Obiettivo Proliferation is one of the physiological processes regulated by cAMP. The cAMP action mechanism involved variations in gene expression. CREM gene is one of cAMP effectors at nuclear level that has been discovered in the last years. Evidence have been accumulated that indicate a possible role of CREM in regulation of cell proliferation. In particular it is significant that CREM proteins regulate protooncogene c-fos and cyclin A gene expression, and their function is controlled by important cell cycle regulators such as p70S6 kinase and the antioncogene p53. The research project proposed aims at improving the actual knowledge on transcription factor CREM and specifically on his role in the regulation of cellular proliferation and transformation. The approach consists in a series of different experiments to test directly CREM transforming properties and its antioncogene ability, through increased expression or specific elimination of different CREM proteins both in vitro and in vivo. Campo scientifico natural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programma(i) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Argomento(i) 0302 - Post-doctoral research training grants TL05 - Cell Biology Invito a presentare proposte Data not available Meccanismo di finanziamento RGI - Research grants (individual fellowships) Coordinatore Centre National de la Recherche Scientifique Contributo UE Nessun dato Indirizzo 1,Rue Laurent Fries 1 67404 Illkirch Francia Mostra sulla mappa Costo totale Nessun dato Partecipanti (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto Not available Italia Contributo UE Nessun dato Indirizzo Mostra sulla mappa Costo totale Nessun dato
