Control of secretion in neurons and neuronendocrine cells

Projektinformationen

ID Finanzhilfevereinbarung: INTAS-94-2953

Projekt abgeschlossen

Startdatum 1 Juni 1995

Enddatum 31 Mai 1997

Finanziert unter

• International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993-

Gesamtkosten

Keine Daten

EU-Beitrag

€ 45 000,00

Koordiniert durch

Max-Planck Gesellschaft zur Förderung der Wissenschaften eV
Germany

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Verwertbare Ergebnisse

Control of secretion in neurons and neuroendocrine cells

Biophysical and biochemical methods were used to study exocytosis and secretion by neurons and neuroendocrine cells at the level of living, single cells. Patch clamp and conventional microelectrode recording were used to study the activity of calcium channels controlling the release of neurotransmitter. The cytosolic changes in calcium (2+) concentrations accompanying neuronal excitation were measured by microfluorimetry. Electrophysiologic recording from the postsynaptic cell, and electrochemical recording with carbon microfibres reported the release of neurotransmitter. Biochemical measurements on a latrotoxin-like protein were aimed at elucidating the mechanism of membrane fusion.