louis Pépin, Timo Leppänen, Samu Kainulainen
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The relationship between sleep parameters and symptoms of depression, anxiety, and stress in sleep-disordered breathing

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Using the Electrodermal Activity Signal and Machine Learning for Diagnosing Sleep

Autori: Jacopo Piccini, Elias August, María Óskarsdóttir, Erna Sif Arnardóttir
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A Comparison of Signal Combinations for Deep Learning-Based Simultaneous Sleep Staging and Respiratory Event Detection

Autori: Riku Huttunen, Timo Leppanen, Brett Duce, Erna S Arnardottir, Sami Nikkonen, Sami Myllymaa, Juha Toyras, Henri Korkalainen
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Sufficient Stability Conditions for a Class of Switched Systems With Multiple Steady States

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Orofacial Myofunctional Therapy for Patients with Obstructive Sleep Apnea—A Mixed Methods Study of Facilitators and Barriers to Treatment Adherence

Autori: Diana Dobran Hansen, Unn Tinbod, Xin Feng, Toril Dammen, Harald Hrubos-Strøm, Helge Skirbekk
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A comparative analysis of unsupervised machine‐learning methods in <scp>PSG</scp>‐related phenotyping

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Review and perspective on sleep-disordered breathing research and translation to clinics

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Consumer sleep technology for the screening of obstructive sleep apnea and snoring: current status and a protocol for a systematic review and meta-analysis of diagnostic test accuracy

Autori: Gabriel Natan Pires, Erna Sif Arnardóttir, Anna Sigridur Islind, Timo Leppänen, Walter T. McNicholas
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Toward Sleep Study Automation: Detection Evaluation of Respiratory-Related Events

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Desaturation event scoring criteria affect the perceived severity ofnocturnal hypoxic load

Autori: Tuomas Karhu, Timo Leppänen, Henri Korkalainen, Sami Myllymaa, Brett Duce, Juha Töyräs, Sami Nikkonen
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Editore: Elsevier BV
DOI: 10.1016/j.sleep.2022.09.024

Duration of respiratory events in obstructive sleep apnea: In search of paradoxical results

Two Sides of the Same Pillow: Unfolding the Relationship between Objective and Subjective Sleep Quality with Unsupervised Learning.

Autori: Biedebach, L., Islind, A.S., Óskarsdóttir, M., Arnardóttir, E.S.
Pubblicato in: 2023
Editore: International Conference of Information Systems (ICIS)

Towards a Deeper Understanding of Sleep Stages through their Representation in the Latent Space of Variational Autoencoders

Autori: Biedebach L, Rusanen M, Þórðarson B. Þ, Arnardóttir ES, Óskarsdóttir M, Nikkonen S, Korkalainen H, Myllymaa S, Töyräs J, Kainulainen S, Leppänen T and Islind AS
Pubblicato in: Proceedings of the 56th Hawaii International Conference on System Sciences 2023 (HICSS), 2023
Editore: HICSS

The impact of sleep architecture on visuospatial working memory in OSA

Autori: Elena Richert, Erna S Arnardottir, Kamilla Johannsdottir
Pubblicato in: Nordic Sleep Conference 2023, 2023
Editore: https://www.nordic-sleep.com/
DOI: 10.13140/rg.2.2.33963.41764

Designing and Developing Layered-Modular Architecture for Data-driven Health Platform

Autori: Sveinbjarnarson, B.F., Islind, A.S., Arnardóttir, E.S.
Pubblicato in: 2023
Editore: Italian Conference of Information Systems (itAIS)

Pharmacotherapeutic profile of sleep apnea patients

Autori: Stefan Mihaicuta, Mihai Udrescu, Adrian Militaru, Alexandru Topirceanu, Lucretia Udrescu
Pubblicato in: Clinical and epidemiological respiratory sleep medicine, Numero Journal 2023 62(suppl 67), 2025, Pagina/e PA3003
Editore: European Respiratory Society
DOI: 10.1183/13993003.congress-2023.pa3003

Human-AI Collaboration: From Explainable AI to Co-Creating Meaning

Autori: Hardarson, Emil & Ivarsson, Frida & Islind, Anna & Arnardottir, Erna & Óskarsdóttir, María & Islind, Anna
Pubblicato in: Australasian Conference on Information Systems, 2024
Editore: Australasian Conference on Information Systems 2024

Exploration of Sleep Events in the Latent Space of Variational Autoencoders on a Breath-by-Breath Basis.

