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Contenuto archiviato il 2022-12-23

Applications of new complexes of platinum group metals (Rh,Ru,Ir) as potential catalyst precursors for stereo- and enantioselective organic reactions

Obiettivo



Platinum group metals are essential to the world economy. Most of them are produced in the NIS and used all over the world mainly as catalysts for key processes in the chemical and pharmaceutical industries. Platinum group metals are so important today that the development of a new chemical or pharmaceutical process often requires the development of a new catalyst.

This joint research programme is devoted to the chemistry of the platinum group metals with the aim of developing new catalysts for fine organic synthesis. In the last few years, the demand for selective organic reactions has grown rapidly, and particularly the demand for enantiomerically pure compounds. The main reason for this development is that many pharmaceutical and chemical compounds have (or will have) to be available in an optically active form.

The participating groups in this project have an unquestionable complementary know-how in the synthesis of transition-metal complexes (especially of metal-carbene and metal-carborane complexes) and in their application in organic catalysis. The catalysts they have introduced into carbene chemistry (e.g. for olefin cyclopropanation and olefin metathesis) and for the activation of terminal alkynes have been considered a breakthrough and have led to numerous applications in fine organic synthesis.

The main purpose of this project goes along these lines but with special emphasis directed towards asymmetric catalysis : the design of novel complexes of platinum group metals (Rh, Ru, and Ir) associated with a variety of optically active ligands (carboxylates, carboxamides, phosphines, isolobal p-dicarbollyl and p-cyclopentadienyl ligands) and their application as homogeneous catalysts or catalyst precursors for stereo- and enantioselective organic reactions. Among these, hydrogenation and especially hydrosilylation, hydroformylation and cyclopropanation are of utmost importance in organic synthesis and have not yet found satisfactory solutions. In metathesis reactions, emphasis will be laid essentially on functionalized olefins with the final goal of synthesizing optically active polymers or copolymers.

Programma(i)

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Meccanismo di finanziamento

Meccanismo di finanziamento (o «Tipo di azione») all’interno di un programma con caratteristiche comuni. Specifica: l’ambito di ciò che viene finanziato; il tasso di rimborso; i criteri di valutazione specifici per qualificarsi per il finanziamento; l’uso di forme semplificate di costi come gli importi forfettari.

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Coordinatore

Université de Liège
Contributo UE
Nessun dato
Indirizzo
Sart-Tilmant B.6
4000 Liège
Belgio

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Costo totale

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Partecipanti (4)

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