Control of secretion in neurons and neuronendocrine cells

Informazioni relative al progetto

ID dell’accordo di sovvenzione: INTAS-94-2953

Progetto chiuso

Data di avvio 1 Giugno 1995

Data di completamento 31 Maggio 1997

Finanziato da

• International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993-

Costo totale

Nessun dato

Contributo UE

€ 45 000,00

Coordinato da

Max-Planck Gesellschaft zur Förderung der Wissenschaften eV
Germany

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Risultati sfruttabili

Control of secretion in neurons and neuroendocrine cells

Biophysical and biochemical methods were used to study exocytosis and secretion by neurons and neuroendocrine cells at the level of living, single cells. Patch clamp and conventional microelectrode recording were used to study the activity of calcium channels controlling the release of neurotransmitter. The cytosolic changes in calcium (2+) concentrations accompanying neuronal excitation were measured by microfluorimetry. Electrophysiologic recording from the postsynaptic cell, and electrochemical recording with carbon microfibres reported the release of neurotransmitter. Biochemical measurements on a latrotoxin-like protein were aimed at elucidating the mechanism of membrane fusion.