Autori: Holm, B., Islind, A.S., Arnardóttir, E.S., Óskarsdóttir, M.
Pubblicato in: 2023
Editore: Proceedings of the 56th Hawaii International Conference on System Sciences

NUDGING WI NUDGING WITH DIGNI TH DIGNITY: A CRI Y: A CRITICAL EXAMIN TICAL EXAMINATION OF WHEN TION OF WHENAND HOW TO USE DIGITAL NUDGING

Autori: Lisa Schmitz Elena Richert Marta K. Lárusdóttir Erna Sif Arnardottir Anna Sigríður Islind
Pubblicato in: 15th Scandinavian Conference on Information Systems, 2024
Editore: IRIS (Information Systems Research in Scandinavia)

Application of the Schur Complement in Sum of Squares Optimisation

Autori: Elias August, Sigurdur Hafstein, Jacopo Piccini, Stefania Andersen, Anna Bavarsad
Pubblicato in: Proceedings of the 21st International Conference on Informatics in Control, Automation and Robotics, 2024, Pagina/e 424-431, ISBN 978-989-758-717-7
Editore: SCITEPRESS - Science and Technology Publications
DOI: 10.5220/0013016200003822

Towards a Digital Sleep Diary Standard.

Autori: Schmitz, L., Sveinbjarnarson, B. F., Gunnarsson, G. N., Davíðsson, Ó. A., Davíðsson, Þ. B., Arnardottir, E. S, Óskarsdóttir, M. & Islind, A. S.
Pubblicato in: Americas Conference on Information Systems (AMCIS), Minneapolis, USA, August 2022, 2022
Editore: Americas Conference on Information Systems (AMCIS)

Worsening hypoxic load impairs cardiorespiratory coupling

Autori: Salla Hietakoste, Pablo Armañac-Julián, Tuomas Karhu, Raquel Bailón, Saara Sillanmäki, Juha Töyräs, Timo Leppänen, Sami Myllymaa, Samu Kainulainen
Pubblicato in: 2024 13th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO), 2024, Pagina/e 1-2
Editore: IEEE
DOI: 10.1109/esgco63003.2024.10767029

Lyapunov Function Computation for Linear Switched Systems: Comparison of SDP and LP Approaches

Autori: Stefania Andersen, Elias August, Sigurdur Hafstein, Jacopo Piccini
Pubblicato in: Proceedings of the 13th International Conference on Simulation and Modeling Methodologies, Technologies and Applications, 2023, Pagina/e 61-70, ISBN 978-989-758-668-2
Editore: SCITEPRESS - Science and Technology Publications
DOI: 10.5220/0012084100003546

Detailed characterization of hypoxemia events enhances assessment of obstructive sleep apnea severity: Association of hypoxic load with impaired vigilance and lung-to-finger circulation time

Autori: Pahari, Purbanka
Pubblicato in: Numero 17, 2025, ISBN 978-952-61-5383-4
Editore: Itä-Suomen yliopisto | University of Eastern Finland

Enhanced home sleep apnea testing with a patient-applied EEG electrode set

Autori: Kalevo, Laura
Pubblicato in: Numero 17, 2022, ISBN 978-952-61-4674-4
Editore: Itä-Suomen yliopisto | University of Eastern Finland

Nocturnal hypoxic load in the evaluation of the progression of sleep apnea

Autori: Karhu, Tuomas
Pubblicato in: Numero 17, 2023, ISBN 978-952-61-4936-3
Editore: Itä-Suomen yliopisto | University of Eastern Finland

New Pathways for Unsupervised Machine Learning in Digital Health: Applications and Future Potentials for Sleep

Autori: Luka Biedebach
Pubblicato in: 2025
Editore: Reykjavik University

Self-applied electroencephalography sensor techniques for home-based sleep recordings

