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Quality of skin as a barrier to ultra-fine particles

Ziel

Today' s population is increasingly exposed to ultrafine particles (<20 nm; e.g. Aerosil, TiO2) contained in body care and household products. Tape stripping studies and recent ion microscopy pilot studies revealed that such particles in, liposomal formulations penetrate the horny layer with large concentrations at the stratum granulosum and the possible risk of further penetration into vital tissue, especially for skin with an impaired barrier function. Here, apart from electron microscopy, high-resolution ion-microscopy techniques will be employed on skin cross-sections from biopsies (pig, human), which yield elemental maps of both the epidermis and dermis with ppm sensitivity for Ti or higher sensitivity with radiotracers (labelled TiO2) on pig skin. Pathways for percutaneous uptake and clearance will be studied. If such particles penetrate into the dermis, in-situ studies of tissue and in-vitro studies of particle-cell interactions follows.

Koordinator

UNIVERSITAET LEIPZIG
Adresse
Linnestrasse 5
04103 Leipzig
Deutschland

Beteiligte (6)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Frankreich
Adresse
Rue Michel Ange 3
75794 Paris
INSTITUTO TECNOLOGICO E NUCLEAR
Portugal
Adresse
Estrada Nacional 10
2686-953 Sacavem
JAGIELLONIAN UNIVERSITY
Polen
Adresse
St..anna's Street 8
31 008 Krakow
THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLEAR PHYSICS
Polen
Adresse
152,Radzikowskiego 152
31 342 Krakow
UNIVERSITE DE BORDEAUX I
Frankreich
Adresse
Cours De La Libération 351
33405 Talence
UNIVERSITY OF DEBRECEN
Ungarn
Adresse
Nagyerdei Krt. 98
4012 Debrecen