Risultati finali
The second technique investigated for the deposition of dendrimers coatings is the Langmuir-Blodgett process. This technique offers the advantage of depositing one layer per time with smooth properties and by means of a simple procedure.
Moreover the deposited layers are inherently compatible with an aqueous environment, facilitating the bio-compatibility of eventual bio-medical applications.
One potential barrier for the dissemination of this technique is represented by the low grade of adhesion between adjacent layers when compared to other techniques.
The main goal of the project is represented by the development of macromolecules based multi-layers to be used as coatings for bio-medical materials.
Several different types of dendrimer macromolecules were synthesised to verify their suitability as bio-compatible coatings.
The synthesized molecules present two very interesting characteristics that open the way to different potential applications in the bio-medical and pharmaceutical sectors:
- The first and most interesting characteristic is represented by the possibility to functionalise the outer surface of the macromolecules with ad hoc chosen terminations; this is particularly appealing for bio-compatible coatings, in which a compatibility between prostheses and external environment must be established in order to avoid rejection;
- The second characteristic is represented by the presence of large voids inside the macromolecules volume, that could be positively exploited in applications such as drugs delivery and drugs release.
Further R&D work is needed to fully understand the potentiality of these macromolecules for the bio-medical and pharmaceutical sectors.
One of the investigated techniques for the deposition of dendrimers multi-layers is a single layer-by-layer deposition in which subsequent layers are kept sticked to the inner ones by means of electrostatic forces.
The strong interaction between adjacent layers, obtained by means of a tailored architecture of the layers, results in an excellent adhesion of the multi-layer coating to the substrate. A good adhesion between substrate and coating is fundamental for the utilisation of coated materials in applications in which frictions and stresses are present.
Various flat substrates were investigated, with different multi-layer combinations deposited on them. In particular, good adhesion properties were verified with stainless steel, silicon and plastic substrates.
Further R&D investigation is needed to verify the adhesion properties on odd-shaped substrates.
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