Autori: Rusanen, Matias
Pubblicato in: Numero 2, 2024, ISBN 978-952-61-5089-5
Editore: Itä-Suomen yliopisto | University of Eastern Finland

Design and Development of Digital Health Platforms

Autori: Lisa Schmitz
Pubblicato in: 2024
Editore: Reykjavik University

Nocturnal heart rate variability in obstructive sleep apnea: Novel digital biomarker for acutely increased cardiac workload

Autori: Hietakoste, Salla
Pubblicato in: Numero 20, 2024, ISBN 978-952-61-4936-3
Editore: Itä-Suomen yliopisto | University of Eastern Finland

The Role of Physical Activity and Exercise in Sleep-Disordered Breathing

Autori: Katrin Yr Fridgeirsdottir
Pubblicato in: 2025, ISBN 978-9935-539-95-3
Editore: Reykjavik University

Model-Based Electrodermal Activity Sleep EventsDetection Algorithm

Autori: Jacopo Piccini
Pubblicato in: 2025
Editore: Reykjavik University

Bridging Human and Artificial Intelligence: MachineLearning, Data Platforms, and Decision SupportSystems in Sleep Research

Autori: Benedikt Holm
Pubblicato in: 2025
Editore: Reykjavik University

Cardiopulmonary Phenotyping during Sleep - Innovative Signal Processing for Precision Medicine in Sleep Apnea

Autori: Strassberger, Christian
Pubblicato in: 2025, ISBN 978-91-8115-015-5
Editore: University of Gothenburg

Scaling Data Governance Through Automation andDynamic Data Spaces

Autori: Bjarki Freyr Sveinbjarnarson
Pubblicato in: 2025
Editore: Reykjavik University

Novel computational methods for improved sleep apnea diagnostics: special focus on stroke patients

Autori: Leino, Akseli
Pubblicato in: Numero 17, 2022, ISBN 978-952-61-4698-0
Editore: Itä-Suomen yliopisto | University of Eastern Finland

Numerical Computations of Lyapunov Functions for Switched Linear Systems

Autori: Stefania Andersen, Elias August, Sigurdur Hafstein, Jacopo Piccini
Pubblicato in: Lecture Notes in Networks and Systems, Simulation and Modeling Methodologies, Technologies and Applications, 2024, Pagina/e 192-213, ISBN 978-3-031-77603-8
Editore: Springer Nature Switzerland
DOI: 10.1007/978-3-031-77603-8_10

Pulse Oximetry: The Working Principle, Signal Formation, and Applications

Autori: T. Leppänen, S. Kainulainen, H. Korkalainen, S. Sillanmäki, A. Kulkas, J. Töyräs, S. Nikkonen
Pubblicato in: Advances in Experimental Medicine and Biology book series (AEMB,volume 1384), 2022, ISBN 978-3-031-06413-5
Editore: Springer, Cham
DOI: 10.1007/978-3-031-06413-5_12

Poster sessions

Autori: Gabriel Pires, Erna S. Arnardottir, Jose Miguel Saavedra, Sergio Tufik1, Walter McNicholas
Pubblicato in: Journal of Sleep Research, Numero 33, 2024, Pagina/e Poster 583 and poster 817, ISSN 0962-1105
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jsr.14291

The Sleep Revolution – a model for other disease assessment and follow-up

Autori: E. S. Arnardóttir
Pubblicato in: European Psychiatry, Numero 68, 2025, Pagina/e S12-S12, ISSN 0924-9338
Editore: Elsevier Masson
DOI: 10.1192/j.eurpsy.2025.80

aSAGA: Automatic Sleep Analysis with Gray Areas

Autori: Rusanen, Matias; Jouan, Gabriel; Huttunen, Riku; Nikkonen, Sami; Sigurðardóttir, Sigríður; Töyräs, Juha; Duce, Brett; Myllymaa, Sami; Arnardottir, Erna Sif; Leppänen, Timo; Islind, Anna Sigridur; Kainulainen, Samu; Korkalainen, Henri
Pubblicato in: Numero 15, 2023
Editore: Cornell University
DOI: 10.48550/arxiv.2310.02032

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