Obiettivo This proposal is related to zoometric coetaneous leishmaniasis (ZCL) which remains a serious unresolved public health problem worldwide. The project consists to refine the validity of classical (leishmanin skin test) and new (antibodies to sand flysaliva, cytotoxic Tcell response) parameters for a better understanding of thepathogenesis of L. major infection and to develop mathematical models for the prediction of the dynamics of infection and the outcome of control measures. The study design consists of a prospective population study of individuals living into different ZCL foci. The effect of host-related factors on the clinical expression of the infection will be assessed considering environmental factors. This will permit a better knowledge of key parameters governing dynamics of infection and will prepare the ground for better evaluation of anti-leishmanialdrugs and vaccines. Campo scientifico medical and health scienceshealth sciencespublic healthmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesmathematicsapplied mathematicsmathematical model Programma(i) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Argomento(i) Data not available Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE Contributo UE Nessun dato Indirizzo Campus at Silwood Park, Road A329 (Virginia Water SW7 2AZ LONDON Regno Unito Mostra sulla mappa Costo totale Nessun dato Partecipanti (3) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM Paesi Bassi Contributo UE Nessun dato Indirizzo Meibergdreef 9, Academisch Medisch Centrum 1105 AZ AMSTERDAM Mostra sulla mappa Costo totale Nessun dato INSTITUT PASTEUR DE TUNIS Tunisia Contributo UE Nessun dato Indirizzo Place Pasteur 13 1002 TUNIS Mostra sulla mappa Costo totale Nessun dato MINISTRY OF HEALTH OF JORDAN Giordania Contributo UE Nessun dato Indirizzo Khalid Bin Al-Walid AMMAN Mostra sulla mappa Costo totale Nessun dato